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Fulltext Characterization of multidrug-resistant Acinetobacter baumannii strain ATCC BAA1605 using whole-genome sequencing

Ten KE, Md Zoqratt MZH, Ayub Q, Tan HS

BMC Res Notes, 2021 Mar 04;14(1):83.
PMID: 33663564 DOI: 10.1186/s13104-021-05493-z

OBJECTIVE: The nosocomial pathogen, Acinetobacter baumannii, has acquired clinical significance due to its ability to persist in hospital settings and survive antibiotic treatment, which eventually resulted in the rapid spread of this bacterium with antimicrobial resistance (AMR) phenotypes. This study used a multidrug-resistant A. baumannii (strain ATCC BAA1605) as a model to study the genomic features of this pathogen.
RESULTS: One circular chromosome and one circular plasmid were discovered in the complete genome of A. baumannii ATCC BAA1605 using whole-genome sequencing. The chromosome is 4,039,171 bp long with a GC content of 39.24%. Many AMR genes, which confer resistance to major classes of antibiotics (beta-lactams, aminoglycosides, tetracycline, sulphonamides), were found on the chromosome. Two genomic islands were predicted on the chromosome, one of which (Genomic Island 1) contains a cluster of AMR genes and mobile elements, suggesting the possibility of horizontal gene transfer. A subtype I-F CRISPR-Cas system was also identified on the chromosome of A. baumannii ATCC BAA1605. This study provides valuable genome data that can be used as a reference for future studies on A. baumannii. The genome of A. baumannii ATCC BAA1605 has been deposited at GenBank under accession no. CP058625 and CP058626.
WITHDRAWN: Sustainable liquid membrane separation using interfacial engineering of deep eutectic solvent and cellulose acetate

Mubashir M, Jusoh N, Majeed Z, Rambabu K, Banat F, Tao Y

J Hazard Mater, 2020 Oct 27.
PMID: 33153798 DOI: 10.1016/j.jhazmat.2020.124345

This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
Fulltext Ultrasonic-Assisted Technique as a Novel Method for Removal of Naphthenic Acid from Model Oil Using Piperidinium-Based Ionic Liquids

Khaidzir S, Masri AN, Ruslan MSH, Abdul Mutalib MI

ACS Omega, 2021 Apr 13;6(14):9629-9637.
PMID: 33869943 DOI: 10.1021/acsomega.1c00189

In this study, piperidinium-based ionic liquids (IL) containing trifluoromethanesulfonate, phenolate, and dicyanamide anions were synthesized. Using the ILs, extraction of naphthenic acid from highly acidic oil with a total acid number (TAN) of 1.44 was studied. Two agitation techniques have been implemented for the extraction process, which were mechanical stirring and ultrasonic-assisted irradiation. 1-Butyl-1-methylpiperidinium phenolate [BMPi][Phe] showed the best potential in extracting naphthenic acid from oil, with complete removal of naphthenic acid with IL-to-oil ratios of 0.010 and 0.0025 for the mechanical stirring method and the ultrasonic-assisted method, respectively. Ultrasonic-assisted extraction process shows very good potential in enhancing the extraction efficiency of naphthenic acid. Optimization and study on the effects of ultrasonic parameters, namely, IL-to-oil ratio, ultrasonic amplitude, and time, were studied through response surface methodology (RSM). Using [BMPi][Phe], the optimum conditions obtained are IL-to-oil ratio of 0.03, 53.91% of amplitude, and 4.29 min of extraction time. Under these optimum conditions, 100% removal of naphthenic acid was achieved.
The effects of additional hollow cylinder coated to external fixator screws for treating pilon fracture: A biomechanical perspective

Ramlee MH, Seng GH, Ros Felip A, Abdul Kadir MR

Injury, 2021 Aug;52(8):2131-2141.
PMID: 33745700 DOI: 10.1016/j.injury.2021.03.017

