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Fulltext The frequency of pulmonary hypertension in newborn with intrauterine growth restriction

Abbas G, Shah S, Hanif M, Shah A, Rehman AU, Tahir S, et al.

Sci Rep, 2020 05 15;10(1):8064.
PMID: 32415157 DOI: 10.1038/s41598-020-65065-2

Intrauterine growth restriction (IUGR) is a clinical definition applied to neonates born with clinical features of malnutrition and in-utero growth retardation irrespective of their birth weight percentile. This study was aimed to determine the frequency of pulmonary hypertension (PH) in neonates with IUGR. In this descriptive cross-sectional study, we followed 96 neonates with IUGR (≤28 days) and 38 neonates without IUGR born in the department of the neonatal intensive care unit children hospital complex Multan, Pakistan. We analyzed certain factors such as gender, gestational age (GA) (weeks), birth weight (BW in kg), weight percentile (WP) for GA, meconium aspiration syndrome (MAS), birth asphyxia (BA) and respiratory distress syndrome (RDS) for pulmonary hypertension (PH) in IUGR and non-IUGR group. GA was measured by the Ballard scoring system. Echocardiography was performed for all patients by the pediatric cardiologist to measure pulmonary arterial (PA) pressure using Bernoulli's equation. Out of total 96 IUGR neonates, 33.3% (n = 32) suffered from PH, of which 65.3% (n = 18) were male and 43.7% (n = 14) were female. The percentages of IUGR neonates with BA, MAS and RDS were 34.4%, 18.8% and 22.9% respectively. The data were analyzed using the SPSS-16 software to test the statistical significance of the results. A p-value less than 0.05 was considered significant. When the chi-square test was applied, it depicted that MAS was significantly associated with PH in IUGR neonates (p = 0.0001) compared to non-IUGR neonates. Our findings suggested an increased chance of PH in IUGR neonates and MAS may be a strong factor.
Fulltext Genome-wide identification of Aedes albopictus long noncoding RNAs and their association with dengue and Zika virus infection

Azlan A, Obeidat SM, Theva Das K, Yunus MA, Azzam G

PLoS Negl Trop Dis, 2021 01;15(1):e0008351.
PMID: 33481791 DOI: 10.1371/journal.pntd.0008351

The Asian tiger mosquito, Aedes albopictus (Ae. albopictus), is an important vector that transmits arboviruses such as dengue (DENV), Zika (ZIKV) and Chikungunya virus (CHIKV). Long noncoding RNAs (lncRNAs) are known to regulate various biological processes. Knowledge on Ae. albopictus lncRNAs and their functional role in virus-host interactions are still limited. Here, we identified and characterized the lncRNAs in the genome of an arbovirus vector, Ae. albopictus, and evaluated their potential involvement in DENV and ZIKV infection. We used 148 public datasets, and identified a total of 10, 867 novel lncRNA transcripts, of which 5,809, 4,139, and 919 were intergenic, intronic and antisense respectively. The Ae. albopictus lncRNAs shared many characteristics with other species such as short length, low GC content, and low sequence conservation. RNA-sequencing of Ae. albopictus cells infected with DENV and ZIKV showed that the expression of lncRNAs was altered upon virus infection. Target prediction analysis revealed that Ae. albopictus lncRNAs may regulate the expression of genes involved in immunity and other metabolic and cellular processes. To verify the role of lncRNAs in virus infection, we generated mutations in lncRNA loci using CRISPR-Cas9, and discovered that two lncRNA loci mutations, namely XLOC_029733 (novel lncRNA transcript id: lncRNA_27639.2) and LOC115270134 (known lncRNA transcript id: XR_003899061.1) resulted in enhancement of DENV and ZIKV replication. The results presented here provide an important foundation for future studies of lncRNAs and their relationship with virus infection in Ae. albopictus.
Fulltext Characteristics of COVID-19 epidemic and control measures to curb transmission in Malaysia

Ng CFS, Seposo XT, Moi ML, Tajudin MABA, Madaniyazi L, Sahani M

Int J Infect Dis, 2020 Dec;101:409-411.
PMID: 33075527 DOI: 10.1016/j.ijid.2020.10.027

