Displaying publications 1 - 20 of 120 in total

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  1. A new species of clearwing moth (Lepidoptera: Sesiidae: Osminiini) from Peninsular Malaysia, exhibiting bee-like morphology and behaviour
    Skowron MA, Munisamy B, Hamid SB, Węgrzyn G
    Zootaxa, 2015;4032(4):426-34.
    PMID: 26624378 DOI: 10.11646/zootaxa.4032.4.7
    A new species of Sesiidae, tribe Osminiini from Peninsular Malaysia, Heterosphecia pahangensis Skowron, displaying numerous bee-mimicking features, is described. DNA barcodes showed significant differences with related taxa. However, the paucity of Sesiidae barcodes from Southeast Asia prevents meaningful taxonomic comparisons. The closest match out of published data on Sesiidae barcodes is Heterosphecia bantanakai, Arita & Gorbunov (2000a) from the tribe Osminiini, which has 9.98% sequence divergence from Heterosphecia pahangensis. Photographs of the moth in its natural habitat are shown. Behavioural aspects, such as mud-puddling and mode of flight, are described and presented in a video.
    Matched MeSH terms: Bees
  2. Revision of the bee genus Bathanthidium Mavromoustakis (Hymenoptera: Apoidea: Megachilidae: Anthidiini) with description of a new species from China
    Niu ZQ, Ascher JS, Griswold T, Zhu CD
    Zootaxa, 2019 Aug 15;4657(1):zootaxa.4657.1.3.
    PMID: 31716797 DOI: 10.11646/zootaxa.4657.1.3
    This revision of the bee genus Bathanthidium Mavromoustakis, 1953, treats 12 species, with 11 recorded from China, including Bathanthidium fengkaiense Niu Zhu, sp. nov.. Two species are proposed as new combinations in genus Bathanthidium: Anthidium (s. str.) bicolor Wu, 2004, A. (s. str.) monganshanensis Wu, 2004. The two new combinations (B. bicolor, B. monganshanense) are in Bathanthidium (Manthidium), previously considered to include only the type species from Burma and Laos (published records from northeastern India and Malaysia are based on misinterpreted localities). Trachusa (Paraanthidium) concavum (Wu, 1962) and Stelis siamensis Friese, 1925 are synonymized with B. binghami (Friese, 1901). Bathanthidium circinatum Wu, 2004 is transferred to Pseudoanthidium Friese forming the new combination P. (s. str.) circinatum (Wu, 2004). The distribution of each species is given, new distribution sites are marked by asterisk (*) especially. Our results confirm that the genus Bathanthidium has higher species diversity than previously documented and that this diversity is centered in China.
    Matched MeSH terms: Bees
  3. Fulltext New and little-known species of the genus Sphecodes Latreille (Hymenoptera, Halictidae) from Southeast Asia
    Astafurova YV, Proshchalykin MY, Schwarz M
    Zookeys, 2020;937:31-88.
    PMID: 32547298 DOI: 10.3897/zookeys.937.51708
    The available information about the cleptoparasitic bees of the genus Sphecodes in Southeast Asia is summarized. Thirty-one species are currently known from this area. Four new species are described: Sphecodes discoverlifei Astafurova & Proshchalykin, sp. nov. (Laos), S. engeli Astafurova & Proshchalykin, sp. nov. (Laos, Vietnam), S. ilyadadaria Astafurova, sp. nov. (Indonesia), and S. pseudoredivivus Astafurova & Proshchalykin, sp. nov. (Laos). Nine species are newly recorded from South East Asia: S. chaprensis Blüthgen, 1927 (Laos), S. howardi Cockerell, 1922 (Malaysia, Myanmar, Thailand), S. kershawi Perkins, 1921 (Indonesia, Malaysia, Myanmar, Thailand), S. laticeps Meyer, 1920 (Thailand, Vietnam), S. montanus Smith, 1879 (Laos), S. sauteri Meyer, 1925 (Laos), S. sikkimensis Blüthgen, 1927 (Laos, Myanmar), S. simlaensis Blüthgen, 1924 (Laos), and S. turneri Cockerell, 1916 (Laos). Based on type specimens, new synonymies have been proposed for Sphecodes kershawi Perkins, 1921 = S. javanensis Blüthgen, 1927, syn. nov.; S. simlaensis Blüthgen, 1924 = S. simlaellus Blüthgen, 1927, syn. nov.; S. laticeps Meyer, 1920 = S. biroi mariae Cockerell, 1930, syn. nov. Lectotypes are designated for Sphecodes biroi Friese, 1909, S. simlaellus Blüthgen, 1927, and S. laticeps Meyer, 1920. The female of Sphecodes sauteri Meyer, 1925, and the male of S. turneri Cockerell, 1916 are described for the first time.
