Displaying publications 1 - 20 of 39 in total

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  1. Fulltext Antimicrobial Activities of Starch-Based Biopolymers and Biocomposites Incorporated with Plant Essential Oils: A Review
    Syafiq R, Sapuan SM, Zuhri MYM, Ilyas RA, Nazrin A, Sherwani SFK, et al.
    Polymers (Basel), 2020 Oct 19;12(10).
    PMID: 33086533 DOI: 10.3390/polym12102403
    Recently, many scientists and polymer engineers have been working on eco-friendly materials for starch-based food packaging purposes, which are based on biopolymers, due to the health and environmental issues caused by the non-biodegradable food packaging. However, to maintain food freshness and quality, it is necessary to choose the correct materials and packaging technologies. On the other hand, the starch-based film's biggest flaws are high permeability to water vapor transfer and the ease of spoilage by bacteria and fungi. One of the several possibilities that are being extensively studied is the incorporation of essential oils (EOs) into the packaging material. The EOs used in food packaging films actively prevent inhibition of bacteria and fungi and have a positive effect on food storage. This work intended to present their mechanical and barrier properties, as well as the antimicrobial activity of anti-microbacterial agent reinforced starch composites for extending product shelf life. A better inhibition of zone of antimicrobial activity was observed with higher content of essential oil. Besides that, the mechanical properties of starch-based polymer was slightly decreased for tensile strength as the increasing of essential oil while elongation at break was increased. The increasing of essential oil would cause the reduction of the cohesion forces of polymer chain, creating heterogeneous matrix and subsequently lowering the tensile strength and increasing the elongation (E%) of the films. The present review demonstrated that the use of essential oil represents an interesting alternative for the production of active packaging and for the development of eco-friendly technologies.
    Matched MeSH terms: Drug Packaging
  2. Fulltext Antimicrobial effects on starch-based films incorporated with lysozymes
    Nozieana Khairuddin, Ida Idayu Muhamad
    Pertanika Journal of Science & Technology, 2009;17(1):-.
    MyJurnal
    An antimicrobial (AM) Active Packaging can be made by incorporating and immobilizing suitable AM agents into food package matrices and applying a bio switch concept. A starchbased film was prepared and incorporated with an antimicrobial agent, i.e. lysozyme with EDTA as a chelating agent. This film was then inoculated with the bacteria Escherichia coli and Bacillus subtilis to carry out the microbial contamination study. The inhibition of both E. coli and B. subtilis by the AM film was clearly observed as a clear zone formation in the culture agar test. The film appearance showed that lysozymes could give a better inhibition to the growth of E. coli and to B. subtilis, at a satisfying inhibition rate. From the broth test, the decreased in the optical densities were found to be 65.83% and 91.30%, suggesting an effective growth inhibition of E. coli and B. subtilis, respectively. Physically, the film which was incorporated with lysozymes was found to be slightly different from the control film. The moisture content of the film, with lysozymes, was found to be below 10.5%, as compared to the control, after 24 hours of formation in the storage at ambient temperature.
    Matched MeSH terms: Drug Packaging
  3. Fulltext Application of artificial neural networks for the optimisation of wetting contact angle for lead free Bi-Ag soldering alloys
    Nima Ghamarian, Azmah Hanim, M.A., Nahavandi, M., Zulkarnain Zainal, Lim, Hong Ngee
    Pertanika Journal of Science & Technology, 2017;25(4):1255-1260.
    MyJurnal
    In the recent years, electronic packaging provides significant research and development challenges
    across multiple disciplines such as performance, materials, reliability, thermals and interconnections.
