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Fulltext Prenylated flavonols from the leaves of macaranga gigantea (rchb.F. & Zoll.)

M. Sulaiman M. Johari, Norizan Ahmat, Aisyah S. Kamarozaman, M. Hamizan M. Isa

Scientific Research Journal, 2019;16(1):29-40.
MyJurnal

The genus Macaranga comes from the family of Euphorbiaceae and it is the only genus in the subtribe Macaranginae that have a large genus with 300 species of which 27 species were found in Peninsular Malaysia. This plant grows as shrubs or trees that can grow up to 15 m tall and known for their mutual associations with ants. Fresh or dried leaves of some Macaranga species were used by traditional healers to treat swellings, cuts, sores, boils and bruises. The isolation of chemical constituent from this genus has been shown to produce numerous results of phenolic compounds, such as flavonoids and stilbenoids. In this paper, we report the isolation of a prenylated flavonol, glyasperin A (1), together with a simple flavone apigenin (2) from the methanolic extract of the leaves of Macaranga gigantea. The structure of both compounds has been elucidated based on its spectroscopic data, including mass spectroscopy (MS), infrared (IR), ultraviolet-visible (UV-Vis), 1D and 2D nuclear magnetic resonance (NMR) spectra and comparison with the previous literature.
Fulltext Comparison of breastfeeding practice using deuterium oxide dose to mother technique with maternal recall breastfeeding practice among mothers in Klang Valley

Chong, Guey Yong, Noor Zahila Mat Isa, Norimah Abdul Karim, Nik Shanita Safii

Jurnal Sains Kesihatan Malaysia, 2019;17(1):107-113.
MyJurnal

The assessment of exclusive breastfeeding is important to invest the efforts to promote and support breastfeeding practices. Hence this study was carried out to compare breastfeeding practices among mothers using deuterium dose to mother technique with maternal recall breastfeeding practice. A total of 30 mother-infant pairs from a university hospital and government health clinics in Klang Valley participated and completed the study. Mother-infant pairs were recruited into the study when infants were aged 3 months ± 1 week. Anthropometric measurements (height, weight, waist circumference for mother; length and weight for infant) were carried out. Socio-demographic questionnaire was self-administered while breastfeeding practices were interview administered using maternal recall breastfeeding practice questionnaire (MRBF). This was followed by baseline saliva collection of mother-infant pairs before dose and 6 days after mothers were given 30 ± 0.01 g of D2 O. The post dose saliva sample of mother-infant pairs were collected 6 times at day 1,2,3,4,13 and 14.The results showed that majority of mothers (57%) were university graduates but majority were stay at home mothers. Meanwhile, mothers had BMI with mean 25 ± 4 kg/m2 . The results from MRBF questionnaire showed that all mothers were practicing exclusive breastfeeding and their infant never received any water sources other than their breast milk. However, the deuterium dose to mother technique revealed only 3% of mothers were actually practicing exclusive breastfeeding. From the isotopic data, the calculated mean intake of milk was 721 ± 243 g/day while the mean non-milk oral intake of 122 ± 22 g/ day. In contrast exclusive breastfeeding infants received only 10 g/day non milk oral intake, demonstrating exclusive breastfeeding practice of mothers. There were different breastfeeding practice reported from mother using deuterium oxide dose to mother technique with maternal recall breastfeeding practice.
Fulltext Knowledge, attitude and practice towards available anti-smoking campaign among adults in Kuantan