The first wave of COVID-19 epidemic began in late January in Malaysia and ended with a very small final size. The second wave of infections broke out in late February and grew rapidly in the first 3 weeks. Authorities in the country responded quickly with a series of control strategies collectively known as the Movement Control Order (MCO) with different levels of intensity matching the progression of the epidemic. We examined the characteristics of the second wave and discussed the key control strategies implemented in the country. In the second wave, the epidemic doubled in size every 3.8 days (95% confidence interval [CI]: 3.3, 4.5) in the first month and decayed slowly after that with a halving time of approximately 3 weeks. The time-varying reproduction number Rt peaked at 3.1 (95% credible interval: 2.7, 3.5) in the 3rd week, declined sharply thereafter and stayed below 1 in the last 3 weeks of April, indicating low transmissibility approximately 3 weeks after the MCO. Experience of the country suggests that adaptive triggering of distancing policies combined with a population-wide movement control measure can be effective in suppressing transmission and preventing a rebound.
Fulltext Protective efficacy of inactivated Newcastle disease virus vaccines prepared in two different oil-based adjuvants

Aljumaili OA, Bello MB, Yeap SK, Omar AR, Ideris A

Onderstepoort J Vet Res, 2020 Sep 28;87(1):e1-e7.
PMID: 33054260 DOI: 10.4102/ojvr.v87i1.1865

Despite the availability of Newcastle disease (ND) vaccines for more than six decades, disease outbreaks continue to occur with huge economic consequences to the global poultry industry. The aim of this study is to develop a safe and effective inactivated vaccine based on a recently isolated Newcastle disease virus (NDV) strain IBS025/13 and evaluate its protective efficacy in chicken following challenge with a highly virulent genotype VII isolate. Firstly, high titre of IBS025/13 was exposed to various concentrations of binary ethylenimine (BEI) to determine the optimal conditions for complete inactivation of the virus. The inactivated virus was then prepared in form of a stable water-in-oil emulsion of black seed oil (BSO) or Freund's incomplete adjuvant (FIA) and used as vaccines in specific pathogen-free chicken. Efficacy of various vaccine preparations was also evaluated based on the ability of the vaccine to protect against clinical disease, mortality and virus shedding following challenge with highly virulent genotype\VII NDV isolate. The results indicate that exposure of NDV IBS025/13 to 10 mM of BEI for 21 h at 37 °C could completely inactivate the virus without tempering with the structural integrity of the viral hemagglutin-neuraminidase protein. More so, the inactivated vaccines adjuvanted with either BSO- or FIA-induced high hemagglutination inhibition antibody titre that protected the vaccinated birds against clinical disease and in some cases virus shedding, especially when used together with live attenuated vaccines. Thus, genotype VII-based NDV-inactivated vaccines formulated in BSO could substantially improve poultry disease control particularly when combined with live attenuated vaccines.
Telomerase reverse transcriptase downregulation by RNA interference modulates endoplasmic reticulum stress and mitochondrial energy production

Mohd Zain MZ, Ismail NH, Ahmad N, Sulong S, Karsani SA, Abdul Majid N

Mol Biol Rep, 2020 Oct;47(10):7735-7743.
PMID: 32959195 DOI: 10.1007/s11033-020-05848-y

Telomerase is a cancer promoting ribonucleoprotein complex and is a potential therapeutic target for cancer. In this study, the effects of telomerase downregulation on the whole cell proteome were investigated. Understanding how the effect of downregulation on the whole proteome profile will generate a greater understanding of the possible roles played by telomerase in cancer. Downregulation was achieved by RNA interference (RNAi), targeting the telomerase reverse transcriptase (TERT) subunits of telomerase. Transfection of TERT siRNA downregulates TERT gene expression and induced downregulation of telomerase activity. Investigation of the effect of silencing TERT in telomerase was further validated through proteomic analysis by performing 2-dimension electrophoresis (2DE) coupled with MALDI-TOF/TOF. 12 protein spots in HeLa cells were reported to be significantly differentially expressed with 11 of them were upregulated and 1 downregulated. Through STRING analysis, differentially expressed proteins demonstrated strong associations with endoplasmic reticulum stress marker and mitochondrial energy production marker. In conclusions, the result exhibited novel integrated proteomic response involving endoplasmic reticulum stress and mitochondrial energy production in response to the TERT downregulation in cervical cancer cells.
Fulltext Is There an Interconnection between Epithelial-Mesenchymal Transition (EMT) and Telomere Shortening in Aging?

Imran SAM, Yazid MD, Idrus RBH, Maarof M, Nordin A, Razali RA, et al.

