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  1. Mohd Jamil N, Rosli N, Muhammad N
    J Public Health Res, 2021 Sep 24;11(1).
    PMID: 34558879 DOI: 10.4081/jphr.2021.2130
    BACKGROUND: This research aimed to model the outbreak of COVID-19 in Malaysia and develop a GUI-based model.

    DESIGN AND METHODS: The model is an improvement of the susceptible, infected, recovery, and death (SIRD) compartmental model.  The epidemiological parameters of the infection, recovery, and death rates were formulated as time dependent piecewise functions by incorporating the control measures of lockdown, social distancing, quarantine, lockdown lifting time and the percentage of people who abide by the rules. An improved SIRD model was solved via the 4th order Runge-Kutta (RK4) method and 14 unknown parameters were estimated by using Nelder-Mead algorithm and pattern-search technique. The publicly available data for COVID-19 outbreak in Malaysia was used to validate the performance of the model. The GUI-based SIRD model was developed to simulate the number of active cases of COVID-19 over time by considering movement control order (MCO) lifted date and the percentage of people who abide the rules.

    RESULTS: The simulator showed that the improved SIRD model adequately fitted Malaysia COVID-19 data indicated by low values of root mean square error (RMSE) as compared to other existing models. The higher the percentage of people following the SOP, the lower the spread of disease. Another key point is that the later the lifting time after the lockdown, the lower the spread of disease.

    CONCLUSIONS: These findings highlight the importance of the society to obey the intervention measures in preventing the spread of the COVID-19 disease.

  2. Li KS, Ali A, Muhammad II
    Acta Sci Pol Technol Aliment, 2017 Jul-Sep;16(3):283-292.
    PMID: 29055976 DOI: 10.17306/J.AFS.0497
    BACKGROUND: Perah seed is one of the most underutilized oilseeds, containing high nutritional values and high percentage of α-linoleneic acid, which may have a high potential in food and pharmaceutical applica- tions. The main objective of this study was to evaluate the influence of microwave (MW) cooking on the proximate composition and antioxidant activity of perah seeds.

    METHODS: In this study, the proximate composition and amygdalin concentration of MW ir- radiated perah seeds were determined. The total phenolic content (TPC), Maillard reaction products (MRPs) and antioxidant activity of methanol (PME), 70% methanol in water (PMW), ethanol (PEE), 70% ethanol  in water (PEW) extracts and methanol extract of oil (PMO) were evaluated during MW cooking. The anti- oxidant activity was evaluated using multiple assays, namely DPPH radical scavenging activity, β-Carotene bleaching assay, and reducing power.

    RESULTS: Microwave cooking did not significantly increase crude lipid and carbohydrate content, and the amounts of other nutrients such as ash, crude protein and fibre remained almost unchanged. As evaluated  by HPLC, the amygdalin concentration in the seeds was reduced by MW cooking. The TPC, MRP and anti- oxidant activity of the solvent extracts of perah seeds increased significantly with increasing roasting time. Of all the extracts, PMW at all MW cooking times displayed the highest antioxidant effectiveness. However, thermal treatment significantly reduced the antioxidant properties of PMO. The values for TPC, MRP and antioxidant effectiveness of the samples were ranked in the following order: PMW > PEW > PME > PEE > PMO, in both control and microwaved samples.

    CONCLUSIONS: In determining the overall quality of the products, MW cooking time was found to be a critical factor. Solubilization of phenolic compounds and formation of MRPs during MW cooking could have caused the increase in antioxidant activity of the perah seeds.
  3. Md Noh MSF, Muhammad SJSS
    Pan Afr Med J, 2017 Jun 23;27:138.
    PMID: 28904667 DOI: 10.11604/pamj.2017.27.138.12227
  4. Nathan T, Muthupalaniappen L, Muhammad NA
    Malays Fam Physician, 2022 Nov 30;17(3):114-120.
    PMID: 36606161 DOI: 10.51866/oa.25
    INTRODUCTION: Digital device helps children enhance academic, cognitive and psychomotor skills. However, prolonged use causes physical inactivity, poor interpersonal skills and communication problems. Information on digital device use among young children in Malaysia is currently limited. Hence, this study aimed to determine the prevalence of digital device utilisation among preschool children in Kota Setar District, Kedah.