Mohamad Helmy Jaafar, Normalina Alias, Afzan Mat Yusof, Muhammad Lokman Md. Isa

Malaysian Journal of Medicine and Health Sciences, 2019;15(3):61-66.
MyJurnal

Introduction: This study was conducted to determine the association between knowledge, attitude and practice among Kuantan community towards anti-smoking campaign. An anti-smoking campaign can be referred to as a series of ads programs that are introduced through various objective approaches to give awareness to people on the negative impacts of smoking behavior. The objectives of this study are (i) to investigate the association between so- cio-demographic data (gender, income, education level) and level of knowledge towards anti-smoking campaign; (ii) to find out the association between socio-demographic data (gender, income, education level) and level of attitude against anti-smoking campaigns; (iii) to study the association between socio-demographic data (gender, income, education level) and level of practice towards anti-smoking campaigns; and (iv) to find out the correlation between level of knowledge with level of attitude, level of knowledge with level of practice, and level of attitude with level of practice towards anti-smoking campaigns. Methods: A descriptive cross-sectional study was conducted among adult Kuantan community and convenience sampling was used to collect the data. A validated questionnaire was used to collect data. Statistical analysis of the data was carried out using SPSS and association of variables was an- alysed using Chi-square test. Results: This study found that level of knowledge did not affect the attitude level of the community. However, level of knowledge did affect the level of practice towards the anti-smoking campaign. Conclusion: It revealed that respondents with high level of knowledge also had good level of practice towards an- ti-smoking campaign.
Fulltext A 10-week pedometer-based walking program induced weight loss and improved metabolic health in community-dwelling adults

Roselina Mokhtar, Hazariah Abd Halim, Mohd Hanif Zailani, Afendi Isa, Nor Farah Mohamad Fauzi

Jurnal Sains Kesihatan Malaysia, 2019;17(1):21-29.
MyJurnal

Walking 10,000 steps daily is associated with beneficial health outcomes. Recent systematic reviews have suggested that pedometers may be an effective motivational tool to promote walking. The aim of this study was to study the effectiveness of a 10-week, pedometer-based walking intervention to improve physical activity, body composition and metabolic health indices in a sample of suburban community-dwelling adults not meeting current physical activity recommendations. After screening, 34 overweight/obese individuals (mean age: 46 ± 8 years, mean BMI: 28.3 ± 4.2 kg/m2) were accepted into the walking program conducted by the Health Promotion Community Centre, Bangi. Subjects were instructed to increase their steps by 3000 steps daily above their baseline values for 10 weeks. Daily step count, body weight, BMI, waist circumference, as well as blood pressure, fasting glucose and lipids were evaluated at baseline and following the 10-week intervention. Thirty-one participants completed the program with 100% adherence. The average daily steps recorded during the 10-week intervention was 9693 ± 2196 steps per day. Mean daily steps increased from 8679 ± 2567 steps in Week 1 to 10,766 ± 3200 steps in Week 10 (p = 0.040). Overall, there were reductions in body weight (-1.13%, p = 0.010), waist circumference (-3.5%, p = 0.001) and BMI (-1.41%, p = 0.008) as well as fasting blood glucose (-8.5%, p = 0.003) and systolic blood pressure (-4.8%, p = 0.007) following the intervention. The findings of this study demonstrated that a goal-driven, pedometer-based walking intervention for 10 weeks resulted in a modest reduction in body weight and improved metabolic health outcomes in overweight/obese, community-dwelling adults.
Fulltext Spectrum of penetrating cardiac injuries from flying feathers

Muhamad, N.A.R., Tuan Hairulnizam, T.K., Jessie, D.H., Rashidi, A., Jeewadas, B., Isa, A.Z., et al.

Malaysian Journal of Emergency Medicine, 2018;3(1):0-0.
MyJurnal

Flying feather is a traditional street weapon, which is believed to be originated from Philippine. It is a famous weapon in Tawau, Sabah, shot within short distance and being used with the aim to debilitate the victims. Some may even apply poison at the tip of the weapon. We report two cases of severe chest injuries in resulting from flying feathers. Case 1, a 25-year old man sustained left sided hemothorax with anterior right ventricle injury. He underwent thoracotomy and was discharged well. Case 2, a 40-year old man, presented to emergency department with no signs of life, sustained penetrating injury to the left second intercostal muscle, the pericardium and the anterior wall of the right ventricle adjacent to the interventricular septum. These cases highlight the severity spectrum of cardiac injury resulting from flying feathers.
Fulltext Personal and psychosocial risk factor for low back pain among automotive manual handling workers in Selangor, Malaysia

Noor Sazarina Mad Isa @ Yahya, Baba Md Deros, Ahmad Rasdan Ismail, Mazrura Sahani

Int J Public Health Res, 2014;4(1):412-418.
MyJurnal

Introduction It is well known that low back pain among working population is a global
problem throughout the world. However, the current situation of occupational
low back pain in Malaysia is still vague due to limited number of studies
conducted locally.