    New technologies and techniques frequently adopted can be implemented in soldering alloys of
    semiconductor sectors in terms of optimisation. Wetting contact angle or wettability of solder alloys
    is one of the important factors which has got the attention of scholars. Hence in this study, due to the
    remarkable similarity over classical solder alloys (Pb-Sn), Bi-Ag solder was investigated. Data were
    collected through the effects of aging time variation and different weight percentages of Ag in solder
    alloys. The contact angle of the alloys with Cu plate was measured by optical microscopy. Artificial
    neural networks (ANNs) were applied on the measured datasets to develop a numerical model for further
    simulation. Results of the experiments and simulations showed that the coefficient of determination (R2
    )
    is around 0.97, which signifies that the ANN set up is appropriate for the evaluation.
    Matched MeSH terms: Drug Packaging
  4. Fulltext Assessment of medication adherence and the costs associated with a calendar blister pack intervention among hypertensive patients in Malaysia: A randomized controlled trial
    Tan BY, Shafie AA, Hassali MAA, Saleem F
    SAGE Open Med, 2017;5:2050312117709189.
    PMID: 28839933 DOI: 10.1177/2050312117709189
    OBJECTIVES: To assess the efficacy and costs of a calendar blister packaging intervention used to improve medication adherence.

    METHOD: A parallel randomized controlled trial was conducted with 73 hypertensive patients (intervention group = 35, control group = 38) at Hospital Kulim, Malaysia, for 7 months.

    RESULTS: The intervention group demonstrated a significant improvement in medication possession ratio (p 

    Matched MeSH terms: Drug Packaging
  5. Fulltext Characterisation of biodegradable protein based films from gelatin alternative: a review
    Nazmi, N. N. M., Isa, M. I. N., Sarbon, N. M.
    International Food Research Journal, 2020;27(6):971-987.
    MyJurnal
    Protein-based films are thin and flexible films derived from protein sources. They are
    completely biodegradable and used in food engineering, packaging, drug recovery, and other
    applications. In food packaging, gelatin is widely used due to properties such as low cost,
    availability, functional attributes, mechanical (flexibility and tension) and optical (brightness
    and opacity) strength, barrier against gas flow, and structural resistance to water and
    microorganisms. Therefore, this paper reviews the characterisation of biodegradable
    protein-based films from gelatin alternatives, mainly from fish and chicken skin, as food
    packaging materials. The properties of film packaging derived from gelatin alternatives were
    compared with films derived from mammalian gelatin. The findings showed that the blended
    gelatin alternatives with polysaccharide improved physical properties such as water vapour
    permeability, gas permeability, light transmission and transparency, thermal properties,
    microstructure, colour, and heat sealability. Moreover, improvements in mechanical
    properties such as tensile strength and elongation at break were also investigated. This review
    also comes out with suggestions for future research on the compatibility between gelatin films
    and food ingredients. This paper provides a comprehensive overview that promotes the
    development of biodegradable blended films from gelatin alternatives for packaging
    applications in the food industry and related fields.
    Matched MeSH terms: Drug Packaging
  6. Characteristics of thermoplastic sugar palm Starch/Agar blend: Thermal, tensile, and physical properties
    Jumaidin R, Sapuan SM, Jawaid M, Ishak MR, Sahari J
    Int J Biol Macromol, 2016 Aug;89:575-81.
    PMID: 27177458 DOI: 10.1016/j.ijbiomac.2016.05.028
    The aim of this work is to study the behavior of biodegradable sugar palm starch (SPS) based thermoplastic containing agar in the range of 10-40wt%. The thermoplastics were melt-mixed and then hot pressed at 140°C for 10min. SEM investigation showed good miscibility between SPS and agar. FT-IR analysis confirmed that SPS and agar were compatible and inter-molecular hydrogen bonds existed between them. Incorporation of agar increased the thermoplastic starch tensile properties (Young's modulus and tensile strength). The thermal stability and moisture uptake increased with increasing agar content. The present work shows that starch-based thermoplastics with 30wt% agar content have the highest tensile strength. Higher content of agar (40wt%) resulted to more rough cleavage fracture and slight decrease in the tensile strength. In conclusion, the addition of agar improved the thermal and tensile properties of thermoplastic SPS which widened the potential application of this eco-friendly material. The most promising applications for this eco-friendly material are short-life products such as packaging, container, tray, etc.
