Displaying publications 221 - 240 of 305 in total

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  1. Fulltext River pollution relationship to the national health indicated by under-five child mortality rate: a case study in Malaysia
    Mohd Aqmin Abdul Wahab, Adzleen Mohmood, Nur Khaliesah Jamadon, Amir Syahir
    Bioremediation Science and Technology Research, 2015;3(1):20-26.
    MyJurnal
    The trend of global under-five child mortality rate showed a steady decrease at -3.14% per year
    approaching the United Nations millennium development goals target (-4.0% reduction per year
    from 1990-2015). This rate is usually inversely proportional to the nations GDP. However, the
    progress in the recent years (2006-2012) in Malaysia has raised a disturbing concern with an
    annual average increment of +0.81% per year. Thus, there is an urgent need to identify the
    reasons of such risky ecosystem. By analyzing recorded data on river pollution from 2007-
    2012, we found that river pollution has high correlation with the gross domestic products, not at
    the same year, but for two years prior that indicates a lag time. We also found that under-five
    child mortality has strong correlation with the river pollutions. The development-pollutionhealth
    triangular cycle needs to be put in a balanced to ensure the nation prosperity and
    sustainability of the nation.
    Matched MeSH terms: Goals
  2. Antimicrobial stewardship for acute-care hospitals: An Asian perspective
    Apisarnthanarak A, Kwa AL, Chiu CH, Kumar S, Thu LTA, Tan BH, et al.
    Infect Control Hosp Epidemiol, 2018 10;39(10):1237-1245.
    PMID: 30227898 DOI: 10.1017/ice.2018.188
    Inappropriate use of antibiotics is contributing to a serious antimicrobial resistance problem in Asian hospitals. Despite resource constraints in the region, all Asian hospitals should implement antimicrobial stewardship (AMS) programs to optimize antibiotic treatment, improve patient outcomes, and minimize antimicrobial resistance. This document describes a consensus statement from a panel of regional experts to help multidisciplinary AMS teams design programs that suit the needs and resources of their hospitals. In general, AMS teams must decide on appropriate interventions (eg, prospective audit and/or formulary restriction) for their hospital, focusing on the most misused antibiotics and problematic multidrug-resistant organisms. This focus is likely to include carbapenem use with the goal to reduce carbapenem-resistant gram-negative bacteria. Rather than initially trying to introduce a comprehensive, hospital-wide AMS program, it would be practical to begin by pilot testing a simple program based on 1 achievable core intervention for the hospital. AMS team members must work together to determine the most suitable AMS interventions to implement in their hospitals and how best to put them into practice. Continuous monitoring and feedback of outcomes to the AMS teams, hospital administration, and prescribers will enhance sustainability of the AMS programs.
    Matched MeSH terms: Goals
  3. Fulltext Data on organochlorine concentration levels in soil of lowland paddy field, Kelantan, Malaysia
    Osman BE, Khalik WMAWM
    Data Brief, 2018 Oct;20:999-1003.
    PMID: 30225314 DOI: 10.1016/j.dib.2018.08.178
    The main goal of this research work is to measure the concentration levels of organochlorine residue in soil. The potential health risk of this pollutant on human was also determined. 10 samples were taken from a lowland paddy field situated in Kelantan, Malaysia. Physical parameters namely soil pH, organic carbon content, water content and particle size were identified to evaluate the quality of soil from the agriculture site. Soxhlet extraction and florisil clean-up process were applied to isolate 10 targeted organochlorine compounds prior to the final determination using a gas chromatography-electron capture detector. Soil from the lowland has characteristics such as slightly acidic, low organic carbon content, high water content and texture dominated by the sandy type. Concentration levels of six detected organochlorine pesticides were calculated in µg/kg. Hazard quotient value in all samples was less than the acceptable risk level HQ ≤ 1, thus reflecting the status of soil in the subjected area as unlikely to pose any adverse health effects.
    Matched MeSH terms: Goals
  4. Fulltext Classification of Visual and Non-visual Learners Using Electroencephalographic Alpha and Gamma Activities
    Jawed S, Amin HU, Malik AS, Faye I
    Front Behav Neurosci, 2019;13:86.
