Displaying publications 1 - 20 of 429 in total

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  1. Fulltext Innovation of buying and selling process for used reference materials
    Zuraini Jusoh, Nur Amirah Zainal, Nurhidayah Abu Bakar, Dina Adriana Mohd Rahmatullah, Nur Zulaikha Ab Rahman, Farah Adibah Ahmad Zaifuddin, et al.
    Jurnal Inovasi Malaysia, 2020;4(1):132-149.
    MyJurnal
    Students need the used of reference materials because they want to save their money for daily expenses. It is also as their side income if they become as a seller. However, the available buying and selling process using Whatsapp as a medium seen inefficient because the user was faced with several problems. Among the problems were incomplete advertisements information, sale status cannot be updated automatically and the process of buying and selling takes too long. Therefore, the construction of the BOOKU webpage is recommended to solve the problems. There was a several methods used in problem selection phase such as brain storming, preliminary study of problems, verification and validation as well as T-shape Matrix. Ishikawa diagram has been used to identify the cause and effect of the problem in terms of material, process, human and environmental factors. A review from user also was carried out to obtain an endorsement of the problem in hand. Then the SWOT analysis method was used to assess the suggestion solution. After the completion construction of BOOKU webpage, a few trials were carried out to ensure the BOOKU webpage functioned properly. Again, a review from the user was carried out based on the trials results. The result showed majority of users was agreed on the BOOKU webpage as a good solution for identified problems. The BOOKU webpage can provide a completed advertisement, automatically updated the sale status and the buying and selling process has been shorten from seven days to one day. For the spin-off project, the BOOKU website is planned to be devoted to the borrowing service for used of reference materials. Meanwhile for the purpose of replicating, the BOOKU webpage can be adapted in the school level. In conclusion, the BOOKU webpage can increase the quality of available process. It also can optimize the use of manpower and time.
    Matched MeSH terms: Hand
  2. Calcinosis of hand and axilla in polymyositis/dermatomyositis
    Zulkifli A
    Med J Malaysia, 1979 Jun;33(4):362-4.
    PMID: 522752
    Matched MeSH terms: Hand
  3. Fulltext Influencing factors for cholera and diarrhoea: water sanitation and hygiene in impoverished rural villages of Beluran District, Sabah Malaysia
    Zin, Thant, SabaiAung, Tin, Sahipudin Saupin, Myint, Than, KhinSN, Daw, Aung, Meiji Soe, et al.
    Malaysian Journal of Public Health Medicine, 2015;15(1):0-0.
    MyJurnal
    The lower percentage of water, sanitation and hygiene are the root causes of diarrhoea and cholera. Cholera is a sudden onset of acute watery diarrhoea which can progress to severe dehydration and death if untreated. The current pandemic, Vibrio Cholera O1 started in 1961. This study explores water, sanitation, hygiene and cholera and diarrhoea in three affected villages of Beluran District, Sabah Malaysia to support effective and timely public health intervention. This cross sectional study uses purposive sampling. All (114) households were interviewed and household water samples collected. The study reported lower coverage improved sanitation facilities (35.3% to 52.3%), no latrine at home (37% to 63%), improved water supply (52% to 60%), and prevalence of hand washing after toilet (57% - 74%). For water quality, Ecoli was present in household water (32% to 37%) but Vibrio cholerae was not isolated in any of the water samples tested. Statistically significant associations were found for; 1) occupation−nonagriculture and unimproved sanitation facility and 2) house ownership and correct knowledge of ORS preparation. Predictors for household water quality were: latrine at home, and improved household toilet. Aggressive strategies to improve water supply, sanitation and hygiene−hand washing after toilet−were recommended for future prevention of cholera and diarrhoea in the affected area.
    Matched MeSH terms: Hand Disinfection
  4. Fulltext The Nexus of Sports-Based Development and Education of Mental Health and Physical Fitness
    Zhang T, Liu H, Lu Y, Wang Q
    Int J Environ Res Public Health, 2023 Feb 20;20(4).
    PMID: 36834432 DOI: 10.3390/ijerph20043737
    Physical inactivity has increased globally, particularly in developed nations. A high proportion of the human population is unable to meet the physical activity recommendation of the World Health Organisation due to hypertension, metabolic syndrome, obesity, and other medical conditions. Non-communicable diseases and mental health problems are becoming more prevalent, particularly in low and middle-income nations. This study aimed to determine the effectivenessof a mentorship programmeon university students' mental health and physical fitness. The intervention comprised the effects of sports-based development and education on physical fitness and mental health. A total of 196 and 234 students from two universities were randomly assigned to the intervention and control groups, respectively. The primary outcomes were engagement in physical activities (number of push-ups for 1 min, the strength of hand grip (kg), and the Jump test while standing (cm)), body fat proportion and psychological resilience, self-efficacy, and relationship with family and schoolmates. Participants in the control group had access to a web-based health education game, whereas the intervention group wassubjected to intensive interventional activities for one month based on the eight principles of the National Research Council and Institute of Medicine. Data were analysed using Analysis of Variance (ANOVA) to compare the physical and mental components between the intervention and control groups. Relative to baseline, all the physical health components (push-ups, sit-ups, and jump tests), psychological resilience, relationship with family members, and self-efficacy increased significantly in the intervention compared to the control group. Body fat composition was significantly reduced in the intervention when compared tothe control group. In conclusion, the mentorship programme effectively improved the participants' physical and psychological health and could be developed further for application in a larger population.
    Matched MeSH terms: Hand Strength
  5. Fulltext Social media use as a predictor of handwashing during a pandemic: evidence from COVID-19 in Malaysia
    Zhang SX, Graf-Vlachy L, Looi KH, Su R, Li J
    Epidemiol Infect, 2020 10 23;148:e261.
    PMID: 33092675 DOI: 10.1017/S0950268820002575
    Although handwashing is an effective way to prevent infections, there is scarce evidence on predictors of handwashing during a pandemic. This paper aims to identify behavioural and demographic predictors of handwashing. The study surveyed 674 adults in Malaysia in May 2020 regarding whether the time spent on social media predicted handwashing contingent on gender and number of children. More time spent on social media was positively associated with handwashing for males with three or more children. However, for males without children, social media use was negatively associated with handwashing. The association was not significant for males with one or two children. For females, more time spent on social media was significantly linked to more handwashing only for females with one child. Gender, a traditional predictor of handwashing, was a useful predictor only for those who spent more than three hours per day on social media and had at most one child. Number of children was a novel negative predictor for males who did not use social media and who averaged one hour per day on social media, a positive predictor for males who spent lots of time on social media, but not a predictor for females. In sum, social media use predicts handwashing, and is thus a helpful variable for use in targeted health communication during a pandemic - particularly through social media. Further, more conventional predictors like gender and number of children exhibit contingency effects with social media use.
    Matched MeSH terms: Hand Disinfection*
  6. Fulltext Isolated facial palsy due to intra-aural tick (ixodoidea) infestation
    Zamzil Amin, A., Baharudin, A., Shahid, H., Din Suhaimi, S., Nor Affendie, M.J.
    Archives of Orofacial Sciences, 2007;2(1):51-53.
    MyJurnal
    A tick in the ear is a very painful condition and removal is difficult because it grips firmly to the external auditory canal or tympanic membrane. Facial paralysis is a rarely reported localised neurological complication of an intra-aural tick infestation. The pathophysiology of localised paralysis is discussed, together with the safe way of handling patients with an intra-aural tick infestation.
    Matched MeSH terms: Hand Strength
  7. Atmospheric PCDDs/PCDFs levels and occurrences in Southeast Asia: A review
    Zain SMSM, Latif MT, Baharudin NH, Anual ZF, Mohd Hanif N, Khan MF
    Sci Total Environ, 2021 Aug 20;783:146929.
    PMID: 34088111 DOI: 10.1016/j.scitotenv.2021.146929
    Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are toxic compounds derived from anthropogenic sources that stay in the environment for long periods. Ambient air has become the most important pathway for the transfer of PCDDs/PCDFs from emission sources to the environment. This review intends to summarise the information available on atmospheric PCDDs/PCDFs in the countries of Southeast Asia to provide a detailed description of the trends in PCDDs/PCDFs emissions, key sources, and levels in urban, rural, and industrial air as reported in peer-reviewed literature since 2000 and by the United Nations Environment Programme. As the largest country in Southeast Asia, Indonesia is the major PCDDs/PCDFs emitter, accounting for 72.81% of the total release of PCDDs/PCDFs in the air from all available inventories in this region, while Brunei Darussalam is the lowest emitter, contributing to less than 0.02%. Open burning processes have become the largest source of ambient PCDDs/PCDFs in the region (69.62%), followed by waste incineration (10.69%), and ferrous and non-ferrous metal production (8.78%). PCDDs/PCDFs levels in rural areas ranged between 10 and 38 fg TEQ m-3; however, where open burning waste has occurred, the levels rose to 12-29 times higher. In urban areas, ambient levels were 15 times greater than in rural areas, varying from 23 to 565 fg TEQ m-3. Atmospheric concentrations near industrial palm oil and waste incinerator sites were between 64 and 1530 fg TEQ m-3. The non-cancer risk of ambient exposure to PCDDs/PCDFs through inhalation is low among populations near facilities emitting PCDDs/PCDFs. The lack of local technical capacity, the high economic costs, and the lack of established human resource capacities have been the major challenges in conducting ambient PCDDs/PCDFs studies in most countries in the region.
    Matched MeSH terms: Hand
  8. Fulltext A biomechanical study of grip and pinch strength among Malaysian elderly population
    Zahari Taha, Ruhaizin Sulaiman
    Pertanika Journal of Science & Technology, 2011;19(2):293-305.
    MyJurnal
    The physical strength of the elderly aged above 60 years is typically 10 to 30% less than the young adult population of ages between 25 to 35 years. This reduction of strength has a strong impact on the activity of the daily living (ADL) of the elderly population. There has been little research done studying on the physical strength of the elderly population in Malaysia. The objective of this study was to determine the static strength of the elderly population in Malaysia. In particular, the grip and pinch strength were investigated as these two static strengths are extensively used in their instrumental activity of daily living (IADL). The results were then compared to the strength of the university students. A total of 30 subjects (15 males and 15 females) participated in the study. Their age ranged between 60 to 83 years, with the mean of age of 67.1 years. The comparison group comprised a total of 30 university students (20 male, 10 female) aged between 23 to 24 years, with the mean of age of 23.2 years. Grip and pinch strengths of both groups were measured and analysed using a descriptive statistics. It was found that the elderly male subjects are stronger in both strength measurements than their female counterpart. The 95th percentile of the female grip strength was slightly lower than that of the male while the male pinch strength was 31.07% higher. It was also found that the male students had higher strengths compared to the females. The grip strength of the elderly was 30.66% lower than the university student, while their pinch strength was 13.42% lower. Both static strengths of the elderly were found to be lower than those of the university students. This supported the research hypotheses postulating that the static strength had a negative correlation with age. In terms of gender differences, the male subjects were found to be stronger than the females.
    Matched MeSH terms: Hand Strength
  9. Shifts in mosquito diversity and abundance along a gradient from oil palm plantations to conterminous forests in Borneo
    Young KI, Buenemann M, Vasilakis N, Perera D, Hanley KA
    Ecosphere, 2021 Apr;12(4).
    PMID: 33996190 DOI: 10.1002/ecs2.3463
    Deforestation precipitates spillover of enzootic, vector-borne viruses into humans, but specific mechanisms for this effect have rarely been investigated. Expansion of oil palm cultivation is a major driver of deforestation. Here, we demonstrate that mosquito abundance decreased over ten stepwise distances from interior forest into conterminous palm plantations in Borneo. Diversity in interior plantation narrowed to one species, Aedes albopictus, a potential bridge vector for spillover of multiple viruses. A. albopictus was equally abundant across all distances in forests, forest-plantation edge, and plantations, while A. niveus, a known vector of sylvatic dengue virus, was found only in forests. A. albopictus collections were significantly female-biased in plantation but not in edge or forest. Our data reveal that the likelihood of encountering any mosquito is greater in interior forest and edge than plantation, while the likelihood of encountering A. albopictus is equivalent across the gradient sampled from interior plantation to interior forest.
    Matched MeSH terms: Hand
  10. Enterovirus A71 and coxsackievirus A16 show different replication kinetics in human neuronal and non-neuronal cell lines
    Yogarajah T, Ong KC, Perera D, Wong KT
    Arch Virol, 2017 Mar;162(3):727-737.
