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Structural, Optical and Antibacterial Efficacy of Pure and Zinc-Doped Copper Oxide against Pathogenic Bacteria

Khalid A 1 , Ahmad P 2 , Alharthi AI 3 , Muhammad S 1 , Khandaker MU 4 , Rehman M 5 Show all authors , Faruque MRI 6 , Din IU 3 , Alotaibi MA 3 , Alzimami K 7 , Bradley DA 4

Affiliations 

  • 1 Department of Physics, Hazara University Mansehra, Khyber Pakhtunkhwa 21300, Pakistan
  • 2 Department of Physics, University of Azad Jammu and Kashmir, Muzaffarabad 13100, Pakistan
  • 3 Department of Chemistry, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia
  • 4 Center for Applied Physics and Radiation Technologies, School of Engineering and Technology, Sunway University, Bandar Sunway 47500, Selangor, Malaysia
  • 5 Department of Microbiology, Hazara University, Mansehra KPK 21300, Pakistan
  • 6 Space Science Centre, Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, Malaysia
  • 7 Department of Radiological Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433, Saudi Arabia
Nanomaterials (Basel), 2021 Feb 10;11(2).
PMID: 33578945 DOI: 10.3390/nano11020451

Abstract

Copper oxide and Zinc (Zn)-doped Copper oxide nanostructures (CuO-NSs) are successfully synthesized by using a hydrothermal technique. The as-obtained pure and Zn-doped CuO-NSs were tested to study the effect of doping in CuO on structural, optical, and antibacterial properties. The band gap of the nanostructures is calculated by using the Tauc plot. Our results have shown that the band gap of CuO reduces with the addition of Zinc. Optimization of processing conditions and concentration of precursors leads to the formation of pine needles and sea urchin-like nanostructures. The antibacterial properties of obtained Zn-doped CuO-NSs are observed against Gram-negative (Pseudomonasaeruginosa,Klebsiellapneumonia,Escherichiacoli) and Gram-positive (Staphylococcusaureus) bacteria via the agar well diffusion method. Zn doped s are found to have more effective bacterial resistance than pure CuO. The improved antibacterial activity is attributed to the reactive oxygen species (ROS) generation.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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