Affiliations 

  • 1 School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, KwaZulu-Natal, South Africa; Biomedical Research and Training Institute, Harare, Zimbabwe. Electronic address: nhidzaagness@gmail.com
  • 2 School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, KwaZulu-Natal, South Africa
  • 3 Universitetet i Oslo Avdeling for samfunnsmedisin, Womens' Clinic, Oslo, Norway
  • 4 Institute of Research and Molecular Medicine (INFORMI), Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia
  • 5 Biomedical Research and Training Institute, Harare, Zimbabwe
  • 6 Immunology Department, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe
  • 7 School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, KwaZulu-Natal, South Africa; Biochemistry Department, University of Zimbabwe, Harare, Zimbabwe
J Microbiol Immunol Infect, 2020 Aug;53(4):612-621.
PMID: 30583941 DOI: 10.1016/j.jmii.2018.11.005

Abstract

BACKGROUND: Asymptomatic Entamoeba histolytica infections in pregnant women puts infants at risk of infection through vertical transmission or transmission during breastfeeding in high HIV prevalence areas. The study aimed at investigating the immune response to asymptomatic E.histolytica infection in pregnant women and their infants in a high HIV burdened setting in Harare, Zimbabwe.

METHODOLOGY: Serum samples from 39 predominantly breastfeeding mother-infant pairs were analyzed for inflammatory cytokine and immunoglobulin profiles using BIOPLEX. The infants' ages ranged from 10 days to 14 weeks.

RESULTS: IL-1r, IL-4, IL-9, IL-12p70, IL-17a, G-CSF and PDGF-BB were significantly raised in E. histolytica infected compared to non-infected lactating mothers (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Similar publications