Fulltext

A prospective evaluation of plasma polyphenol levels and colon cancer risk

Murphy N 1 , Achaintre D 1 , Zamora-Ros R 2 , Jenab M 1 , Boutron-Ruault MC 3 , Carbonnel F 3 Show all authors , Savoye I 3 , Kaaks R 4 , Kühn T 4 , Boeing H 5 , Aleksandrova K 6 , Tjønneland A 7 , Kyrø C 7 , Overvad K 8 , Quirós JR 9 , Sánchez MJ 10 , Altzibar JM 11 , María Huerta J 11 , Barricarte A 11 , Khaw KT 12 , Bradbury KE 13 , Perez-Cornago A 13 , Trichopoulou A 14 , Karakatsani A 14 , Peppa E 14 , Palli D 15 , Grioni S 16 , Tumino R 17 , Sacerdote C 18 , Panico S 19 , Bueno-de-Mesquita HBA 20 , Peeters PH 21 , Rutegård M 22 , Johansson I 23 , Freisling H 1 , Noh H 1 , Cross AJ 24 , Vineis P 25 , Tsilidis K 24 , Gunter MJ 1 , Scalbert A 1

Affiliations 

  • 1 Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
  • 2 Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
  • 3 CESP, INSERM U1018, Univ. Paris-Sud, UVSQ, Université Paris-Saclay, Villejuif Cedex, France
  • 4 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 5 Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
  • 6 Department of Epidemiology, Nutrition, Immunity and Metabolism Start-up Lab, Potsdam-Rehbrücke, Germany
  • 7 Danish Cancer Society Research Center, Copenhagen, Denmark
  • 8 Department of Public Health, Aarhus University, Aarhus, Denmark
  • 9 Public Health Directorate, Asturias, Spain
  • 10 Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain
  • 11 CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
  • 12 Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  • 13 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
  • 14 Hellenic Health Foundation, Athens, Greece
  • 15 Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy
  • 16 Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • 17 Cancer Registry and Histopathology Department, Civic - M.P. Arezzo" Hospital, ASP Ragusa, Ragusa, Italy
  • 18 Unit of Cancer Epidemiology, , Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy
  • 19 Dipartimento di Medicina Clinica e Sperimentale, Federico II University, Naples, Italy
  • 20 Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven, BA, 3720, The Netherlands
  • 21 Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
  • 22 Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden
  • 23 Department of Odontology, Umeå University, Umeå, Sweden
  • 24 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
  • 25 MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Int J Cancer, 2018 Oct 01;143(7):1620-1631.
PMID: 29696648 DOI: 10.1002/ijc.31563

Abstract

Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95% CI] = 0.79-0.93; qvalue  = 0.01) and homovanillic acid (OR per log2 -value, 1.46, 95% CI = 1.16-1.84; qvalue  = 0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR = 0.61, 95% CI = 0.41-0.91, ptrend  = 0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR = 1.72, 95% CI = 1.17-2.53, ptrend  

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications