MyMedR

Peutz-Jeghers syndrome and its complications. First case report from Malaysia with review of literature

Joishy SK, Leela MP, Balasegaram M

Am J Surg, 1979 Nov;138(5):716-20.

We report for the first time from Malaysia a patient with Peutz-Jeghers syndrome complicated by successive intussusceptions requiring extensive small bowel resection. Our experience is compared with that of other authors by a review of the literature highlighting important points in the diagnosis and management of complications in Peutz-Jeghers syndrome.

Fulltext Mercury release from a Sn-Cu-Zn free amalgam

Lui JL, Tong SL, Teh SK

Ann Dent, 1994;1(1):1-4.

MyJurnal

The mercury controversy related to dental amalgam is still continuing. In Malaysia, part of, this controversy has been attributed to a recently - introduced dental amalgam claimed to be non-mercury releasing and causing no mercury toxicity. The purpose of this study was to investigate whether this amalgam, Composil, was indeed non-mercury releasing. Six specimens each of Composil and a control (GS-80) were incubated at 3TC in deionised-distilled water. The daily mercury release was determined over a four-week study period using the stationary cold-vapour atomic absorption spectrometric method. The mean mercury release of Composil was 30.9 Ilg/cm2/ 24hr whilst that of GS-80 was 0.9 Ilg/cm2124hr and the difference was found to be highly significant (P < 0.00l). Results of this study therefore did not substantiate the manufacturer's claim. The release of mercury from amalgam restorations and their implications in clinical practice were also discussed.

Positron emission mammography is a useful adjunct in assessment of dense breasts

Kumar SK, Trujillo PB, Ucros GR

Med J Malaysia, 2017 04;72(2):138-140.

PMID: 28473683

Worldwide breast cancer remains as the most common malignancy in women and the numbers who form a subgroup with dense breast parenchyma are substantial. In addition to mammography, the adjuncts used for further evaluation of dense breasts have been anatomically based modalities such as ultrasound and magnetic resonance imaging. The practice of functionally based imaging of breasts is relatively new but has undergone rapid progress over the past few years with promising results. The value of positron emission mammography is demonstrated in patients with dense breasts and mammographically occult disease.

[3 Malayan trematodes]

Rohde K, Lee SK, Lim HW

Ann Parasitol Hum Comp, 1968 Jan-Feb;43(1):33-43.

PMID: 4192885

Fulltext Student learning disability experiences, training and services needs of secondary school teachers

Teoh HJ, Cheong SK, Woo PJ

Malaysian Journal of Psychiatry, 2008;17(2):1-14.

MyJurnal

107 secondary school teachers were surveyed to find out about their observations of children with learning disorders at schools. The respondents reported that the most commonly observed disorders involved difficulty paying attention, difficulty learning a second language, being fidgety and having difficulty sitting still, and having poor comprehension. They also indicated that whilst some children made fun of their classmates with learning disorder, others tried to assist their classmates. The most common reaction of parents was to send the child for lots of tuition, and to be very frustrated with the child. In addition, some parents neglected their children’s learning disorder, and many did not seem to realise how serious the problem was. When it came to the needs of teachers, the most common need that the teachers reported was to have the parents cooperate with them and to have support from the education authorities. The paper discusses the implications of these findings and proposes suggestions for dealing with the training needs of teachers working in the area of learning disorders.

Response to radioactive phosphorus treatment of polycythaemia rubra vera in Malaysians: analysis of 8 cases

Zulkifli A, Chelvam P, Weng Hwa N, Dharmalingam SK

Med J Malaysia, 1979 Jun;33(4):346-8.

PMID: 392273

Treatment of thyrotoxicosis with radioactive iodine: a report on 137 cases

Dharmalingam SK, Taek YS, Mahadev V

Med J Malaya, 1970 Sep;25(1):3-7.

PMID: 4249493

Plasmodium inui-like infection producing a presumably fatal illness in a leaf monkey Presbytis johnii--a previously undescribed host

Das SK, Strauss JM, Chee CT

Med J Malaya, 1966 Jun;20(4):323.