Int J Mol Sci, 2021 Apr 09;22(8).
PMID: 33918710 DOI: 10.3390/ijms22083888

Epithelial-Mesenchymal Transition (EMT) was first discovered during the transition of cells from the primitive streak during embryogenesis in chicks. It was later discovered that EMT holds greater potential in areas other than the early development of cells and tissues since it also plays a vital role in wound healing and cancer development. EMT can be classified into three types based on physiological functions. EMT type 3, which involves neoplastic development and metastasis, has been the most thoroughly explored. As EMT is often found in cancer stem cells, most research has focused on its association with other factors involving cancer progression, including telomeres. However, as telomeres are also mainly involved in aging, any possible interaction between the two would be worth noting, especially as telomere dysfunction also contributes to cancer and other age-related diseases. Ascertaining the balance between degeneration and cancer development is crucial in cell biology, in which telomeres function as a key regulator between the two extremes. The essential roles that EMT and telomere protection have in aging reveal a potential mutual interaction that has not yet been explored, and which could be used in disease therapy. In this review, the known functions of EMT and telomeres in aging are discussed and their potential interaction in age-related diseases is highlighted.
Fulltext New data on Thelohanellus nikolskii Achmerov, 1955 (Myxosporea, Myxobolidae) a parasite of the common carp (Cyprinus carpio, L.): The actinospore stage, intrapiscine tissue preference and molecular sequence

Borzák R, Borkhanuddin MH, Cech G, Molnár K, Hallett SL, Székely C

Int J Parasitol Parasites Wildl, 2021 Aug;15:112-119.
PMID: 33996443 DOI: 10.1016/j.ijppaw.2021.04.004

Thelohanellus nikolskii, Achmerov, 1955 is a well-known myxozoan parasite of the common carp (Cyprinus carpio L.). Infection regularly manifests in numerous macroscopic cysts on the fins of two to three month-old pond-cultured carp fingerlings in July and August. However, a Thelohanellus infection is also common on the scales of two to three year-old common carp in ponds and natural waters in May and June. Based on myxospore morphology and tissue specificity, infection at both sites seems to be caused by the same species, namely T. nikolskii. This presumption was tested with molecular biological methods: SSU rDNA sequences of myxospores from fins of fingerlings and scales of older common carp were analysed and compared with each other and with related species available in GenBank. Sequence data revealed that the spores from the fins and scales represent the same species, T. nikolskii. Our study revealed a dichotomy in both infection site and time in T. nikolskii-infections: the fins of young carp are infected in Summer and Autumn, whereas the scales of older carp are infected in Spring. Myxosporean development of the species is well studied, little is known, however about the actinosporean stage of T. nikolskii. A previous experimental study suggests that aurantiactinomyxon actinospores of this species develop in Tubifex tubifex, Müller, 1774. The description included spore morphology but no genetic sequence data (Székely et al., 1998). We examined >9000 oligochaetes from Lake Balaton and Kis-Balaton Water Reservoire searching for the intraoligochaete developmental stage of myxozoans. Five oligochaete species were examined, Isochaetides michaelseni Lastochin, 1936, Branchiura sowerbyi Beddard, 1892, Nais sp., Müller, 1774, Dero sp. Müller, 1774 and Aelosoma sp. Ehrenberg, 1828. Morphometrics and SSU rDNA sequences were obtained for the released actinospores. Among them, from a single Nais sp., the sequence of an aurantiactinomyxon isolate corresponded to the myxospore sequences of T. nikolskii.
Fulltext Use of complementary and alternative therapies for the treatment of dysmenorrhea among undergraduate pharmacy students in Malaysia: a cross sectional study

Abubakar U, Zulkarnain AI, Samri F, Hisham SR, Alias A, Ishak M, et al.

BMC Complement Med Ther, 2020 Sep 18;20(1):285.
PMID: 32948163 DOI: 10.1186/s12906-020-03082-4