    METHOD: A cross-sectional study at government preschools in Kota Setar District was conducted from February to April 2020. Selection of preschools and students was done using multistage simple randomisation. A self-administered questionnaire containing demographic and digital device use details was filled by parents.

    RESULTS: The prevalence of digital device use among preschool children was 95.9% and mostly used smartphones (94.2%). Most children (95%) did not own the device, and usage was under supervision (95.7%). The reason for supervision was to prevent exposure to inappropriate content (70.5%). The common reasons for allowing digital device use were for educational (37.4%) and entertainment purposes (36%) through videos (30.9%) and games (30.2%). Approximately 21.5% and 50.3% of the children spent more than 1 and 2 hours on digital devices during weekdays and weekends, respectively.

    CONCLUSION: The prevalence of digital device use among the preschool children in Kota Setar District was very high. Most of them used digital devices for educational and entertainment purposes under parental supervision. However, some exceeded the recommended screen time on weekends. These findings could promote awareness of digital device use among young children and help design public health awareness programmes and future policies.

  5. Tuang GJ, Muhammad A, Zahedi FD
    Ear Nose Throat J, 2023 Jan;102(1):NP1-NP2.
    PMID: 33393821 DOI: 10.1177/0145561320984561
    Though a common symptom, epistaxis should never be overlooked as the implications may be consequential. Nasal leech infestation represents an unusual etiology of recurrent epistaxis. The leeches release enzymes to anaesthetize the attachment site to facilitate the feeding process. Given the inconspicuous area of infestation and the absence of pain, there is often a delayed treatment. A detailed history taking and physical examination remain paramount in the assessment of recurrent epistaxis.
  6. Kaman N, Ishak A, Muhammad J
    PeerJ, 2023;11:e14919.
    PMID: 36874971 DOI: 10.7717/peerj.14919
    BACKGROUND: Caregivers are directly involved in managing the daily basic needs of children with autism spectrum disorder (ASD). The knowledge and attitudes of these caregivers are important to achieving success in their roles. Thus, this study aimed to determine what constitutes good knowledge, attitudes, and associated factors among caregivers toward children with ASD.

    METHODS: A cross-sectional study was conducted among 128 caregivers of children with ASD in Kota Bharu, Kelantan from May to August 2020, using convenience sampling. Validated questionnaires were used to assess the knowledge and attitudes toward children with ASD. The data were analyzed using SPSS version 24. Descriptive statistics and simple and multiple logistic regression analyses were then performed.

    RESULTS: The response rate was 100%. The proportion of good knowledge and attitudes toward children with ASD among caregivers was 85.1% and 88.3%, respectively. Factors significantly associated with good knowledge were being female (OR (95% CI) 2.79 [0.99-7.90]) and ASD children being non-first-born children (OR (95% CI) 0.41 [0.15-1.12]). Factors significantly associated with good attitudes were age of 30 years and older (OR (95% CI) 0.13 [0.03-0.62]) and caregiver having other children with other types of learning difficulties (OR (95% CI) 0.15 [0.04, 0.52]).

    CONCLUSIONS: The proportion of caregivers with good knowledge of ASD and good attitudes toward children with ASD was high. The caregiver's age and sex, the position of the ASD child among the siblings, and the presence of other types of learning disorders in the family need to be considered when managing children with ASD.

  7. Muhammad J, Ngah ND, Ahmad I
    Korean J Fam Med, 2023 Jan;44(1):44-52.
    PMID: 36709960 DOI: 10.4082/kjfm.22.0016
    BACKGROUND: A written asthma action plan (WAAP) is one of the treatment strategies to achieve good asthma control in children.

    METHODS: This randomized controlled trial was conducted to observe the effect of WAAP on asthma control and quality of life using the Asthma Control Questionnaire and Pediatric Asthma Quality of Life Questionnaire (PAQLQ) at baseline and after 3 months. A repeated measure analysis of variance was used to analyze the mean score difference between the two groups.