Objective A cross sectional study was conducted among three automotive industry
workers in Selangor, Malaysia from October 2010 to April 2011.
Methods This study aims to determine the prevalence and risk factors of low back pain
among automotive industry workers performing manual material handling
tasks using self-administered questionnaire survey.

Results A modified Standardised Nordic Questionnaire was used to assess low back
pain problem, to obtain personal and psychosocial risk factors information.
The prevalence of low back pain showed increment in the point prevalence of
57.9%, 49.5%, and 35.1 % for 12 months, one month, and of 7 days
respectively. Working hour, frequency of overtime, stress at work, work
pace, and faster movement were found to be significantly associated with the
12 months prevalence for low back pain.

Conclusions This finding indicates that psychosocial risk factors are associated to the
occurrence of low back pain.
Fulltext Electrodeposition of copper coating on 304 stainless steel substrate: physicochemical properties and antibacterial activity

Nik Norziehana Che Isa, Yusairie Mohd, Mohammad Hafizudden Mohd Zaki, Sharifah Aminah Syed Mohamad

Pertanika Journal of Science & Technology, 2017;25(104):29-40.
MyJurnal

Non antimicrobial touch surface materials such as stainless steel can act as a medium for transmitting
microbes, leading to the increase of hospital-acquired infections and antibiotic-resistant microbes.
Copper can be used to replace the current non-antimicrobial touch surfaces, however, the high cost of
solid copper hampers copper from being the ideal choice. Therefore, stainless steel touch surfaces coated
with copper can become the option for a low cost yet effective alternative. In this study, electrodeposition
technique was used to coat copper on 304 stainless steel surface using 0.01 M CuSO4 solution, at pH 1.
The electrodeposition process was done using chronoamperometry by applying –0.25 V vs. Ag/AgCl for
15 min. Morphological observation revealed that 304 stainless steel surface was uniformly coated with
compact and dense copper. EDAX analysis showed the composition of copper of 98.9 wt. %, ranging
in diameter from 60-90 nm grain size. Thickness of the coating was approximately 105.8 nm. The
antibacterial property of copper coating was analysed by both Gram negative E. coli and Gram positive
S. aureus. Results indicated that copper coating has excellent antibacterial behaviour in destroying both
bacteria. E. coli was more sensitive to the biocidal action of the copper coating of which 100 % reduction
was observed within 5 min of exposure. As for S. aureus, a 100% reduction was achieved only after 10
min of exposure.
Fulltext Second-hand smoke exposure and psychological distress amongst non-smoking pregnant women in Malaysia

Siti Munira Yasin, Khairul Mizan Taib, Mohd Rodi Isa, Mohd Ariff Fadzil, Mohd Razilan Abdul Kadir

Pertanika Journal of Science & Technology, 2017;25(104):181-190.
MyJurnal

This study aimed to examine the association between second-hand smoke (SHS) exposure and psychological distress amongst non-smoking pregnant women. A cross-sectional study was used to obtain a representative sample of non-smoking pregnant women attending health clinics (n = 661) across six states in Malaysia. The duration of SHS exposure inside and outside the house was recorded from the participants. Psychological distress was assessed via General Health Questionnaire (GHQ12). The analyses were conducted using a logistic regression adjusted for demographic variables and other variables. Amongst non-smoking pregnant women, the prevalence of global SHS exposure and psychological distress was 80.4% and 64.2%, respectively. In the multivariate adjusted odds ratio (OR) models for psychological distress and the duration of SHS exposures, there was an OR of 1.04 (95% CI: 0.61-1.77) for individuals with SHS exposure of 1-4 hours/week, 0.44 (95% CI: 0.23-0.81) for SHS exposure of 5-14 hours/week and 0.84 (95% CI: 0.32-2.22) for exposures of >15 hours/week compared to those with no SHS exposure outside the home. Meanwhile, SHS exposure outside the house with the duration of 5-14 hours might have temporary calming effects against psychological distress. Nonetheless, more research is needed to ascertain this.
Fulltext One-time prolonged ultrasound exposure during early pregnancy affects bone strength in young aged Oryctolagus cuniculus

Che Isa, I.N., Md Dom, S., Abdul Razak, H.R., Hashim, U.F.