    Matched MeSH terms: Bees
  4. Fulltext Can egg yolk antibodies terminate the CSBV infection in apiculture?
    Li A, Wang Q, Huang Y, Hu L, Li S, Wang Q, et al.
    Virus Res, 2023 Apr 15;328:199080.
    PMID: 36882131 DOI: 10.1016/j.virusres.2023.199080
    Chinese sacbrood virus (CSBV) is the most severe pathogen of Apis cerana, which leads to serious fatal diseases in bee colonies and eventual catastrophe for the Chinese beekeeping industry. Additionally, CSBV can potentially infect Apis mellifera by bridging the species barrier and significantly affect the productivity of the honey industry. Although several approaches, such as feeding royal jelly, traditional Chinese medicine, and double-stranded RNA treatments, have been employed to suppress CSBV infection, their practical applicabilities are constrained due to their poor effectiveness. In recent years, specific egg yolk antibodies (EYA) have been increasingly utilized in passive immunotherapy for infectious diseases without any side effects. According to both laboratory research and practical use, EYA have demonstrated superior protection for bees against CSBV infection. This review provided an in-depth analysis of the issues and drawbacks in this field in addition to provide a thorough summary of current advancements in CSBV studies. Some promising strategies for the synergistic study of EYA against CSBV, including the exploitation of novel antibody drugs, novel TCM monomer/formula determination, and development of nucleotide drugs, are also proposed in this review. Furthermore, the prospects for the future perspectives of EYA research and applications are presented. Collectively, EYA would terminate CSBV infection soon, as well as will provide scientific guidance and references to control and manage other viral infections in apiculture.
    Matched MeSH terms: Bees
  5. Fulltext OBSERVATION OF FLOWER VISITORS TO DETERMINE THEIR POTENTIAL ROLE AS POLLINATORS OF Ixora coccinae AND Ruellia simplex
    Fakhriah Kamaruddin, Mohamed Nor Zalipah
    UMT Journal of Undergraduate Research, 2020;2(1):61-70.
    MyJurnal
    This study aimed to determine the potential pollinating agents of Ixora coccinae and Ruellia simplex at Universiti Malaysia Terengganu (UMT) campus based on the foraging activities of the flower visitors. The diurnal observations (0700 hr to 1800 hr) were conducted for a total of 144 hours and 96 hours for I. coccinae, for R. simplex respectively. The flower visitor activities (landing or hovering at the flowers) and the time spent at the flowers however were recorded for only the first 10 minutes of every hour between 0700 hr and 1000 hr for four days. A total of 383 flower visitations was recorded by 17 insect species and a bird species, the olive-backed sunbird (Cinnyris jugularis). For I. coccinae, the most common visitors were Apis cerana, Heterotrigona itama and Xylocopa confusa, in which all species were found to show only landing behaviour to forage at the flowers, and the time spent foraging at the flowers was not significantly different between the species (Kruskal-Wallis test, H = 1.323, df = 2, p = 0.055). For R. simplex, the most common visitors were A. cerana with 100% landing, and C. jugularis which recorded 80% landing and 20% hovering during their visits to the flowers. Between the two, A. cerana recorded significantly longer time spent at the flowers as compared to C. jugularis (Mann-Whitney test, U = 17.355, p < 0.001). Based on the visitation rate and feeding behaviour of the flower visitors, A. cerana, H. itama and X. confusa were the potential pollinating agents for I. coccinae while for R. simplex, A. cerana showed higher potential to be a pollinating agent as compared to C. jugularis. Therefore, this study highlighted the importance of recording the behaviour of each flower visitor to determine the relative contribution to the pollination success of the plant species visited.