    PMID: 27878462 DOI: 10.1007/s00705-016-3157-4
    Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are closely related enteroviruses that cause hand, foot and mouth disease (HFMD) in children. Serious neurological complications almost always occur in EV-A71 infection, but are rare in CV-A16 infection. Based on the hypothesis that this may be because EV-A71 infects neuronal cells more easily than CV-A16, we compared virus infection, replication and spread of EV-A71 and CV-A16 in SK-N-SH cells. We found that CV-A16 invariably showed significantly lower replication and caused less necrotic cell death in SK-N-SH cells, compared with EV-A71. This was not due to a lower proportion of CV-A16-infected cells, since both viruses showed similar proportions of infected cells at all time points analyzed. Furthermore, reduced replication of CV-A16 in SK-N-SH cells does not appear to be due to limited viral receptor availability, which might limit viral entry, because experiments with viral RNA-transfected cells showed the same results as for live virus infections. On the other hand, no differences were observed between EV-A71 and CV-A16 in RD cells and results were generally similar in RD cells for both viruses. Taken together, our findings suggest that the poor growth of CV-A16 and EV-A71in SK-N-SH cells, compared with RD cells, may be due to cell type-specific restrictions on viral replication and spread. Furthermore, the lower viral replication and necrotic cell death in CV-A16-infected SK-N-SH cells, compared with EV-A71-infected SK-N-SH cells, is consistent with the lower prevalence of neurotropism observed in CV-A16-associated HFMD outbreaks. Nonetheless, in vivo data and more extensive comparisons of different viral strains are essential to confirm our findings.
    Matched MeSH terms: Hand, Foot and Mouth Disease
  11. Florid peripheral stigmata of staphylococcus aureus infective endocarditis
    Yew KL, Razali F
    Acute Card Care, 2015;17(2):32.
    PMID: 26458028 DOI: 10.3109/17482941.2015.1066822
    Matched MeSH terms: Hand/pathology*
  12. Fulltext T Cell Immunity To Enterovirus 71 Infection In Humans And Implications For Vaccine Development
    Yee PTI, Poh CL
    Int J Med Sci, 2018;15(11):1143-1152.
    PMID: 30123051 DOI: 10.7150/ijms.26450
    Enterovirus 71 (EV-A71) is one of the major pathogens causing hand, foot and mouth disease (HFMD). Some strains can lead to neurological disease and fatality in children. Up to date, there is no FDA-approved vaccine to prevent severe HFMD and mortality. Although the inactivated vaccine has advanced to production in China, lack of long-term protection and the requirement of multiple boosters have necessitated the development of other types of vaccines. Recent studies indicate that cellular and not humoral immunity determines the clinical outcome of EV-A71 infections. High levels of cytokines such as IL-1β, IL-6, IL-10 and IFN-γ tend to correlate with clinical severity in patients with pulmonary edema and encephalitis. The live attenuated vaccine may serve as the preferred choice as it can induce excellent humoral and cellular immunity as well as live-long immunity. Expression of certain HLA alleles such as TNF-α promoter type II (-308 allele), HLA-A33 and HLA-DR17 responses have been linked to severe HFMD. However, the high variability of MHC genes could restrict T cell recognition and be a major obstacle in the design of peptide vaccines. Hence, the development of a T cell universal vaccine (incorporating both CD4+ and CD8+ T cell epitopes) that induces broad, multifunctional and cross-reactive CD8+ T cell responses maybe desirable.
    Matched MeSH terms: Hand, Foot and Mouth Disease/immunology
  13. Fulltext Development of live attenuated Enterovirus 71 vaccine strains that confer protection against lethal challenge in mice
    Yee PTI, Tan SH, Ong KC, Tan KO, Wong KT, Hassan SS, et al.
    Sci Rep, 2019 03 18;9(1):4805.
