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  1. Fulltext Two-Dimensional Non-Carbon Materials-Based Electrochemical Printed Sensors: An Updated Review
    Falina S, Anuar K, Shafiee SA, Juan JC, Manaf AA, Kawarada H, et al.
    Sensors (Basel), 2022 Dec 01;22(23).
    PMID: 36502059 DOI: 10.3390/s22239358
    Recently, there has been increasing interest in electrochemical printed sensors for a wide range of applications such as biomedical, pharmaceutical, food safety, and environmental fields. A major challenge is to obtain selective, sensitive, and reliable sensing platforms that can meet the stringent performance requirements of these application areas. Two-dimensional (2D) nanomaterials advances have accelerated the performance of electrochemical sensors towards more practical approaches. This review discusses the recent development of electrochemical printed sensors, with emphasis on the integration of non-carbon 2D materials as sensing platforms. A brief introduction to printed electrochemical sensors and electrochemical technique analysis are presented in the first section of this review. Subsequently, sensor surface functionalization and modification techniques including drop-casting, electrodeposition, and printing of functional ink are discussed. In the next section, we review recent insights into novel fabrication methodologies, electrochemical techniques, and sensors' performances of the most used transition metal dichalcogenides materials (such as MoS2, MoSe2, and WS2), MXenes, and hexagonal boron-nitride (hBN). Finally, the challenges that are faced by electrochemical printed sensors are highlighted in the conclusion. This review is not only useful to provide insights for researchers that are currently working in the related area, but also instructive to the ones new to this field.
    Matched MeSH terms: Transition Elements*
  2. Potential application of 2D nano-layered MXene in analysing and remediating endocrine disruptor compounds and heavy metals in water
    Rozaini MNH, Khoo KS, Abdah MAAM, Ethiraj B, Alam MM, Anwar AF, et al.
    Environ Geochem Health, 2024 Mar 11;46(3):111.
    PMID: 38466501 DOI: 10.1007/s10653-024-01917-4
    With the advancement of technologies and growth of the economy, it is inevitable that more complex processes are deployed, producing more heterogeneous wastewater that comes from biomedical, biochemical and various biotechnological industries. While the conventional way of wastewater treatment could effectively reduce the chemical oxygen demand, pH and turbidity of wastewater, trace pollutants, specifically the endocrine disruptor compounds (EDCs) that exist in µg L-1 or ng L-1 have further hardened the detection and removal of these biochemical pollutants. Even in small amounts, EDC could interfere human's hormone, causing severe implications on human body. Hence, this review elucidates the recent insights regarding the effectiveness of an advanced 2D material based on titanium carbide (Ti3C2Tx), also known as MXene, in detecting and removing EDCs. MXene's highly tunable feature also allows its surface chemistry to be adjusted by adding chemicals with different functional groups to adsorb different kinds of EDCs for biochemical pollution mitigation. At the same time, the incorporation of MXene into sample matrices also further eases the analysis of trace pollutants down to ng L-1 levels, thereby making way for a more cleaner and comprehensive wastewater treatment. In that sense, this review also highlights the progress in synthesizing MXene from the conventional method to the more modern approaches, together with their respective key parameters. To further understand and attest to the efficacy of MXene, the limitations and current gaps of this potential agent are also accentuated, targeting to seek resolutions for a more sustainable application.
    Matched MeSH terms: Transition Elements*
  3. Current Innovations of Metal Hexacyanoferrates-Based Nanocomposites toward Electrochemical Sensing: Materials Selection and Synthesis Methods
    Lee PK, Woi PM
    Crit Rev Anal Chem, 2020;50(5):393-404.
    PMID: 31335176 DOI: 10.1080/10408347.2019.1642733
    Mixed valence transition metal hexacyanoferrates (MeHCF)-Prussian blue and its analogs receive enormous research interest in the electrochemical sensing field. In recent years, conducting materials such as conducting polymer, carbon nanomaterial, and noble metals have been used to form nanocomposites with MeHCF. The scope of this review offers the reasons behind the preparation of various MeHCF based nanocomposite toward electrochemical detection. We primarily focus on the current progress of the development of MEHCF-based nanocomposites. The synthesis methods for these nanocomposites are also reviewed and discussed.
    Matched MeSH terms: Transition Elements/analysis*
  4. Ultrahigh-current-density niobium disulfide catalysts for hydrogen evolution
    Yang J, Mohmad AR, Wang Y, Fullon R, Song X, Zhao F, et al.
    Nat Mater, 2019 12;18(12):1309-1314.
    PMID: 31451781 DOI: 10.1038/s41563-019-0463-8
    Metallic transition metal dichalcogenides (TMDs)1-8 are good catalysts for the hydrogen evolution reaction (HER). The overpotential and Tafel slope values of metallic phases and edges9 of two-dimensional (2D) TMDs approach those of Pt. However, the overall current density of 2D TMD catalysts remains orders of magnitude lower (~10-100 mA cm-2) than industrial Pt and Ir electrolysers (>1,000 mA cm-2)10,11. Here, we report the synthesis of the metallic 2H phase of niobium disulfide with additional niobium (2H Nb1+xS2, where x is ~0.35)12 as a HER catalyst with current densities of >5,000 mA cm-2 at ~420 mV versus a reversible hydrogen electrode. We find the exchange current density at 0 V for 2H Nb1.35S2 to be ~0.8 mA cm-2, corresponding to a turnover frequency of ~0.2 s-1. We demonstrate an electrolyser based on a 2H Nb1+xS2 cathode that can generate current densities of 1,000 mA cm-2. Our theoretical results reveal that 2H Nb1+xS2 with Nb-terminated surface has free energy for hydrogen adsorption that is close to thermoneutral, facilitating HER. Therefore, 2H Nb1+xS2 could be a viable catalyst for practical electrolysers.
    Matched MeSH terms: Transition Elements
  5. Impact of UV radiation on Mxene-mediated tubulin dissociation and mitochondrial apoptosis in breast cancer cells
    Tan EW, Simon SE, Numan A, Khalid M, Tan KO
    Colloids Surf B Biointerfaces, 2024 Mar;235:113793.
    PMID: 38364521 DOI: 10.1016/j.colsurfb.2024.113793
    Breast cancer is a global health concern that requires personalized therapies to prevent relapses, as conventional treatments may develop resistance over time. Photothermal therapy using spectral radiation or intense light emission is a broad-spectrum treatment that induces hyperthermia-mediated cancer cell death. MXene, a two-dimensional material, has been reported to have potential biological applications in photothermal therapy for cancer treatment. In this study, we investigated the apoptotic activity of MXene and UV-irradiated MXene in MCF-7 breast cancer cells by treating them with varying concentrations of MXene. The cytotoxicity of MXene and UV was evaluated by analyzing cellular morphology, nuclei condensation, caspase activation, and apoptotic cell death. We also assessed the effect of the combined treatment on the expression and cellular distribution of Tubulin, a key component of microtubules required for cell division. At low concentrations of MXene (up to 100 µg/ml), the level of cytotoxicity in MCF-7 cells was low. However, the combined treatment of MXene and UV resulted in a synergistic increase in cytotoxicity, causing rounded cellular morphology, condensed nuclei, caspase activation, and apoptotic cell death. Furthermore, the treatment reduced Tubulin protein expression and cellular distribution, indicating a potent inducer of cell death with potential application for cancer treatment. The study demonstrates that the combined treatment of MXene and UVB irradiation is a promising strategy for inducing apoptotic cell death in breast cancer cells, suggesting its potential as a therapeutic intervention for breast cancer.
    Matched MeSH terms: Transition Elements*
  6. Highly electrochemically active Ti3C2Tx MXene/MWCNT nanocomposite for the simultaneous sensing of paracetamol, theophylline, and caffeine in human blood samples
    Mari E, Duraisamy M, Eswaran M, Sellappan S, Won K, Chandra P, et al.
