Immunological axis of curcumin-loaded vesicular drug delivery systems

Chellappan DK 1 , Ng ZY 1 , Wong JY 1 , Hsu A 2 , Wark P 2 , Hansbro N 3 Show all authors , Taylor J 4 , Panneerselvam J 1 , Madheswaran T 1 , Gupta G 5 , Bebawy M 4 , Hansbro PM 3 , Dua K 3

Affiliations 

  • 1 School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
  • 2 School of Medicine & Public Health, The University of Newcastle, Newcastle, NSW 2308, Australia
  • 3 School of Biomedical Sciences & Pharmacy, University of Newcastle, Newcastle, NSW 2308, Australia
  • 4 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia
  • 5 School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, Rajasthan 302017, India
Future Med Chem, 2018 04 01;10(8):839-844.
PMID: 29620416 DOI: 10.4155/fmc-2017-0245

Abstract

Several vesicular systems loaded with curcumin have found their way in the therapeutic applications of several diseases, primarily acting through their immunological pathways. Such systems use particles at a nanoscale range, bringing about their intended use through a range of complex mechanisms. Apart from delivering drug substances into target tissues, these vesicular systems also effectively overcome problems like insolubility and unequal drug distribution. Several mechanisms are explored lately by different workers, and interest over vesicular curcumin has been renewed in the past decade. This commentary discusses several immunological targets in which curcumin is employed in a vesicular form.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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