    Matched MeSH terms: Bees
  6. Fulltext The Phosphofructokinase and Pyruvate Kinase Genes in Apis andreniformis and Apis cerana indica: Exon Intron Organisation and Evolution
    Shullia NI, Raffiudin R, Juliandi B
    Trop Life Sci Res, 2019 Jan;30(1):89-107.
    PMID: 30847035 DOI: 10.21315/tlsr2019.30.1.6
    Genes related to carbohydrate metabolism have evolved rapidly in eusocial bees, including honey bees. However, the characterisation of carbohydrate metabolism genes has not been reported in Apis andreniformis or Apis cerana indica. This study aimed to characterise phosphofructokinase (PFK) and pyruvate kinase (PK) genes in these honey bee species and to analyse the evolution of the genus Apis using these genes. This study found the first data regarding A. andreniformis PFK and PK-like nucleotide sequences. A BLAST-n algorithm-based search showed that A. andreniformis and A. c. indica PFK and PK genes were homologous with those of Apis florea and Apis cerana cerana from Korea, respectively. Multiple alignments of PFKs from five Apis species showed many exon gains and losses, but only one among the PKs. Thus, the exon-intron organisation of the PK genes may be more conserved compare with that of the PFKs. Another evolutionary pattern indicated that more nucleotide substitutions occurred in Apis' PK than PFK genes. Deduced PFK amino acid sequences revealed a PFK consensus pattern of 19 amino acids, while the deduced PK amino acid sequences were predicted to have barrel and alpha/beta domains. Based on these two metabolism-related genes, The Neighbour-joining and Maximum likelihood phylogenetic trees are congruent and revealed that the A. andreniformis and A. florea group were in the basal position. Apis mellifera, A. cerana, and Apis dorsata formed a monophyletic clade, although the positions of A. mellifera and A. dorsata were different in the nucleotide- and amino acid-based phylogenetic trees.
    Matched MeSH terms: Bees
  7. Diurnal-activity Patterns of the Small Bee-eater (Merops orientalis) in Southern India
    Ali AH, Asokan S
    Trop Life Sci Res, 2015 Apr;26(1):9-20.
    PMID: 26868589
    The diurnal time-activity patterns of the Small Bee-eater (Merops orientalis) were studied between 2005 and 2006 in the Nagapattinam District of Southern India. Bee-eaters were observed to spend an average of 52.5% of their day time scanning, 21.3% feeding, 13.3% flying, 8.8% resting and 4.1% engaging in preening activities. The time spent on scanning varied among seasons in 2005 (p<0.05) and among time blocks (p<0.05), but it did not vary among years or habitats (p>0.05). The feeding patterns differed among years, seasons within years, time blocks and habitats (p<0.05). The flying habits varied among years, time blocks and habitats (p<0.05) but did not change between seasons within years (p>0.05). The resting habits differed among years and habitats (p<0.05) but did not differ among seasons within years or time blocks (p>0.05). Preening differed among years and time blocks (p<0.05) but did not vary among seasons within years or habitats (p>0.05). We conclude that several factors, such as food availability, environmental factors and predation threats, may affect the diurnal activity patterns of Bee-eaters between habitats and seasons; a further study could clarify this conclusion.
    Matched MeSH terms: Bees
  8. Fulltext Characterization of major allergens of royal jelly Apis mellifera
    Rosmilah M, Shahnaz M, Patel G, Lock J, Rahman D, Masita A, et al.
    Trop Biomed, 2008 Dec;25(3):243-51.