    Mikrochim Acta, 2024 Mar 20;191(4):212.
    PMID: 38509344 DOI: 10.1007/s00604-024-06273-9
    The facile fabrication is reported of highly electrochemically active Ti3C2Tx MXene/MWCNT (3D/1D)-modified screen-printed carbon electrode (SPE) for the efficient simultaneous electrochemical detection of paracetamol, theophylline, and caffeine in human blood samples. 3D/1D Ti3C2Tx MXene/MWCNT nanocomposite was synthesized using microwave irradiation and ultrasonication processes. Then, the Ti3C2Tx/MWCNT-modified SPE electrode was fabricated and thoroughly characterized towards its physicochemical and electrochemical properties using XPS, TEM, FESEM, XRD, electrochemical impedance spectroscopy, cyclic voltammetry, and differential pulse voltammetry techniques. As-constructed Ti3C2Tx-MWCNT/SPE offers excellent electrochemical sensing performance with good detection limits (0.23, 0.57, and 0.43 µM) and wide linear ranges (1.0 ~ 90.1, 2.0 ~ 62.0, and 2.0-90.9 µM) for paracetamol, caffeine, and theophylline, respectively,  in the human samples. Notably, the non-enzymatic electroactive nanocomposite-modified electrode has depicted a semicircle Nyquist plot with low charge transfer resistance (Rct∼95 Ω), leading to high ionic diffusion and facilitating an excellent electron transfer path. All the above results in efficient stability, reproducibility, repeatability, and sensitivity compared with other reported works, and thus, it claims its practical utilization in realistic clinical applications.
    Matched MeSH terms: Transition Elements*
  7. Electrical and magneto-transport properties of magneto-resistive La 0.7 Ca 0.28 Sr 0.2 MnO3 prepared at different sintering temperature
    Ewe L, Ramli R, Lim K, Abd-Shukor R
    Sains Malaysiana, 2012;41:761-768.
    The effects of strontium doping on the electrical and magneto-transport properties of magneto resistive La0.7Ca0.28Sr0.02MnO3 at different sintering temperatures have been studied. The samples were prepared by the co-precipitation technique (COP) and sintered at 1120, 1220 and 1320 oC. XRD patterns revealed that the samples have an orthorhombic structure and the diffraction patterns can be indexed with the Pbnm space group. The insulator metal transition, TIM increased linearly from 261 K to 272 K with the increase in sintering temperature. The magnetoresistance (MR) measurements were made in magnetic fields from 0.1 to 1 T at room temperature. The percentage of MR increased with increasing of magnetic field and sintering temperature for all samples. The electrical resistivity data were fitted with several equations in the metallic (ferromagnetic) and insulator (paramagnetic) regime. The density of states at the Fermi level N(EF) and the activation energy (Ea) of electron hopping were estimated by using variable range hopping and small polaron hopping model.
    Matched MeSH terms: Transition Elements
  8. Fulltext Visualizing copper assisted graphene growth in nanoscale
    Rosmi MS, Yusop MZ, Kalita G, Yaakob Y, Takahashi C, Tanemura M
    Sci Rep, 2014;4:7563.
    PMID: 25523645 DOI: 10.1038/srep07563
    Control synthesis of high quality large-area graphene on transition metals (TMs) by chemical vapor deposition (CVD) is the most fascinating approach for practical device applications. Interaction of carbon atoms and TMs is quite critical to obtain graphene with precise layer number, crystal size and structure. Here, we reveal a solid phase reaction process to achieve Cu assisted graphene growth in nanoscale by in-situ transmission electron microscope (TEM). Significant structural transformation of amorphous carbon nanofiber (CNF) coated with Cu is observed with an applied potential in a two probe system. The coated Cu particle recrystallize and agglomerate toward the cathode with applied potential due to joule heating and large thermal gradient. Consequently, the amorphous carbon start crystallizing and forming sp(2) hybridized carbon to form graphene sheet from the tip of Cu surface. We observed structural deformation and breaking of the graphene nanoribbon with a higher applied potential, attributing to saturated current flow and induced Joule heating. The observed graphene formation in nanoscale by the in-situ TEM process can be significant to understand carbon atoms and Cu interaction.