BACKGROUND: Dysmenorrhea is a common problem that affects female students' quality of life and academic activities. Complementary and alternative therapies (CATs) are used for the treatment of dysmenorrhea. This study investigated the practices and perceptions of female undergraduate students with dysmenorrhea towards CATs.
METHODS: This was a cross-sectional study conducted among undergraduate pharmacy students in a public university in Malaysia using a validated and pre-tested self-administered questionnaire. The study was conducted in November and December 2019. The data was analysed using descriptive and inferential statistical tests.
RESULTS: Of the 318 female undergraduate students invited, 219 completed the questionnaire (response rate: 68.9%) with 52% aged between 21 and 23 years. The prevalence of dysmenorrhea was 72.1%, and the prevalence of ever-use and current use of CATs was 70.3 and 54.4%, respectively. Bed rest (71.5%), hot compress/heating pad (47.5%) and massage (43.0%) were the most common CATs used by the respondents. The most common reasons for using CAT were to reduce the need for analgesics (61.4%), efficacy (37.3%) and recommendation by others (32.9%). About 23 and 9% of the respondents believed that CATs were equally "effective" and "more effective" than analgesics, respectively. Reducing the need for analgesics (AOR: 4.066, 95% CI: 2.136-7.739) and those who agreed that CATs are effective (AOR: 2.701, 95% CI: 1.337-5.457) were independently associated with the current use CATs for the treatment of menstrual pain.
CONCLUSION: The prevalence of ever-use and current use of CATs is high among female undergraduate pharmacy students. Bed rest and heat applications are the most common CATs used. Reducing the need for analgesics and efficacy are the factors associated with the current use of CATs. Students should be educated about the safe and effective use of CATs to reduce adverse effects and improve their quality of life.
Synthesis of high 4-hydroxybutyrate copolymer by Cupriavidus sp. transformants using one-stage cultivation and mixed precursor substrates strategy

Syafiq IM, Huong KH, Shantini K, Vigneswari S, Aziz NA, Amirul AA, et al.

Enzyme Microb Technol, 2017 Mar;98:1-8.
PMID: 28110659 DOI: 10.1016/j.enzmictec.2016.11.011

Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] copolymer is noted for its high biocompatibility, which makes it an excellent candidate for biopharmaceutical applications. The wild-type Cupriavidus sp. USMAA1020 strain is able to synthesize P(3HB-co-4HB) copolymers with different 4HB monomer compositions (up to 70mol%) in shaken flask cultures. Combinations of 4HB carbon precursors consisting of 1,6-hexanediol and γ-butyrolactone were applied for the production of P(3HB-co-4HB) with different 4HB molar fraction. A sharp increase in 4HB monomer composition was attained by introducing additional copies of PHA synthase gene (phaC), responsible for P(3HB-co-4HB) polymerization. The phaC of Cupriavidus sp. USMAA1020 and Cupriavidus sp. USMAA2-4 were cloned and heterologously introduced into host, wild-type Cupriavidus sp. USMAA1020. The gene dosage treatment resulted in the accumulation of 93mol% 4HB by the transformant strains when grown in similar conditions as the wild-type USMAA1020. The PHA synthase activities for both transformants were almost two-fold higher than the wild-type. The ability of the transformants to produce copolymers with high 4HB monomer composition was also tested in large scale production system using 5L and 30L bioreactors with a constant oxygen mass transfer rate. The 4HB monomer composition could be maintained at a range of 83-89mol%. The mechanical and thermal properties of copolymers improved with increasing 4HB monomer composition. The copolymers produced could be tailored for specific biopharmaceutical applications based on their properties.
Fulltext Environmental hazard assessment of industrial and municipal waste materials with the applications of RES2-D method and 3-D Oasis Montaj modeling: A case study at Kepong, Kuala Lumpur, Peninsula Malaysia

Arifin MH, Kayode JS, Ismail MKI, Abdullah AM, Embrandiri A, Nazer NSM, et al.

J Hazard Mater, 2021 03 15;406:124282.
PMID: 33199149 DOI: 10.1016/j.jhazmat.2020.124282

Environmental hazards, industrial, and municipal wastes geochemical and geophysical assessments were carried out at an industrial waste disposal (IWD) site at Bukit Kepong, Kuala Lumpur, Malaysia. RES2-D geophysical method was applied, capable of identification and quantification of the industrial wastes; buried hazardous materials (BHM) and their effects on the subsurface stratum, from the moderately saturated zones, to fully saturated zones housing the aquifer units underneath the water table. Six RES2-D survey profiles were respectively acquired along E-W, and N-S directions. The perpendicular arrangement of the RES2-D survey lines, was tenaciously designed to make possible, the industrial waste materials (IWM)and municipal solid waste (MSW) quantification, with sufficient length of survey lines set at 200 m, and electrode spacing of 5 m, to cover as much details segments of the IWM and MSW as possible. The six RES2-D inversion results, helped in the subsurface stratum classification into three layers, namely; soft layers, which encompasses the waste materials, with varied resistivity values i.e., 0-100 Ω-m, at 10-15 m depths. The consolidated layers produced varied resistivity values i.e., 101-400 Ω-m, at 15-20 m depths. The bedrock has the highest resistivity values i.e., 401-2000 Ω-m, at depths > 20 m. The estimated volume of the waste materials was 312,000 m 3, using 3-D Oasis Montaj modeling via rectangular prism model generated from the inverted RES2-D. Results from the geochemical analysis helped in the validation of the site as a potential contaminated zone with severe health effects.
Fulltext The Inter-Relation of Corporate Social Responsibility at Employee Level, Servant Leadership, and Innovative Work Behavior in the Time of Crisis from the Healthcare Sector of Pakistan

Ahmad N, Scholz M, Arshad MZ, Jafri SKA, Sabir RI, Khan WA, et al.

