In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds

Babar ZM 1 , Jaswir I 1 , Tareq AM 2 , Ali Reza ASM 2 , Azizi WM 3 , Hafidz M 1 Show all authors , Ahfter F 2 , Hasan M 2 , Farhad S 2 , Uddin MMR 2 , Ichwan SJ 4 , Ahmed QU 5 , Taher M 6 , Mawa I 7

Affiliations 

  • 1 International Institute for Halal Research & Training (INHART), International Islamic University Malaysia, Gombak, Kuala Lumpur, Malaysia
  • 2 Department of Pharmacy, International Islamic University Chittagong, Kumira, Bangladesh
  • 3 PICOMS International College, Batu Muda, Kuala Lumpur, Malaysia
  • 4 Faculty of Dentistry, International Islamic University Malaysia (IIUM), Jalan Hj. Ahmad Shah, Bandar Indera Mahkota, Pahang, Malaysia
  • 5 Faculty of Pharmacy, Department of Pharmaceutical Chemistry, International Islamic University Malaysia (IIUM), Jalan Hj. Ahmad Shah, Bandar Indera Mahkota, Pahang, Malaysia
  • 6 Faculty of Pharmacy, Department of Pharmaceutical Technology, International Islamic University Malaysia (IIUM), Jalan Hj. Ahmad Shah, Bandar Indera Mahkota, Pahang, Malaysia
  • 7 Department of Microbiology, University of Science and Technology Chittagong, Khulshi, Bangladesh
Nat Prod Res, 2021 Aug;35(16):2793-2798.
PMID: 31578877 DOI: 10.1080/14786419.2019.1667348

Abstract

The WSE is a highly polar, gummy and mucilaginous bioactive content of the Nigella sativa (L.) seeds. This study reports the anxiolytic and anti-inflammatory effects of WSE investigated using Elevated Plus Maze (EPM) and Hole-Board Test (HBT) in adult mice and human RBCs haemolysis inhibition and protein denaturation respectively. The oral WSE treatment (100 & 200 mg/kg b.w/day) for 72 hours has exhibited slightly better anxiolytic effect (p 

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