    PMID: 31133829 DOI: 10.3389/fnbeh.2019.00086
    This study analyzes the learning styles of subjects based on their electroencephalo-graphy (EEG) signals. The goal is to identify how the EEG features of a visual learner differ from those of a non-visual learner. The idea is to measure the students' EEGs during the resting states (eyes open and eyes closed conditions) and when performing learning tasks. For this purpose, 34 healthy subjects are recruited. The subjects have no background knowledge of the animated learning content. The subjects are shown the animated learning content in a video format. The experiment consists of two sessions and each session comprises two parts: (1) Learning task: the subjects are shown the animated learning content for an 8-10 min duration. (2) Memory retrieval task The EEG signals are measured during the leaning task and memory retrieval task in two sessions. The retention time for the first session was 30 min, and 2 months for the second session. The analysis is performed for the EEG measured during the memory retrieval tasks. The study characterizes and differentiates the visual learners from the non-visual learners considering the extracted EEG features, such as the power spectral density (PSD), power spectral entropy (PSE), and discrete wavelet transform (DWT). The PSD and DWT features are analyzed. The EEG PSD and DWT features are computed for the recorded EEG in the alpha and gamma frequency bands over 128 scalp sites. The alpha and gamma frequency band for frontal, occipital, and parietal regions are analyzed as these regions are activated during learning. The extracted PSD and DWT features are then reduced to 8 and 15 optimum features using principal component analysis (PCA). The optimum features are then used as an input to the k-nearest neighbor (k-NN) classifier using the Mahalanobis distance metric, with 10-fold cross validation and support vector machine (SVM) classifier using linear kernel, with 10-fold cross validation. The classification results showed 97% and 94% accuracies rate for the first session and 96% and 93% accuracies for the second session in the alpha and gamma bands for the visual learners and non-visual learners, respectively, for k-NN classifier for PSD features and 68% and 100% accuracies rate for first session and 100% accuracies rate for second session for DWT features using k-NN classifier for the second session in the alpha and gamma band. For PSD features 97% and 96% accuracies rate for the first session, 100% and 95% accuracies rate for second session using SVM classifier and 79% and 82% accuracy for first session and 56% and 74% accuracy for second session for DWT features using SVM classifier. The results showed that the PSDs in the alpha and gamma bands represent distinct and stable EEG signatures for visual learners and non-visual learners during the retrieval of the learned contents.
    Matched MeSH terms: Goals
  5. Fulltext Social support as a mediator of the influence of optimism towards happiness among adolescents in higher education. [Sokongan sosial sebagai pengantara pengaruh optimistik ke atas kebahagiaan remaja di pengajian tinggi]
    Mahirah M, Balan R
    Jurnal Psikologi Malaysia, 2018;32(1):82-96.
    Happiness is the natural goal of life for every human being. Every indivdual is trying to find happiness because it describes a good life. Therefore, this study aims to examine an influence on happiness, which is optimistic, using a positive psychological strength,. Social support is utilized as an external quality as it supports the optimistic influence towards happiness. The study was conducted on 436 adolescents in higher education, aged between 18 and 25 years old. The quantitative study uses a set of questionnaires to obtain the data, Extended Life Orientation Test for optimistic measurements, Inventory of Socially Supportive Behavior Short Form measures social support, and Oxford Happiness Questionnaire measures adolescents happiness. Descriptively, adolescents in higher education showed high optimism (Min = 3.77, SP = .62), while moderate social support for the three forms of support, namely guidance support (Min = 3.07, SP = .81), emotional support (Min = 3.17, SP = .99) and tangible support (Min = 2.82, SP = .95). Adolescents in higher education reported having a moderate level of happiness (Min = 3.39, S.P = .92). The findings show that guidance and emotion support mediating the influence of optimistic towards happiness among adolescents in higher education. Tangible support does not play any role. The implication of the study is to adolescents that even the positive attitudes of optimistic can enhance their happiness, but the guidance and emotional support from significant people can further reinforce those influences.