An external fixator is a promising medical device that could provide optimum stability and reduce the rate of complications in treating bone fracture during intervention period. It is noted that the biomechanics behaviour of device can be altered by introducing more features such as material suitability and additional components. Therefore, this study was conducted via finite element method to investigate the effects of additional hollow cylinder coated with external fixator screws in treating Type III pilon fracture. Finite element models which have been validated with experimental data were used to simulate stresses at the pin-bone interface and relative micromovement at interfragmentary fractures during swing (70 N load) and stance phases (350 N load). All bones and external fixators were assigned with isotropic material properties while the cartilages were simulated with hyper-elastic. For the hollow cylinder, polyethylene was assigned due to its properties which are equivalent to the bone. From the results, it is found that stresses at the pin-bone interface for the coated screws were reduced to 54% as compared to the conventional fixator. For the micromovement, there was no difference between both models, whereby the value was 0.03 mm. The results supported previously published literature, in which high stresses are unavoidable at the interface, fortunately, those stresses did not exceed the ultimate strength of bone, which is safe for treating patients. In conclusion, if patients are allowed to bear weight bearing, the external fixator with coated screws is a more favourable option to be fixed into the bone to avoid complications at the interface.
Fulltext Improving the appropriateness of therapeutic drug monitoring sampling in Hospital Sultanah Nur Zahirah, Kuala Terengganu

Lukman Nul Hakim Md Khairi, Farah Syakirah Ahmad, Aimi Shazana Muhammad Anuar, Nurul Ain Wan Omar, Nurul Najmi Muhammad, Nurulhayati Abd. Jamal, et al.

Q Bulletin, 2020;1(29):28-35.
MyJurnal

Therapeutic drug monitoring (TDM) is a valuable clinical tool in optimisation of drug regimens. However, improper utilisation of TDM may lead to significant resource wastage and expose patients to avoidable trauma, toxicity, therapeutic failure and prolonged hospitalisation. This study aimed to reduce the percentage of inappropriate TDM sampling to our proposed standard of less than 20% within a four-month intervention period. A cross-sectional study was undertaken from January to December 2015 at the inpatient setting of Hospital Sultanah Nur Zahirah. Gentamicin and Vancomycin analytes were studied because these analytes accounted for 69.2% of total samples received in 2014. TDM Monitoring Form was used to collect sampling and dosage information to assess sampling appropriateness. A closed-ended self-administered questionnaire was distributed to a group of medical doctors to assess their knowledge on appropriate Gentamicin and Vancomycin TDM sampling method pre- and post-intervention. Prior to the intervention phase in October to December 2014, 79.4% of TDM were inappropriately sampled. The main contributing factors were inadequate knowledge among medical doctors, lack of sampling reminders for new TDM requests, and misunderstanding on sampling information for repeated TDM requests. 60-minute face-to-face educational sessions on TDM sampling method were conducted specifically for staff at the General Medical and Paediatric Departments, and two continuing medical education (CME) slots were held at the hospital level. Guidelines on TDM sampling was initiated and laminated copies were distributed to all wards. Implementation of TDM Alert System which consisted of digital reminders and physical stickers was also introduced. The interventions were able to reduce the inappropriate sampling percentage from 79.4% to 41.8% post-intervention, and to 19.1% in the recent monitoring phase of January until June 2019. Continuous close monitoring and sustainable implementation of the measures are vital as TDM sampling appropriateness may affect clinical interpretation of the results.
Fulltext Co-creation or Co-destruction: A Perspective of Online Customer Engagement Valence

Siddique J, Shamim A, Nawaz M, Faye I, Rehman M

Front Psychol, 2020;11:591753.
PMID: 33613353 DOI: 10.3389/fpsyg.2020.591753

The increasing interest in online shopping in recent years has increased the importance of understanding customer engagement valence (CEV) in a virtual service network. There is yet a comprehensive explanation of the CEV concept, particularly its impact on multi-actor networks such as web stores. Therefore, this study aims to fill this research gap. In this study, past literature in the marketing and consumer psychology field was critically reviewed to understand the concept of CEV in online shopping, and the propositional-based style was employed to conceptualize the CEV within the online shopping (web stores) context. The outcomes demonstrate that the valence of customer engagement is dependent on the cognitive interpretation of signals that are prompted by multiple actors on a web store service network. If the signals are positively interpreted, positive outcomes such as service co-creation are expected, but if they are negatively interpreted, negative outcomes such as service co-destruction are predicted. These notions create avenues for future empirical research and practical implications.
Fulltext Correction to: COVID‑19 and therapy with essential oils having antiviral, anti‑inflammatory, and immunomodulatory properties

Asif M, Saleem M, Saadullah M, Yaseen HS, Al Zarzour R

Inflammopharmacology, 2021 Apr;29(2):577.
PMID: 33609198 DOI: 10.1007/s10787-021-00788-w
The role of financial development, R&D expenditure, globalization and institutional quality in energy consumption in India: New evidence from the QARDL approach

Godil DI, Sharif A, Ali MI, Ozturk I, Usman R

J Environ Manage, 2021 May 01;285:112208.
PMID: 33618139 DOI: 10.1016/j.jenvman.2021.112208

