Synergistic effects of chitosan scaffold and TGFβ1 on the proliferation and osteogenic differentiation of dental pulp stem cells derived from human exfoliated deciduous teeth

Farea M 1 , Husein A 2 , Halim AS 3 , Abdullah NA 4 , Mokhtar KI 4 , Lim CK 5 Show all authors , Berahim Z 6 , Mokhtar K 6

Affiliations 

  • 1 Conservative Department, School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address: ghorafi44@yahoo.com
  • 2 Conservative Department, School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address: adamkck@usm.my
  • 3 Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address: ashalim@usm.my
  • 4 Oral Biology Unit, School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
  • 5 Skin Research and Innovation Centre, Research and Development Division, WIPRO Manufacturing Services Sdn Bhd, Persiaran Subang Permai, Taman Perindustrian Subang, 47610 Subang Jaya, Selangor, Malaysia
  • 6 Conservative Department, School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Arch Oral Biol, 2014 Dec;59(12):1400-11.
PMID: 25222336 DOI: 10.1016/j.archoralbio.2014.08.015

Abstract

Multipotent stem cells derived from human exfoliated deciduous teeth (SHED) represent a promising cell source for tissue regeneration. In the present study we decided to test the inductive effect of chitosan and transforming growth factor-β1 (TGFβ1) as a scaffold/factor combination on SHED proliferation and osteogenic differentiation.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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