    Study site: Universiti Malaysia Sabah (UMS)
    Matched MeSH terms: Goals
  6. Reassessment of physico-chemical water quality in Setiu Wetland, Malaysia
    Suratman S, Hussein A, Latif M, Weston K
    Sains Malaysiana, 2014;43:1127-1131.
    Setiu Wetland is located in the southern part of South China Sea, Malaysia. This wetland has diverse ecosystems that represent a vast array of biological diversity and abundance in utilizable natural resources. However, there are large scales of aquaculture activities within and nearby the wetland which could threaten the ecosystems of this area. Thus, the main goal of the study was to assess the impact of these activities through the measurement of physico-chemical water quality parameters and then compare this to a previous study carried out in the same study area. The parameters (salinity, temperature, pH, dissolved oxygen, biological oxygen demand and total suspended solids) were monitored monthly at the surface water from July to October 2008. The results showed that the impact of aquaculture activities on the water quality in the area with dissolved oxygen and total suspended solids concentrations were considerably lower than those observed previously. With respect to the Malaysian Marine Water Quality Criteria and Standard, most of the level of parameters measured remained Class 1, suggesting the physico-chemical environment were in line with sustainable conservation of the marine protected areas and marine parks of this wetland area.
    Matched MeSH terms: Goals
  7. Fulltext The de novo transcriptome of workers head of the higher group termite Globitermes sulphureus Haviland (Blattodea: Termitidae)
    Hussin NA, Najimudin N, Ab Majid AH
    Heliyon, 2019 Dec;5(12):e02969.
    PMID: 31872129 DOI: 10.1016/j.heliyon.2019.e02969
    The subterranean termite Globitermus sulphureus is an important Southeast Asian pest with limited genomic resources that causes damages to agriculture crops and building structures. Therefore, the main goal of this study was to survey the G. sulphureus transcriptome composition. Here, we performed de novo transcriptome for G. sulphureus workers' heads using Illumina HiSeq paired-end sequencing technology. A total of 88, 639, 408 clean reads were collected and assembled into 243, 057 transcripts and 193, 344 putative genes. The transcripts were annotated with the Trinotate pipeline. In total, 27, 061 transcripts were successfully annotated using BLASTX against the SwissProt database and 17, 816 genes were assigned to 47, 598 GO terms. We classified 14, 223 transcripts into COG classification, resulting in 25 groups of functional annotations. Next, a total of 12, 194 genes were matched in the KEGG pathway and 392 metabolic pathways were predicted based on the annotation. Moreover, we detected two endogenous cellulases in the sequences. The RT-qPCR analysis showed that there were significant differences in the expression levels of two genes β-glucosidase and endo-β-1,4-glucanase between worker and soldier heads of G. sulphureus. This is the first study to characterize the complete head transcriptome of a higher termite G. sulphureus using a high-throughput sequencing. Our study may provide an overview and comprehensive molecular resource for comparative studies of the transcriptomics and genomics of termites.
    Matched MeSH terms: Goals
  8. Fulltext Relationship between goal orientation and aggressiveness among under 18 handball players
    Siti Aishah Md Yusop, Shaharudin Abd Aziz, Nelfianty Mohd Rasyid
    Jurnal Sains Sukan & Pendidikan Jasmani, 2018;7(2):32-41.
    MyJurnal
    The purpose of this study is to identify the relationship between goal orientation and aggressiveness among under 18 handball players in Negeri Sembilan. This study used survey method using Task and Ego Orientation in Sport Questionaire (TEOSQ) and The Judgement About Moral Behavior in Youth Sport Questionaire (JAMBYSQ). The respondents are the Under 18 handball players that represent eight districts in Negeri Sembilan (n = 192, 96 male and 96 females). Data were analyzed using descriptive statistics (percent, frequency, mean and standard deviation) and inferential statistics (t-test) and correlation. The findings showed that the orientation pattern of the female players were higher than the male players for both the task orientation and the ego. The results of the t-test showed that female handball players have higher levels of cognitive and somatic anxiety than male players. However, from the aspect of aggression, the findings showed that female players are more likely to show aggressive action compared to male. In conclusion, the findings showed that there was a significant relationship between goal orientation and aggression among under 18 handball players. Indirectly, this study stressed the importance of goal orientation. Coaches also need to put more focus on the task-orientation compared to ego-orientation.
    Matched MeSH terms: Goals
  9. Fulltext Acute effects of unilateral versus bilateral resistance training on heart rate, blood pressure and rate of perceived exertion
    Nur Khairunisa Abu Talip, Zulkifli Abdul Kadir
    Jurnal Sains Sukan & Pendidikan Jasmani, 2018;7(2):61-75.
    MyJurnal
    Resistance training (RT) refers to a method of physical conditioning of complex programming which consists of progressive and various training techniques to achieve the desired training goals. An appropriate programme design is the key to success; where exercise selection is one of the critical factors. The selection of exercise will expose different stimulation as in the application of the specific adaptation on imposed demand principle. The option of choosing either bilateral (BI) or unilateral (UNI) exercise is an important decision to perform in the construction of any strength or RT programme. This study aimed to investigate the physiological responses of unilateral versus bilateral acute RT on heart rate (HR), blood pressure (BP) and rate of perceived exertion (RPE). Sixteen (n = 16) trained women with mean age of 23.31 (SD = 1.35) years old went through a total body exercise session for each unilateral and bilateral protocols which both consisted of major muscles group for 80% 1RM, 10 repetitions to maximal effort for 3 sets. The results revealed that all variables examined including HR, systolic blood pressure (SBP), diastolic blood pressure (DBP) and RPE were statistically changed (p < .001) across the times. Apart from that, unilateral and bilateral RT imposed significantly different stimulus on SBP (p < .05).
    Matched MeSH terms: Goals
  10. Fulltext Effectiveness of An Educational Intervention of Breast Cancer Screening Practices Uptake, Knowledge, and Beliefs among Yemeni Female School Teachers in Klang Valley, Malaysia: A Study Protocol for a Cluster-Randomized Controlled Trial
    Noman S, Shahar HK, Abdul Rahman H, Ismail S
    Int J Environ Res Public Health, 2020 02 12;17(4).
    PMID: 32059587 DOI: 10.3390/ijerph17041167
    Breast cancer is the most common cancer spread among women worldwide. Whereas many studies have discussed the significance of breast cancer screening among women in various countries, few have attempted to discuss this topic among female school teachers. As teachers educate and communicate with students, this may play an essential role in health education and in promoting healthy behavior, such as breast cancer screening. The primary goal of this study is to develop and implement an educational intervention of breast cancer screening and evaluate its effectiveness among Yemeni female school teachers in Malaysia. This was carried out as per the health belief model. A cluster-randomized controlled trial was conducted among 183 Yemeni female school teachers in twelve schools in Klang Valley, Malaysia. A random assignment of the target schools was made to include them within the intervention or control group. Participants in the intervention group were offered a 90-minute session for one-day educational intervention on breast cancer screening. On the other hand, participants in the control group were offered the same educational materials at the end of the study. Relevant data was collected at baseline, one month following the intervention, and then three- and six-months follow-up assessments. Analysis of such data was done via IBM SPSS software 25.0 by generalized estimating equations (GEE) to assess the differential changes over time. A primary outcome embodied in breast cancer screening practice uptake was expected. Secondary outcomes include the target group's knowledge on and beliefs of breast cancer screening. This study intends to contribute to the credibility and effectiveness of utilizing a theory-based breast cancer screening intervention in order to raise the awareness of women on conducting breast cancer screening.
    Matched MeSH terms: Goals
  11. Fulltext Asian consensus on assessment and management of mild to moderate plaque psoriasis with topical therapy
    Imafuku S, Zheng M, Tada Y, Zhang X, Theng C, Thevarajah S, et al.
    J Dermatol, 2018 Jul;45(7):805-811.
    PMID: 29740870 DOI: 10.1111/1346-8138.14338
    A working group of dermatologists in Asian countries assessed the current status of psoriatic management in the region to prepare a consensus report on topical treatment in mild to moderate plaque psoriasis. Even though the association of psoriasis with systemic comorbidities is increasingly acknowledged, psoriasis is still lower in health-care priority lists in the region. The psychosocial impact of psoriasis may be greater in Asian countries due to cultural norms and social discrimination. Non-adherence to treatment is also common among Asians. The current care given to patients with mild to moderate psoriasis needs to be streamlined, enhanced and organized with a patient-centered care approach to achieve better outcomes. A comprehensive assessment of the disease severity and its impact on a patient's life is required before initiating treatment. Education and active involvement of the patient in the treatment plan is an important part of psoriatic management. It is recommended to personalize topical treatment to meet the needs of the patient, depending on disease severity, psychosocial impact, the patient's expectations and, more importantly, the patient's willingness and ability to actively follow the treatment procedure. Fixed-dose combination of corticosteroid and vitamin D analogs is the preferred topical medication for both initial and maintenance phases of treatment. The fast containment of the disease is the goal of the initial phase of 4-8 weeks and it demands a potent fast-acting topical therapy. Satisfactory control of the disease and prevention of relapses should be achieved during the maintenance phase with twice a week or weekend applications.
    Matched MeSH terms: Goals
  12. Fulltext Effectiveness of a pharmacist-led structured group-based intervention in improving medication adherence and glycaemic control among type 2 diabetes mellitus patients: A randomized controlled trial
    Ting CY, Ahmad Zaidi Adruce S, Lim CJ, Abd Jabar AHA, Ting RS, Ting H, et al.
    Res Social Adm Pharm, 2021 02;17(2):344-355.
    PMID: 32327398 DOI: 10.1016/j.sapharm.2020.03.026
    BACKGROUND: A pharmacist-led structured group-based intervention (MEDIHEALTH) was formulated to improve medication adherence among Malay type 2 diabetes mellitus (T2DM) patients in the Malaysian state of Sarawak.

    OBJECTIVES: The objective of this study was to examine the effectiveness of MEDIHEALTH and its mechanism of impact for improving medication adherence and the glycated haemoglobin (HbA1c) level.

    METHODS: A two group and parallel randomised controlled trial with a twelve months follow-up period was conducted at two primary health clinics in Malaysia that were surrounded by Malay communities. Malay T2DM patients whose HbA1c was >7% and total score on the Self-Efficacy for Appropriate Medication Use Scale (SEAMS) was <26 were recruited and parallelly randomised to the MEDIHEALTH or usual care (control) groups. The extended theory of planned behaviour was employed to test the mechanism of impact. Repeated measure analysis of variance was used to assess the difference in the estimated marginal mean of the SEAMS scores and HbA1c level between the intervention and control groups at different times.

    RESULTS: A total of 142 participants were recruited and randomised; three from the intervention group and eight from the control group withdrew before receiving any treatment. Hence, 68 participants in the intervention group and 63 in the control group were included for analyses. The MEDIHEALTH group had a significantly greater increase in the SEAMS score compared to the control group (p 
    Matched MeSH terms: Goals
  13. Fulltext Optimizing Glycemic Control Through Titration of Insulin Glargine 100 U/mL: A Review of Current and Future Approaches with a Focus on Asian Populations
    Deerochanawong C, Bajpai S, Dwipayana IMP, Hussein Z, Mabunay MA, Rosales R, et al.
    Diabetes Ther, 2017 Dec;8(6):1197-1214.
    PMID: 29094298 DOI: 10.1007/s13300-017-0322-z
    Various data have demonstrated inadequate glycemic control amongst Asians with type 2 diabetes mellitus (T2DM), possibly on account of suboptimal titration of basal insulin-an issue which needs to be further examined. Here we review the available global and Asia-specific data on titration of basal insulin, with a focus on the use of insulin glargine 100 U/mL (Gla-100). We also discuss clinical evidence on the efficacy and safety of titrating Gla-100, different approaches to titration, including some of the latest technological advancements, and guidance on the titration of basal insulin from international and local Asian guidelines. The authors also provide their recommendations for the initiation and titration of basal insulin for Asian populations. Discussion of the data included in this review and in relation to the authors' clinical experience with treating T2DM in Asian patients is also included. Briefly, clinical studies demonstrate the achievement of adequate glycemic control in adults with T2DM through titration of Gla-100. However, studies investigating approaches to titration, specifically in Asian populations, are lacking and need to be conducted. Given that the management of insulin therapy is a multidisciplinary team effort involving endocrinologists, primary care physicians, nurse educators, and patients, greater resources and education targeted at these groups are needed regarding the optimal titration of basal insulin. Technological advancements in the form of mobile or web-based applications for automated dose adjustment can aid different stakeholders in optimizing the dose of basal insulin, enabling a larger number of patients in Asia to reach their target glycemic goals with improved outcomes.
