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Fulltext trans-Di-chlorido-bis-(dimethyl sulfoxide-κO)bis-(4-fluoro-benzyl-κC(1))tin(IV): crystal structure and Hirshfeld surface analysis

Amin NABM, Hussen RSD, Lee SM, Halcovitch NR, Jotani MM, Tiekink ERT

Acta Crystallogr E Crystallogr Commun, 2017 May 01;73(Pt 5):667-672.
PMID: 28529772 DOI: 10.1107/S2056989017005072

The Sn(IV) atom in the title diorganotin compound, [Sn(C7H6F)2Cl2(C2H6OS)2], is located on a centre of inversion, resulting in the C2Cl2O2 donor set having an all-trans disposition of like atoms. The coordination geometry approximates an octa-hedron. The crystal features C-H⋯F, C-H⋯Cl and C-H⋯π inter-actions, giving rise to a three-dimensional network. The respective influences of the Cl⋯H/H⋯Cl and F⋯H/H⋯F contacts to the mol-ecular packing are clearly evident from the analysis of the Hirshfeld surface.

Matched MeSH terms: Humans
Fulltext 1-Butyl-1-chloro-3-methyl-3H-2,1λ(4)-benzoxa-tellurole: crystal structure and Hirshfeld analysis

Zukerman-Schpector J, Cunha R, Omori ÁT, Sousa Madureira L, Tiekink ERT

Acta Crystallogr E Crystallogr Commun, 2017 Apr 01;73(Pt 4):564-568.
PMID: 28435722 DOI: 10.1107/S2056989017003887

Two independent mol-ecules comprise the asymmetric unit in the title benzoxatellurole compound, C12H17ClOTe. The mol-ecules, with the same chirality at the methine C atom, are connected into a loosely associated dimer by Te⋯O inter-actions, leading to a {⋯Te-O}2 core. The resultant C2ClO2 donor set approximates a square pyramid with the lone pair of electrons projected to occupy a position trans to the n-butyl substituent. Inter-estingly, the Te(IV) atoms exhibit opposite chirality. The major difference between the independent mol-ecules relates to the conformation of the five-membered chelate rings, which is an envelope with the O atom being the flap, in one mol-ecule and is twisted about the O-C(methine) bond in the other. No directional inter-molecular inter-actions are noted in the mol-ecular packing beyond the aforementioned Te⋯O secondary bonding. The analysis of the Hirshfeld surface reveals the dominance of H⋯H contacts, i.e. contributing about 70% to the overall surface, and clearly differentiates the immediate crystalline environments of the two independent mol-ecules in terms of both H⋯H and H⋯Cl/Cl⋯H contacts.

Matched MeSH terms: Humans
(Tris{2-[(5-chloro-2-oxido-benzyl-idene-κO)amino-κN]eth-yl}amine-κN)-ytterbium(III): crystal structure and Hirshfeld surface analysis

Lee SM, Lo KM, Tan SL, Tiekink ER

Acta Crystallogr E Crystallogr Commun, 2016 Oct 1;72(Pt 10):1390-1395.
PMID: 27746926

The Yb(III) atom in the title complex, [Yb(C27H24Cl3N4O3)] [systematic name: (2,2',2''-{(nitrilo)-tris-[ethane-2,1-di-yl(nitrilo)-methylyl-idene]}tris-(4-chloro-phenolato)ytterbium(III)], is coordinated by a trinegative, hepta-dentate ligand and exists within an N4O3 donor set, which defines a capped octa-hedral geometry whereby the amine N atom caps the triangular face defined by the three imine N atoms. The packing features supra-molecular layers that stack along the a axis, sustained by a combination of aryl-C-H⋯O, imine-C-H⋯O, methyl-ene-C-H⋯π(ar-yl) and end-on C-Cl⋯π(ar-yl) inter-actions. A Hirshfeld surface analysis points to the major contributions of C⋯H/ H⋯C and Cl⋯H/H⋯Cl inter-actions (along with H⋯H) to the overall surface but the Cl⋯H contacts are at distances greater than the sum of their van der Waals radii.

Matched MeSH terms: Humans
Fulltext Role of immunopathology in clinical course of malaria: a review

Wynn AA, Myint O

Borneo Journal of Medical Sciences, 2018;12(3):3-10.
MyJurnal

Malaria is a major health problem in various parts of the world especially affecting the tropical countries. It affects the vital organs causing severe complicated malaria. Clinical syndromes like severe cerebral anaemia, coagulation abnormalities, respiratory distress and severe anaemia can increase the mortality of malaria infected cases. Variation in individual susceptibility and severity and type of clinical presentations of malaria raises the need for study of both the parasite and host immune reactions as well as the contribution of inflammatory cytokines in malaria pathogenesis. This study explored the immunopathological basis and advances of severe malaria and their importance in pathogenesis of malaria and its complications. Previous and ongoing studies indicate that changes in endothelium during the sequestration of parasites in organs causes disruption of endothelial barrier function leading to serious effects of malaria. Parasite and host factors contribute to disturbance of cytokine regulation and escape of parasites from the immune system of the host. Immunopathological changes and dysregulation of cytokine production play central role in pathogenesis and disease severity in malaria.

Matched MeSH terms: Humans
Fulltext Case Report: The Use of Intravenous SMOFlipid Infusion to Treat Severe Asparaginase-Induced Hypertriglyceridemia in Two Pediatric Acute Lymphoblastic Leukemia Patients

Lau SCD, Loh CK, Alias H

Front Pediatr, 2021;9:660627.
PMID: 33968859 DOI: 10.3389/fped.2021.660627

Asparaginase-induced hypertriglyceridemia can have a spectrum of clinical presentations, from being asymptomatic to having life-threatening thrombosis or hyperviscosity syndrome. At present, there is no recommendation on routine lipid monitoring during asparaginase-containing treatment phase, nor a standardized guideline on its management. Two cases are presented here to illustrate the effects of concurrent infection on asparaginase-induced hypertriglyceridemia in patients with high-risk ALL and the use of SMOFlipid infusion as a treatment option in an acute situation.

Matched MeSH terms: Humans
Tetralogy of Fallot correction with transannular patch reconstruction in a patient with an anomalous right coronary artery and an unusual course of the right ventricular branch

Gonzalez SA, Sivalingam S

Indian J Thorac Cardiovasc Surg, 2021 May;37(3):329-333.
PMID: 33967425 DOI: 10.1007/s12055-020-01074-0

Anomalous coronary arteries occur in as many as 12% of patients with tetralogy of Fallot (TOF). In patients with this condition, pulmonary hypoplasia can be prohibitive in performing a valve-sparing repair, subsequently resulting in various techniques to preserve the anomalous coronary artery. The management strategy is often complex in such a situation. We report on a case of TOF with an anomalous right coronary artery crossing the right ventricular outflow tract, with an unusual course of the right ventricular (RV) branch, which precluded placement of a valved conduit. In this case, we performed a successful repair with mobilization of the anomalous coronary artery and reconstruction of the right ventricular outflow tract with a limited transannular patch.

Matched MeSH terms: Humans
Fulltext An Infratemporal Meningioma: A Diagnostic Dilemma

Kaur A, Ali R, Omar E, Hashim H

J Radiol Case Rep, 2021 Jan;15(1):1-10.
PMID: 33717402 DOI: 10.3941/jrcr.v15i1.3898

A 46-year-old male presented with painless, recurrent bilateral ear discharge and an enlarging right temporal swelling. There were no neurological deficits. Imaging revealed an enhancing, soft tissue mass at the right infratemporal region involving the right temporalis muscle with a small, enhancing intradural component and associated hyperostosis of the greater wing of the right sphenoid bone. Tumour debulking of the right temporalis tumour was performed. Tumour invasion of the right temporalis muscle was noted intraoperatively. Histopathological result was consistent with fibrous meningioma WHO Grade 1 involving surgical resection margins. Follow-up MRI revealed residual right temporal extracranial component. Thus, plans were made for a second stage tumour debulking, however at time of writing, surgery had not been performed. This case highlights the differing appearances of the common meningioma occurring extracranially with elaboration of its differential diagnosis and management.

Matched MeSH terms: Humans
Fulltext The effects of plyometric training on speed, agility and power components among under-16 athletes

Yusop Ahmad, Nur Fifie Shakilla Diekin

Jurnal Sains Sukan & Pendidikan Jasmani, 2020;9(2):63-69.
MyJurnal

This study was conducted to determine the effects of plyometric training on power, speed and agility on under 16 athletes. Thirty-two males from various background of sports were randomly selected as subjects. Subjects were divided into two groups which are intervention (N=16) and control (N=16). Subjects performed training for five weeks. Test batteries used includes 30-m sprint, 30 feet shuttle run and vertical jump to look at the effects of plyometric training given. Data that were obtained was analysed using T-test. Analysis showed that treatment group manage to improve performance in all the three tests while no significant differences between pre and post-test among control group for all the three tests. Based on the result, plyometric training that were given could improve power, speed and agility.