    RESULTS: There was no significant difference in mean score for asthma control at baseline between groups (F[degree of freedom (df)]=1.17 [1, 119], P=0.282). However, at 3 months, a significant difference in mean scores between groups was observed (F[df]=7.32 [1, 119], P=0.008). The mean±standard deviation (SD) scores in the intervention and control groups were 0.96±0.53 and 1.21±0.49, respectively. For the analysis of the PAQLQ, no significant difference was observed in the mean score for the quality of life baseline in both groups. There were significant mean score changes for the quality of life (F[df]=10.9 [1, 119], P=0.001) at 3 months follow-up, where those in the intervention group scored a mean±SD score of 6.19±0.45, and those in the control group scored 5.94±0.38. A time-group interaction analysis using repeated-measures analysis of variance showed significant differences in mean score changes (F[df]=5.03 [1, 116], P=0.027) and (F[df]=11.55 [1, 116], P=0.001) where a lower mean score was observed in the intervention group, indicating better asthma control and quality of life, respectively. A significant (P<0.001) negative Pearson correlation between asthma control and quality of life (-0.65) indicated a moderate correlation.

    CONCLUSION: WAAP, along with standard asthma treatment, improves asthma care.

  8. Azam M, Uddin I, Khan S, Tariq M
    Environ Sci Pollut Res Int, 2022 Dec;29(58):87746-87763.
    PMID: 35821313 DOI: 10.1007/s11356-022-21835-1
    This study examines the impact of energy consumption, urbanization, and globalization on environmental degradation proxied by carbon emissions (CO2) in the South Asian Association for Regional Cooperation (SAARC) countries, namely Sri Lanka, Pakistan, Maldives, Nepal, Bhutan, Bangladesh, and India using data over the period 1990-2018. The cross-sectional autoregressive distributed lag (CS-ARDL), pooled mean group (PMG), and Dumitrescu and Hurlin (D-H) Granger causality techniques are employed for the empirical analysis. First and second-generation panel unit root tests are used to determine the stationary level of all data series which reveals mixed order of integration. The empirical findings show that urbanization, gross domestic product (GDP) per capita income, energy consumption, industrial growth, globalization, and financial development cause CO2 emissions, while the other variables, namely arable land and innovation, put negative effects on CO2 emissions. Moreover, the D-H heterogeneous test results exhibit that bi-directional relationship exists between CO2 and arable land, urbanization, industrial growth, and financial development, while a unidirectional causality exists between CO2 emissions and GDP per head income. These findings suggest that planned urbanization, investment in renewable energy sources, and effective strategies regarding the economic and financial integration with the global economies are required for a clean and green environment.
  9. Zubair M, Anwar F, Ashraf M, Uddin MK
    Int J Mol Sci, 2012;13(4):4608-4622.
    PMID: 22605998 DOI: 10.3390/ijms13044608
    The present study reports the composition and variation of fatty acids, sterols, tocopherols and γ-oryzanol among selected varieties namely Basmati Super, Basmati 515, Basmati 198, Basmati 385, Basmati 2000, Basmati 370, Basmati Pak, KSK-139, KS-282 and Irri-6 of Pakistani rice (Oryza sativa L). Oil content extracted with n-hexane from different varieties of brown rice seed (unpolished rice) ranged from 1.92% to 2.72%. Total fatty acid contents among rice varieties tested varied between 18240 and 25840 mg/kg brown rice seed. The rice tested mainly contained oleic (6841-10952 mg/kg) linoleic (5453-7874 mg/kg) and palmitic acid (3613-5489 mg/kg). The amounts of total phytosterols (GC and GC-MS analysis), with main contribution from β-sitosterol (445-656 mg/kg), campesterol (116-242 mg/kg), Δ(5)-avenasterol (89-178 mg/kg) and stigmasterol (75-180 mg/kg) were established to be 739.4 to 1330.4 mg/kg rice seed. The content of α-, γ- and δ-tocopherols as analyzed by HPLC varied from 39.0-76.1, 21.6-28.1 and 6.5-16.5 mg/kg rice seed, respectively. The amounts of different γ-oryzanol components (HPLC data), identified as cycloartenyl ferulate, 24-methylene cycloartanyl ferulate, campesteryl ferulate and β-sitosteryl ferulate, were in the range of 65.5-103.6, 140.2-183.1, 29.8-45.5 and 8.6-10.4 mg/kg rice seed, respectively. Overall, the concentration of these bioactives was higher in the Basmati rice cultivars showing their functional food superiority. In conclusion, the tested varieties of Pakistani rice, especially the Basmati cultivars, can provide best ingredients for functional foods.
  10. Ishaque A, Shahzad F, Muhammad FH, Usman Y, Ishaque Z
    Malays Fam Physician, 2016;11(2-3):9-15.
    PMID: 28461852
    INTRODUCTION: Diabetes mellitus (DM) has evolved as a major public health concern worldwide, as its prevalence is increasing exponentially. Pakistan now ranks seventh among the countries with the highest burden of DM. It is expected to become one of the major causes of morbidity within the next 25 years. Therefore, finding an effective way to identify individuals at risk of developing diabetes is a necessity. The Finnish Diabetes Risk Score (FINDRISC) has proved to be an effective noninvasive screening tool for identifying individuals at risk for developing diabetes. The objective of this study was to determine the frequency of individuals who are at risk for developing DM and their risk of developing DM over the next 10 years using the FINDRISC tool.