Pertanika Journal of Science & Technology, 2017;25(1):359-370.
MyJurnal

The use of prenatal ultrasound has become controversial as it is increasingly being performed for business
and social interests rather than for medical use. This nonmedical use of the modality has violated the
US FDA guideline. Ultrasound scans have been proven to increase temperature in insonated tissue and
their effects have been investigated via phantom and animal experiments. Absorption coefficient of the
bone is the highest compared with any other structure. Thus, exposure to ultrasound, especially during
osteogenesis, can cause significant damage to developing foetus. Twenty-two pregnant does of known
gestation were enrolled in the control and experimental groups. No exposure was given to the control
group while the experimental groups were exposed accordingly to the prenatal ultrasound in the 1st,
2nd and 3rd stage for 30, 60 and 90 minutes respectively. A total of 142 subjects aged between 1 and 5
months were analysed for bone strength. The Tb.Th of the experimental group was reduced significantly
as compared to the control group. Po, TMD and empty lacunae were higher in the experimental group.
It is thus concluded that one-time prenatal ultrasound can affect bone strength in young subjects.
Acute and repeated dose 28-day oral toxicity of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) nanoparticles in Sprague-Dawley rats

Leong YH, Isa ASM, Mohamed Mahmood M, Moey CEJ, Utar Z, Soon YI, et al.

Regul Toxicol Pharmacol, 2018 Jun;95:280-288.
PMID: 29567329 DOI: 10.1016/j.yrtph.2018.03.011

This study aimed to investigate the oral acute and subacute toxicity of Poly [3-hydroxybutyrate-co-4-hydroxybutyrate], P(3HB-co-4HB) in the form of nanoparticles in Sprague-Dawley rats. Acute oral administration of P(3HB-co-4HB) nanoparticles was performed as a single dose up to 2000 mg/kg in six female rats for 14 days. Subacute toxicity study via oral administration for 28 days at doses of 0 (control), 500, 1000 and 2000 mg/kg in rats (10 rats in each group, female:male = 1:1) was conducted. The estimated lethal dose (LD50) of P(3HB-co-4HB) nanoparticles was >2000 mg/kg. No mortality, unusual changes in behaviour, adverse clinical signs, abnormal changes in body weights or food consumption were observed on all animals treated with P(3HB-co-4HB) nanoparticles during 14 days of the acute toxicity study. In the subacute test, there was no mortality and toxicologically significant changes in clinical signs, body weights, food consumption, hematology, clinical biochemistry, urinalysis, macroscopic findings, organ weights as well as histopathological examination were observed.
Mass attenuation coefficient of tannin-added Rhizophora spp. particleboards at 16.59-25.56 keV photons, and 137Cs and 60Co gamma energies

Yusof MFM, Hamid PNKA, Tajuddin AA, Hashim R, Bauk S, Isa NM, et al.

Radiol Phys Technol, 2017 Sep;10(3):331-339.
PMID: 28718054 DOI: 10.1007/s12194-017-0408-3

The aim of this study was to determine the suitability of tannin-added Rhizophora spp. particleboards as phantom materials in the application of low- and high-energy photons. The tannin-added Rhizophora spp. particleboards and density plug phantoms were created with a target density of 1.0 g/cm3. The elemental composition and effective atomic number of the particleboards were measured using energy dispersive X-ray analysis. The mass attenuation coefficient of the particleboards for low-energy photons were measured using the attenuation of X-ray fluorescence. The mass attenuation coefficients of high-energy photons were measured using the attenuation of 137Cs and 60Co gamma energies. The results were compared to the calculated value of water using XCOM calculations. The results showed that the effective atomic number and mass attenuation coefficients of tannin-added Rhizophora spp. particleboards were similar to those of water, indicating the suitability of tannin-added Rhizophora spp. particleboards as phantom materials for low- and high-energy photons.
Formulation of a Sustained Release Docetaxel Loaded Cockle Shell-Derived Calcium Carbonate Nanoparticles against Breast Cancer

Hammadi NI, Abba Y, Hezmee MNM, Razak ISA, Jaji AZ, Isa T, et al.