PMID: 4224342

Fulltext Incidence of nasopharyngeal carcinoma in Malaysia, with special reference to the state of Selangor

Armstrong RW, Kutty MK, Dharmalingam SK

Br. J. Cancer, 1974 Jul;30(1):86-94.

PMID: 4413823

A "registry" of all known cases of nasopharyngeal carcinoma in Malaysia, 1968-72, was established. Attention was focused on the State of Selangor where conditions are best for case finding. Age-adjusted incidence rates among Chinese males and females were 17·3 and 7·3 per 100,000; among Malay males and females, the rates were 2·5 and 0·3 and among Indian males, 1·1. The detailed ethnicity of 192 cases in Selangor was established. Estimated incidence rates for the Chinese sub-groups agreed with the pattern observed elsewhere: highest among the Cantonese, lowest among the Hokkien/Teochiu, with the Khek in between. There was no correlation between histological type and sub-ethnic group among the Chinese cases.

Fulltext Novel Anodic Catalyst Support for Direct Methanol Fuel Cell: Characterizations and Single-Cell Performances

Abdullah N, Kamarudin SK, Shyuan LK

Nanoscale Res Lett, 2018 Apr 03;13(1):90.

PMID: 29616360 DOI: 10.1186/s11671-018-2498-1

This study introduces a novel titanium dioxide carbon nanofiber (TiO2-CNF) support for anodic catalyst in direct methanol fuel cell. The catalytic synthesis process involves several methods, namely the sol-gel, electrospinning, and deposition methods. The synthesized electrocatalyst is compared with other three electrocatalysts with different types of support. All of these electrocatalysts differ based on a number of physical and electrochemical characteristics. Experimental results show that the TiO2-CNF support gave the highest current density at 345.64 mA mgcatalyst-1, which is equivalent to 5.54-fold that of carbon support while the power density is almost double that of the commercial electrocatalyst.

Immediate hypersensitivity to bee pollen granules

Kanneppady SK, Kanneppady SS, Chaubal T, Bapat R

QJM, 2018 Oct 01;111(10):753-754.

PMID: 29788120 DOI: 10.1093/qjmed/hcy100

Dengue fever with compartment syndrome of the right arm

Khoo C, Chu G, Rosaida MS, Chidambaram SK

J R Coll Physicians Edinb, 2016 Dec;46(4):241-243.

PMID: 28504777 DOI: 10.4997/JRCPE.2016.406

A 44-year-old woman was admitted to our hospital with dengue fever. She developed a haematoma in the right arm at the site of a previous arterial line insertion. Due to coexisting thrombocytopenia, the bleeding was severe enough to cause compartment syndrome. An emergency fasciotomy was performed and her limb salvaged. The case illustrates one important potential complication of this common infectious disease.

Study on the physical and chemical composition of agro wastes for the production of 5-hydroxymethylfurfural

Shamsul NS, Kamarudin SK, Rahman NA

Bioresour Technol, 2018 Jan;247:821-828.

PMID: 30060418 DOI: 10.1016/j.biortech.2017.09.140

Treated sludge, goat manure, sugarcane bagasse, empty fruit bunches of oil palm (EFBP) and dry leaves are agro wastes that have high potential for use as feedstocks for the production of 5-hydroxymethylfurfural (5-HMF). The focus of this study is to investigate the production of 5-HMF from agro wastes via co-hydrothermal (CHT) treatment and extraction. Present study include examine on agro waste's physical and chemical properties and also their thermal degradation behaviour. The analysis of the bio-oil products is conducted by FTIR and GC-MS. Co-hydrothermal experiments were conducted at a temperature of 300°C with an experimental time of 15min, followed by alcohol extraction. Highest carbon and hydrogen content are 45.94% and 6.49% (dry leaves) with maximum high heating value 18.39MJ/kg (dry leaves) and fix carbon value 6.60 (goat manure). Through CHT about 39% 5-HMF, 22.97% carboxylic acids, 0.97% of aromatic and 0.73% aldehyde obtained.

