Fulltext

Nipah shell disorder, modes of infection, and virulence

Goh GK 1 , Dunker AK 2 , Foster JA 3 , Uversky VN 4

Affiliations 

  • 1 Goh's BioComputing, Singapore, Republic of Singapore. Electronic address: gohsbiocomputing@yahoo.com
  • 2 Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: kedunker@iupui.edu
  • 3 Department of Biological Sciences, University of Idaho, Moscow, ID, USA; Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, ID, USA. Electronic address: foster@uidaho.edu
  • 4 Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow region, Russia. Electronic address: vuversky@health.usf.edu
Microb Pathog, 2020 Apr;141:103976.
PMID: 31940461 DOI: 10.1016/j.micpath.2020.103976

Abstract

The Nipah Virus (NiV) was first isolated during a 1998-9 outbreak in Malaysia. The outbreak initially infected farm pigs and then moved to humans from pigs with a case-fatality rate (CFR) of about 40%. After 2001, regular outbreaks occurred with higher CFRs (~71%, 2001-5, ~93%, 2008-12). The spread arose from drinking virus-laden palm date sap and human-to-human transmission. Intrinsic disorder analysis revealed strong correlation between the percentage of disorder in the N protein and CFR (Regression: r2 = 0.93, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications