Displaying publications 261 - 280 of 963 in total

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  1. Fulltext Bioactives from probiotics for dermal health: functions and benefits
    Lew LC, Liong MT
    J Appl Microbiol, 2013 May;114(5):1241-53.
    PMID: 23311666 DOI: 10.1111/jam.12137
    Probiotics have been extensively reviewed for decades, emphasizing on improving general gut health. Recently, more studies showed that probiotics may exert other health-promoting effects beyond gut well-being, attributed to the rise of the gut-brain axis correlations. Some of these new benefits include skin health such as improving atopic eczema, atopic dermatitis, healing of burn and scars, skin-rejuvenating properties and improving skin innate immunity. Increasing evidence has also showed that bacterial compounds such as cell wall fragments, their metabolites and dead bacteria can elicit certain immune responses on the skin and improve skin barrier functions. This review aimed to underline the mechanisms or the exact compounds underlying the benefits of bacterial extract on the skin based on evidences from in vivo and in vitro studies. This review could be of help in screening of probiotic strains with potential dermal enhancing properties for topical applications.
    Matched MeSH terms: Skin/immunology*; Skin/microbiology*; Skin Physiological Phenomena
  2. Fulltext Estimation of Inhibitory Effect against Tyrosinase Activity through Homology Modeling and Molecular Docking
    Nokinsee D, Shank L, Lee VS, Nimmanpipug P
    Enzyme Res, 2015;2015:262364.
    PMID: 26788364 DOI: 10.1155/2015/262364
    Tyrosinase is a key enzyme in melanogenesis. Generally, mushroom tyrosinase from A. bisporus had been used as a model in skin-whitening agent tests employed in the cosmetic industry. The recently obtained crystal structure of bacterial tyrosinase from B. megaterium has high similarity (33.5%) to the human enzyme and thus it was used as a template for constructing of the human model. Binding of tyrosinase to a series of its inhibitors was simulated by automated docking calculations. Docking and MD simulation results suggested that N81, N260, H263, and M280 are involved in the binding of inhibitors to mushroom tyrosinase. E195 and H208 are important residues in bacterial tyrosinase, while E230, S245, N249, H252, V262, and S265 bind to inhibitors and are important in forming pi interaction in human tyrosinase.
    Matched MeSH terms: Skin Lightening Preparations
  3. A simple pharmacopoeia for out-station skin clinics
    Pettit JHS
    Trop Doct, 1977 Jul;7(3):107-10.
    PMID: 142324
    Matched MeSH terms: Skin Diseases/drug therapy*; Skin Ulcer/drug therapy
  4. Fulltext An Adaptive Deep Learning Framework for Dynamic Image Classification in the Internet of Things Environment
    Jameel SM, Hashmani MA, Rehman M, Budiman A
    Sensors (Basel), 2020 Oct 14;20(20).
    PMID: 33066579 DOI: 10.3390/s20205811
    In the modern era of digitization, the analysis in the Internet of Things (IoT) environment demands a brisk amalgamation of domains such as high-dimension (images) data sensing technologies, robust internet connection (4 G or 5 G) and dynamic (adaptive) deep learning approaches. This is required for a broad range of indispensable intelligent applications, like intelligent healthcare systems. Dynamic image classification is one of the major areas of concern for researchers, which may take place during analysis under the IoT environment. Dynamic image classification is associated with several temporal data perturbations (such as novel class arrival and class evolution issue) which cause a massive classification deterioration in the deployed classification models and make them in-effective. Therefore, this study addresses such temporal inconsistencies (novel class arrival and class evolution issue) and proposes an adapted deep learning framework (ameliorated adaptive convolutional neural network (CNN) ensemble framework), which handles novel class arrival and class evaluation issue during dynamic image classification. The proposed framework is an improved version of previous adaptive CNN ensemble with an additional online training (OT) and online classifier update (OCU) modules. An OT module is a clustering-based approach which uses the Euclidean distance and silhouette method to determine the potential new classes, whereas, the OCU updates the weights of the existing instances of the ensemble with newly arrived samples. The proposed framework showed the desirable classification improvement under non-stationary scenarios for the benchmark (CIFAR10) and real (ISIC 2019: Skin disease) data streams. Also, the proposed framework outperformed against state-of-art shallow learning and deep learning models. The results have shown the effectiveness and proven the diversity of the proposed framework to adapt the new concept changes during dynamic image classification. In future work, the authors of this study aim to develop an IoT-enabled adaptive intelligent dermoscopy device (for dermatologists). Therefore, further improvements in classification accuracy (for real dataset) is the future concern of this study.
    Matched MeSH terms: Skin Diseases
  5. Natural ingredients in cosmetics from Malaysian plants: a review
    Hasmida Mohd-Nasir, Siti Hamidah Mohd-Setapar
    Sains Malaysiana, 2018;47:951-959.
    Consumer consciousness on the concept of natural-based ingredients triggers the natural cosmetics market to grow. The
    active compounds in natural ingredients offer valuable bioactivities such as antioxidant, photoprotection, anti-aging
    and anti-inflammatory actions that useful for skincare, hair care and dental care. This review presents an overview on
    natural ingredient, especially plant-derived, used in cosmetic products and the examples of Malaysian plants used for
    cosmetic purposes.
    Matched MeSH terms: Skin Care
  6. A treatment of perforating ulcers in leprosy
    Mehta H
    Journal of the Malaya Branch of the British Medical Association, 1938;2:88-90.
    Matched MeSH terms: Skin Ulcer
  7. Cutaneous Warm and Cool Sensation Thresholds and the Inter-threshold Zone in Malaysian and Japanese Males
    Lee JY, Saat M, Chou C, Hashiguchi N, Wijayanto T, Wakabayashi H, et al.
    J Therm Biol, 2010 Feb;35(2):70-76.
    PMID: 28799915 DOI: 10.1016/j.jtherbio.2009.11.002
    The purpose of this study was to investigate ethnic differences in cutaneous thermal sensation thresholds and the inter-threshold sensory zone between tropical (Malaysians) and temperate natives (Japanese). The results showed that (1) Malaysian males perceived warmth on the forehead at a higher skin temperature (Tsk) than Japanese males (p<0.05), whereas cool sensations on the hand and foot were perceived at a lower Tsk in Malaysians (p<0.05); (2) Overall, the sensitivity to detect warmth was greater in Japanese than in Malaysian males; (3) The most thermally sensitive body region of Japanese was the forehead for both warming and cooling, while the regional thermal sensitivity of Malaysians had a smaller differential than that of Japanese; (4) The ethnic difference in the inter-threshold sensory zone was particularly noticeable on the forehead (1.9±1.2C for Japanese, 3.2±1.6°C for Malaysians, p<0.05). In conclusion, tropical natives had a tendency to perceive warmth at a higher Tsk and slower at an identical speed of warming, and had a wider range of the inter-threshold sensory zone than temperate natives.
    Matched MeSH terms: Skin Temperature
  8. Efficient Prediction of In Vitro Piroxicam Release and Diffusion From Topical Films Based on Biopolymers Using Deep Learning Models and Generative Adversarial Networks
    Salma H, Melha YM, Sonia L, Hamza H, Salim N
    J Pharm Sci, 2021 06;110(6):2531-2543.
    PMID: 33548245 DOI: 10.1016/j.xphs.2021.01.032
    The purpose of this study was to simultaneously predict the drug release and skin permeation of Piroxicam (PX) topical films based on Chitosan (CTS), Xanthan gum (XG) and its Carboxymethyl derivatives (CMXs) as matrix systems. These films were prepared by the solvent casting method, using Tween 80 (T80) as a permeation enhancer. All of the prepared films were assessed for their physicochemical parameters, their in vitro drug release and ex vivo skin permeation studies. Moreover, deep learning models and machine learning models were applied to predict the drug release and permeation rates. The results indicated that all of the films exhibited good consistency and physicochemical properties. Furthermore, it was noticed that when T80 was used in the optimal formulation (F8) based on CTS-CMX3, a satisfactory drug release pattern was found where 99.97% of PX was released and an amount of 1.18 mg/cm2 was permeated after 48 h. Moreover, Generative Adversarial Network (GAN) efficiently enhanced the performance of deep learning models and DNN was chosen as the best predictive approach with MSE values equal to 0.00098 and 0.00182 for the drug release and permeation kinetics, respectively. DNN precisely predicted PX dissolution profiles with f2 values equal to 99.99 for all the formulations.
    Matched MeSH terms: Skin
  9. Quantitative study of mast cells in Kimura's disease
    Wong KT, Shamsol S
    J Cutan Pathol, 1999 Jan;26(1):13-6.
    PMID: 10189239
    The association of mast cells with typical lesions of Kimura's disease was investigated by quantitative methods after immunohistochemical staining for Factor VIII-related antigen and counterstaining with toluidine blue. Formalin-fixed, paraffin-embedded, tissue sections from 9 confirmed cases of Kimura's disease were examined after staining to estimate mast cell and blood vessel densities by counting 100 random fields under oil immersion. There was a statistically significant increase of both mast cells and blood vessels in Kimura's disease (p<0.01) compared with normal skin and reactive lymph node controls. However, as far as the individual Kimura's disease lesion is concerned, there was generally no correlation between areas with mast cell increase and the degree of vascularity. Moreover, when lesions of less than 1 year's duration were compared with older lesions, there appeared to be a relative decrease in mast cells and a concomitant increase in vascularity in the latter. These results confirmed that mast cells are associated with Kimura's disease, and suggest that they may be involved in its early pathogenesis, although its possible role in angiogenesis may not be direct.
    Matched MeSH terms: Skin/blood supply; Skin/pathology; Skin/chemistry
  10. Wound healing effect of Haruan (Channa striatus) spray
    Laila L, Febriyenti F, Salhimi SM, Baie S
    Int Wound J, 2011 Oct;8(5):484-91.
    PMID: 21722317 DOI: 10.1111/j.1742-481X.2011.00820.x
    Haruan (Channa striatus) is a type of fresh water fish in Malaysia that is known to promote wound healing. Haruan water extract has been formulated in an aerosol system which can produce a film for wound dressing. As topical preparation, Haruan spray needs to be evaluated in terms of the possibility to cause irritation reaction or toxic response. Three experiments were carried out to evaluate the safety of Haruan spray which are Primary Skin Irritation test, Intracutaneous test and Systemic Injection test. The result shows that Haruan spray gave no significant responses to all the above tests. The investigation of the effect of Haruan spray as wound dressing in the healing process was performed in Sprague-Dawley rats where 6-cm long full-thickness incision wound and burn wound were made on the back of the animals. Haruan spray was tested and compared with blank formula as control. Tensile strength test of treated wound was carried out at the 3rd, 6th, 9th and 12th day after wounding and treatment. The burn wounds contraction was measured daily for 21 days. Results showed that haruan water extract spray formula is not only effective but also safe for application to both incision and burn wounds.
    Matched MeSH terms: Skin/injuries*; Skin/pathology; Skin/physiopathology
  11. Fulltext Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
    Aziz J, Shezali H, Radzi Z, Yahya NA, Abu Kassim NH, Czernuszka J, et al.
    Skin Pharmacol Physiol, 2016;29(4):190-203.
    PMID: 27434176 DOI: 10.1159/000447017
    Collagen and elastin networks make up the majority of the extracellular matrix in many organs, such as the skin. The mechanisms which are involved in the maintenance of homeostatic equilibrium of these networks are numerous, involving the regulation of genetic expression, growth factor secretion, signalling pathways, secondary messaging systems, and ion channel activity. However, many factors are capable of disrupting these pathways, which leads to an imbalance of homeostatic equilibrium. Ultimately, this leads to changes in the physical nature of skin, both functionally and cosmetically. Although various factors have been identified, including carcinogenesis, ultraviolet exposure, and mechanical stretching of skin, it was discovered that many of them affect similar components of regulatory pathways, such as fibroblasts, lysyl oxidase, and fibronectin. Additionally, it was discovered that the various regulatory pathways intersect with each other at various stages instead of working independently of each other. This review paper proposes a model which elucidates how these molecular pathways intersect with one another, and how various internal and external factors can disrupt these pathways, ultimately leading to a disruption in collagen and elastin networks.
    Matched MeSH terms: Skin/metabolism*; Skin/pathology; Skin/ultrastructure
  12. Recent Update on Nanoemulgel as Topical Drug Delivery System
    Choudhury H, Gorain B, Pandey M, Chatterjee LA, Sengupta P, Das A, et al.
    J Pharm Sci, 2017 07;106(7):1736-1751.