Intraoperative frozen section sentinel lymph node assessment in breast cancer: A tertiary institution experience

Lai SK, Masir N, Md Pauzi SH

Malays J Pathol, 2018 Aug;40(2):121-128.

PMID: 30173228 MyJurnal

INTRODUCTION: Intraoperative frozen section lymph node assessment helps to predict axillary lymph node metastasis in breast cancer. However, the accuracy of this frozen section analysis may vary among institutions. This study describes our institution's experience in intraoperative analysis of sentinel lymph node and aims to determine the accuracy, sensitivity and specificity of our assessment.

MATERIALS AND METHODS: We retrospectively analysed the histopathological material and data from 82 breast cancer patients diagnosed over a period of four years who underwent intraoperative frozen section evaluation of sentinel lymph nodes.

RESULTS: Frozen section analysis detected metastasis in 13 out of 82 cases and definitive pathological examination on the paraffin section confirmed these positive findings. There was no false positive case (specificity of 100%). The true positive cases comprised seven macrometastases, five micrometastases and one isolated tumour cells. Sampling error was noted in two cases in which the malignant cells were only present in the deeper final paraffin sections (false negative rate of 13.3%). The test sensitivity was 86.7% and the accuracy rate was 97.5%. These findings are comparable to other published data.

CONCLUSION: Intraoperative frozen section analysis is a safe and reliable method for assessment of sentinel lymph node. Knowledge on limitation of frozen section analysis with diligent evaluation of frozen section specimen will be beneficial in reducing interpretation error.

Fulltext Screening for thalassaemia in pregnant women: a laboratory perspective

George E, Khoo SK, Mokhtar AB, Nor Aini U

Malaysian Journal of Medicine and Health Sciences, 2005;1(2):111-117.

Aims: To investigate whether in Malaysia, a mean corpuscular volume (MCV) less than 80 fl and a mean corpuscular haemoglobin (MCH) less than 27 pg will identify carriers in pregnant women with severe forms of thalassaemia, a-thal 1 (a0) and classical b (b0)-thalassaemia. The results from this study will aid the implementation of a national program to screen for thalassaemia.
Methods: For classical b (b0)-thalassaemia, blood samples collected in EDTA from 153 pregnant women were taken for full blood counts and haemoglobin subtyping by automated blood counting and high performance liquid chromatography (HPLC) respectively. For a-thal 1 (a0), the full blood counts were obtained from archives of 30 pregnant women who were genotyped positive for the a-thal 1 (a0) during prenatal diagnosis for Hb Barts hydrops fetalis. The effects of storage on MCV, MCH and Hb A2 were determined by tests done daily for 3 weeks.
Results: By correlating red cell indices with high performance liquid chromatography and genotypic data, we show that mean corpuscular volume (MCV) <80 fl and mean corpuscular haemoglobin <27pg is able to detect all heterozygous carriers of a-thal 1 (a0) and classical b (b0)-thalassaemia. On storage, the MCV of heterozygous carriers with classical b (b0)-thalassaemia rose at 1% a day after 24 hours reaching a mean of 80 fl by day 15. However, the MCH and Hb A2 were stable for 3 weeks.
Conclusion: A mean corpuscular volume (MCV) <80 fl and mean corpuscular haemoglobin <27pg should be recommended as cut-off values for screening of carriers of a-thal 1 (a0) and classical b (b0)-thalassaemia. In blood samples, not processed within a day, MCH with a cut-off value of 27 pg is the recommended choice for screening of carriers. Keywords: Screen, thalassaemia, pregnant, MCV, MCH

Mandibular hemangio-ameloblastoma

Arora S, Kanneppady SK, Banavar SR, Jnanendrappa N

QJM, 2019 Aug 01;112(8):615-616.

PMID: 31120127 DOI: 10.1093/qjmed/hcz117

A case of pulmonary tuberculosis masquerading as lung carcinoma

Tan KT, Kannan SK, Rajahram GS

Med J Malaysia, 2019 12;74(6):547-548.