    Matched MeSH terms: Transition Elements
  9. Fulltext Scalable Mesoporous Platinum Diselenide Nanosheet Synthesis in Water
    Ali Umar A, Md Saad SK, Mat Salleh M
    ACS Omega, 2017 Jul 31;2(7):3325-3332.
    PMID: 31457657 DOI: 10.1021/acsomega.7b00580
    Newly discovered two-dimensional (2D) atomic crystals (nanosheet) of platinum diselenide (PtSe2) have progressively attracted attention due to their expected high performance in catalysis, sensing, electronics, and optoelectronics applications. Further extraordinary physicochemical properties are expected if these nanosheets of platinum diselenide can possess mesoporosity as this may enable a high range of molecular adsorption, enhancing their functionalities in catalysis, batteries, supercapacitors, and sensing. Here, we present for the first time a straightforward, aqueous-phase synthetic strategy for the preparation of scalable nanosheets of platinum diselenide with mesoporous structure via a surfactant-templated self-assembly followed by a thermal annealing phase-transformation process. We used hexamethylenetetramine as a hexagonal honeycomb (sp2-sp3 orbital) scaffold for assembling the Pt and Se organic complexes to form the nanosheet structure, which is stable, preserving the 2D structure and mesoporosity during a thermal annealing at 500 °C. Density functional theory analysis then indicated that the mesoporous nanosheets of platinum diselenide exhibit a high free-energy and large density of π electrons crossing the Fermi level, inferring a high-catalytic performance. This effortless strategy is currently being extended to the synthesis of other transition metal dichalcogenides, including the preparation of multi-metal atomic dichalcogenide nanosheets, for a wide variety of scientific and technological applications.
    Matched MeSH terms: Transition Elements
  10. Structural and luminescence properties of Fe3+ doped antimony lead borophosphate glass
    Leong PM, Eeu TY, Leow TQ, Pang XG, Zuhairi Ibrahim, Rosli Hussin
    Sains Malaysiana, 2014;43:915-922.
    Structural and luminescence properties of borophosphate glasses with different modifier doped with transition metal ions have been investigated in this study. The glass sample from the series of xPb 30 4:0 .2Sb20 3:0.3B 20 3:(0 .5-x)P 20 5 and ySb 20 3:0 .2Pb 30 4:(0 .5-y)B 20 3:0 .3P 20 5where x 20 mol% and 0 y 0 .1 5mol% , respectively, were doped with 0.01 mol% of Fe 20 3 system have been prepared using the melt-quenching technique. The structural properties of samples had been studied using fourier transform infrared (FT-m) spectroscopy. The FT-IR study showed the network structure of the studied glasses based on the B 20 3-P 20 5host with the 5b203 and Pb203 modifiers. The results of FT-IR showed traces of B03 and B04 with the introduction of 5b203 and Pb203 modifiers. With the increasing content of B203 which replacing content of P205 in the glass network, the intensity of the borate band decreases and shifted to lower frequency. uv-Vis spectroscopy analysed the transition of Fe3+ from ground state to excited state in the ultraviolet spectral region. The photoluminescence of samples were studied using photoluminescence spectroscopy. The result of photoluminescence spectroscopy showed the effect of photoluminescence enhancement by doping Fe3+ as activator.
    Matched MeSH terms: Transition Elements
  11. Indolenine meso-substituted dibenzotetraaza[14]annulene and its coordination chemistry toward the transition metal ions Mn(III), Fe(III), Co(II), Ni(II), Cu(II), and Pd(II)
    Khaledi H, Olmstead MM, Ali HM, Thomas NF
    Inorg Chem, 2013 Feb 18;52(4):1926-41.
