Isolating the metabolic pathways involved in the hepatoprotective effect of Muntingia calabura against CCl4-induced liver injury using LC/MS Q-TOF

Rofiee MS 1 , Yusof MI 1 , Abdul Hisam EE 1 , Bannur Z 1 , Zakaria ZA 2 , Somchit MN 2 Show all authors , Teh LK 3 , Salleh MZ 4

Affiliations 

  • 1 Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, 42300 Selangor, Malaysia
  • 2 Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, 42300 Selangor, Malaysia; Department of Biomedical Science, Faculty of Medicine and Health Sciences,Universiti Putra Malaysia UPM, 43400 Serdang, Selangor, Malaysia
  • 3 Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, 42300 Selangor, Malaysia; Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, 42300 Selangor, Malaysia. Electronic address: tehlaykek@puncakalam.uitm.edu.my
  • 4 Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, 42300 Selangor, Malaysia; Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Bandar Puncak Alam, 42300 Selangor, Malaysia. Electronic address: zakisalleh@puncakalam.uitm.edu.my
J Ethnopharmacol, 2015 May 26;166:109-18.
PMID: 25792013 DOI: 10.1016/j.jep.2015.03.016

Abstract

Muntingia calabura L. has been used in Southeast Asia and tropical America as antipyretic, antiseptic, analgesic, antispasmodic and liver tonic. This study aims to determine the acute toxicity and the metabolic pathways involved in the hepatoprotective mechanism of M. calabura.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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