Pharm Res, 2017 06;34(6):1193-1203.
PMID: 28382563 DOI: 10.1007/s11095-017-2135-1

PURPOSE: Here, we explored the formulation of a calcium carbonate nanoparticle delivery system aimed at enhancing docetaxel (DTX) release in breast cancer.
METHODS: The designed nano- anticancer formulation was characterized thorough X-ray diffraction (XRD), Fourier transformed infrared (FTIR), transmission electron microscopy (TEM) and field emission scanning electron microscopy (FESEM) and Brunauer-Emmett-Teller (BET) methods. The nano- anticancer formulation (DTX- CaCO3NP) was evaluated for drug delivery properties thorough in vitro release study in human body simulated solution at pH 7.4 and intracellular lysosomal pH 4.8.
RESULTS: Characterization revealed the successful synthesis of DTX- CaCO3NP, which had a sustained release at pH 7.4. TEM showed uniformly distributed pleomorphic shaped pure aragonite particles. The highest entrapment efficiency (96%) and loading content (11.5%) were obtained at docetaxel to nanoparticles ratio of 1:4. The XRD patterns revealed strong crystallizations in all the nanoparticles formulation, while FTIR showed chemical interactions between the drug and nanoparticles with negligible positional shift in the peaks before and after DTX loading. BET analysis showed similar isotherms before and after DTX loading. The designed DTX- CaCO3NP had lower (p 0.05) effects at 48 h and 72 h. However, the DTX- CaCO3NP released less than 80% of bond DTX at 48 and 72 h but showed comparable effects with free DTX.
CONCLUSIONS: The results showed that the developed DTX- CaCO3NP released DTX slower at pH 7.4 and had comparable cytotoxicity with free DTX at 48 and 72 h in MCF-7 cells.
Fulltext Transcriptome analysis of Rafflesia cantleyi flower stages reveals insights into the regulation of senescence

Mohd-Elias NA, Rosli K, Alias H, Juhari MA, Abu-Bakar MF, Md-Isa N, et al.

Sci Rep, 2021 Dec 08;11(1):23661.
PMID: 34880337 DOI: 10.1038/s41598-021-03028-x

Rafflesia is a unique plant species existing as a single flower and produces the largest flower in the world. While Rafflesia buds take up to 21 months to develop, its flowers bloom and wither within about a week. In this study, transcriptome analysis was carried out to shed light on the molecular mechanism of senescence in Rafflesia. A total of 53.3 million high quality reads were obtained from two Rafflesia cantleyi flower developmental stages and assembled to generate 64,152 unigenes. Analysis of this dataset showed that 5,166 unigenes were differentially expressed, in which 1,073 unigenes were identified as genes involved in flower senescence. Results revealed that as the flowers progress to senescence, more genes related to flower senescence were significantly over-represented compared to those related to plant growth and development. Senescence of the R. cantleyi flower activates senescence-associated genes in the transcription activity (members of the transcription factor families MYB, bHLH, NAC, and WRKY), nutrient remobilization (autophagy-related protein and transporter genes), and redox regulation (CATALASE). Most of the senescence-related genes were found to be differentially regulated, perhaps for the fine-tuning of various responses in the senescing R. cantleyi flower. Additionally, pathway analysis showed the activation of genes such as ETHYLENE RECEPTOR, ETHYLENE-INSENSITIVE 2, ETHYLENE-INSENSITIVE 3, and ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR, indicating the possible involvement of the ethylene hormone response pathway in the regulation of R. cantleyi senescence. Our results provide a model of the molecular mechanism underlying R. cantleyi flower senescence, and contribute essential information towards further understanding the biology of the Rafflesiaceae family.
Fulltext A systematic review of the outcomes of osteoporotic fracture patients after hospital discharge: morbidity, subsequent fractures, and mortality

Nazrun AS, Tzar MN, Mokhtar SA, Mohamed IN

Ther Clin Risk Manag, 2014;10:937-48.
PMID: 25429224 DOI: 10.2147/TCRM.S72456

PURPOSE:
Osteoporotic fracture is the main complication of osteoporosis. The current management is to discharge patients as early as possible so they can get back to their daily activities. Once discharged, there are three main issues relating to morbidity, mortality, and risk of a subsequent fracture that need to be addressed and discussed. Therefore, the aim of this systematic review was to summarize and evaluate the evidence from published literature, to determine the outcome of osteoporotic fracture patients after their hospital discharge.