    Matched MeSH terms: Drug Packaging
  7. Fulltext Coffee packaging: Consumer perception on appearance, branding and pricing
    Harith, Z.T., Ting, C.H., Zakaria, N.N.A.
    International Food Research Journal, 2014;21(3):849-853.
    MyJurnal
    In determining consumer’s acceptance of any products in the market, packaging appearance, branding and pricing of the products are important. This study focused on consumer’s perception towards the outlook of the coffee packaging which resulted in influencing their purchasing decision through survey study. This current study was done on three main issues namely appropriateness of appearance, branding and pricing as reflected by the first impression towards the product’s packaging. Survey was done targeting on consumers (n = 100) reside in Kelantan, Malaysia through printed and online questionnaires distribution. Results obtained shows that consumers notice the differences possessed by each coffee packaging in the market and they purchase what they like based on their perception. According to Pearson Correlation, respondents also have the opinion that appearance, branding and pricing are correlated to each other in order to convey the correct messages to the correct group of people (p-value > 0.5). Response from the respondents reflected the behaviour of consumers reside in Kelantan that the overall outlook (packaging appearance, branding and pricing) of a coffee packaging were taken into consideration during their buying process. Therefore, it is crucial for the packaging itself to be able to create emotional attachment in consumers’ mind during their first glimpse.
    Matched MeSH terms: Drug Packaging
  8. Death by 'ice': fatal methamphetamine intoxication of a body packer case detected by postmortem computed tomography (PMCT) and validated by autopsy
    Bin Abdul Rashid SN, Rahim AS, Thali MJ, Flach PM
    Forensic Sci Med Pathol, 2013 Mar;9(1):82-7.
    PMID: 23404531 DOI: 10.1007/s12024-012-9395-1
    Fatal acute methamphetamine (MA) poisoning in cases of internal drug trafficking is rarely described in the literature. This case study reports an MA 'body packer' who died from fatal methamphetamine intoxication due to leaking drug packages in the alimentary tract. The deceased was examined by postmortem computed tomography (PMCT), and the results were correlated to subsequent autopsy and toxicological findings. The deceased was arrested by the police when he was found disoriented in the city of Kuala Lumpur. He was transferred to the emergency department on suspicion of drug abuse. The initial drug screening was reactive for amphetamines. Shortly after admission to the hospital, he died despite rigorous resuscitation attempts. The postmortem plain chest and abdominal radiographs revealed multiple suspicious opacities in the gastrointestinal tract attributable to body packages. An unenhanced whole body PMCT revealed twenty-five drug packages, twenty-four in the stomach and one in the transverse colon. At least two were disintegrating, and therefore leaking. The autopsy findings were consistent with the PMCT results. Toxicology confirmed the diagnosis of fatal methamphetamine intoxication.
    Matched MeSH terms: Drug Packaging
  9. Fulltext Development and Characterization of Biodegradable Composite Films Based on Gelatin Derived from Beef, Pork and Fish Sources
    Nur Hanani ZA, Beatty E, Roos YH, Morris MA, Kerry JP
    Foods, 2013 Jan 02;2(1):1-17.
    PMID: 28239092 DOI: 10.3390/foods2010001
    The objectives of this study were to develop composite films using various gelatin sources with corn oil (CO) incorporation (55.18%) and to investigate the mechanical and physical properties of these films as potential packaging films. There were increases (p < 0.05) in the tensile strength (TS) and puncture strength (PS) of films when the concentration of gelatin increased. The mechanical properties of these films were also improved when compared with films produced without CO. Conversely, the water barrier properties of composite films decreased (p < 0.05) when the concentration of gelatin in composite films increased. Comparing with pure gelatin films, water and oxygen barrier properties of gelatin films decreased when manufactured with the inclusion of CO.
