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A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

Papadimitriou N 1 , Muller D 2 , van den Brandt PA 3 , Geybels M 3 , Patel CJ 4 , Gunter MJ 5 Show all authors , Lopez DS 6 , Key TJ 7 , Perez-Cornago A 7 , Ferrari P 5 , Vineis P 2 , Weiderpass E 5 , Boeing H 8 , Agudo A 9 , Sánchez MJ 10 , Overvad K 11 , Kühn T 12 , Fortner RT 12 , Palli D 13 , Drake I 14 , Bjartell A 15 , Santiuste C 16 , Bueno-de-Mesquita BH 2 , Krogh V 17 , Tjønneland A 18 , Lauritzen DF 19 , Gurrea AB 16 , Quirós JR 20 , Stattin P 21 , Trichopoulou A 22 , Martimianaki G 22 , Karakatsani A 22 , Thysell E 23 , Johansson I 24 , Ricceri F 25 , Tumino R 26 , Larrañaga N 27 , Khaw KT 28 , Riboli E 2 , Tzoulaki I 1 , Tsilidis KK 29

Affiliations 

  • 1 Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
  • 2 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, London, W2 1PG, UK
  • 3 Department of Epidemiology, GROW School for Oncology and Developmental Biology, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands
  • 4 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
  • 5 International Agency for Research on Cancer, Lyon, France
  • 6 Department of Preventive Medicine and Community Health, UTMB School of Medicine, Galveston, TX, USA
  • 7 Nuffield Department of Population Health, Cancer Epidemiology Unit, University of Oxford, Oxford, UK
  • 8 Department of Epidemiology, German Institute for Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
  • 9 Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
  • 10 Escuela Andaluza de Salud Pública, Granada, Spain
  • 11 Department of Public Health, Aarhus University, Aarhus, Denmark
  • 12 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 13 Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy
  • 14 Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
  • 15 Department of Urology, Lund University, Malmö, Sweden
  • 16 CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
  • 17 Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
  • 18 Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark
  • 19 Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • 20 Public Health Directorate, Asturias, Spain
  • 21 Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
  • 22 Hellenic Health Foundation, Athens, Greece
  • 23 Department of Medical Biosciences, Pathology, Department of Biobank Research, Umeå University, Umeå, Sweden
  • 24 Departments of Odontology, Section of Cardiology, Biobank Research, Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
  • 25 Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
  • 26 Cancer Registry and Histopathology Unit, "M.P.Arezzo" Hospital, Ragusa, Italy
  • 27 Epidemiology and Health Information, Public Health Division of Gipuzkoa, Basque Regional Health Department, San Sebastian, Spain
  • 28 Clinical Gerontology Unit, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
  • 29 Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece. k.tsilidis@imperial.ac.uk
Eur J Nutr, 2020 Oct;59(7):2929-2937.
PMID: 31705265 DOI: 10.1007/s00394-019-02132-z

Abstract

PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive.

METHODS: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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