• 1 Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata 741249, India
  • 2 Department of Biotechnology, University of Engineering & Management, Kolkata 700160, India
  • 3 Department of Food Technology and Bio-Chemical Engineering, Jadavpur University, Kolkata 700032, India
  • 4 Department of Bioscience and Bioinformatics, Khallikote University, Berhampur 761008, India
  • 5 School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
  • 6 Centre of Excellence, Khallikote University, Berhampur 761008, India
Polymers (Basel), 2021 Apr 12;13(8).
PMID: 33921239 DOI: 10.3390/polym13081242


Bacteria are considered as the major cell factories, which can effectively convert nitrogen and carbon sources to a wide variety of extracellular and intracellular biopolymers like polyamides, polysaccharides, polyphosphates, polyesters, proteinaceous compounds, and extracellular DNA. Bacterial biopolymers find applications in pathogenicity, and their diverse materialistic and chemical properties make them suitable to be used in medicinal industries. When these biopolymer compounds are obtained from pathogenic bacteria, they serve as important virulence factors, but when they are produced by non-pathogenic bacteria, they act as food components or biomaterials. There have been interdisciplinary studies going on to focus on the molecular mechanism of synthesis of bacterial biopolymers and identification of new targets for antimicrobial drugs, utilizing synthetic biology for designing and production of innovative biomaterials. This review sheds light on the mechanism of synthesis of bacterial biopolymers and its necessary modifications to be used as cell based micro-factories for the production of tailor-made biomaterials for high-end applications and their role in pathogenesis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.