    Matched MeSH terms: Drug Packaging
  10. Fulltext Development and evaluation of acceptance of a web based education module for reducing risk of mild cognitive impairment among older adults
    Suzana Shahar, Divya Vanoh, Intan Hafizah Mohd Ishak, Zahara Abdul Manaf, Rosdinom Razali, Nazlena Mohd Ali, et al.
    Jurnal Sains Kesihatan Malaysia, 2018;16(101):233-234.
    MyJurnal
    Relatively less comprehensive web based programme has been developed for detecting risk of mild cognitive impairment (MCI) and further impart preventive strategies and lifestyle education. Thus, this study has developed a comprehensive web based programme for early screening of risk of MCI together with education package for preventing MCI known as WESIHAT 2.0. WESIHAT 2.0 is a senior friendly website which has appropriate design interface facilitating access of older people especially with the use of touch-screen technology. WESIHAT 2.0 has incorporated four major components namely TUA WELLNESS screening tool, which is a comprehensive, online based, 10-item screening tool for detecting risk of MCI, 10-guides for preventing MCI, health diary and healthy food. Evaluation of acceptance of WESIHAT 2.0 was done among 71 people which comprised of 30 older people and 30 caregivers, chosen equally based on ethnic composition and 11 health care professionals who has experience working in the field of geriatric and 2 freelance website developer. All older people and caregivers stated that the content of website was very useful for preventing MCI, however, about 36.4% of health professionals stated several improvements needed to be done before releasing the end-product to the users. Comments given were smaller font size (27.3), addition of more pictures (27.3%), using simpler terms (36.4%) and changing certain design for better view of older people (18.2%). Amendments were made based on each comment given and the finalized website were used for a 6-month intervention programme for neuroprotection among older people who failed to achieve successful aging. It is timely for an online based approach for prevention of MCI. WESIHAT 2.0 is the first website in Malaysia which has been accepted by all older people and caregiver and more than half of healthcare professionals to prevent memory decline.
    Matched MeSH terms: Drug Packaging
  11. Development of expert system for biobased polymer material selection: food packaging application
    Sanyang ML, Sapuan SM
    J Food Sci Technol, 2015 Oct;52(10):6445-54.
    PMID: 26396389 DOI: 10.1007/s13197-015-1759-6
    Biobased food packaging materials are gaining more attention owing to their intrinsic biodegradable nature and renewability. Selection of suitable biobased polymers for food packaging applications could be a tedious task with potential mistakes in choosing the best materials. In this paper, an expert system was developed using Exsys Corvid software to select suitable biobased polymer materials for packaging fruits, dry food and dairy products. If - Then rule based system was utilized to accomplish the material selection process whereas a score system was formulated to facilitate the ranking of selected materials. The expert system selected materials that satisfied all constraints and selection results were presented in suitability sequence depending on their scores. The expert system selected polylactic acid (PLA) as the most suitable material.
    Matched MeSH terms: Drug Packaging
  12. Dimensional and structural stability of gamma irradiated stacked die quad flat no leads (QFN)
    Siew PF, Wan Yusmawati Wan Yusoff, Azman Jalar
    Sains Malaysiana, 2014;43:827-832.
    The physical properties and structural stability of the Quad Flat No-Leads (QFN) package with different gamma radiation doses have been investigated. The packages were irradiated with Co-60 gamma radiation with varying doses of 5 Gy, 50 Gy, 500 Gy, 5 kGy and 50 kGy with operating dose of 2.54 kGylh at room temperature. The infinite focus microscope (IFM) was used to measure the dimensional change and slantinglwarpage behaviour, while the 3D CT Scan X-ray machine was used to determine the occurrence of deflection on a wire in package due to exposure. It is believed that radiation effect on ceramic filler in the epoxy mold compound (EMC) plays an important role to induce the defects and resulted in swelling of the package. The slantinglwarpage behaviour is believed to be caused by the swelling behaviour of ceramic filler and further induced structural stability. The induced stress on the EMC structural after the dimensional change and slantinglwarpage failure leads to the occurrence of wire sweep. The finding suggests that defect production in swelled ceramic filler leads to the occurrence of dimensional and structure instability.