The aim of this research is to explore the association between financial development, research and development (R&D) expenditures, globalization, institutional quality, and energy consumption in India by using the quarterly data of 1995-2018. Quantile Autoregressive Distributed Lag (QARDL) approach is employed to examine the relationship. An application of the QARDL approach suggests that the R&D, financial development, globalization, and institutional quality significantly influence energy utilization in India. R&D and institutional quality have a negative effect on energy utilization which shows that due to the increase in the quality of institutions and R&D in the country, energy utilization is likely to decrease. However, globalization and financial performance have a positive influence on energy which depicts that due to the increase in financial performance and globalization in India the energy consumption is likely to increase. According to the outcomes of this research, India should make a policy to ease the penalties of energy utilization by monitoring resource transfer by means of globalization and by implementing energy conversation procedures through the advancement of the financial sector.
Fulltext Microwave Breast Imaging Using Compressed Sensing Approach of Iteratively Corrected Delay Multiply and Sum Beamforming

Islam MT, Islam MT, Samsuzzaman M, Kibria S, Chowdhury MEH

Diagnostics (Basel), 2021 Mar 08;11(3).
PMID: 33800188 DOI: 10.3390/diagnostics11030470

Microwave imaging (MI) is a consistent health monitoring technique that can play a vital role in diagnosing anomalies in the breast. The reliability of biomedical imaging diagnosis is substantially dependent on the imaging algorithm. Widely used delay and sum (DAS)-based diagnosis algorithms suffer from some significant drawbacks. The delay multiply and sum (DMAS) is an improved method and has benefits over DAS in terms of greater contrast and better resolution. However, the main drawback of DMAS is its excessive computational complexity. This paper presents a compressed sensing (CS) approach of iteratively corrected DMAS (CS-ICDMAS) beamforming that reduces the channel calculation and computation time while maintaining image quality. The array setup for acquiring data comprised 16 Vivaldi antennas with a bandwidth of 2.70-11.20 GHz. The power of all the channels was calculated and low power channels were eliminated based on the compression factor. The algorithm involves data-independent techniques that eliminate multiple reflections. This can generate results similar to the uncompressed variants in a significantly lower time which is essential for real-time applications. This paper also investigates the experimental data that prove the enhanced performance of the algorithm.
Fulltext Impact of complementary and alternative medicines on antiepileptic medication adherence among epilepsy patients

Farrukh MJ, Makmor-Bakry M, Hatah E, Jan TH

BMC Complement Med Ther, 2021 Feb 04;21(1):50.
PMID: 33541336 DOI: 10.1186/s12906-021-03224-2

BACKGROUND: The aim of this study was to assess the knowledge, attitude, and practice of complementary and alternative medicine (CAM) and its impact on antiepileptic drug (AED) adherence among patients with epilepsy.
METHODS: A cross-sectional study was carried out on 100 epilepsy patients, aged 18 years or older that did not have any physical or psychiatric illness. A patient-administered questionnaire was used to assess their knowledge, attitude towards, practice, and perceived effectiveness (KAPP) of CAM. Established adherence assessment tools were used to determine patient medication adherence.
RESULTS: The prevalence of CAM usage was found to be at 58%. CAM was used more frequently by males (n = 32, 60.4%) than by females (n = 26, 55.3%; p = 0.609). The most commonly used CAM included vitamins and minerals (36%), ginseng (16%), antioxidants (15%), and acupuncture (12%). A significant number of patients had low knowledge of (59%) and a positive attitude (54%) toward complementary and alternative medicine. Main reasons for using CAM were a lower price, better availability, and inadequate seizure control by AEDs. About 43% of the patients who used CAM informed their doctor. Prevalence of non-adherence to AED therapy was found to be 68%. A significant association was found between non-adherence and CAM usage (p
Development and characterization of an LED-based detector for dosimetry in diagnostic radiology

