Affiliations 

  • 1 Department of Mechanical Engineering, Faculty of Engineering, Centre of Advanced Materials (CAM), University of Malaya, Kuala Lumpur 50603, Malaysia. katayoon@um.edu.my
  • 2 Department of Mechanical Engineering, Faculty of Engineering, Centre of Advanced Materials (CAM), University of Malaya, Kuala Lumpur 50603, Malaysia
  • 3 Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
  • 4 Malaysia-Japan International Institute of Technology (MJIIT), Universiti Teknologi Malaysia, 54100 Kuala Lumpur, Malaysia
IET Nanobiotechnol, 2019 May;13(3):262-268.
PMID: 31053688 DOI: 10.1049/iet-nbt.2018.5066

Abstract

In this study, the authors synthesised silver nanoparticles (AgNPs) using autoclave as a simple, unique and eco-friendly approach. The effect of Zingiber officinale extract was evaluated as a reducing and stabiliser agent. According to transmission electron microscopy results, the AgNPs were in the spherical shape with a particle size of ∼17 nm. The biomedical properties of AgNPs as antibacterial agents and free radical scavenging activity were estimated. Synthesised AgNPs showed significant 1,1-diphenyl-2-picryl-hydrazyl free radical scavenging. Strong bactericidal activity was shown by the AgNPs on Gram-positive and Gram-negative bacteria. A maximum inhibition zone of ∼14 mm was obtained for epidermidis at a concentration of 60 μg/ml for sample fabricated at 24 h. The AgNPs also showed a significant cytotoxic effect against MCF-7 breast cancer cell lines with an half maximal inhibitory concentration value of 62 μg/ml in 24 h by the MTT assay. It could be concluded that Z. officinale extract can be used effectively in the production of potential antioxidant and antimicrobial AgNPs for commercial application.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.