    Matched MeSH terms: Drug Packaging
  13. Fulltext Effect of different types of plastic packaging films on the moisture and aflatoxin contents of pistachio nuts during storage
    Shakerardekani A, Karim R
    J Food Sci Technol, 2013 Apr;50(2):409-11.
    PMID: 24425936 DOI: 10.1007/s13197-012-0624-0
    Pistachio nut (Pistacia vera L.) is one of the popular tree nuts in the world. Proper selection of packaging materials is necessary to prevent absorption of moisture and aflatoxin formation which will influence the overall product quality and safety. This research is undertaken to study the effect of different type of flexible packaging films on the moisture and aflatoxin contents of whole pistachio nuts during storage at ambient temperature (22-28 °C) and relative humidity of 85-100%. Five types of plastic films tested were low density polyethylene (LDPE) which serves as the control, food-grade polyvinyl chloride (PVC), nylon (LDPE/PA), polyamide/polypropylene (PA/PP) and polyethylene terephthalate (PET). The moisture content and aflatoxin content of pistachio nuts were measured using oven drying method and HPLC, respectively. Sample were analysed at 0, 2, 4, 6, 8 and 10 months during the storage period. Results showed that there was an increase in moisture content with the increase in storage time of pistachio nuts. The increase in moisture content was associated with the aflatoxin level of pistachio nuts during storage time. All the packaging materials except LDPE delayed the moisture absorption and aflatoxin formation of the product. The most suitable packaging materials for maintaining the quality and safety of pistachio nuts is PET films followed by nylon, PA/PP and PVC. The shelf-life of pistachio can be extended from 2 months (Control) to 5 months when PET is used as the packaging material.
    Matched MeSH terms: Drug Packaging
  14. Fulltext Effect of modified atmosphere packaging on microbial flora changes in fishery products
    Velu, S., Abu Bakar, F., Mahyudin, N.A., Saari, N., Zaman, M.Z.
    International Food Research Journal, 2013;20(1):17-26.
    MyJurnal
    Modified atmosphere packaging (MAP) has become a popular method for packaging foods as it can extend the shelf life of food with minimal quality defect. Oxygen, nitrogen and carbon dioxide are the common gases used in MAP, Oxygen and carbon dioxide inclusive as only these two gaseous have the preservative effects on the packed food product. Their effect on microbial changes of any food product throughout storage period is highly depend on type of the product and packaging materials, appropriate gas composition, storage temperature, the ratio between gas and product volume, and hygienic manner during processing and packaging. MAP with highest percentage of carbon dioxide is proven to be more effective than vacuum packaging in inhibiting the growth of spoilage and pathogenic bacteria in many fishery products. This article reviews the consequences of MAP towards microbial changes in fishery products.
    Matched MeSH terms: Drug Packaging
  15. Electrochemical corrosion behaviour of Pb-free SAC 105 and SAC 305 Solder Alloys: a comparative study
    Fayeka M, Haseeb A, Fazal MA
    Sains Malaysiana, 2017;46:295-302.
    Sn-Ag based solder alloy seems to be a promising lead-free solder for the application on electronic assembly. The corrosion behavior of different lead free solder alloys such as Sn-3.0Ag, Sn-1.0Ag-0.5Cu and Sn-3.0Ag-0.5Cu was investigated in 3.5% NaCl solution by potentiodynamic polarization and electrochemical impedance spectroscopy. Scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD) were used to characterize the samples after the tests. The results showed that the addition of 0.5 wt. % copper with Sn-3.0 Ag solder alloy led to a better corrosion resistance while lowering of Ag content from 3.0 to 1.0 wt. % decreased the resistance. Sn-3.0Ag-0.5Cu exhibits a better corrosion resistance in terms of increased charge transfer resistance and impedance values as well as the lowest capacitance. These characteristics signify its suitability for the application in electronic packaging.
