Internal radiation dosimetry of orally administered radiotracers for the assessment of gastrointestinal motility

Yeong CH 1 , Ng KH 1 , Abdullah BJJ 1 , Chung LY 2 , Goh KL 3 , Perkins AC 4

Affiliations 

  • 1 Departments of Biomedical Imaging, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; University of Malaya Research Imaging Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 2 Departments of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 3 Departments of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 4 Radiological and Imaging Sciences and Nottingham Digestive Diseases Biomedical Research Unit, Department of Medical Physics, University of Nottingham, A Floor, Medical School, Queen׳s Medical Centre, Nottingham, NG7 2UH, United Kingdom. Electronic address: Alan.Perkins@nottingham.ac.uk
Appl Radiat Isot, 2014 Dec;94:216-220.
PMID: 25222875 DOI: 10.1016/j.apradiso.2014.08.009

Abstract

Radionuclide imaging using (111)In, (99m)Tc and (153)Sm is commonly undertaken for the clinical investigation of gastric emptying, intestinal motility and whole gut transit. However the documented evidence concerning internal radiation dosimetry for such studies is not readily available. This communication documents the internal radiation dosimetry for whole gastrointestinal transit studies using (111)In, (99m)Tc and (153)Sm labeled formulations. The findings were compared to the diagnostic reference levels recommended by the United Kingdom Administration of Radioactive Substances Advisory Committee, for gastrointestinal transit studies.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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