Affiliations 

  • 1 *Department of Paediatrics, University of Malaya Medical Centre †University of Malaya Cancer Research Institute, University of Malaya, Kuala Lumpur ‡Department of Paediatrics, Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia
J Pediatr Hematol Oncol, 2015 Jul;37(5):391-5.
PMID: 25929614 DOI: 10.1097/MPH.0000000000000344

Abstract

Review of the management of 6 young girls with vaginal yolk sac tumor over 25 years showed that the α-fetoprotein levels normalized in 5/6 within 4 cycles of primary cisplatin, bleomycin, etoposide (PEB)/carboplatin, etoposide, bleomycin (JEB)/cisplatin, vinblastine, bleomycin (PVB) chemotherapy. Radioimaging revealed residual tissue but viable tumor was found in only 1 of 2 biopsied. Resection/biopsy is necessary to avoid giving additional primary chemotherapy or to identify patients who need different treatment. If markers do not decay appropriately, PEB/JEB/PVB chemotherapy should not be continued. Taxol-containing salvage chemotherapy regimens, adjuvant modern radiotherapeutic treatment, and fertility-saving curative surgery should then be considered. Despite having mostly advanced disease, 5/6 patients were cured, 2 with chemotherapy alone.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.