Int J Environ Res Public Health, 2021 04 27;18(9).
PMID: 33925322 DOI: 10.3390/ijerph18094608

Organizational crisis can serve as a base to provide an opportunity to an organization for enhancing individuals, organizations, and communities. The healthcare sector is one of those sectors that remains under continuous pressure to provide high-quality service delivery to the patients. Hence, the requirement of innovation for this sector is huge when compared to other sectors. The majority of the previous studies have investigated the phenomenon of CSR at the employee's level (CSR-E) to influence employee behavior positively. However, the importance of CSR-E to enhance the innovative capability of the employees at the workplace is not well-explored in extant literature. Moreover, it is not clear from previous studies how the concept of servant leadership can explain the employee's engagement towards innovative work behavior (EIB). Thus, the current survey aims to test the relationship of CSR-E and EIB in the healthcare sector of Pakistan with the mediating effect of servant leadership. The data of the current study were obtained through a self-administered (paper-pencil) survey and they were analyzed through the structural equation modeling (SEM) technique. The empirical results of SEM analysis revealed that CSR-E and EIB are positively related and servant leadership partially mediates this relationship. The findings of the current study will be helpful for policymakers to improve their understanding towards CSR-E to induce EIB in the time of crisis. At the same time, the current study also highlights the importance of servant leadership to the policymakers in encouraging the employees to display their innovative capability at the workplace to serve their organization during the time of crisis.
Fulltext Association of Physicochemical Characteristics, Aggregate Indices, Major Ions, and Trace Elements in Developing Groundwater Quality Index (GWQI) in Agricultural Area

Harun HH, Kasim MRM, Nurhidayu S, Ash'aari ZH, Kusin FM, Karim MKA

Int J Environ Res Public Health, 2021 04 25;18(9).
PMID: 33923119 DOI: 10.3390/ijerph18094562

The aim of this study was to propose a groundwater quality index (GWQI) that presents water quality data as a single number and represents the water quality level. The development of the GWQI in agricultural areas is vital as the groundwater considered as an alternative water source for domestic purposes. The insufficiency of the groundwater quality standard in Malaysia revealed the importance of the GWQI development in determining the quality of groundwater. Groundwater samples were collected from thirteen groundwater wells in the Northern Kuala Langat and the Southern Kuala Langat regions from February 2018 to January 2019. Thirty-four parameters that embodied physicochemical characteristics, aggregate indicator, major ions, and trace elements were considered in the development of the GWQI. Multivariate analysis has been used to finalize the important parameters by using principal component analysis (PCA). Notably, seven parameters-electrical conductivity, chemical oxygen demand (COD), magnesium, calcium, potassium, sodium, and chloride were chosen to evaluate the quality of groundwater. The GWQI was then verified by comparing the groundwater quality in Kota Bharu, Kelantan. A sensitivity analysis was performed on this index to verify its reliability. The sensitivity GWQI has been analyzed and showed high sensitivity to any changes of the pollutant parameters. The development of GWQI should be beneficial to the public, practitioners, and industries. From another angle, this index can help to detect any form of pollution which ultimately could be minimized by controlling the sources of pollutants.
Knowledge and Perceptions Towards Cardiovascular Disease Prevention Among Patients with Type 2 Diabetes Mellitus: A Review of Current Assessments and Recommendations

Elnaem MH, Elrggal ME, Syed N, Naqvi AA, Hadi MA

Curr Diabetes Rev, 2021;17(4):503-511.
PMID: 32928091 DOI: 10.2174/1573399816666200914140939