    PMID: 23363432 DOI: 10.1021/ic302150j
    A new dibenzotetraaza[14]annulene bearing two 3,3-dimethylindolenine fragments at the meso positions (LH(2)), has been synthesized through a nontemplate method. X-ray crystallography shows that the whole molecule is planar. The basicity of the indolenine ring permits the macrocycle to be protonated external to the core and form LH(4)(2+)·2Cl(-). Yet another structural modification having strong C-H···π interactions was found in the chloroform solvate of LH(2). The latter two modifications are accompanied by a degree of nonplanar distortion. The antiaromatic core of the macrocycle can accommodate a number of metal ions, Mn(III), Fe(III), Co(II), Ni(II) and Cu(II), to form complexes of [Mn(L)Br], [Mn(L)Cl], [Fe(LH(2))Cl(2)](+)·Cl(-), [Co(L)], [Ni(L)], and [Cu(L)]. In addition, the reaction of LH(2) with the larger Pd(II) ion leads to the formation of [Pd(2)(LH(2))(2)(OAc)(4)] wherein the macrocycle acts as a semiflexible ditopic ligand to coordinate pairs of metal ions via its indolenine N atoms into dinuclear metallocycles. The compounds LH(2), [Co(L)], and [Ni(L)] are isostructural and feature close π-stacking as well as linear chain arrangements in the case of the metal complexes. Variable temperature magnetic susceptibility measurements showed thermally induced paramagnetism in [Ni(L)].
    Matched MeSH terms: Transition Elements/chemistry*
  12. An overview of photocatalytic degradation: photocatalysts, mechanisms, and development of photocatalytic membrane
    Koe WS, Lee JW, Chong WC, Pang YL, Sim LC
    Environ Sci Pollut Res Int, 2020 Jan;27(3):2522-2565.
    PMID: 31865580 DOI: 10.1007/s11356-019-07193-5
    Photocatalysis is an ecofriendly technique that emerged as a promising alternative for the degradation of many organic pollutants. The weaknesses of the present photocatalytic system which limit their industrial applications include low-usage of visible light, fast charge recombination, and low migration ability of the photo-generated electrons and holes. Therefore, various elements such as noble metals and transition metals as well as non-metals and metalloids (i.e., graphene, carbon nanotube, and carbon quantum dots) are doped into the photocatalyst as co-catalysts to enhance the photodegradation performance. The incorporation of the co-catalyst which alters the photocatalytic mechanism was discussed in detail. The application of photocatalysts in treating persistent organic pollutants such as pesticide, pharmaceutical compounds, oil and grease and textile in real wastewater was also discussed. Besides, a few photocatalytic reactors in pilot scale had been designed for the effort of commercializing the system. In addition, hybrid photocatalytic system integrating with membrane filtration together with their membrane fabrication methods had also been reviewed. This review outlined various types of heterogeneous photocatalysts, mechanism, synthesis methods of biomass supported photocatalyst, photocatalytic degradation of organic substances in real wastewater, and photocatalytic reactor designs and their operating parameters as well as the latest development of photocatalyst incorporated membrane.
    Matched MeSH terms: Transition Elements
  13. Synthesis, crystal structures and characterization of late first row transition metal complexes derived from benzothiazole core: anti-tuberculosis activity and special emphasis on DNA binding and cleavage property
    Netalkar PP, Netalkar SP, Budagumpi S, Revankar VK
    Eur J Med Chem, 2014 May 22;79:47-56.