    PMID: 19287364 MyJurnal
    Royal jelly is widely consumed in the community and has perceived benefits ranging from promoting growth in children and improvement of general health status to enhancement of longevity for the elderly. However, royal jelly consumption has been linked to contact dermatitis, acute asthma, anaphylaxis and death. High prevalence of positive skin tests to royal jelly have been reported among atopic populations in countries with a high rate of royal jelly consumption. The present study is aimed to identify the major allergens of royal jelly. Royal jelly extract was separated by sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE) and 2-dimensional electrophoresis (2-D). Immunoblotting of the SDS-PAGE and 2-D profiles were performed to identify the allergenic spots. Spots were then excised from the 2-D gel, digested with trypsin and analyzed by mass spectrometry. The SDS-PAGE of royal jelly extract revealed 18 bands between 10 to 167 kD. Western blot of the fractionated proteins detected 15 IgE-binding bands between 14 to 127 kD with seven major allergens of 32, 40, 42, 49, 55, 60 and 67 kD using serum from 53 subjects with royal jelly allergy. The 2-D gel fractionated the royal jelly proteins to more than 50 different protein spots. Out of these, 30 spots demonstrated specific IgE affinity to the sera tested. Eight spots of the major royal jelly allergens were selected for mass-spectrometry analysis. Digested tryptic peptides of the spots were compared to the amino acid sequence search in protein databases which identified the fragments of royal jelly homologus to major royal jelly protein 1 (MRJ1) and major royal jelly protein 2 (MRJ2). In conclusion, the major allergens of royal jelly are MRJ1 and MRJ2 in our patients' population.
    Matched MeSH terms: Bees/immunology*
  9. Fulltext A modified active appearance model based on an adaptive artificial bee colony
    Abdulameer MH, Sheikh Abdullah SN, Othman ZA
    ScientificWorldJournal, 2014;2014:879031.
    PMID: 25165748 DOI: 10.1155/2014/879031
    Active appearance model (AAM) is one of the most popular model-based approaches that have been extensively used to extract features by highly accurate modeling of human faces under various physical and environmental circumstances. However, in such active appearance model, fitting the model with original image is a challenging task. State of the art shows that optimization method is applicable to resolve this problem. However, another common problem is applying optimization. Hence, in this paper we propose an AAM based face recognition technique, which is capable of resolving the fitting problem of AAM by introducing a new adaptive ABC algorithm. The adaptation increases the efficiency of fitting as against the conventional ABC algorithm. We have used three datasets: CASIA dataset, property 2.5D face dataset, and UBIRIS v1 images dataset in our experiments. The results have revealed that the proposed face recognition technique has performed effectively, in terms of accuracy of face recognition.
    Matched MeSH terms: Bees/physiology
  10. Fulltext Optimization of power utilization in multimobile robot foraging behavior inspired by honeybees system
    Ahmad FA, Ramli AR, Samsudin K, Hashim SJ
    ScientificWorldJournal, 2014;2014:153162.
    PMID: 24949491 DOI: 10.1155/2014/153162
    Deploying large numbers of mobile robots which can interact with each other produces swarm intelligent behavior. However, mobile robots are normally running with finite energy resource, supplied from finite battery. The limitation of energy resource required human intervention for recharging the batteries. The sharing information among the mobile robots would be one of the potentials to overcome the limitation on previously recharging system. A new approach is proposed based on integrated intelligent system inspired by foraging of honeybees applied to multimobile robot scenario. This integrated approach caters for both working and foraging stages for known/unknown power station locations. Swarm mobile robot inspired by honeybee is simulated to explore and identify the power station for battery recharging. The mobile robots will share the location information of the power station with each other. The result showed that mobile robots consume less energy and less time when they are cooperating with each other for foraging process. The optimizing of foraging behavior would result in the mobile robots spending more time to do real work.
    Matched MeSH terms: Bees
  11. Fulltext Acute renal failure due to multiple bee stings--case reports
    Ramanathan M, Lam HS
    Med J Malaysia, 1990 Dec;45(4):344-6.
    PMID: 2152058
    This report deals with a father and his son who developed acute renal failure following multiple bee stings. The renal lesion in these patients appears to be due to rhabdomyolysis caused by the bee venom. The other mechanisms are also discussed. The need for clinicians to be aware of acute renal failure as a complication of bee stings is stressed.
    Matched MeSH terms: Bees*
  12. Fulltext Anti-Cancer Properties of Heterotrigona itama sp. Honey Via Induction of Apoptosis in Malignant Glioma Cells
    Ahmad F, Seerangan P, Mustafa MZ, Osman ZF, Abdullah JM, Idris Z
    Malays J Med Sci, 2019 Mar;26(2):30-39.
    PMID: 31447606 MyJurnal DOI: 10.21315/mjms2019.26.2.4
    Background: There has been increasing evidence showing that stingless bee honey exhibits anti-oxidant, anti-inflammatory and anti-cancer properties. Pharmacologically-active components in honey such as flavonoids and phenolic constituents are known to contribute to its medicinal benefits. To the best of our knowledge, this is the first study on evaluating anti-cancer effects of locally-produced Malaysian stingless bee honey from Heterotrigona itama sp. on malignant glioma cells.

    Methods: Proliferation and apoptosis studies of U-87 MG cells following stingless bee honey treatment were carried out using MTS assay and acridine orange/propidium iodide dual staining, respectively.

    Results: Results demonstrated time and dose-dependent cytotoxicity using 0.625%, 1.25% and 10% stingless bee honey (P < 0.05). IC50 values were calculated using cells treated with 10% stingless bee honey. It was also observed that 10% stingless bee honey induced nuclear shrinkage, chromatin condensation and nucleus fragmentation, indicating that cellular changes were consistent with the apoptotic characteristics of the cells.

    Conclusion: These data provide a good basis for further evaluation of the medicinal properties of stingless bee honey from Heterotrigona itama sp. This source of honey may serve as a potential therapy for malignant glioma.

    Matched MeSH terms: Bees
  13. Fulltext Neuroscience Club in SKKK3 and SMSTMFP: The Brain Apprentice Project
    Mohd Ibrahim SD, Muda M
    Malays J Med Sci, 2015 Jul-Aug;22(4):64-8.
    PMID: 26715909 MyJurnal
    Sekolah Menengah Sains Tengku Muhammad Faris Petra (SMSTMFP) and Sekolah Kebangsaan Kubang Kerian (3) (SKKK3) were selected by the Department of Neurosciences, Universiti Sains Malaysia (USM), in 2011 to be a 'school-based Neuroscience Club' via the 'Knowledge Transfer Programme (KTP) - Community' project. This community project was known as "The Brain Apprentice Project". The objectives of this project were to promote science and the neurosciences beyond conventional classroom teachings whilst guiding creativity and innovation as well as to assist in the delivery of neuroscience knowledge through graduate interns as part of the cultivation of neuroscience as a fruitful future career option. All of the planned club activities moulded the students to be knowledgeable individuals with admirable leadership skills, which will help the schools produce more scientists, technocrats and professionals who can fulfil the requirements of our religion, race and nation in the future. Some of the activities carried out over the years include the "My Brain Invention Competition", "Mini Brain Bee Contest", "Recycled Melody" and "Brain Dissection". These activities educated the students well and improved their confidence levels in their communication and soft skills. The participation of the students in international-level competition, such as the "International Brain Bee", was one of the ways future professionals were created for the nation. The implementation of Neuroscience Club as one of the organisations in the school's cocurriculum was an appropriate step in transferring science and neuroscience knowledge and skills from a higher education institution, namely USM, to both of the schools, SMSTMFP and SKKK3. The club members showed great interest in all of the club's activities and their performance on the Ujian Pencapaian Sekolah Rendah (UPSR) or Primary School Achievement Test and Sijil Pelajaran Malaysia (SPM) or Malaysian Certificate of Education examinations improved tremendously.
    Matched MeSH terms: Bees
  14. Fulltext Review of the medicinal effects of tualang honey and a comparison with manuka honey
    Ahmed S, Othman NH
    Malays J Med Sci, 2013 May;20(3):6-13.
    PMID: 23966819 MyJurnal
    Tualang honey (TH) is a Malaysian multifloral jungle honey. In recent years, there has been a marked increase in the number of studies published in medical databases regarding its potential health benefits. The honey is produced by the rock bee (Apis dorsata), which builds hives on branches of tall Tualang trees located mainly in the north-western region of Peninsular Malaysia. This review collates the results of the various studies of TH that range from research on tissue culture to randomised control clinical trials. Findings thus far show that, TH has antimicrobial, anti-inflammatory, antioxidant, antimutagenic, antitumor, and antidiabetic properties, in addition to wound-healing attributes. Some of its properties are similar to the well-researched Manuka honey (New Zealand and/or Australian monofloral honey). Distinct differences include higher phenolics, flavonoids, and 5-(hydroxymethyl) furfural (HMF). Compared with Manuka honey, TH is also more effective against some gram-negative bacterial strains in burn wounds.
    Matched MeSH terms: Bees
  15. Fulltext Stingless Bee Honey, the Natural Wound Healer: A Review
    Abd Jalil MA, Kasmuri AR, Hadi H
    Skin Pharmacol Physiol, 2017;30(2):66-75.
    PMID: 28291965 DOI: 10.1159/000458416
    BACKGROUND: The stingless bee is a natural type of bee that exists in almost every continent. The honey produced by this bee has been widely used across time and space. The distinctive feature of this honey is that it is stored naturally in the pot (cerumen), thus contributing to its beneficial properties, especially in the wound healing process.

    METHODS: In this article, several studies on stingless bee honey that pointed out the numerous therapeutic profiles of this honey in terms of its antioxidant, antimicrobial, anti-inflammatory, as well as moisturizing properties are reviewed. All of these therapeutic properties are related to wound healing properties.

    RESULTS: Antioxidant in stingless bee honey could break the chain of free radicals that cause a detrimental effect to the wounded area. Furthermore, the antimicrobial properties of stingless bee honey could overcome the bacterial contamination and thus improve the healing rate. Moreover, the anti-inflammatory attribute in this honey could protect the tissue from highly toxic inflammatory mediators. The moisturizing properties of the honey could improve wound healing by promoting angiogenesis and oxygen circulation.

    CONCLUSION: The application of honey to the wound has been widely used since ancient times. As a result, it is essential to understand the pharmacological mechanism of the honey towards the physiology of the wounded skin in order to optimize the healing rate in the future.

    Matched MeSH terms: Bees
  16. Fulltext Stingless bee honey, a novel source of trehalulose: a biologically active disaccharide with health benefits
    Fletcher MT, Hungerford NL, Webber D, Carpinelli de Jesus M, Zhang J, Stone ISJ, et al.
    Sci Rep, 2020 07 22;10(1):12128.
    PMID: 32699353 DOI: 10.1038/s41598-020-68940-0
    Stingless bee (Meliponini) honey has long been considered a high-value functional food, but the perceived therapeutic value has lacked attribution to specific bioactive components. Examination of honey from five different stingless bee species across Neotropical and Indo-Australian regions has enabled for the first time the identification of the unusual disaccharide trehalulose as a major component representing between 13 and 44 g per 100 g of each of these honeys. Trehalulose is an isomer of sucrose with an unusual α-(1 → 1) glucose-fructose glycosidic linkage and known acariogenic and low glycemic index properties. NMR and UPLC-MS/MS analysis unambiguously confirmed the identity of trehalulose isolated from stingless bee honeys sourced across three continents, from Tetragonula carbonaria and Tetragonula hockingsi species in Australia, from Geniotrigona thoracica and Heterotrigona itama in Malaysia and from Tetragonisca angustula in Brazil. The previously unrecognised abundance of trehalulose in stingless bee honeys is concrete evidence that supports some of the reported health attributes of this product. This is the first identification of trehalulose as a major component within a food commodity. This study allows the exploration of the expanded use of stingless bee honey in foods and identifies a bioactive marker for authentication of this honey in associated food standards.
    Matched MeSH terms: Bees
  17. Fulltext Dynamic microbiome evolution in social bees
    Kwong WK, Medina LA, Koch H, Sing KW, Soh EJY, Ascher JS, et al.
    Sci Adv, 2017 Mar;3(3):e1600513.
