Shear wave elastography accurately detects chronic changes in renal histopathology

Leong SS 1 , Wong JHD 1 , Md Shah MN 1 , Vijayananthan A 1 , Jalalonmuhali M 2 , Chow TK 3 Show all authors , Sharif NHM 4 , Ng KH 1

Affiliations 

  • 1 Department of Biomedical Imaging, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia
  • 4 Renal Unit, Faculty of Medicine, Universiti Teknologi Mara, Selangor, Malaysia
Nephrology (Carlton), 2021 Jan;26(1):38-45.
PMID: 33058334 DOI: 10.1111/nep.13805

Abstract

AIM: Renal biopsy is the gold standard for the histological characterization of chronic kidney disease (CKD), of which renal fibrosis is a dominant component, affecting its stiffness. The aim of this study was to investigate the correlation between kidney stiffness obtained by shear wave elastography (SWE) and renal histological fibrosis.

METHODS: Shear wave elastography assessments were performed in 75 CKD patients who underwent renal biopsy. The SWE-derived estimates of the tissue Young's modulus (YM), given as kilopascals (kPa), were measured. YM was correlated to patients' renal histological scores, broadly categorized into glomerular, tubulointerstitial and vascular scores.

RESULTS: Young's modulus correlates significantly with tubulointerstitial score (ρ = 0.442, P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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