    Matched MeSH terms: Drug Packaging
  16. Fulltext Epoxidized Jatropha Oil as a Sustainable Plasticizer to Poly(lactic Acid)
    Chieng BW, Ibrahim NA, Then YY, Loo YY
    Polymers (Basel), 2017 Jun 02;9(6).
    PMID: 30970882 DOI: 10.3390/polym9060204
    A renewable resource, epoxidized jatropha oil (EJO), was used as a green plasticizer and added to poly(lactic acid) (PLA). EJO was compounded into PLA at different contents. The addition of 3 wt % EJO to the PLA demonstrates significant improvement in flexibility, which leads to a percentage increase of about 7000% in elongation at break. This tensile result was confirmed by surface morphology analysis with clear proof of plastic deformation in EJO-plasticized PLA. EJO imparts a good heat stabilization effect. Thermal stability of PLA was enhanced upon addition of EJO, which is due to their good interaction and plasticizer dispersion within the PLA matrix. This EJO-plasticized PLA has wide applications in various industries, such as packaging of food and non-food products.
    Matched MeSH terms: Drug Packaging
  17. Fulltext Evaluation of physicochemical changes of spray-dried honey jackfruit (Artocarpus heterophyllus Lam.) powder during storage
    Wong, C. W., Leow, R. K. S., Lim, W. Y., Siew, Z. Z.
    International Food Research Journal, 2020;27(2):366-375.
    MyJurnal
    The present work was undertaken to investigate the effect of different packaging materials, namely polyethylene terephthalate (PET) and aluminium laminated polyethylene (ALP) on the physicochemical properties and microbiological stability of spray-dried honey jackfruit powder over seven weeks of storage at 38 ± 2°C and 90% relative humidity. The moisture content of honey jackfruit powder packaged in PET was doubled (12.32%) than of those packaged in ALP (5.31%). The water activity (aw) of the powders were lower than 0.6 for both packaging materials, thus considered shelf-stable. Hygroscopicity increased up to 42.44 and 39.84% for powder packaged in PET and ALP, respectively. The angle of repose for powders flowability increased to 19° (ALP) and 28° (PET), which indicated that the powders flowabili- ty significantly decreased upon storage. The degree of caking for powder packaged in ALP (43.69%) was much less severe than that of PET (84.51%). Powder packaged in ALP showed good solubility (81.07 - 99.01%) and satisfactory microbiological results (< log 2.58 CFU/g). The results recommended that ALP packaging was better suited for keeping spray-dried honey jackfruit powder.
    Matched MeSH terms: Drug Packaging
  18. Fulltext Kajian kesihatan respiratori berkaitan pencemaran udara akibat lalu lintas dalam kalangan kanak-kanak sekolah rendah dengan rujukan kepada Sekolah Kebangsaan Langgar dan Sekolah Kebangsaan Demit, Kota Bharu, Kelantan
    Haliza Abdul Rahman, Noraini Mansor, Noor Aini Hussain
    Jurnal Sains Kesihatan Malaysia, 2011;9(1):13-21.