Damulira E, Yusoff MNS, Omar AF, Mohd Taib NH

Phys Med Biol, 2021 Apr 12;66(8).
PMID: 33725685 DOI: 10.1088/1361-6560/abef44

Light-emitting diodes (LEDs) could be a potential dosimetry candidate because they are radiation hard, spectrally selective, direct band gap, and low-cost devices. Thus, an LED-based detector prototype was designed and characterized for dosimetry. A 20 × 20 cm2array of surface mount device LED chips was sandwiched in photovoltaic mode between two intensifying screens to form a dosimetric system. The system was enclosed in a light-tight air cavity using black vinyl tape. The screens converted diagnostic x-ray beams into fluorescent blue light. LEDs, applied in detector mode, converted the fluorescent light into radiation-induced currents. A digital multimeter converted the analog currents into digital voltage signals. Prototype characterization was executed using (a) IEC 61267's RQR 7 (90 kVp) and RQR 8 (100 kVp) beam qualities, and (b) low (25 mAs) and high (80 mAs) beam quantities. A standard dosimeter probe was simultaneously exposed with the prototype to measure the prototype's absorbed dose. In all exposures, the x-ray beams were perpendicularly incident on both the dosimeter and prototype, at a fixed source to detector distance-60 cm. The LED array prototype's minimum detectable dose was 0.139 mGy, and the maximum dose implemented herein was ∼13 mGy. The prototype was 99.18% and 98.64% linearly sensitive to absorbed dose and tube current-time product (mAs), respectively. The system was ±4.69% energy, ±6.8% dose, and ±7.7% dose rate dependent. Two prototype data sets were 89.93% repeatable. We fabricated an ultrathin (5 mm), lightweight (130 g), and a relatively low-cost LED-based dosimetric prototype. The prototype executed a simple, efficient, and accurate real-time dosimetric mechanism. It could thus be an alternative to the current passive dosimetric systems.
Fulltext Fractional order mathematical modeling of novel corona virus (COVID-19)

Ahmad W, Sarwar M, Shah K, Ahmadian A, Salahshour S

Math Methods Appl Sci, 2021 Feb 03.
PMID: 33821069 DOI: 10.1002/mma.7241

In this manuscript, the mathematical model of COVID-19 is considered with eight different classes under the fractional-order derivative in Caputo sense. A couple of results regarding the existence and uniqueness of the solution for the proposed model is presented. Furthermore, the fractional-order Taylor's method is used for the approximation of the solution of the concerned problem. Finally, we simulate the results for 50 days with the help of some available data for fractional differential order to display the excellency of the proposed model.
Fulltext Prevalence of occupational diseases among small and medium industry workers in Malaysia: a systematic review

Muhammad Zubir Yusof, Nik Ahmad Kamal Nik Mahmod, Nor Azlina A. Rahman, Ailin Razali, Niza Samsuddin, Nik Mohamed Nizan Nik Mohamed, et al.

Journal of Clinical and Health Sciences, 2019;4(2):4-30.
MyJurnal

Occupational diseases are one of the major health problems related to workplace hazards.
However, the epidemiological data for this problem is scarce especially among Small and
Medium Industry (SMI) workers. These workers are vulnerable to occupational health problem
due to lack of knowledge and implementation of health and safety in the workplace. In Malaysia,
most of the SMI workers have limited coverage for basic occupational health services which
may worsen their health. Thus, this article aims to provide a review on the burden of
occupational health problems among them. The electronic and library searches were used to
extract the information from both published and unpublished articles that were not limited to any
year of publication until 2017. One hundred and ninety-six published articles and 198
unpublished articles were retrieved from the database. Only 19 published articles and 25
unpublished articles met the eligibility criteria. Prevalence data of occupational
diseases/poisoning, including overall and body specific (musculoskeletal disorders) was
extracted in raw data from the eligible studies. Prevalent statistics on occupational
musculoskeletal diseases (1.3% - 97.6%), noise-induced hearing loss (29.4% - 73.3%),
occupational skin diseases (10.5% - 84.3%), respiratory (1.9% - 92.2%) and occupational
poisoning (14.9% - 17.7%) among the working population is different within published papers
compared to unpublished ones. In Malaysia, there are no specific statistic that give a true picture
of the burden of occupational diseases in the SMI. However, this review concludes that
musculoskeletal diseases are significant occupational problems among SMI workers.
Synthesis of tungsten oxide/ amino-functionalized sugarcane bagasse derived-carbon quantum dots (WO3/N-CQDs) composites for methylene blue removal

Nugraha MW, Zainal Abidin NH, Supandi, Sambudi NS

Chemosphere, 2021 Aug;277:130300.
PMID: 33774232 DOI: 10.1016/j.chemosphere.2021.130300

