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Intake of individual fatty acids and risk of prostate cancer in the European prospective investigation into cancer and nutrition

Perez-Cornago A 1 , Huybrechts I 2 , Appleby PN 1 , Schmidt JA 1 , Crowe FL 3 , Overvad K 4 Show all authors , Tjønneland A 5 , Kühn T 6 , Katzke V 6 , Trichopoulou A 7 , Karakatsani A 7 , Peppa E 7 , Grioni S 8 , Palli D 9 , Sacerdote C 10 , Tumino R 11 , Bueno-de-Mesquita HB 12 , Larrañaga N 13 , Sánchez MJ 14 , Quirós JR 15 , Ardanaz E 14 , Chirlaque MD 14 , Agudo A 16 , Bjartell A 17 , Wallström P 18 , Chajes V 19 , Tsilidis KK 20 , Aune D 21 , Riboli E 21 , Travis RC 1 , Key TJ 1

Affiliations 

  • 1 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
  • 2 Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France
  • 3 Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
  • 4 Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus C, Denmark
  • 5 Danish Cancer Society Research Center, Copenhagen, Denmark
  • 6 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 7 Hellenic Health Foundation, Athens, Greece
  • 8 Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • 9 Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy
  • 10 Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy
  • 11 Department of Cancer Registry and Histopathology, "Civic - M.P. Arezzo" Hospital ASP, Ragusa, Italy
  • 12 Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
  • 13 Department of Basque Regional Health, Public Health Division of Gipuzkoa-BIODONOSTIA, Guipúzcoa, Spain
  • 14 CIBER of Epidemiology and Public Health, Madrid, Spain
  • 15 Public Health Directorate, Asturias, Spain
  • 16 Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain
  • 17 Department of Translational Medicine, Medical Faculty, Lund University, Malmö, Sweden
  • 18 Nutrition Epidemiology Research Group, Department of Clinical Sciences, Lund University, Malmö, Sweden
  • 19 Department of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
  • 20 Department of Hygiene and Epidemiology, University of Ioannina, School of Medicine, Ioannina, Greece
  • 21 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Int J Cancer, 2020 Jan 01;146(1):44-57.
PMID: 30807653 DOI: 10.1002/ijc.32233

Abstract

The associations of individual dietary fatty acids with prostate cancer risk have not been examined comprehensively. We examined the prospective association of individual dietary fatty acids with prostate cancer risk overall, by tumor subtypes, and prostate cancer death. 142,239 men from the European Prospective Investigation into Cancer and Nutrition who were free from cancer at recruitment were included. Dietary intakes of individual fatty acids were estimated using center-specific validated dietary questionnaires at baseline and calibrated with 24-h recalls. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After an average follow-up of 13.9 years, 7,036 prostate cancer cases and 936 prostate cancer deaths were ascertained. Intakes of individual fatty acids were not related to overall prostate cancer risk. There was evidence of heterogeneity in the association of some short chain saturated fatty acids with prostate cancer risk by tumor stage (pheterogeneity

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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