    METHODS: A cross-sectional survey was conducted on 241 adults. The data were collected using the FINDRISC questionnaire followed by calculation of a summated score and analysis to determine the association between the risk factors under study and the risk of developing diabetes.

    RESULTS: Out of 241 study participants, 137 (56.8%) were men and 104 (43.1%) were women. Our study showed that 129 (53.5%) participants had low risk, 68 (28.2%) had slightly elevated risk, 27 (11.2%) had moderate risk and 17 (7%) had high risk of developing DM.

    CONCLUSION: The general population should be educated about the importance of healthy lifestyle, with special emphases on maintaining an ideal body mass index and a low-risk waist circumference, along with daily fruit and vegetable intake and physical activity of at least 30 min/day.

  11. Hameed SS, Hassan R, Muhammad FF
    PLoS One, 2017;12(11):e0187371.
    PMID: 29095904 DOI: 10.1371/journal.pone.0187371
    In this work, gene expression in autism spectrum disorder (ASD) is analyzed with the goal of selecting the most attributed genes and performing classification. The objective was achieved by utilizing a combination of various statistical filters and a wrapper-based geometric binary particle swarm optimization-support vector machine (GBPSO-SVM) algorithm. The utilization of different filters was accentuated by incorporating a mean and median ratio criterion to remove very similar genes. The results showed that the most discriminative genes that were identified in the first and last selection steps included the presence of a repetitive gene (CAPS2), which was assigned as the gene most highly related to ASD risk. The merged gene subset that was selected by the GBPSO-SVM algorithm was able to enhance the classification accuracy.
  12. Abd Jalil MA, Shuid AN, Muhammad N
    PMID: 22973405 DOI: 10.1155/2012/714512
    Popularly known as "the silent disease" since early symptoms are usually absent, osteoporosis causes progressive bone loss, which renders the bones susceptible to fractures. Bone fracture healing is a complex process consisting of four overlapping phases-hematoma formation, inflammation, repair, and remodeling. The traditional use of natural products in bone fractures means that phytochemicals can be developed as potential therapy for reducing fracture healing period. Located closely near the equator, Malaysia has one of the world's largest rainforests, which are homes to exotic herbs and medicinal plants. Eurycoma longifolia (Tongkat Ali), Labisia pumila (Kacip Fatimah), and Piper sarmentosum (Kaduk) are some examples of the popular ethnic herbs, which have been used in the Malay traditional medicine. This paper focuses on the use of natural products for treating fracture as a result of osteoporosis and expediting its healing.
  13. Haouas I, Haseeb M, Azam M, Rehman ZU
    Environ Sci Pollut Res Int, 2023 Jul;30(31):77077-77095.
    PMID: 37249784 DOI: 10.1007/s11356-023-27835-z
    Every country intends to enhance national production by achieving sustainable development. The purpose of this study is to examine whether there exists any long-run association among environmental deterioration measured by territorial emissions in CO2, demographic factors (total population, population density, and urban population) and some other variables, namely, energy use, per capita income, energy intensity, and industrial value added for the 16 countries from the Middle East and North African (MENA) over 1990-2018. We implemented the generalized method of moments (GMM), fully