• 1 Department of Obstetrics and Gynecology, Jingdezhen First People's Hospital, Jingdezhen, Jiangxi Province, China
  • 2 Department of Gynecological Oncology, Jiujiang Maternal and Child Health Hospital, Jiujiang, Jiangxi Province, China
  • 3 Nanchang University, Nanchang City, Jiangxi Province, China
  • 4 Department of Gynecology of Traditional Chinese Medicine, Binzhou Hospital of Traditional Chinese Medicine, Binzhou, Shandong, China
  • 5 Institute of Nano Electronic Engineering, Universiti Malaysia Perlis (UniMAP), Kangar, Perlis, 01000, Malaysia
  • 6 Department of Gynecology, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi Province, China
PMID: 33786878 DOI: 10.1002/bab.2155


A highly sensitive silica-alumina (Si-Al)-modified capacitive non-Faradaic glucose biosensor was introduced to monitor gestational diabetes. Glucose oxidase (GOx) was attached to the Si-Al electrode surface as the probe through amine-modification followed by glutaraldehyde premixed GOx as aldehyde-amine chemistry. This Si-Al (∼50 nm) modified electrode surface has increased the current flow upon binding of GOx with glucose. Capacitance values were increased by increasing the glucose concentrations. A mean capacitance value was plotted and the detection limit was found as 0.03 mg/mL with the regression coefficient value, R² = 0.9782 [y = 0.8391x + 1.338] on the linear range between 0.03 and 1 mg/mL. Further, a biofouling experiment with fructose and galactose did not increase the capacitance, indicating the specific glucose detection. This Si-Al-modified capacitance sensor detects a lower level of glucose presence and helps in monitoring gestational diabetes.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.