PMID: 31929486

Tuberculosis is a nimble chameleon. It can manifest itself in various ways with atypical clinical and radiographic findings. In this report we discuss the importance of radiographic findings (nodular or mass-like forms) requiring a correlation with microbiological and histopathological results to differentiate lung cancer from TB.

Malnutrition, low diet quality and its risk factors among older adults with low socio-economic status: a scoping review

Nazri NS, Vanoh D, Leng SK

Nutr Res Rev, 2021 06;34(1):107-116.

PMID: 32727634 DOI: 10.1017/S0954422420000189

Low socio-economic status (SES) is often associated with various health-related problems. Therefore, the present paper aims to review the available literature to identify the prevalence of malnutrition, prevalence of poor diet quality and its associated risk factors among older adults with low SES. A literature search was performed using four databases, namely PubMed, Google Scholar, Springer and Science Direct. The search terms used were 'diet quality', 'nutritional status', 'dietary intake', 'overweight', 'obesity', 'underweight', 'older people' and 'low socioeconomic status (SES)'. The overall prevalence of undernutrition among older adults with low SES worldwide was in the range of 28·9 to 48 %, while overnutrition was reported to be between 8·1 to 28·2 %. In Asia, the prevalence of undernourished older adults ranged from 3 to 64·9 %, while 2·5 to 32·8 % were overnourished. Most of the studies (60 %) included in the present review used BMI as the tool to identify malnutrition, but none of the nutritional screening tools were considered to be the 'gold standard'. For dietary assessment, FFQ and multiple 24 h dietary recall improved the estimation of individual dietary intake. Risk factors for poor diet quality included financial hardship, functional limitation, sex, place of residence, smoking and oral health. Poor nutritional status, especially lack of good-quality diet, and thinness are prevalent among older adults with low SES. Hence, it is important to establish nutrition-related programmes and intervention studies among this group of individuals for improving their health status and quality of life.

Fulltext Predicting Quadruple Semitendinosus Graft Size for Anterior Cruciate Ligament Reconstruction by Patient Anthropometric Variables: A Cohort Study of 280 Cases

Singhal D, Kanodia N, Singh R, Singh SK, Agrawal S

Malays Orthop J, 2021 Nov;15(3):71-77.

PMID: 34966498 DOI: 10.5704/MOJ.2111.011

Introduction: Pre-operative identification of patients with inadequate hamstring graft for anterior cruciate ligament reconstruction is still a subject of interest. The purpose of this study is to correlate dimension of a harvested dimensions graft with patient physical anthropometric variables.

Materials and methods: This cohort study included 280 patients (male = 226, female = 54) scheduled for primary anterior cruciate ligament (ACL) reconstruction. Interrelationships between quadruple semitendinosus (ST) graft and anthropometric parameters (age, sex, height, weight, and BMI) were assessed using Pearson Correlation test and regression analysis. Difference among gender was analysed using Mann Whitney and t test. The observed graft diameter was also compared with the literature using Bland - Altman plot.

Results: Mean age of cohort was 29 years (range, 17-50 years), mean height was 1.69m (range, 1.6-1.9m), mean weight was 75 kg (range, 50-116kg) and mean BMI was 26kg/m2 (range 16.65-40.40kg/m2). Mean quadruple length of harvested ST graft was 7cm (7.1±0.6 cm, range, 5.6-8.8cm) and mean diameter was 8mm (8.2±0.8mm, range, 6.5-10mm). Only height and weight were significantly correlated with graft length and diameter in both sex (p value <0.05). Female, compared to male, had significantly smaller (p<0.0001) and thinner graft (p<0.0001). There was a strong agreement between the literature and our observed graft diameter, but with an overestimated graft diameter in 18.5% of the cases.

Conclusion: Among anthropometric parameter, only height and weight had moderate positive correlation with graft diameter. Males had longer and wider ST graft in contrast to age-matched female group.

Fulltext Pre-Hospital Orthopaedic Trauma Care in a Developing Country During COVID-19 Pandemic

Soni AS, Garg SK, Singhal A

Malays Orthop J, 2021 Nov;15(3):154.

PMID: 34966514 DOI: 10.5704/MOJ.2111.027

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