    PMID: 28435856 DOI: 10.1126/sciadv.1600513
    The highly social (eusocial) corbiculate bees, comprising the honey bees, bumble bees, and stingless bees, are ubiquitous insect pollinators that fulfill critical roles in ecosystem services and human agriculture. Here, we conduct wide sampling across the phylogeny of these corbiculate bees and reveal a dynamic evolutionary history behind their microbiota, marked by multiple gains and losses of gut associates, the presence of generalist as well as host-specific strains, and patterns of diversification driven, in part, by host ecology (for example, colony size). Across four continents, we found that different host species have distinct gut communities, largely independent of geography or sympatry. Nonetheless, their microbiota has a shared heritage: The emergence of the eusocial corbiculate bees from solitary ancestors appears to coincide with the acquisition of five core gut bacterial lineages, supporting the hypothesis that host sociality facilitates the development and maintenance of specialized microbiomes.
    Matched MeSH terms: Bees/microbiology*
  18. Long live the queen
    Law YH
    Science, 2021 Mar 26;371(6536):1302-1305.
    PMID: 33766870 DOI: 10.1126/science.371.6536.1302
    Matched MeSH terms: Bees/genetics; Bees/physiology*
  19. Fulltext The stingless bee honey protects against hydrogen peroxide-induced oxidative damage and lipopolysaccharide-induced inflammation in vitro
    Ooi TC, Yaacob M, Rajab NF, Shahar S, Sharif R
    Saudi J Biol Sci, 2021 May;28(5):2987-2994.
    PMID: 34025176 DOI: 10.1016/j.sjbs.2021.02.039
    Oxidative stress, DNA damage, and unresolved inflammation are the predisposing factors of many chronic and degenerative diseases, including cancer. Stingless bee honey (SBH) is recognized to have high medicinal value by traditional medicine practitioners and has been used to treat various illnesses traditionally. This study aimed to determine the antioxidant, anti-inflammatory, and genoprotective effects of SBH by using in vitro cell culture models. The sugar content, total phenolic content, radical scavenging activity, and ferric reducing antioxidant power (FRAP) of SBH were determined in this study. Then, the protective effect of SBH against hydrogen peroxide (H2O2)-induced cell death and DNA damage was studied by using WIL2-NS human lymphoblastoid cell line, while the lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophages cell line was used to study the anti-inflammatory effects of SBH. Results from this present study showed that the major sugar contents of SBH were fructose (19.39 + 0.01%) and glucose (14.03 ± 0.03%). Besides, the total phenolic content, the radical scavenging activity, and the FRAP value of SBH were 15.38 ± 0.02 mg GAE/100 g of honey, 34.04 ± 0.21%, and 206.77 + 1.76 μM AAE/100 g honey respectively. Pretreatment with SBH protected WIL2-NS cells from H2O2-induced cell death and DNA damage (p 
    Matched MeSH terms: Bees
  20. Malaysian tualang honey and its potential anti-cancer properties: a review
    Ahmad Firdaus Khalid, Yoke KY, Jun JT
    Sains Malaysiana, 2018;47:2705-2711.
    The use of honey as a therapeutic agent dates back at 8000 years and has markedly increased interest into its potential
    health benefits. The by-products of the flower nectar have a complex chemical composition which promotes benefits in
    underlying mechanism of human diseases. Malaysian Tualang Honey (MTH) is a multifloral jungle honey produced by
    the rock bee (Apis dorsata). This review consolidates the results of carious studies involving biochemical assays of tissue
    culture and animal trials of anti-cancer properties of MTH. Often studied in the context of breast cancer cell lines, MTH
    has promising data for possible mechanisms in anti-cancer activity. These include apoptosis via depolarization of the
    mitochondrial membrane, caspase-dependent apoptosis, reduction of angiogenesis and the promotion of cell cycle arrest
    without posing cytotoxic effect on normal cell lines. Despite positive outcomes in tissue cultures, the oral administration
    of MTH in breast cancer animal models showed slower tumour progression, reduction in tumour size and better grading
    of histological features. The alleviation of breast carcinogenesis via modulation of hematologic, estrogenic and apoptotic
    activities promotes MTH as a promising anticancer agent. With confidence in a conclusion that MTH is a useful treatment
    for cancer, further experimental and clinical studies should be conducted.
    Matched MeSH terms: Bees
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