    PMID: 28412398 DOI: 10.1016/j.xphs.2017.03.042
    Being an emerging transdermal delivery tool, nanoemulgel, has proved to show surprising upshots for the lipophilic drugs over other formulations. This lipophilic nature of majority of the newer drugs developed in this modern era resulting in poor oral bioavailability, erratic absorption, and pharmacokinetic variations. Therefore, this novel transdermal delivery system has been proved to be advantageous over other oral and topical drug delivery to avoid such disturbances. These nanoemulgels are basically oil-in-water nanoemulsions gelled with the use of some gelling agent in it. This gel phase in the formulation is nongreasy, which favors user compliance and stabilizes the formulation through reduction in surface as well as interfacial tension. Simultaneously, it can be targeted more specifically to the site of action and can avoid first-pass metabolism and relieve the user from gastric/systemic incompatibilities. This brief review is focused on nanoemulgel as a better topical drug delivery system including its components screening, formulation method, and recent pharmacokinetic and pharmacodynamic advancement in research studies carried out by the scientists all over the world. Therefore, at the end of this survey it could be inferred that nanoemulgel can be a better and effective drug delivery tool for the topical system.
    Matched MeSH terms: Skin/metabolism; Skin Absorption*
  13. Fulltext Optimization of process condition for extraction of gelatin from red tilapia skin (Oreochromis niloticus) by High Pressure Processing (HPP)
    Yusof, N., Jaswir, I., Jamal, P., Jami, M.S., Octavianti, F.
    International Food Research Journal, 2017;24(101):0-0.
    MyJurnal
    Extraction of gelatin using traditional acid-base pretreatment method has several limitations
    such as time consuming and causes serious water pollution. Chemical treatment often being used
    as an alternative process to overcome the weaknesses of the conventional method. However,
    excessive chemical elements would damage the structure of the gelatin due to its high sensitivity
    to the acid content. High Pressure Processing (HPP) is a novel and environmental friendly
    method that has been suggested to assist gelatin extraction. Pressurization during pretreatment
    could reduce the extraction time and amount of acid used. It also has a potential in enhancing the
    properties of the gelatin extract and increasing the gelatin yield. In this research, One-Factor-
    at-Time (OFAT) and optimization study were done to determine the optimum parameters for
    extraction of gelatin assisted by HPP from red tilapia skin. Four parameters; applied pressure,
    pressure holding time, ratio of acid to skin and extraction time have been selected for the OFAT
    design and concentration of the gelatin extract and percentage of yield gelatin were evaluated.
    From OFAT, optimum technical parameters for response surface optimization design were 250
    MPa pressure, 7.5 ml of acid to 1 g of skin and 12 hours extraction time. Pressure holding
    time was fixed for 10 min. FCCCD has been used for optimization study. Results from the
    data shows that the optimum conditions for gelatin extraction from red tilapia skin were 250
    MPa for pressure, 10 min of pressure holding time, 7.5 ml of acid for 1 g of skin and 12 hours
    of extraction time while the maximum concentration and yield were 19.51 mg/ml and 32.04%
    (320.4 mg/g), respectively. These findings proved that HPP could increase the concentration
    and the yield of the gelatin while reducing the chemical waste and shortening the extraction
    process.
    Matched MeSH terms: Skin
  14. In Vitro and In Vivo Skin Distribution of 5α-Reductase Inhibitors Loaded Into Liquid Crystalline Nanoparticles
    Madheswaran T, Baskaran R, Yoo BK, Kesharwani P
    J Pharm Sci, 2017 11;106(11):3385-3394.
    PMID: 28652158 DOI: 10.1016/j.xphs.2017.06.016
    In this study, we developed positively charged liquid crystalline nanoparticles (LCN) coated with chitosan (CHI) to enhance the skin permeation and distribution of 5α-reductase inhibitors for the treatment of androgenetic alopecia. LCN and surface-modified LCN (CHI-LCN) were prepared by ultrasonication method, and their physicochemical properties were characterized. In vitro and in vivo skin permeation and retention were studied using porcine abdominal skin and mice skin using the Franz diffusion cell. Skin distribution and cellular uptake of LCN and CHI-LCN were also investigated. The particle size and surface charge were 244.9 ± 2.1 nm and -19.2 ± 1.1 mV, respectively, for LCNs and 300.0 ± 7.6 nm and 24.7 ± 2.4 mV, respectively, for CHI-LCN. The permeation of 5α-reductase inhibitors was significantly greater with CHI-LCN compared with LCN, whereas there was no significant difference observed in the skin distribution. In fluorescence studies, fluorescence intensity was higher for CHI-LCNs throughout the skin, whereas more intense fluorescence was seen only in the epidermis layer for LCN. CHI-LCN showed greater cellular uptake than LCN, resulting in internalization of 98.5 ± 1.9% of nanoparticles into human keratinocyte cells. In conclusion, surface modification of LCN with CHI is a promising strategy for increasing skin permeation of 5α-reductase inhibitors for topical delivery.