INTRODUCTION: Patients with type 2 diabetes mellitus (T2DM) are at significantly higher risk of developing cardiovascular diseases (CVD). There is a scarcity of literature reviews that describe and summarize T2DM patients' knowledge and perception about CVD prevention.
OBJECTIVES: To describe and summarize the assessment of knowledge and perceptions about CVD risk and preventive approaches among patients with T2DM.
METHODS: A scoping review methodology was adopted, and three scientific databases, Google Scholar, Science Direct, and PubMed were searched using predefined search terms. A multistage screening process that considered relevancy, publication year (2009-2019), English language, and article type (original research) was followed. We formulated research questions focused on the assessment of levels of knowledge and perceptions of the illness relevant to CVD prevention and the identification of associated patients' characteristics.
RESULTS: A total of 16 studies were included. Patients were not confident to identify CVD risk and other clinical consequences that may occur in the prognostic pathway of T2DM. Furthermore, patients were less likely to identify all CV risk factors indicating a lack of understanding of the multi-- factorial contribution of CVD risk. Patients' beliefs about medications were correlated with their level of adherence to medications for CVD prevention. Many knowledge gaps were identified, including the basic disease expectations at the time of diagnosis, identification of individuals' CVD risk factors, and management aspects. Knowledge and perceptions were affected by patients' demographic characteristics, e.g., educational level, race, age, and area of residence.
CONCLUSION: There are knowledge gaps concerning the understanding of CVD risk among patients with T2DM. The findings necessitate educational initiatives to boost CVD prevention among patients with T2DM. Furthermore, these should be individualized based on patients' characteristics, knowledge gaps, disease duration, and estimated CVD risk.
Fulltext Comparison of Retrospective and Prospective Falls Reporting Among Community-Dwelling Older People: Findings From Two Cohort Studies

Romli MH, Mackenzie L, Tan PJ, Chiew RO, Tan SH, Tan MP

Front Public Health, 2021;9:612663.
PMID: 33777881 DOI: 10.3389/fpubh.2021.612663

Background: While prospective recording is considered as the gold standard, retrospective recall is widely utilized for falls outcomes due to its convenience. This brings about the concern on the validity of falls reporting in Southeast Asian countries, as the reliability of falls recall has not previously been studied. This study aimed to evaluate the reliability of retrospective falls recall compared to prospective falls recording. Methods: A secondary analysis of data from two prospective recording methods, falls diary and falls calendar, from two different research projects were obtained and analyzed. Retrospective falls recall was collected either through phone interview or follow-up clinic by asking the participants if they had fallen in the past 12 months. Results: Two-hundred-sixty-eight and 280 elderly participated in the diary and calendar groups, respectively. Moderate (46%) and poor (11%) return rates were found on completed diary and calendar recording. Under-(32%) and overreporting (24%) of falls were found in diary compared to only 4% of overreporting for the calendar. Retrospective recall method achieved 57% response rate for the diary group (followed up at clinic) and 89% for the calendar group (followed up via telephone interview). Agreement between retrospective and prospective reporting was moderate for the diary (kappa =0.44; p < 0.001) and strong for the calendar (kappa = 0.89; p < 0.001). Conclusion: Retrospective recall is reliable and acceptable in an observation study within healthy community older adults, while the combination of retrospective and prospective falls recording is the best for an intervention study with frailer older population. Telephone interview is convenient, low cost, and yielded a high response rate.
Fulltext Electrocardiogram-Based Emotion Recognition Systems and Their Applications in Healthcare-A Review

Hasnul MA, Aziz NAA, Alelyani S, Mohana M, Aziz AA

Sensors (Basel), 2021 Jul 23;21(15).
PMID: 34372252 DOI: 10.3390/s21155015

Affective computing is a field of study that integrates human affects and emotions with artificial intelligence into systems or devices. A system or device with affective computing is beneficial for the mental health and wellbeing of individuals that are stressed, anguished, or depressed. Emotion recognition systems are an important technology that enables affective computing. Currently, there are a lot of ways to build an emotion recognition system using various techniques and algorithms. This review paper focuses on emotion recognition research that adopted electrocardiograms (ECGs) as a unimodal approach as well as part of a multimodal approach for emotion recognition systems. Critical observations of data collection, pre-processing, feature extraction, feature selection and dimensionality reduction, classification, and validation are conducted. This paper also highlights the architectures with accuracy of above 90%. The available ECG-inclusive affective databases are also reviewed, and a popularity analysis is presented. Additionally, the benefit of emotion recognition systems towards healthcare systems is also reviewed here. Based on the literature reviewed, a thorough discussion on the subject matter and future works is suggested and concluded. The findings presented here are beneficial for prospective researchers to look into the summary of previous works conducted in the field of ECG-based emotion recognition systems, and for identifying gaps in the area, as well as in developing and designing future applications of emotion recognition systems, especially in improving healthcare.
Fulltext LoRa Communications as an Enabler for Internet of Drones towards Large-Scale Livestock Monitoring in Rural Farms