    Matched MeSH terms: Goals
  14. Fulltext Zebrafish as a Model for Epilepsy-Induced Cognitive Dysfunction: A Pharmacological, Biochemical and Behavioral Approach
    Kundap UP, Kumari Y, Othman I, Shaikh MF
    Front Pharmacol, 2017;8:515.
    PMID: 28824436 DOI: 10.3389/fphar.2017.00515
    Epilepsy is a neuronal disorder allied with distinct neurological and behavioral alterations characterized by recurrent spontaneous epileptic seizures. Impairment of the cognitive performances such as learning and memory is frequently observed in epileptic patients. Anti-epileptic drugs (AEDs) are efficient to the majority of patients. However, 30% of this population seems to be refractory to the drug treatment. These patients are not seizure-free and frequently they show impaired cognitive functions. Unfortunately, as a side effect, some AEDs could contribute to such impairment. The major problem associated with conducting studies on epilepsy-related cognitive function is the lack of easy, rapid, specific and sensitive in vivo testing models. However, by using a number of different techniques and parameters in the zebrafish, we can incorporate the unique feature of specific disorder to study the molecular and behavior basis of this disease. In the view of current literature, the goal of the study was to develop a zebrafish model of epilepsy induced cognitive dysfunction. In this study, the effect of AEDs on locomotor activity and seizure-like behavior was tested against the pentylenetetrazole (PTZ) induced seizures in zebrafish and epilepsy associated cognitive dysfunction was determined using T-maze test followed by neurotransmitter estimation and gene expression analysis. It was observed that all the AEDs significantly reversed PTZ induced seizure in zebrafish, but had a negative impact on cognitive functions of zebrafish. AEDs were found to modulate neurotransmitter levels, especially GABA, glutamate, and acetylcholine and gene expression in the drug treated zebrafish brains. Therefore, combination of behavioral, neurochemical and genenetic information, makes this model a useful tool for future research and discovery of newer and safer AEDs.
    Matched MeSH terms: Goals
  15. Pharmacophore Based Virtual Screening Approach to Identify Selective PDE4B Inhibitors
    Gaurav A, Gautam V
    Iran J Pharm Res, 2017;16(3):910-923.
    PMID: 29201082
    Phosphodiesterase 4 (PDE4) has been established as a promising target in asthma and chronic obstructive pulmonary disease. PDE4B subtype selective inhibitors are known to reduce the dose limiting adverse effect associated with non-selective PDE4B inhibitors. This makes the development of PDE4B subtype selective inhibitors a desirable research goal. To achieve this goal, ligand based pharmacophore modeling approach is employed. Separate pharmacophore hypotheses for PDE4B and PDE4D inhibitors were generated using HypoGen algorithm and 106 PDE4 inhibitors from literature having thiopyrano [3,2-d] Pyrimidines, 2-arylpyrimidines, and triazines skeleton. Suitable training and test sets were created using the molecules as per the guidelines available for HypoGen program. Training set was used for hypothesis development while test set was used for validation purpose. Fisher validation was also used to test the significance of the developed hypothesis. The validated pharmacophore hypotheses for PDE4B and PDE4D inhibitors were used in sequential virtual screening of zinc database of drug like molecules to identify selective PDE4B inhibitors. The hits were screened for their estimated activity and fit value. The top hit was subjected to docking into the active sites of PDE4B and PDE4D to confirm its selectivity for PDE4B. The hits are proposed to be evaluated further using in-vitro assays.