    Matched MeSH terms: Skin/metabolism; Skin Absorption*
  15. A facile synthesis method of hydroxyethyl cellulose-silver nanoparticle scaffolds for skin tissue engineering applications
    Zulkifli FH, Hussain FSJ, Zeyohannes SS, Rasad MSBA, Yusuff MM
    Mater Sci Eng C Mater Biol Appl, 2017 Oct 01;79:151-160.
    PMID: 28629002 DOI: 10.1016/j.msec.2017.05.028
    Green porous and ecofriendly scaffolds have been considered as one of the potent candidates for tissue engineering substitutes. The objective of this study is to investigate the biocompatibility of hydroxyethyl cellulose (HEC)/silver nanoparticles (AgNPs), prepared by the green synthesis method as a potential host material for skin tissue applications. The substrates which contained varied concentrations of AgNO3(0.4%-1.6%) were formed in the presence of HEC, were dissolved in a single step in water. The presence of AgNPs was confirmed visually by the change of color from colorless to dark brown, and was fabricated via freeze-drying technique. The outcomes exhibited significant porosity of >80%, moderate degradation rate, and tremendous value of water absorption up to 1163% in all samples. These scaffolds of HEC/AgNPs were further characterized by SEM, UV-Vis, ATR-FTIR, TGA, and DSC. All scaffolds possessed open interconnected pore size in the range of 50-150μm. The characteristic peaks of Ag in the UV-Vis spectra (417-421nm) revealed the formation of AgNPs in the blend composite. ATR-FTIR curve showed new existing peak, which implies the oxidation of HEC in the cellulose derivatives. The DSC thermogram showed augmentation in Tgwith increased AgNO3concentration. Preliminary studies of cytotoxicity were carried out in vitro by implementation of the hFB cells on the scaffolds. The results substantiated low toxicity of HEC/AgNPs scaffolds, thus exhibiting an ideal characteristic in skin tissue engineering applications.
    Matched MeSH terms: Skin
  16. Malignant melanoma of the ear canal presenting as wart
    Rafiqahmed Vasiwala, Ismail Burud
    International e-Journal of Science, Medicine & Education, 2016;10(1):47-48.
    MyJurnal
    Malignant melanoma is a rare malignancy of the external auditory canal. The vast majority of them occur in the areas of the body that are exposed to the sun. Early histological examination may possibly favor better prognosis. We report a case of a 38-year-old female who presented with a small mass in right ear canal, earache and minimum discharge since 4 months. Initially scraping was done in the ENT clinic. Subsequently she had a wide excision done by the end aural approach at a different hospital. A year later the patient presented with a swelling involving the ear canal which extended to the helix and supratemporal region with the histology report as malignant melanoma. A literature review of the disease, radiological findings, immunohistochemical features and treatment options are discussed.
    Matched MeSH terms: Skin Neoplasms
  17. Fulltext Morel-lavallee lesion: a forgotten cause of bleeding in trauma
    Khor, C. C., Tan, T. L.
    Medicine & Health, 2017;12(2):363-367.
    MyJurnal
    The Morel-Lavallee lesion is a rare soft tissue injury that occurs due to traumatic shearing force on skin surface causing separation of skin and subcutaneous tissue resulting in hematoma. This case report depicts a 22-year-old gentleman who was involved in a motor vehicle accident. He complained of pain and swelling over lower back. He was treated for soft tissue injury and admitted for pain control. One day post-trauma, he complained of increased swelling over the back. His hemoglobin dropped from 12.2g/dL to 10.7g/dL. Diagnosis of Morel-Lavallae lesion was made. Initially no surgical intervention was planned. However, in view of worsening of swelling, bedside aspiration was performed and subsequently a pigtail catheter was inserted to drain the hematoma. In total, 2.05 litre of liquefied hematoma was drained. Thus, Morel-Lavallee lesion is an uncommon soft tissue injury that can cause significant bleeding following trauma.