METHODS:
The MEDLINE and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases were searched, using the terms "osteoporosis", "fracture", "osteoporotic fracture", "hip fracture", and "vertebral fracture". We included only human studies published in English between 2004 and 2014. The reference lists of included studies were thoroughly reviewed in search for other relevant studies.

RESULTS:
A total of 18 studies met the selection criteria. Most were observational and cohort studies. Out of all the studies, five studies looked into the morbidity, six studies looked into the risk of subsequent fractures, and seven studies looked into mortality. Vertebral fracture caused the greatest health burden, but hip fracture patients were the main users of informal care after hospital discharge. There was an increased risk of a subsequent fracture after a primary fracture compared with the control group, a cohort comparison, or the general population. Osteoporotic fractures, especially hip fractures, are associated with higher mortality rate despite the advances in the management of osteoporotic fracture cases.

CONCLUSION:
There is strong evidence to show that after hospital discharge, osteoporotic fracture patients are faced with higher morbidity, subsequent fractures, and mortality.

KEYWORDS:
hip fracture; osteoporosis; vertebral fracture
Dioxin-like polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans in seafood samples from Malaysia: estimated human intake and associated risks

Leong YH, Gan CY, Majid MI

Arch Environ Contam Toxicol, 2014 Jul;67(1):21-8.
PMID: 24651928 DOI: 10.1007/s00244-014-0019-5

A total of 127 and 177 seafood samples from Malaysia were analyzed for polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs), respectively. The World Health Organization-toxic-equivalency quotients (WHO-TEQ) of PCDD/Fs varied from 0.13 to 1.03 pg TEQ g(-1), whereas dl-PCBs ranged from 0.33 to 1.32 pg TEQ g(-1). Based on food-consumption data from the global environment monitoring system-food contamination monitoring and assessment programme, calculated dietary exposures to PCDD/Fs and dl-PCBs from seafood for the general population in Malaysia were 0.042 and 0.098 pg TEQ kg(-1) body weight day(-1), respectively. These estimations were quite different from the values calculated using the Malaysian food-consumption statistics (average of 0.313 and 0.676 pg TEQ kg(-1) body weight day(-1) for PCDD/Fs and PCBs, respectively). However, both of the dietary exposure estimations were lower than the tolerable daily intake recommended by WHO. Thus, it is suggested that seafood from Malaysia does not pose a notable risk to the health of the average consumer.
Reliability and validity of television food advertising questionnaire in Malaysia

Zalma AR, Safiah MY, Ajau D, Khairil Anuar MI

Health Promot Int, 2015 Sep;30(3):523-30.
PMID: 24150531 DOI: 10.1093/heapro/dat072

Interventions to counter the influence of television food advertising amongst children are important. Thus, reliable and valid instrument to assess its effect is needed. The objective of this study was to determine the reliability and validity of such a questionnaire. The questionnaire was administered twice on 32 primary schoolchildren aged 10-11 years in Selangor, Malaysia. The interval between the first and second administration was 2 weeks. Test-retest method was used to examine the reliability of the questionnaire. Intra-rater reliability was determined by kappa coefficient and internal consistency by Cronbach's alpha coefficient. Construct validity was evaluated using factor analysis. The test-retest correlation showed moderate-to-high reliability for all scores (r = 0.40*, p = 0.02 to r = 0.95**, p = 0.00), with one exception, consumption of fast foods (r = 0.24, p = 0.20). Kappa coefficient showed acceptable-to-strong intra-rater reliability (K = 0.40-0.92), except for two items under knowledge on television food advertising (K = 0.26 and K = 0.21) and one item under preference for healthier foods (K = 0.33). Cronbach's alpha coefficient indicated acceptable internal consistency for all scores (0.45-0.60). After deleting two items under Consumption of Commonly Advertised Food, the items showed moderate-to-high loading (0.52, 0.84, 0.42 and 0.42) with the Scree plot showing that there was only one factor. The Kaiser-Meyer-Olkin was 0.60, showing that the sample was adequate for factor analysis. The questionnaire on television food advertising is reliable and valid to assess the effect of media literacy education on television food advertising on schoolchildren.
Fulltext Challenges in imaging and histopathological assessment of a giant cell tumour with secondary aneurysmal cyst in the patella