    Matched MeSH terms: Goals
  16. Multimodality Techniques in Microsurgical Clipping as the Gold Standard Treatment in the Management of Basilar Tip Aneurysm: A Case Series
    Seng LB, Yamada Y, Rajagopal N, Mohammad AA, Teranishi T, Miyatani K, et al.
    Asian J Neurosurg, 2018 11 22;13(4):1148-1157.
    PMID: 30459884 DOI: 10.4103/ajns.AJNS_159_18
    Introduction: Basilar aneurysms represent 5%-7% of all intracranial aneurysms. The main goal of open surgery is to achieve complete obliteration of the aneurysmal sac using minimal invasive technique while emphasizing on avoidance of complication.

    Materials and Methods: We performed a retrospective cohort study of nine cases of unruptured basilar tip aneurysm referred to the Fujita Health University Banbuntane-Hotokukai Hospital, Japan. The objective of the study was to analyze the surgical outcomes of unruptured basilar tip aneurysm.

    Results: Nine patients with unruptured basilar tip aneurysm were referred to our hospital between 2015 and 2017. The median size of the aneurysm and age were 4.00 mm (interquartile range [IQR] = 3.25-6.75 mm) and 58 years (IQR = 54-70 years), respectively. Five patients (55.6%) were presented with multiple intracranial aneurysms. Surgical adjuncts such as intraoperative neuromonitoring, intraoperative indocyanine green (ICG) angiography with dual-image videoangiography (DIVA), and neuroendoscope were used. Two patients developed transient postoperative oculomotor nerve palsy which resolved spontaneously. The median duration of surgery and days of hospitalization were 292 min (IQR = 237.5-350.5 min) and 12 days (IQR = 12-25 days), respectively. There was no mortality recorded in this case series.

    Conclusion: Microsurgical clipping of basilar tip aneurysm is safe in unruptured basilar tip aneurysm with a low risk of postoperative mortality or morbidity. All complications reported in this case series were transient with no long-term sequalae. The improved safety profile of microsurgical technique is due to the availability of intraoperative neuromonitoring, neuroendoscope, ICG, and DIVA. The application of multimodality technique in neurovascular surgery has also helped to achieve complication avoidance. The obliteration of the aneurysmal sac helps to restore the laminar blood flow in the bifurcation and distal blood vessels and improves the brain perfusion.

    Matched MeSH terms: Goals
  17. Fulltext Self-determination and goal orientation in track and field
    Chin NS, Khoo S, Low WY
    J Hum Kinet, 2012 Jun;33:151-61.
    PMID: 23486244 DOI: 10.2478/v10078-012-0054-0
    This study investigated gender, age group and locality differences in adolescent athletes' self-determination motivation and goal orientations in track and field. It also examined the relationship between the self-determination theory and achievement goal theory. A total of 632 (349 boys, 283 girls) adolescent athletes (aged 13-18 years) completed the Sports Motivation Scale and Task and Ego Orientation in Sport Questionnaire. Results indicated significant differences between gender on intrinsic motivation, extrinsic motivation, amotivation (t(630) = 4.10, p < 0.05) and ego orientation (t(630) = 2.48, p < 0.05). Male students reported higher intrinsic motivation, extrinsic motivation, amotivation and ego orientation. A significant difference was found between age groups on task orientation (t(630) = 1.94, p < 0.05) and locality on ego orientation (t(630) = 1.94, p < 0.05). Older athletes showed significantly higher task orientation. Rural athletes had higher ego orientation whereas urban athletes have higher intrinsic motivation. Task orientation was related to intrinsic motivation (r = 0.55, p < 0.01), extrinsic motivation (r = 0.55, p < 0.01), but weakly related to amotivation (r = 0.10, p < 0.01). Ego orientation was related to intrinsic motivation (r = 0.30, p < 0.01), extrinsic motivation (r = 0.36, p < 0.01) and amotivaion (r = 0.36, p < 0.01). Task orientation was related to ego orientation (r = 0.29, p < 0.01). Multiple regression analysis showed intrinsic motivation, extrinsic motivation and amotivation accounted for 30.5% of the variances in task orientation.