Matched MeSH terms: Humans
Fulltext An Overview of the Genetic Variations of the SARS-CoV-2 Genomes Isolated in Southeast Asian Countries

Yap PSX, Tan TS, Chan YF, Tee KK, Kamarulzaman A, Teh CSJ

J Microbiol Biotechnol, 2020 Jul 28;30(7):962-966.
PMID: 32627759 DOI: 10.4014/jmb.2006.06009

Monitoring the mutation dynamics of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical in understanding its infectivity, virulence and pathogenicity for development of a vaccine. In an "age of mobility," the pandemic highlights the importance and vulnerability of regionalization and labor market interdependence in Southeast Asia. We intend to characterize the genetic variability of viral populations within the region to provide preliminary information for regional surveillance in the future. By analyzing 142 complete genomes from South East Asian (SEA) countries, we identified three central variants distinguished by nucleotide and amino acid changes.

Matched MeSH terms: Humans
Photodentistry - an innovative approach to improving students' empathy and learning experiences in comprehensive patient care

Ahmad MS, Radhi DSM, Rusle FF, Zul MF, Jalaluddin J, Baharuddin IH

J Dent Educ, 2020 Nov;84(11):1219-1229.
PMID: 32645212 DOI: 10.1002/jdd.12295

OBJECTIVES: Preparing future dental school graduates to provide comprehensive patient care with empathy requires the completion of adequate training in such practice. This study was undertaken to investigate the effectiveness of the Photodentistry learning activity, which uses visual arts, in improving dental students' empathy and learning experience in comprehensive patient care.
METHODS: All fourth-year undergraduate dental students (n = 69, response rate = 100%) participated in the Photodentistry learning activity developed by specialists from the areas of dentistry, arts, education, and psychology. A survey using the Toronto Empathy Questionnaire (TEQ) was conducted both pretest and posttest, followed by an open-ended written survey of their reflection towards the learning activity. Quantitative data were analyzed via paired t-test (P < 0.05), while qualitative data were analyzed using thematic analysis.
RESULTS: There was a significant increase in both students' total mean empathy score and the individual scores for 8 (out of 16) items of the TEQ after the learning activity. Students stated that they had an improved understanding of managing patients in a comprehensive manner (e.g., managing medically compromised patients, performing treatment planning, communication with patients who have special health care needs). Students also reported the development of skills (e.g., observation, critical thinking) and positive attitudes (e.g., empathy, responsibility) towards patients.
CONCLUSION: Photodentistry is an effective learning approach for improving dental students' empathy and learning experience in comprehensive patient care.

Matched MeSH terms: Humans
Fulltext Investigation of the key factors that influence the girls to enter into child marriage: A meta-synthesis of qualitative evidence

Kohno A, Techasrivichien T, Suguimoto SP, Dahlui M, Nik Farid ND, Nakayama T

PLoS One, 2020;15(7):e0235959.
PMID: 32678862 DOI: 10.1371/journal.pone.0235959

In this study, we synthesized findings from qualitative studies to identify the key factors that influence child marriage. We used a meta-ethnographic approach coupled with thematic synthesis. We searched literature from nine databases, which were in English language, covering areas in public health, psychology, and social science between 2008 and 2018. Twelve studies were included in the synthesis. We identified six main themes: human insecurity and conflict; legal issues; family values and circumstances; religious beliefs; individual circumstances, beliefs, and knowledge; and social norms. Our findings highlight the impact of human insecurity and conflict, as well as legal issues. In spite of global progress scaling up legislation against child marriage, the legal framework is insufficiently enforced in many settings. Most of the included studies were from the Middle East, Africa, and South Asia. Studies from other parts of the world such as Latin America and Southeast Asia, which have the highest rates of child marriage, are needed.

Matched MeSH terms: Humans
Fulltext Likert scale vs. Visual Analogue Scale on vehicle seat discomfort questionnaire: a review

Nur Athirah Diyana Mohammad Yusof, Putri Anis Syahira Mohamad Jamil, Nurul Maizura Hashim, Karmegam Karuppiah, Irniza Rasdi, Shamsul Bahri Mohd Tamrin, et al.