    PMID: 30886246 DOI: 10.1038/s41598-019-41285-z
    Besides causing mild hand, foot and mouth infections, Enterovirus A71 (EV-A71) is associated with neurological complications and fatality. With concerns about rising EV-A71 virulence, there is an urgency for more effective vaccines. The live attenuated vaccine (LAV) is a more valuable vaccine as it can elicit both humoral and cellular immune responses. A miRNA-based vaccine strain (pIY) carrying let-7a and miR-124a target genes in the EV-A71 genome which has a partial deletion in the 5'NTR (∆11 bp) and G64R mutation (3Dp°l) was designed. The viral RNA copy number and viral titers of the pIY strain were significantly lower in SHSY-5Y cells that expressed both let-7a and miR-124a. Inhibition of the cognate miRNAs expressed in RD and SHSY-5Y cells demonstrated de-repression of viral mRNA translation. A previously constructed multiply mutated strain, MMS and the pIY vaccine strain were assessed in their ability to protect 4-week old mice from hind limb paralysis. The MMS showed higher amounts of IFN-γ ex vivo than the pIY vaccine strain. There was absence of EV-A71 antigen in the skeletal muscles and spinal cord micrographs of mice vaccinated with the MMS and pIY strains. The MMS and pIY strains are promising LAV candidates developed against severe EV-A71 infections.
    Matched MeSH terms: Hand, Foot and Mouth Disease/diagnosis; Hand, Foot and Mouth Disease/immunology; Hand, Foot and Mouth Disease/prevention & control*; Hand, Foot and Mouth Disease/virology
  14. Development of Novel miRNA-based Vaccines and Antivirals against Enterovirus 71
    Yee PT, Poh CL
    Curr Pharm Des, 2016;22(44):6694-6700.
    PMID: 27510488 DOI: 10.2174/1381612822666160720165613
    The Hand, Foot and Mouth Disease (HFMD) is caused by Enterovirus 71 (EV-A71) and Coxsackieviruses. Common HFMD symptoms are high fever (≥ 39°C), rashes, and ulcers but complications due to virulent EV-A71 may arise leading to cardiopulmonary failure and death. The lack of vaccines and antiviral drugs against EV-A71 highlights the urgency of developing preventive and treatment agents. Recent studies have reported the emergence of novel antiviral agents and vaccines that utilize microRNAs (miRNAs). They belong to a class of small (19-24 nt) non coding RNA molecules. As miRNAs play a major role in the host regulatory system, there is a huge opportunity for interplay between host miRNAs and EV-A71 expressions. A total of 42 out of 64 miRNAs were up-regulated in EV-A71-infected cells. There was consistent up-regulation of miR-1246 gene expression that targeted the DLG3 gene which contributes to neurological pathogenesis. In contrast, miR-30a that targets calcium channels for membrane transportation was down-regulated. This leads to repression of EV-A71 replication. The impact of host miRNAs on immune activation, shutdown of host protein synthesis, apoptosis, signal transduction and viral replication are discussed. miRNAs have been used in the construction of live attenuated vaccines (LAV) such as the poliovirus LAV that has miRNA binding sites for let-7a or miR-124a. The miRNAbearing vaccine will not replicate in neuronal cells carrying the corresponding miRNA but could still replicate in the gastrointestinal tract and hence remains to act as immunogens. As such, miRNAs are attractive candidates to be developed as vaccines and antivirals.
    Matched MeSH terms: Hand, Foot and Mouth Disease/drug therapy; Hand, Foot and Mouth Disease/prevention & control; Hand, Foot and Mouth Disease/therapy*
  15. Erythematous verrucous plaque on the hand
    Yee EY, Choon SE
    Cutis, 2018 Oct;102(4):223;230;231.
    PMID: 30489556
    Matched MeSH terms: Hand Dermatoses/complications; Hand Dermatoses/diagnosis*; Hand Dermatoses/drug therapy
  16. Rheumatoid arthritis in paintings: a tale of two origins
    Yeap SS
    Int J Rheum Dis, 2009 Dec;12(4):343-7.
    PMID: 20374373 DOI: 10.1111/j.1756-185X.2009.01434.x
    Rheumatoid arthritis (RA) is thought to be a 'recent' disease in that descriptions of it were only noted in the 17th century. However, a study of paintings would suggest that RA could have been present as early as the 15th century, when artists started to paint the human body accurately rather than figuratively. Thus, it was possible to deduce from their paintings the occurrence of various medical conditions. If present, RA with its typical finger deformities should be apparent. This review discusses the known occurrences of RA-type deformities in paintings and places this in the context of the origins of the disease.
    Matched MeSH terms: Hand Deformities, Acquired/etiology; Hand Deformities, Acquired/history*
  17. Fulltext Handwashing at University Hospital
    Yasmin AH, Yasmin MY
    Med J Malaysia, 1993 Jun;48(2):251-2.