    Keywords: degloving injuries, hematoma, trauma
    Matched MeSH terms: Skin
  18. A prospective study evaluating wound healing with sea cucumber gel compared with hydrogel in treatment of skin graft donor sites
    Poh Yuen Wen A, Halim AS, Mat Saad AZ, Mohd Nor F, Wan Sulaiman WA
    Complement Ther Med, 2018 Dec;41:261-266.
    PMID: 30477850 DOI: 10.1016/j.ctim.2018.10.006
    BACKGROUND: Gamat (sea-cucumber) is a natural occurring fauna which is popularly used as traditional medication in Southeast Asian countries. There have been many animal studies done on its' biochemical properties and its' effects in vivo. The effect of gamat on human cutaneous wounds was studied using a split-skin graft donor site wound.

    METHODS: This was a comparative case-control study done on patients in Hospital Universiti Sains Malaysia (Hospital USM), requiring split-thickness skin grafting, whereby, the skin graft donor site was divided to almost equal halves, and applied with both gamat-based gel on one side, with Duoderm® hydrogel on the other side. The epithelialization of the wounds was observed and compared on days 10, 14 and 21. Pain score, and pruritus score were also observed. Repeated measure analysis of variance (ANOVA) test and Paired t-test was used to test statistical significance accordingly.

    RESULTS: No significant differences were seen in rates of epithelialization of wounds on days 10, 14 and 21 (p > 0.01). No significant difference was also seen in the pain score and pruritus score (p > 0.01).

    CONCLUSIONS: A gamat-based gel is comparable to conventional hydrogels in treatment of split-skin graft donor site. No adverse effects were observed in either group.

    Matched MeSH terms: Skin/drug effects; Skin Transplantation*
  19. Fulltext Isolation and characterization of acid soluble collagen (ASC) and pepsin soluble collagen (PSC) extracted from silver catfish (Pangasius sp.) skin
    Hukmi, N.M.M., Sarbon, N.M.
    International Food Research Journal, 2018;25(6):2601-2607.
    MyJurnal
    The aims of this study are to isolate and characterize acid soluble collagen (ASC) and pepsin soluble collagen (PSC) extracted from silver catfish (Pangasius sp.) skin. Isolated ASC and PSC collagen were characterized in terms of chemical composition (moisture, protein, fat and ash content), protein concentration, functional group, solubility, and morphological properties as compared to commercial collagen. Yields of ASC and PSC were 4.27% and 2.27%, respectively. The chemical compositions of raw skin were 34.64%, 2.81%, 3.68%, and 0.31%, while the chemical compositions of ASC and PSC were 94.21%, 3.48%, 0.81%, 59.15%, and 88.25%, 3.46%, 0.92%, and 29.24%, for moisture, protein, fat, and ash, respectively. ASC and PSC had protein concentrations of 2.27 mg/mL and 2.70 mg/mL, respectively. Functional group analysis revealed that both isolated collagens exhibited Amide A, II and III as a fingerprint for collagen structure. The highest solubility was found at pH 4 for ASC, pH 1 for PSC, and pH 5 for commercial collagen. The morphology of the isolated collagens was porous and they contained fibril. In conclusion, the characteristics of the isolated ASC and PSC from silver catfish (Pangasius sp.) skin indicate that value-added collagen can be produced from the alternative source of freshwater fish.
    Matched MeSH terms: Skin
  20. Fulltext Reconstruction of Secondary Type Congenital Hallux Varus with Modification of the Farmer Technique for Cover of Skin Defect: Report of Three Cases
    Sulaiman AR, Munajat I, M-Yusuf H, Nik-Jaffar N, Zarullail NH, Mohd EF, et al.
    Malays Orthop J, 2019 Nov;13(3):72-76.
    PMID: 31890115 DOI: 10.5704/MOJ.1911.013
    The reconstruction of hallux varus deformity involves the release of contracted medial structure and realignment of the phalange, leaving a significant skin defect which requires cover. Farmer described proximal based rotational skin flap from the first web space to cover the defect. This technique may compromise the circulation to the flap and risk to the lateral digital vessels. We modified his technique to address these issues. We report a successful reconstruction using the Farmer's technique on one patient and a modified technique on three patients. We used the excess skin from the extra digit to cover the medial defect. We found this modified technique of skin cover safe without risk of injuring the neurovascular bundle. There was no recurrence of deformity at last foolow-up. All patients were able to wear normal shoes.
    Matched MeSH terms: Skin Transplantation
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