In this present study, the tungsten oxide/amino-functionalized sugarcane bagasse derived-carbon quantum dots (WO3/N-CQDs) composite has successfully been prepared through a simple mixing process. The WO3 was synthesized through a precipitation method, and CQDs were amino-functionalized using ethylenedinitrilotetraacetic acid (EDTA) and ethylenediamine (EDA) through one-pot hydrothermal method. It is revealed that N-CQDs incorporation into WO3 alters the bandgap energy, crystallinity, surface area, and photoluminescence (PL) properties. The produced composites exhibit higher monoclinic WO3 crystallinity, larger surface area, lower bandgap energy and quenched photoluminescence intensity. The as-prepared WO3/N-CQDs composites exhibit better adsorption and photocatalytic degradation performance of methylene blue (MB) than the pristine WO3. It shows that the combination of N-CQDs and WO3 enhanced visible light absorption, by lowering the bandgap energy of WO3 from 2.175 to 1.495 eV. The best performance composite is WO3/N-CQDs EDA 2.5% with an efficiency of 96.86%, removal rate constant of 0.02017/min, and chemical oxidation demand (COD) removal efficiency achieved 84.61%. Moreover, the WO3/N-CQDs EDA 2.5% shows a significant photocatalytic activity even at higher MB initial concentration with 92.93% removal for 50 ppm MB. Subsequently, the composite also has good stability after a sequential 3-times cycle of degradation with 86.85% removal. The increasing photocatalytic performance is affected by the quenching effect of PL and lower bandgap energy. The lower intensity of the PL indicates the reduced charge carrier recombination resulting in increased photocatalytic activity. The combination of N-CQDs and WO3 resulted in improved photodegradation, which shows its significant potential to be utilized for wastewater treatment.
Fulltext Perception and practices of community pharmacists towards antimicrobial stewardship in Lahore, Pakistan

Akbar Z, Saleem Z, Shaukat A, Farrukh MJ

J Glob Antimicrob Resist, 2021 06;25:157-161.
PMID: 33789207 DOI: 10.1016/j.jgar.2021.03.013

OBJECTIVES: Antimicrobial resistance is a major health concern worldwide. Community pharmacists can play an important role in rational antibiotic use. This study aimed to evaluate the perception and practices of community pharmacists regarding antimicrobial stewardship (AMS) in Lahore, Pakistan.
METHODS: A descriptive cross-sectional study was conducted among community pharmacists in Lahore from 1 November 2017 to 31 December 2017. A self-administered questionnaire was used for data collection. Non-probability convenience sampling was performed to select community pharmacists. Descriptive statistics were applied and Mann-Whitney U-tests and Kruskal-Wallis tests were performed to compare independent groups using SPSS v.20.0. A P-value of <0.05 was considered statistically significant. Perception and practice scores were determined to access community pharmacist knowledge regarding AMS. A score of 0.5-1 was considered to be very good.
RESULTS: The overall response rate was 70.9%. Sex, age, work experience and education level did not significantly influence the perception and practices of community pharmacists. Experienced pharmacists showed a better response to AMS. The majority of pharmacists strongly agreed that they educate patients on the use of antimicrobials and resistance-related issues.
CONCLUSION: It was concluded that community pharmacists in Lahore have good perception regarding AMS and they are practicing it well. But there are several gaps in their practices that must be filled, such as dispensing without a prescription and dispensing for a longer duration than prescribed. Additionally, there should be strict implementation of guidelines for dispensing antibiotics in order to rationalise antibiotic use and decrease antimicrobial resistance.
Methotrexate-based ionic liquid as a potent anticancer drug for oral delivery: In vivo pharmacokinetics, biodistribution, and antitumor efficacy

Moshikur RM, Ali MK, Wakabayashi R, Moniruzzaman M, Goto M

Int J Pharm, 2021 Oct 25;608:121129.
PMID: 34562557 DOI: 10.1016/j.ijpharm.2021.121129

Oral delivery of the sparingly soluble drug methotrexate (MTX) is challenging owing to its poor bioavailability and low solubility. To address this challenge, the present study reports the conversion of MTX into a series of five ionic liquids (ILs) comprising a cationic component-i.e., cholinium (Cho), tetramethylammonium (TMA), tetrabutylphosphonium (TBP), or an amino acid ester-and an anionic component-i.e., MTX. The biocompatibility, pharmacokinetics, tissue distribution, and antitumor efficacy of each MTX-based IL were investigated to determine its usefulness as a pharmaceutical. Oral administration to mice revealed that proline ethyl ester MTX (IL[ProEt][MTX]) had 4.6-fold higher oral bioavailability than MTX sodium, followed by aspartic diethyl ester MTX, IL[TBP][MTX], IL[Cho][MTX], and IL[TMA][MTX]. The peak plasma concentration, elimination half-life, area under the plasma concentration, mean absorption time, and body clearance of IL[ProEt][MTX] were significantly (p
The effect of hydroxychloroquine on non-alcoholic fatty liver disease among rheumatoid arthritis patients

Lim CH, Hassan MRA, Tan CL, Ng BH

J R Coll Physicians Edinb, 2021 Sep;51(3):310-317.
PMID: 34528626 DOI: 10.4997/JRCPE.2021.322
Fulltext Effect of Covid-19 pandemic on tourist travel risk and management perceptions

Rahman MK, Gazi MAI, Bhuiyan MA, Rahaman MA

PLoS One, 2021;16(9):e0256486.
PMID: 34469468 DOI: 10.1371/journal.pone.0256486

This study aims to explore the impact of the Covid-19 pandemic on tourists' travel risk and management perceptions. Driven on the effect of the pandemic, we investigate tourists' travel risk and management perceptions and its effect on society using a sample of 716 respondents. The data was collected through social media platforms using a representative sampling method and analyzed applying the PLS-SEM tool. The findings reveal that Covid-19 pandemic has greatly affected travel risk and management perceptions. Travel risk and management perception had a significant association with risk management, service delivery, transportation patterns, distribution channels, avoidance of overpopulated destinations, and hygiene and safety. The results also identified the mediating effect of travel risk and management perceptions. The finding of this study contributes to tourism crises and provides future research insights in the travel and tourism sector and response to change tourists' travel risk and management perceptions in the post-covid recovery period.
Fulltext Silent cries behind closed doors: An online empirical assessment of fear of COVID-19, situational depression, and quality of life among Pakistani citizens

Ashraf MU, Raza S, Ashraf A, Mehmood W, Patwary AK

J Public Aff, 2021 Jul 04.
PMID: 34512182 DOI: 10.1002/pa.2716

The present study aimed to investigate the effects of fear of COVID-19 and situational depression on the quality of life (QOL) of Pakistani citizens. An online cross-sectional survey was conducted on Pakistani citizens via the snowball sampling technique. A total of 377 respondents (256 males and 121 females) participated in this study from August to October 2020. Adapted scales were validated using confirmatory factor analysis, and partial least squares structural equation modelling (PLS-SEM) was applied to the data to test the hypothesised model. The study's findings showed a negative relationship between fear of COVID-19 and QOL. Likewise, a reciprocal relationship was found between situational depression and quality of life. The results indicate that fear of COVID-19 and situational depression during the pandemic have affected the lives of Pakistani citizens. The findings are particularly relevant for improving the QOL by limiting the information received from media and social networks. There is a need to control these mediums and promote community-based interventions to provide accurate knowledge regarding COVID-19. Fear of COVID-19 and situational depression may be reduced in this way. Based on the current findings, psychotherapy and counselling programmes must be planned to minimise the adverse effects of fear of COVID-19 and depression on the QOL of citizens due to the ongoing progression of the pandemic.
Fulltext A Mobile App (FallSA) to Identify Fall Risk Among Malaysian Community-Dwelling Older Persons: Development and Validation Study

Singh DKA, Goh JW, Shaharudin MI, Shahar S

JMIR Mhealth Uhealth, 2021 10 12;9(10):e23663.
PMID: 34636740 DOI: 10.2196/23663

BACKGROUND: Recent falls prevention guidelines recommend early routine fall risk assessment among older persons.
OBJECTIVE: The purpose of this study was to develop a Falls Screening Mobile App (FallSA), determine its acceptance, concurrent validity, test-retest reliability, discriminative ability, and predictive validity as a self-screening tool to identify fall risk among Malaysian older persons.
METHODS: FallSA acceptance was tested among 15 participants (mean age 65.93 [SD 7.42] years); its validity and reliability among 91 participants (mean age 67.34 [SD 5.97] years); discriminative ability and predictive validity among 610 participants (mean age 71.78 [SD 4.70] years). Acceptance of FallSA was assessed using a questionnaire, and it was validated against a comprehensive fall risk assessment tool, the Physiological Profile Assessment (PPA). Participants used FallSA to test their fall risk repeatedly twice within an hour. Its discriminative ability and predictive validity were determined by comparing participant fall risk scores between fallers and nonfallers and prospectively through a 6-month follow-up, respectively.
RESULTS: The findings of our study showed that FallSA had a high acceptance level with 80% (12/15) of older persons agreeing on its suitability as a falls self-screening tool. Concurrent validity test demonstrated a significant moderate correlation (r=.518, P

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