Malaysian Journal of Medicine and Health Sciences, 2019;15(204):159-164.
MyJurnal

Discomfort measurement has usually been attempted by asking the participants to rate the scale of their discomfort which commonly termed as a subjective scale. Various studies had conducted the discomfort level on vehicle seat by using Visual Analogue Scale (VAS) and Likert scale. VAS is a tool that use to measure a discomfort or characteristics in range across a continuum of values. Meanwhile, Likert-scale is a tool consist of items that require respondents to rate their degrees of comfort or discomfort with various declarative statements. Thus, the purpose of this study is to review, discuss and compare between the VAS and Likert scale used on the development and assessment of sitting discomfort survey in seat vehicles. The literature on various topics related to questionnaire development on discomfort in seat vehicle were collected from electronic databases. Four high-quality studies were eligible and met the inclusion and exclusion criteria. Overall, there is no evidence and conclusion that neither visual analogue scale nor Likert scale are better to one another. Therefore, it can be concluded that either of this scale still applicable for the ergonomic research application as both of this scale have their own pros and cons.

Matched MeSH terms: Humans
Fulltext Aplasia Cutis Congenita as a Sole Manifestation of Congenital Varicella Syndrome

Leung AKC, Leong KF, Lam JM

Case Rep Pediatr, 2020;2020:6147250.
PMID: 32774973 DOI: 10.1155/2020/6147250

Aplasia cutis congenita following maternal varicella is well known. On the other hand, aplasia cutis congenita as the sole manifestation of congenital varicella syndrome is very rare. A perusal of the literature revealed only one case. We report two infants with aplasia cutis congenita as the sole manifestation of congenital varicella syndrome.

Matched MeSH terms: Humans
Fulltext Using historical sources as history teaching and learning materials: are students ready to explore?

Kaviza, M.

Malaysian Journal of Social Sciences and Humanities, 2018;3(5):41-47.
MyJurnal

The purpose of this study is to examine the level of readiness amongstudents in terms of knowledge,
skills and attitudes in using historical resources as history teaching and learning materials in secondary
schools. The design of this study is a quantitative research that uses survey method involving a total of
521 form four students from secondary schools using simple random sampling technique. The
questionnaire are used in this study which has been verified by the content expert dan has a good
realiability value. The data were analysed using descriptive and inferential statistics such as MONOVA
and Correlation Pearson using "IBM SPSS Statistics”version 24.The findings of this study indicate that
the level of readiness amongsecondary history students in terms of knowledge, skills and attitudes in
using historical resources as teaching and learning materials are at moderate level. Beside that, school
location influences the level of readiness and there a relationship between levels of readiness with
school location among students.Implication of this study can help history teachers know the level of their student knowledge, skills and attitudes toward using historical sources before carrying out in their
lessons.

Matched MeSH terms: Humans
Fulltext Percutaneous balloon valvuloplasty for critical aortic stenosis in a 3.9-kg infant in Sabah

Ng L, Siva R, Mohd Zain S, Ooi M

Borneo Journal of Medical Sciences, 2019;2(101):13-14.
MyJurnal

Critical aortic stenosis (AS) is very severe narrowing at aortic valve in newborns, causing left ventricular outflow tract obstruction (LVOTO). It is lethal if not treated soon after birth.

Matched MeSH terms: Humans
Aging of the cells: Insight into cellular senescence and detection Methods

Mohamad Kamal NS, Safuan S, Shamsuddin S, Foroozandeh P

Eur J Cell Biol, 2020 Aug;99(6):151108.
PMID: 32800277 DOI: 10.1016/j.ejcb.2020.151108

Cellular theory of aging states that human aging is the result of cellular aging, in which an increasing proportion of cells reach senescence. Senescence, from the Latin word senex, means "growing old," is an irreversible growth arrest which occurs in response to damaging stimuli, such as DNA damage, telomere shortening, telomere dysfunction and oncogenic stress leading to suppression of potentially dysfunctional, transformed, or aged cells. Cellular senescence is characterized by irreversible cell cycle arrest, flattened and enlarged morphology, resistance to apoptosis, alteration in gene expression and chromatin structure, expression of senescence associated- β-galactosidase (SA-β-gal) and acquisition of senescence associated secretory phenotype (SASP). In this review paper, different types of cellular senescence including replicative senescence (RS) which occurs due to telomere shortening and stress induced premature senescence (SIPS) which occurs in response to different types of stress in cells, are discussed. Biomarkers of cellular senescence and senescent assays including BrdU incorporation assay, senescence associated- β-galactosidase (SA-β-gal) and senescence-associated heterochromatin foci assays to detect senescent cells are also addressed.

Matched MeSH terms: Humans
Finding NEEMO: towards organizing smart digital solutions in orthopaedic trauma surgery

Braun BJ, Grimm B, Hanflik AM, Marmor MT, Richter PH, Sands AK, et al.