Behjati M, Mohd Noh AB, Alobaidy HAH, Zulkifley MA, Nordin R, Abdullah NF

Sensors (Basel), 2021 Jul 26;21(15).
PMID: 34372281 DOI: 10.3390/s21155044

Currently, smart farming is considered an effective solution to enhance the productivity of farms; thereby, it has recently received broad interest from service providers to offer a wide range of applications, from pest identification to asset monitoring. Although the emergence of digital technologies, such as the Internet of Things (IoT) and low-power wide-area networks (LPWANs), has led to significant advances in the smart farming industry, farming operations still need more efficient solutions. On the other hand, the utilization of unmanned aerial vehicles (UAVs), also known as drones, is growing rapidly across many civil application domains. This paper aims to develop a farm monitoring system that incorporates UAV, LPWAN, and IoT technologies to transform the current farm management approach and aid farmers in obtaining actionable data from their farm operations. In this regard, an IoT-based water quality monitoring system was developed because water is an essential aspect in livestock development. Then, based on the Long-Range Wide-Area Network (LoRaWAN®) technology, a multi-channel LoRaWAN® gateway was developed and integrated into a vertical takeoff and landing drone to convey collected data from the sensors to the cloud for further analysis. In addition, to develop LoRaWAN®-based aerial communication, a series of measurements and simulations were performed under different configurations and scenarios. Finally, to enhance the efficiency of aerial-based data collection, the UAV path planning was optimized. Measurement results showed that the maximum achievable LoRa coverage when operating on-air via the drone is about 10 km, and the Longley-Rice irregular terrain model provides the most suitable path loss model for the scenario of large-scale farms, and a multi-channel gateway with a spreading factor of 12 provides the most reliable communication link at a high drone speed (up to 95 km/h). Simulation results showed that the developed system can overcome the coverage limitation of LoRaWAN® and it can establish a reliable communication link over large-scale wireless sensor networks. In addition, it was shown that by optimizing flight paths, aerial data collection could be performed in a much shorter time than industrial mission planning (up to four times in our case).
Fulltext Mesenchymal Stem Cells: Current Concepts in the Management of Inflammation in Osteoarthritis

Nurul AA, Azlan M, Ahmad Mohd Zain MR, Sebastian AA, Fan YZ, Fauzi MB

Biomedicines, 2021 Jul 07;9(7).
PMID: 34356849 DOI: 10.3390/biomedicines9070785

Osteoarthritis (OA) has traditionally been known as a "wear and tear" disease, which is mainly characterized by the degradation of articular cartilage and changes in the subchondral bone. Despite the fact that OA is often thought of as a degenerative disease, the catabolic products of the cartilage matrix often promote inflammation by activating immune cells. Current OA treatment focuses on symptomatic treatment, with a primary focus on pain management, which does not promote cartilage regeneration or attenuate joint inflammation. Since articular cartilage have no ability to regenerate, thus regeneration of the tissue is one of the key targets of modern treatments for OA. Cell-based therapies are among the new therapeutic strategies for OA. Mesenchymal stem cells (MSCs) have been extensively researched as potential therapeutic agents in cell-based therapy of OA due to their ability to differentiate into chondrocytes and their immunomodulatory properties that can facilitate cartilage repair and regeneration. In this review, we emphasized current knowledge and future perspectives on the use of MSCs by targeting their regeneration potential and immunomodulatory effects in the treatment of OA.
Perspectives of community pharmacists in Pakistan about practice change and implementation of extended pharmacy services: a mixed method study

Hashmi F, Hassali MA, Saleem F, Saeed H, Islam M, Malik UR, et al.

Int J Clin Pharm, 2021 Aug;43(4):1090-1100.
PMID: 33411180 DOI: 10.1007/s11096-020-01221-y

