Neither male age nor semen parameters influence clinical pregnancy or live birth outcomes from IVF

Mariappen U 1 , Keane KN 2 , Hinchliffe PM 3 , Dhaliwal SS 4 , Yovich JL 5

Affiliations 

  • 1 Hospital Tengku Ampuan Rahimah (HTAR), Klang, Malaysia; PIVET Medical Centre, Leederville, Perth, WA 6007, Australia
  • 2 PIVET Medical Centre, Leederville, Perth, WA 6007, Australia; School of Pharmacy & Biomedical Science, Curtin University, Perth, WA 6102, Australia
  • 3 PIVET Medical Centre, Leederville, Perth, WA 6007, Australia
  • 4 School of Public Health, Curtin University, Perth, WA 6102, Australia
  • 5 PIVET Medical Centre, Leederville, Perth, WA 6007, Australia; School of Pharmacy & Biomedical Science, Curtin University, Perth, WA 6102, Australia. Electronic address: jlyovich@pivet.com.au
Reprod Biol, 2018 Dec;18(4):324-329.
PMID: 30503182 DOI: 10.1016/j.repbio.2018.11.003

Abstract

Advanced age is an increasing trend for both males and females seeking in vitro fertilization (IVF). This retrospective cohort study investigated the outcomes of 1280 IVF-related treatment cycles, selecting the first treatment for couples utilizing autologous gametes and who underwent single fresh embryo transfer. Males aged 40-49 years had a 52% reduction in normal sperm motility, while it was markedly reduced by 79% at 50 years or older. However, neither semen parameters nor male age were predictive of clinical pregnancy or live birth chance. In a combination of age groups, cases with Younger Females had the greatest chance of successful outcomes and this was independent of having a younger or older male partner. Specifically, Young Female-Young Male combinations (≤ 35 years) were the most likely to succeed in achieving a clinical pregnancy or live birth (OR 2.84, p 35 years, respectively) had a similar increased chance (OR 2.07, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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