Relationship between serum high sensitivity C-reactive protein with angiographic severity of coronary artery disease and traditional cardiovascular risk factors

Tajfard M 1 , Tavakoly Sany SB 1 , Avan A 2 , Latiff LA 3 , Rahimi HR 4 , Moohebati M 5 Show all authors , Hasanzadeh M 6 , Ghazizadeh H 2 , Esmaeily H 6 , Doosti H 7 , Taghipour A 6 , Ghayour-Mobarhan M 2 , Ferns GA 8 , Emamian M 9 , Bin Abd Mutalib MS 10

Affiliations 

  • 1 Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • 2 Metabolic Syndrome Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
  • 3 Department of Community Health, Faculty of Medicine and Health Sciences, University Putra Malaysia, Seri Kembangan, Malaysia
  • 4 Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • 5 Department of Cardiology, Ghaem Educational Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  • 6 Department of Biostatistics and Epidemiology, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran
  • 7 Department of Statistics, School of Health, Macquarie University, Sydney, Australia
  • 8 Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK
  • 9 Biochemistry Department, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran
  • 10 Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia
J Cell Physiol, 2019 07;234(7):10289-10299.
PMID: 30548615 DOI: 10.1002/jcp.27945

Abstract

Serum high-sensitivity C-reactive protein (hs-CRP) is predictive of coronary artery disease (CAD). The aim of this study was to examine the possible association of hs-CRP with presence and severity of CAD and traditional CAD risk factors. This case-control study was carried out on 2,346 individuals from September 2011 to May 2013. Of these 1,187 had evidence of coronary disease, and were subject to coronary angiography, and the remainder were healthy controls (n = 1,159). Characteristics were determined using standard laboratory techniques and serum Hs-CRP levels were estimated using enzyme-linked immunosorbent assay (ELISA) kits, and severity of CAD was assessed according to the score of obstruction in coronary artery. Serum hs-CRP levels were higher in those with severe coronary disease, who had stenosis ≥ 50% stenosis of at least one coronary artery (all p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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