    Matched MeSH terms: Goals
  18. Fulltext Effect of Diabetes Mellitus on Tuberculosis Treatment Outcomes among Tuberculosis Patients in Kelantan, Malaysia
    Ahmad SR, Yaacob NA, Jaeb MZ, Hussin Z, Wan Mohammad WMZ
    Iran J Public Health, 2020 Aug;49(8):1485-1493.
    PMID: 33083325 DOI: 10.18502/ijph.v49i8.3892
    Background: There is growing evidence that DM may play an important role in the occurrence of unsuccessful TB treatment outcomes. This study was undertaken to examine the prevalence of DM among TB population, compare the profile of TB patients with and without DM and determine the effect of DM on unsuccessful treatment outcomes among TB patients in Kelantan state, Malaysia from 2012 to 2016.

    Methods: A cross sectional study was conducted in Sep 2017 using data from registered TB cases in Kelantan state, Malaysia from 2012 to 2016. The profile of TB patients with and without DM were compared in univariable analysis. Multiple logistic regression was used to determine association between DM and unsuccessful treatment outcomes.

    Results: A total of 1854 TB patients were diagnosed with DM. The annual proportion was ranging from 26 to 29%. TB patients with DM had an older age, live single, low educational status, poor chest x ray finding and diagnosed with smear positive sputum compared to TB patients without DM. TB patients with DM had three times higher risk to develop unsuccessful TB treatment outcomes compared to TB patients without DM (95% CI 2.47-3.58; P = 0.012) in multivariable analysis.

    Conclusion: Those with DM had the worst prognosis of TB outcomes among the significant risk factors. TB control program in Malaysia will need to expand efforts to focus on treatment of TB-DM patients to improve their cure rates in order to achieve the goals of tuberculosis elimination.

    Matched MeSH terms: Goals
  19. Fulltext Infective Endocarditis and Chronic Kidney Disease: How to Deal with Complications
    Habib Khan Y, Sarriff A, Hayat Khan A, Azreen Syazril A, Mallhi TH
    Malays J Med Sci, 2015 Jul-Aug;22(4):73-5.
    PMID: 26715911 MyJurnal
    Infective endocarditis (IE) is the one of the most important causes of increased mortality and morbidity among haemodialysis patients. The reason for this increasing prevalence of infection among these patients is the use of haemodialysis catheters during dialysis, as these patients are highly susceptible to infections that are easily transmitted via blood access points. The present case was a geriatric end stage renal disease (ESRD) patient who was readmitted to the hospital two days after her scheduled haemodialysis session with symptoms of nosocomial endocarditis. Her concurrent medical complications were hypertension, non-insulin dependent diabetes mellitus, and ischemic heart disease. Based on her previous medical history and current examination, the patient was suspected to have IE due to catheter related infection. The goal of therapy is to manage the comorbidities and infection by provision of appropriate treatment based on close monitoring of the patient condition.
    Matched MeSH terms: Goals
  20. Fulltext Malaysia collaborates with the new york academy of sciences to develop an innovation-based economy
    Wahome M, Rubinstein E
    Malays J Med Sci, 2011 Jul;18(3):1-3.
    PMID: 22135594 MyJurnal
    If Malaysia is to become a high-income country by 2020, it will have to transform into a knowledge-based, innovation economy. This goal will be achieved by developing an atmosphere conducive to experimentation and entrepreneurship at home; while reaching out to partners across the globe. One of Malaysia's newest partnerships is with the New York Academy of Sciences. The Academy has expertise in innovation and higher education and a long history of promoting science, education, and science-based solutions through a global network of scientists, industry-leaders, and policy-makers. Malaysia's Prime Minister, Dato' Sri Mohd Najib Tun Abdul Razak, leveraged the Academy's network to convene a science, technology, and innovation advisory council. This council would provide practical guidance to establish Malaysia as an innovation-based economy. Three initial focus areas, namely palm-oil biomass utilisation, establishment of smart communities, and capacity building in science and engineering, were established to meet short-term and long-term targets.
    Matched MeSH terms: Goals
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