    PMID: 8350809
    Matched MeSH terms: Hand Disinfection*
  18. Fulltext Public Knowledge and Adherence to Hand Hygienic Guidelines for the Prevention of SARS-CoV-2 Transmission: A Cross-sectional Survey from Pakistan
    Yaseen MO, Saif A, Khan TM, Yaseen M
    Disaster Med Public Health Prep, 2022 Oct;16(5):1922-1928.
    PMID: 33762050 DOI: 10.1017/dmp.2021.92
    OBJECTIVE: Good hand hygienic practices are considered an important factor to curb the transmission and emergence of SARS-CoV -2. Various studies, conducted previously during the outbreaks of SARS-CoV and MERS-CoV, have ascertained the effectiveness of adopting good hand hygienic practices to curb the emergence of these viruses. This study aims to explore public hand hygienic practices during the peak pandemic period.

    METHOD: A descriptive cross-sectional study was conducted among the general population of Pakistan to investigate the knowledge and perception about hand hygiene, self-reported hand hygiene practices, adherence to hand hygienic guidelines, and barriers to optimal hand hygiene. Kruskal-Wallis test, Mann-Whitney U test, and Regression model were used for statistical analysis.

    RESULTS: There was a significant difference in area-based knowledge (P = 0.026), beliefs (P = 0.027), and practices (P = 0.002) regarding hand hygiene. The results of regression analysis revealed that people in urban areas were more likely to have better knowledge (β = 0.108, CI = 0.076 - 0.05, P = 0.008) and better adherence (β = 0.115, CI = 0.514 - 2.68, P = 0.004) to hand hygienic practices.

    CONCLUSION: Advertisements on television and other electronic media with appealing slogans could be effective in making people more compliant to optimal hand hygienic practices.

    Matched MeSH terms: Hand Hygiene*
  19. Fulltext Risk Factors Associated with Sarcopenia Among Independently Mobile, Institutionalised Older People in the Klang Valley of Malaysia: A Cross-Sectional Study
    Yap SF, Boo NY, Pramod DS, Thaw Z, Liew SF, Woo LF, et al.
    Malays J Med Sci, 2020 Mar;27(2):120-128.
    PMID: 32788848 MyJurnal DOI: 10.21315/mjms2020.27.2.13
    Background: Studies on sarcopenia among Malaysian older people (OP ≥ 60 years of age) living in the community but not in long-term care (LTC) homes have been reported previously. This study aimed to determine the prevalence of sarcopenia and its risk factors in OP in Malaysian LTC homes.

    Methods: This cross-sectional study was conducted with 202 independently mobile OP (males 32%) in seven LTC homes in the Klang Valley of Malaysia. Trained personnel measured their anthropometrics, body composition, gait speed, hand grip strength and timed up-and-go (TUG) duration. Criteria of the European Working Group on Sarcopenia in Older People (EWGSOP) and of the Asian Working Group for Sarcopenia were used to identify the presence of sarcopenia. The mini-nutritional assessment (MNA) was used to determine their nutritional status. Additionally, logistic regression analysis was performed to identify significant risk factors associated with pre-sarcopenia/sarcopenia.

    Results: Pre-sarcopenia/sarcopenia was detected in 103 (51%) OP. The significant risk factors were body mass index (BMI, weight/height2; adjusted odds ratio [AOR] = 0.44, P < 0.001), percentage of body fat (PBF; AOR = 1.26, P < 0.001), age group (≥ 80 years; AOR = 3.63, P = 0.025) and 'at risk of malnutrition' status (AOR = 2.63, P = 0.049).

    Conclusion: Sarcopenia is common among OP in LCT homes. The risk increases with decreasing BMI, increasing PBF, age ≥ 80 years and suboptimal nutrition status.

    Matched MeSH terms: Hand Strength
  20. The pattern of allergic contact hand dermatitis at a tertiary skin clinic in Sarawak, Malaysia
    Yap FBB
    Dermatitis, 2010 May-Jun;21(3):179-81.
    PMID: 20487668
    Matched MeSH terms: Hand Dermatoses/diagnosis; Hand Dermatoses/etiology*
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