EFORT Open Rev, 2020 Jul;5(7):408-420.
PMID: 32818068 DOI: 10.1302/2058-5241.5.200021

There are many digital solutions which assist the orthopaedic trauma surgeon. This already broad field is rapidly expanding, making a complete overview of the existing solutions difficult.The AO Foundation has established a task force to address the need for an overview of digital solutions in the field of orthopaedic trauma surgery.Areas of new technology which will help the surgeon gain a greater understanding of these possible solutions are reviewed.We propose a categorization of the current needs in orthopaedic trauma surgery matched with available or potential digital solutions, and provide a narrative overview of this broad topic, including the needs, solutions and basic rules to ensure adequate use in orthopaedic trauma surgery. We seek to make this field more accessible, allowing for technological solutions to be clearly matched to trauma surgeons' needs. Cite this article: EFORT Open Rev 2020;5:408-420. DOI: 10.1302/2058-5241.5.200021.

Matched MeSH terms: Humans
Description of the Features and Vibratory Behaviors of the Nyquist Plot Analyzed From Laryngeal High-Speed Videoendoscopy Images

Mohd Khairuddin KA, Ahmad K, Mohd Ibrahim H, Yan Y

J Voice, 2020 Aug 26.
PMID: 32861565 DOI: 10.1016/j.jvoice.2020.07.036

Facilitative playback-based subjective measures offer a more reliable evaluation of the vocal fold vibration than those derived from direct inspection of video playback. One of the measures is a Nyquist plot, which presents the analyzed cycle-to-cycle vibratory information in a graphical form. While the potential is evident, the information of the features of the Nyquist plot, which the evaluation is based on, is still incomplete. The current identified features and their vibratory behaviors may be inadequate to guarantee accurate interpretation of the findings. The present study aims to address this issue by examining the features of the Nyquist plot and their vibratory behaviors. A total of 56 young normophonic speakers, that is, 20 males and 36 females were recruited as the participants. Each of them underwent laryngeal high-speed videoendoscopy to record the images of the vocal fold vibration, which were then analyzed to generate the Nyquist plots. The features were identified by inspecting the properties of the plot points forming the Nyquist plots. For each identified feature, its vibratory behaviors were examined. The results revealed four features: rim contour depicting the longitudinal phase difference; left edge shape signifying the glottal configuration, phase closure, and closed phase duration; rim width and rim pattern visualizing the regularity of glottal areas and the regularity of the intracycle variations, respectively. The findings present a more complete reference of the features and their vibratory behaviors that is pertinent for the Nyquist plot interpretation.

Matched MeSH terms: Humans
Fulltext Montelukast in children with allergic rhinitis amid COVID-19 pandemic

Kow CS, Hasan SS

Acta Paediatr, 2020 10;109(10):2151.
PMID: 32686128 DOI: 10.1111/apa.15491
Matched MeSH terms: Humans
Quantitative Assessment of Root Development after Regenerative Endodontic Therapy: A Systematic Review and Meta-Analysis

Ong TK, Lim GS, Singh M, Fial AV

J Endod, 2020 Dec;46(12):1856-1866.e2.
PMID: 32827507 DOI: 10.1016/j.joen.2020.08.016

INTRODUCTION: The purposes of this review were to appraise the level of evidence of the existing regenerative endodontic therapy (RET) publications, perform a meta-analysis on the survival and healing rates of necrotic immature permanent teeth treated with RET, and run a meta-analysis on the quantitative assessment of the root development of those teeth.
METHODS: Electronic searches were performed in Web of Science, PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and Cochrane Library databases. Two authors independently screened the titles and abstracts for eligibility. The analyses were performed on the clinical outcomes (ie, survival, healing, and root development) of the procedure.
RESULTS: Eleven articles were included in the qualitative and quantitative syntheses. Three studies were randomized controlled trials, 6 were prospective cohort studies, and 2 were retrospective cohort studies. The pooled survival and healing rates were 97.3% and 93.0%, respectively. The pooled rates of root lengthening, root thickening, and apical closure were 77.3%, 90.6%, and 79.1%, respectively. However, if 20% radiographic changes were used as a cutoff point, there were only 16.1% root lengthening and 39.8% root thickening.
CONCLUSIONS: Within the limitations of the present study, it can be concluded that RET yielded high survival and healing rates with a good root development rate. However, clinical meaningful root development after RET was unpredictable.

Matched MeSH terms: Humans

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