modified ordinary least square (FMOLS), robust least square estimators, and panel Granger causality techniques for estimation. The empirical estimates reveal that there exists a long run cointegration among the series. Results also exhibit that energy use, per capita income, energy intensity, industrial value added, population density, total population, and urban population have positive effects on CO2 emissions. Furthermore, in each panel, there is bi-directional causality between population density and CO2 emissions, total population and CO2 emissions, and urban population and CO2 emissions. These findings suggest that the policymakers need not exclusively to focus on the transformation of rural labor from an agricultural-based model to urban regions with powerful, dominant industry and services sectors but also related to the changing of rural establishments into urban spaces is required. These changes in demographics involve changes in the demand for additional transportation services, food, shelter, clothing, and other necessities.
  14. Muhammad Zuki MF, Abu Bakar N
    Data Brief, 2023 Dec;51:109808.
    PMID: 38075603 DOI: 10.1016/j.dib.2023.109808
    The dataset was obtained from a time cross-sectional empirical survey to determine the intention to participate in Family Takaful (Solidarity) products. The survey was collected from 277 academicians in private Islamic Higher Education Institutions in Malaysia, with 272 valid cases. The academicians were chosen because of the various education levels, as education is an influential factor in many previous behavioural studies. The questionnaire was developed using scales based on the previous literature, such as intention, attitude, subjective norms, perceived behavioural intention and institutional trust. The reliability and validity of all variables indicated that the measurement items were appropriate. This dataset brought a novelty by conceptualizing the institutional trust construct to predict the customers' intention to participate in Family Takaful (Solidarity) products. Results indicated that the data is suitable for performing replication studies.
  15. Ali S, Jorge J, Aslam M, Kashif M
    Sci Rep, 2024 Jan 24;14(1):2092.
    PMID: 38267592 DOI: 10.1038/s41598-024-52619-x
    In this article, an attribute control chart is proposed when the lifetime of a product follows a Weibull distribution in two-stage sampling, which is based on the number of failures from a truncated life test. The coefficients of the proposed double sampling attribute control chart and the test duration are determined so that the average run length when the process is in control is close to the target value. An overview is reported on how double sampling np control charts work. Tables reporting the out-of-control average run lengths are given for various shift parameters. A case study is given to illustrate the proposed control chart for industrial use. A comparison of two-stage and single-stage sampling of failure of products is discussed.
  16. Hashim S, Ishak A, Muhammad J
    Korean J Fam Med, 2020 Nov;41(6):416-421.
    PMID: 33242382 DOI: 10.4082/kjfm.19.0060
    BACKGROUND: Breastfeeding is widely recognized as the optimal and natural method of feeding infants. However, there are obstacles that can limit exclusive breastfeeding practices during the first 6 months of an infant's life. This study aimed to determine the prevalence of unsuccessful exclusive breastfeeding and its associated factors among mothers who work as healthcare providers at Universiti Sains Malaysia Hospital.