Background Community pharmacists' role in the primary health care, patient-centered services, beyond traditional dispensing services is well established in the developed world. However, this role is not fully established in low-middle-income countries including Pakistan. Objective To explore community pharmacists' perspectives and preparedness about practice change and associated facilitators and barriers to extended services. Setting A study was conducted involving community pharmacists of Lahore, Pakistan. Method Two phased studies were conducted using mixed-method sequential design. The first phase involved qualitative semi-structured face-to-face interviews with the community pharmacists, while the second phase constituted a questionnaire-based cross-sectional study. Main outcome measure Pharmacists' perspectives about extended pharmacy services, facilitators, barriers and preparedness for the practice change. Results For the first phase, pharmacists were purposively sampled and the saturation yielded a final sample size of fifteen pharmacists (N = 15). The thematic content analysis yielded four distinct themes; (1) current practices and familiarity with extended pharmacy services (2) practice gap between Pakistan and the developed countries (3) facilitators and the preparedness, and (4) barriers towards its implementation and provision. The second part was a questionnaire-based cross-sectional phase, where a total of 348 community pharmacists were approached, while only 242 responded, yielding a response rate of 69.5%. The triangulation of qualitative and quantitative data identified several barriers such as; shortage of pharmacists, lack of knowledge and skills, poor collaboration with general practitioners, failure of customers to pay for extended services. Facilitators and preparedness for the provision of extended pharmacy services were; access to patient notes, follow-up, separate counselling areas, accreditation of specific services and sufficient resources. Conclusion This study's findings call for the implementation and enforcement of Punjab Drug Sale Rules 2007 to facilitate the practice change and provision of comprehensive pharmacy services in Punjab, Pakistan. There is a need for additional laws to define community pharmacists' roles, uniform job description, training, new funding model, separate area, and accreditation of extended pharmacy services in Pakistan.
Fulltext Prevalence and Risk Factors of Bovine Fascioliasis in Kelantan, Malaysia: A Cross-Sectional Study

Ahmad-Najib M, Wan-Nor-Amilah WAW, Kin WW, Arizam MF, Noor-Izani NJ

Trop Life Sci Res, 2021 Jun;32(2):1-14.
PMID: 34367511 DOI: 10.21315/tlsr2021.32.2.1

Bovine fascioliasis is an important zoonotic parasitic disease that causes significant economic losses to the livestock industry. The aim of this study was to determine the prevalence and risk factors of bovine fascioliasis in Kelantan. In this cross-sectional study, a total of 308 stool and blood samples of farmed cattle were collected from December 2017 to June 2018. The stool samples were examined microscopically for the presence of Fasciola spp. eggs following a formalin-ether sedimentation process. The blood samples were subjected to a commercial ELISA kit (Bio-X-Diagnostic, Rochefort, Belgium) for the detection of anti-Fasciola IgG antibody. The association between coprological findings and risk factors was determined using Pearson's chi-square (χ2). The coproprevalence and seroprevalence of bovine fascioliasis was 14.6% and 37.3%, respectively. There were significant (P < 0.05) associations between the risk of infections and the sex, type of feedings, anthelmintic treatment and farm hygiene. Female cattle (OR: 3.104; 95% CI: 1.265, 7.615), feeding by grazing (OR: 4.458; 95% CI: 1.823, 10.90), untreated cattle (OR: 3.833; 95% CI: 1.620, 9.071), non-schedule anthelminthic treatment (OR: 3.927; 95% CI: 1.685, 9.152) and farm that have never been cleaned (OR: 2.829; 95% CI: 1.428, 5.608) showed higher odds of Fasciola spp. infection. These findings suggested bovine fascioliasis is a serious veterinary disease in Kelantan. Thus, appropriate control, prevention and monitoring strategies of this parasitic infection are urgently needed to reduce the burden of the disease.
Fulltext Graphene and Iron Reinforced Polymer Composite Electromagnetic Shielding Applications: A Review

Ayub S, Guan BH, Ahmad F, Oluwatobi YA, Nisa ZU, Javed MF, et al.

Polymers (Basel), 2021 Aug 03;13(15).
PMID: 34372183 DOI: 10.3390/polym13152580

With advancements in the automated industry, electromagnetic inferences (EMI) have been increasing over time, causing major distress among the end-users and affecting electronic appliances. The issue is not new and major work has been done, but unfortunately, the issue has not been fully eliminated. Therefore, this review intends to evaluate the previous carried-out studies on electromagnetic shielding materials with the combination of Graphene@Iron, Graphene@Polymer, Iron@Polymer and Graphene@Iron@Polymer composites in X-band frequency range and above to deal with EMI. VOSviewer was also used to perform the keyword analysis which shows how the studies are interconnected. Based on the carried-out review it was observed that the most preferable materials to deal with EMI are polymer-based composites which showed remarkable results. It is because the polymers are flexible and provide better bonding with other materials. Polydimethylsiloxane (PDMS), polyaniline (PANI), polymethyl methacrylate (PMMA) and polyvinylidene fluoride (PVDF) are effective in the X-band frequency range, and PDMS, epoxy, PVDF and PANI provide good shielding effectiveness above the X-band frequency range. However, still, many new combinations need to be examined as mostly the shielding effectiveness was achieved within the X-band frequency range where much work is required in the higher frequency range.

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