    PMID: 24721314 DOI: 10.1016/j.ejmech.2014.03.083
    Air and moisture stable coordination compounds of late first row transition metals, viz. Co(II), Ni(II), Cu(II) and Zn(II), with a newly designed ligand, 2-(2-benzo[d]thiazol-2-yl)hydrazono)propan-1-ol (LH), were prepared and successfully characterized using various spectro-analytical techniques. The molecular structures of the ligand and nickel complex were unambiguously determined by single-crystal X-ray diffraction method. The [Ni(LH)2]Cl2.3H2O complex is stabilized by intermolecular CH⋯π stacking interactions between the methyl hydrogen and the C18 atom of the phenyl ring (C11-H11B⋯C18) forming 1D zig-zag chain structure. Both, the ligand and its copper complex, were electrochemically active in the working potential range, showing quasi-reversible redox system. The interactions of all the compounds with calf thymus DNA have been comprehensively investigated using electronic absorption spectroscopy, viscosity, electrochemistry and thermal denaturation studies. The cleavage reaction on pBR322 DNA has been monitored by agarose gel electrophoresis. The results showed that the ligand can bind to CT-DNA through partial intercalation, whereas the complexes bind electrostatically. Further, [Ni(LH)2]Cl2.3H2O and [CuLCl(H2O)2] complexes in the series have high binding and cleavage affinity towards pBR322 DNA. Additionally, all the compounds were screened for anti-tuberculosis activity. All the complexes revealed an MIC value of 0.8 μg/mL, which is almost 8 times active than standard used (Streptomycin, 6.25 μg/mL).
    Matched MeSH terms: Transition Elements/chemistry*
  14. CO2 gasification reactivity of biomass char: catalytic influence of alkali, alkaline earth and transition metal salts
    Lahijani P, Zainal ZA, Mohamed AR, Mohammadi M
    Bioresour Technol, 2013 Sep;144:288-95.
    PMID: 23880130 DOI: 10.1016/j.biortech.2013.06.059
    This study investigates the influence of alkali (Na, K), alkaline earth (Ca, Mg) and transition (Fe) metal nitrates on CO2 gasification reactivity of pistachio nut shell (PNS) char. The preliminary gasification experiments were performed in thermogravimetric analyzer (TGA) and the results showed considerable improvement in carbon conversion; Na-char>Ca-char>Fe-char>K-char>Mg-char>raw char. Based on TGA studies, NaNO3 (with loadings of 3-7 wt%) was selected as the superior catalyst for further gasification studies in bench-scale reactor; the highest reactivity was devoted to 5 wt% Na loaded char. The data acquired for gasification rate of catalyzed char were fitted with several kinetic models, among which, random pore model was adopted as the best model. Based on obtained gasification rate constant and using the Arrhenius plot, activation energy of 5 wt% Na loaded char was calculated as 151.46 kJ/mol which was 53 kJ/mol lower than that of un-catalyzed char.
    Matched MeSH terms: Transition Elements/pharmacology*
  15. Fulltext MXene Surface on Multiple Junction Triangles for Determining Osteosarcoma Cancer Biomarker by Dielectrode Microgap Sensor
    Zhou D, Gopinath SCB, Mohamed Saheed MS, Siva Sangu S, Lakshmipriya T
    Int J Nanomedicine, 2020;15:10171-10181.
    PMID: 33363373 DOI: 10.2147/IJN.S284752
    Background: In recent years, nanomaterials have justified their dissemination for biosensor application towards the sensitive and selective detections of clinical biomarkers at the lower levels. MXene is a two-dimensional layered transition metal, attractive for biosensing due to its chemical, physical and electrical properties along with the biocompatibility.

    Materials and Methods: This work was focused on diagnosing osteosarcoma (OS), a common bone cancer, on MXene-modified multiple junction triangles by dielectrode sensing. Survivin protein gene is highly correlated with OS, identified on this sensing surface. Capture DNA was immobilized on MXene by using 3-glycidoxypropyltrimethoxysilane as an amine linker and duplexed by the target DNA sequence.

    Results: The limitation and sensitivity of detection were found as 1 fM with the acceptable regression co-efficient value (y=1.0037⨰ + 0.525; R2=0.978) and the current enhancement was noted when increasing the target DNA concentrations. Moreover, the control sequences of single- and triple-mismatched and noncomplementary to the target DNA sequences failed to hybridize on the capture DNA, confirming the specificity. In addition, different batches were prepared with capture probe immobilized sensing surfaces and proved the efficient reproducibility.