    METHODS: A cross-sectional study was conducted among 295 medical doctors and staff nurses from June to December 2015. Simple random sampling was applied. The data were collected using a self-administered questionnaire and analyzed using IBM SPSS ver. 22.0 (IBM Corp., Armonk, NY, USA). Descriptive statistics and logistic regression analysis were performed.

    RESULTS: The prevalence of unsuccessful exclusive breastfeeding among the study participants was 58.3%. Mothers who preferred formula milk (odds ratio [OR], 4.40; 95% confidence interval [CI], 1.45-13.31) delivered via lower segment cesarean section (OR, 2.31; 95% CI, 1.07-4.98) and produced inadequate breast milk (OR, 4.06; 95% CI, 2.40- 6.89) were significantly associated with unsuccessful exclusive breastfeeding.

    CONCLUSION: The prevalence of unsuccessful exclusive breastfeeding among the study participants was high. Maternal characteristics such as preference towards formula milk, mode of delivery and adequacy of breast milk must be assessed to prevent unsuccessful exclusive breastfeeding among healthcare providers.

  17. Liu C, Jiang M, Muhammad ZA
    PLoS One, 2024;19(12):e0315140.
    PMID: 39637011 DOI: 10.1371/journal.pone.0315140
    Tourism advertising and tourism promotion have over the years been the core functions of tourism departments and major tourist sites. In relation to the progressing development of new media, the mobile short-form videos, which are short, focused, and have an engaging content, appear to be a useful means of advertising tourist destinations. In the digital era, short videos have become a new communication tool between destinations and consumers. This current study, based on the S-O-R model and flow experience, investigated the psychological processes through which TikTok attributes and technology evoke flow and lead to tourists' behavioral intention. Moreover, the TAM, i.e., PU and PEOU, as two technology factors, as well as three content attributes (entertainment, informativeness, and interactivity) were examined. The study utilized a quantitative approach and collected data from 412 respondents in China. The authors adopted the PLS-SEM method to confirm the directions hypothesized in this model. There are significant effects of PU, PEOU, and entertainment on flow experience (telepresence, time distortion, and focused attention). Interactivity impacts telepresence and time distortion, while informativeness impacts focused attention. Moreover, time distortion and focused attention impact tourists' behavioral intention. The results highlight several limitations and offer implications for future research as well.
  18. Muhammad YI, Salim N, Zainal A
    PeerJ Comput Sci, 2024;10:e2346.
    PMID: 39650516 DOI: 10.7717/peerj-cs.2346
    Understanding spoken language is crucial for conversational agents, with intent detection and slot filling being the primary tasks in natural language understanding (NLU). Enhancing the NLU tasks can lead to an accurate and efficient virtual assistant thereby reducing the need for human intervention and expanding their applicability in other domains. Traditionally, these tasks have been addressed individually, but recent studies have highlighted their interconnection, suggesting better results when solved together. Recent advances in natural language processing have shown that pretrained word embeddings can enhance text representation and improve the generalization capabilities of models. However, the challenge of poor generalization in joint learning models for intent detection and slot filling remains due to limited annotated datasets. Additionally, traditional models face difficulties in capturing both the semantic and syntactic nuances of language, which are vital for accurate intent detection and slot filling. This study proposes a hybridized text representation method using a multichannel convolutional neural network with three embedding channels: non-contextual embeddings for semantic information, part-of-speech (POS) tag embeddings for syntactic features, and contextual embeddings for deeper contextual understanding. Specifically, we utilized word2vec for non-contextual embeddings, one-hot vectors for POS tags, and bidirectional encoder representations from transformers (BERT) for contextual embeddings. These embeddings are processed through a convolutional layer and a shared bidirectional long short-term memory (BiLSTM) network, followed by two softmax functions for intent detection and slot filling. Experiments on the air travel information system (ATIS) and SNIPS datasets demonstrated that our model significantly outperformed the baseline models, achieving an intent accuracy of 97.90% and slot filling F1-score of 98.86% on the ATIS dataset, and an intent accuracy of 98.88% and slot filling F1-score of 97.07% on the SNIPS dataset. These results highlight the effectiveness of our proposed approach in advancing dialogue systems, and paving the way for more accurate and efficient natural language understanding in real-world applications.
  19. Muhammad FA, Sudirman R, Zakaria NA
    Tissue Cell, 2025 Apr;93:102677.
    PMID: 39719819 DOI: 10.1016/j.tice.2024.102677
    Malaria is endemic in poverty-stricken regions of the world, and most diagnosis reveal comorbidity with other infectious diseases some of which manifest as a deformity of the structural arrangement of the Red Blood Cells (RBCs) during thin blood smear microscopy. This common occurring deformity is termed rouleaux formation, and it is the stacking together of RBCs like chains of coins. The presence of rouleaux formation indicates either a bacterial infection, connective tissue disease, chronic liver disease, multiple myeloma or diabetes among others, it is a highly common occurrence in malaria infected patients and according to the international council for standardization of hematology (ICSH), microscopists are mandated to report its presence. Hence to develop unbiased automated malaria diagnostic systems capable of being deployed in malaria endemic regions, these systems need to be capable of identifying rouleaux formation and detecting malaria parasite within such type of RBC. Thus, this study developed a thin blood smear dataset with rouleaux formation RBCs infected with two species of malaria parasite: plasmodium falciparum and plasmodium malariae. YOLOv9s architecture was used to benchmark the dataset for the detection of plasmodium parasites and white blood cells in the developed dataset. Comparing the effect of using pretrained weights, YOLOv9s trained from scratch achieved a Precision, Recall and mAP50 of 75.4 %, 76.6 % and 80.3 % while YOLOv9s pretrained on the MS COCO dataset recorded an improvement in performance metrics with an increase in Precision by 0.4 %, an increase in Recall by 5.4 % and an increase in mAP50 by 2.5 .
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