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In Situ Controlled Surface Microstructure of 3D Printed Ti Alloy to Promote Its Osteointegration

Shan L 1 , Kadhum AAH 2 , Al-Furjan MSH 3 , Weng W 4 , Gong Y 5 , Cheng K 6 Show all authors , Zhou M 7 , Dong L 8 , Chen G 9 , Takriff MS 10 , Sulong AB 11

Affiliations 

  • 1 Department of Chemical & Process Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia. p93208@siswa.ukm.edu.my
  • 2 Department of Chemical & Process Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia. amir1719@gmail.com
  • 3 School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China. rayan@hdu.edu.cn
  • 4 School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China. Wengwj@zju.edu.cn
  • 5 School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China. gyp@hdu.edu.cn
  • 6 School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China. Chengkui@zju.edu.cn
  • 7 School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China. myzhou@hdu.edu.cn
  • 8 School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China. lingqingdong@zju.edu.cn
  • 9 School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China. chenguojin@163.com
  • 10 Research Center for Sustainable Process Technology (CESPRO), Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia. sobritakriff@ukm.edu.my
  • 11 Department of Mechanical and Materials Engineering, Universiti Kebangsaan Malaysia, Selangor 43600, Malaysia. abubakar@ukm.edu.my
Materials (Basel), 2019 Mar 10;12(5).
PMID: 30857349 DOI: 10.3390/ma12050815

Abstract

It is well known that three-dimensional (3D) printing is an emerging technology used to produce customized implants and surface characteristics of implants, strongly deciding their osseointegration ability. In this study, Ti alloy microspheres were printed under selected rational printing parameters in order to tailor the surface micro-characteristics of the printed implants during additive manufacturing by an in situ, controlled way. The laser path and hatching space were responsible for the appearance of the stripy structure (S), while the bulbous structure (B) and bulbous⁻stripy composite surface (BS) were determined by contour scanning. A nano-sized structure could be superposed by hydrothermal treatment. The cytocompatibility was evaluated by culturing Mouse calvaria-derived preosteoblastic cells (MC3T3-E1). The results showed that three typical microstructured surfaces, S, B, and BS, could be achieved by varying the 3D printing parameters. Moreover, the osteogenic differentiation potential of the S, B, and BS surfaces could be significantly enhanced, and the addition of nano-sized structures could be further improved. The BS surface with nano-sized structure demonstrated the optimum osteogenic differentiation potential. The present research demonstrated an in situ, controlled way to tailor and optimize the surface structures in micro-size during the 3D printing process for an implant with higher osseointegration ability.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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