Low SF, Hanafiah M, Nurismah MI, Suraya A

BMJ Case Rep, 2013;2013.
PMID: 24057334 DOI: 10.1136/bcr-2013-200790

The patella is an uncommon site for all primary and metastatic bone tumours and primary intra-osseous tumours of the patella are very rare. A majority of the patella tumours are benign. We report a patient with a sudden onset swelling and pain of the right knee following a staircase fall. The plain radiograph showed an expansile multiseptated patella lesion and it was further assessed with an MRI. The radiological findings and the initial histopathological features from a limited sample were suggestive of a primary aneurysmal bone cyst. However, the final histopathological diagnosis from a more adequate specimen was a giant cell tumour with a secondary aneurysmal bone cyst.
Intention of pregnant women to exclusively breastfeed their infants: The role of beliefs in the theory of planned behaviour

Ismail TA, Muda WM, Bakar MI

J Child Health Care, 2014 Jun;18(2):123-32.
PMID: 23728933 DOI: 10.1177/1367493512473857

This study was aimed at identifying behavioural, normative and control belief influencing intention to practise exclusive breastfeeding among pregnant women in Malaysia. An interviewer-guided questionnaire assessing behavioural, normative and control belief was developed based on the findings elicited from focus group discussions. Intention referred to the respondent's intended duration of exclusive breastfeeding, which was measured in weeks. Bivariate correlational analysis, linear regression analysis and independent t test comparing intenders and non-intenders were conducted to identify the composite belief measures and individual beliefs significantly influencing intention. Composite measures of all the beliefs were significantly correlated with intention, but injunctive normative belief and behavioural belief were the only significant factors identified from linear regression analysis. The respondents agreed to comply with four referents of their mother, husband, nurses and mother-in-law. Non-intenders believed that those referents would oppose them practising exclusive breastfeeding for six months. The behavioural belief concerning difficulty to leave the infant significantly differentiated intenders from non-intenders. Exclusive breastfeeding promotion should include the woman's mother, husband and mother-in-law. Nurses should provide accurate and complete information related to breastfeeding practise. Providing support for women to continue the practise even though separated from their infants may improve their intention and practise of exclusive breastfeeding.
Fulltext Assessment of muscle fatigue associated with prolonged standing in the workplace

Halim I, Omar AR, Saman AM, Othman I

Saf Health Work, 2012 Mar;3(1):31-42.
PMID: 22953228 DOI: 10.5491/SHAW.2012.3.1.31

The objectives of this study were to determine the psychological fatigue and analyze muscle activity of production workers who are performing processes jobs while standing for prolonged time periods.
Fulltext Primary clear cell carcinoma of minor salivary gland of the soft palate: a case report

Saleh KA, Nurishmah MI, Firouzeh GN, Goh BS

Med J Malaysia, 2012 Jun;67(3):335-6.
PMID: 23082431 MyJurnal

Clear cells can be found in numerous salivary and non-salivary tumors in the head and neck region, including metastatic lesions. They are rare low-grade tumors accounting for less than 1% of all salivary gland tumors and occur almost exclusively in the intra-oral minor salivary glands. Hyalinizing clear cell carcinoma (HCCC) is an extremely rare and recently described neoplasm predominantly affecting the oral cavity. Histologically, it is characterized by nests of glycogen-rich monomorphic clear cells within a hyaline stroma. HCCC often follows an indolent course with a limited metastatic potential. It is therefore important to differentiate this entity from other more aggressive clear cell tumors including metastatic tumors such as renal cell carcinoma. We hereby report a case of HCCC localized in minor salivary glands specifically in soft palate for its rarity, as well as to discuss the role of immunohistochemical stains, essential for its definitive diagnosis.

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