    MyJurnal
    Perkembangan industri permotoran telah menyebabkan pencemaran udara yang menjadi faktor kepada peningkatan simptom masalah respiratori dalam kalangan kanak-kanak sekolah rendah. Kajian ini mengkaji perkaitan antara peningkatan simptom masalah kesihatan respiratori dalam kalangan kanak-kanak sekolah rendah dengan pendedahan terhadap pencemaran udara akibat lalu lintas. Kajian school-based jenis keratan lintang telah dilakukan di dua buah sekolah di daerah Kota Bharu, Kelantan iaitu Sekolah Kebangsaan Langgar dan Sekolah Kebangsaan Demit dengan melibatkan pelajar berumur 10, 11 dan 12 tahun. Saiz sampel seramai 124 orang (n = 124) dipilih menggunakan corak persampelan kebarangkalian iaitu persampelan rawak mudah. Responden disoal menggunakan instrumen yang telah disahihkan dan diadaptasi dari International Study of Asthma and Allergies in Childhood (ISAAC). Analisis data dilakukan dengan menggunakan Statistical Package For Social Sciences (SPSS). Hasil kajian menunjukkan peningkatan simptom masalah respiratori yang dihadapi oleh pelajar di dua buah sekolah rendah di Kota Bharu adalah berkait rapat dengan pencemaran udara yang berpunca dari lalu lintas dengan p < 0.05. Kajian mendapati pendedahan kepada bahan pencemar udara yang berpunca dari lalu lintas telah meningkatkan simptom masalah respiratori dalam kalangan kanak-kanak sekolah di rendah lokasi kajian.
    Matched MeSH terms: Drug Packaging
  19. Fulltext Mass modeling of Malaysian varieties Pomelo fruit (Citrus Grandis L. Osbeck) with some physical characteristics
    Nur Salihah, B., Norashikin, A.A., Rosnah, S.
    International Food Research Journal, 2015;22(2):0-0.
    MyJurnal
    Knowledge of physical characteristics of Malaysian variety pomelo fruits are necessary for the design of some post harvesting, processing systems such as cleaning, handling, grading and packaging system. For proper development of pomelo grading systems, important relationships between the mass and some physical characteristics of pomelo fruits such as length, width, thickness, surface area, projected areas and volumes must be known. The aim of this research was to measure physical characteristics of two Malaysian varieties of pomelo fruit; Ledang (PO55) and Tambun (PO52) varieties. In this study, the mass of pomelo fruit was evaluated and correlated to measure physical characteristics using Linear, Quadratic, S-curve and Power models. The results showed that the correlation of the mass of pomelo fruit with all measured physical characteristics was significant at the 0.01 probability level. In the nutshell, mass modeling of pomelo fruit for Ledang (PO55) and Tambun (PO52) varieties based on the projected area are recommended according to economical view.
    Matched MeSH terms: Drug Packaging
  20. Migration of antioxidants from polylactic acid films: A parameter estimation approach and an overview of the current mass transfer models
    Samsudin H, Auras R, Mishra D, Dolan K, Burgess G, Rubino M, et al.
    Food Res Int, 2018 01;103:515-528.
    PMID: 29389642 DOI: 10.1016/j.foodres.2017.09.021
    Migration studies of chemicals from contact materials have been widely conducted due to their importance in determining the safety and shelf life of a food product in their packages. The US Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA) require this safety assessment for food contact materials. So, migration experiments are theoretically designed and experimentally conducted to obtain data that can be used to assess the kinetics of chemical release. In this work, a parameter estimation approach was used to review and to determine the mass transfer partition and diffusion coefficients governing the migration process of eight antioxidants from poly(lactic acid), PLA, based films into water/ethanol solutions at temperatures between 20 and 50°C. Scaled sensitivity coefficients were calculated to assess simultaneously estimation of a number of mass transfer parameters. An optimal experimental design approach was performed to show the importance of properly designing a migration experiment. Additional parameters also provide better insights on migration of the antioxidants. For example, the partition coefficients could be better estimated using data from the early part of the experiment instead at the end. Experiments could be conducted for shorter periods of time saving time and resources. Diffusion coefficients of the eight antioxidants from PLA films were between 0.2 and 19×10-14m2/s at ~40°C. The use of parameter estimation approach provided additional and useful insights about the migration of antioxidants from PLA films.
    Matched MeSH terms: Drug Packaging
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