    Conclusion: This microgap device with Mxene-modified multiple junction triangles dielectrode surface is beneficial to quantify the survivin gene at its lower level and diagnosing OS complication levels.

    Matched MeSH terms: Transition Elements/chemistry*
  16. Fulltext Synthesis, characterization and biological evaluation of transition metal complexes derived from N, S bidentate ligands
    Md Yusof EN, S A Ravoof TB, Tiekink ER, Veerakumarasivam A, Crouse KA, Mohamed Tahir MI, et al.
    Int J Mol Sci, 2015 May 15;16(5):11034-54.
    PMID: 25988384 DOI: 10.3390/ijms160511034
    Two bidentate NS ligands were synthesized by the condensation reaction of S-2-methylbenzyldithiocarbazate (S2MBDTC) with 2-methoxybenzaldehyde (2MB) and 3-methoxybenzaldehyde (3MB). The ligands were reacted separately with acetates of Cu(II), Ni(II) and Zn(II) yielding 1:2 (metal:ligand) complexes. The metal complexes formed were expected to have a general formula of [M(NS)2] where M = Cu2+, Ni2+, and Zn2+. These compounds were characterized by elemental analysis, molar conductivity, magnetic susceptibility and various spectroscopic techniques. The magnetic susceptibility measurements and spectral results supported the predicted coordination geometry in which the Schiff bases behaved as bidentate NS donor ligands coordinating via the azomethine nitrogen and thiolate sulfur. The molecular structures of the isomeric S2M2MBH (1) and S2M3MBH (2) were established by X-ray crystallography to have very similar l-shaped structures. The Schiff bases and their metal complexes were evaluated for their biological activities against estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cell lines. Only the Cu(II) complexes showed marked cytotoxicity against the cancer cell lines. Both Schiff bases and other metal complexes were found to be inactive. In concordance with the cytotoxicity studies, the DNA binding studies indicated that Cu(II) complexes have a strong DNA binding affinity.
    Matched MeSH terms: Transition Elements/chemistry*
  17. Fulltext Synthesis, biological evaluation and corrosion inhibition studies of transition metal complexes of Schiff base
    Kashyap S, Kumar S, Ramasamy K, Lim SM, Shah SAA, Om H, et al.
    Chem Cent J, 2018 Nov 20;12(1):117.
    PMID: 30460466 DOI: 10.1186/s13065-018-0487-1
    BACKGROUND: The transition metal complexes formed from Schiff base is regarded as leading molecules in medicinal chemistry. Because of the preparative availability and diversity in the structure of central group, the transition metals are important in coordination chemistry. In the present work, we have designed and prepared Schiff base and its metal complexes (MC1-MC4) and screened them for antimicrobial, anticancer and corrosion inhibitory properties.

    METHODOLOGY: The synthesized metal complexes were characterized by physicochemical and spectral investigation (UV, IR, 1H and 13C-NMR) and were further evaluated for their antimicrobial (tube dilution) and anticancer (SRB assay) activities. In addition, the corrosion inhibition potential was determined by electrochemical impedance spectroscopy (EIS) technique.

    RESULTS AND DISCUSSION: Antimicrobial screening results found complexes (MC1-MC4) to exhibit less antibacterial activity against the tested bacterial species compared to ofloxacin while the complex MC1 exhibited greater antifungal activity than the fluconazole. The anticancer activity results found the synthesized Schiff base and its metal complexes to elicit poor cytotoxic activity than the standard drug (5-fluorouracil) against HCT116 cancer cell line. Metal complex MC2 showed more corrosion inhibition efficiency with high Rct values and low Cdl values.

    CONCLUSION: From the results, we can conclude that complexes MC1 and MC2 may be used as potent antimicrobial and anticorrosion agents, respectively.

    Matched MeSH terms: Transition Elements
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