Displaying publications 21 - 40 of 155 in total

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  1. Quantifying myelin in neonates using magnetic resonance imaging: a systematic literature review
    Arshad NH, Abu Hassan H
    Clin Exp Pediatr, 2023 Dec 06.
    PMID: 38062713 DOI: 10.3345/cep.2023.00514
    This review aimed to assess the usefulness of various magnetic resonance imaging (MRI) techniques for the quantification of neonatal white matter myelination. The Scopus, PubMed, and Web of Science databases were searched to identify studies following the PRISMA (preferred reporting items for systematic reviews and meta-analyses) statement using quantitative MRI techniques to examine samples collected from neonates to quantify myelin. Twelve studies were ultimately included. The results demonstrated that in validation studies, relaxometry is the most frequently explored approach (83.33%), followed by magnetization transfer imaging (8.33%) and a new automatic segmentation technique (8.33%). Synthetic MRI is recommended for quantifying myelin in neonates because of several advantages that outweigh a few negligible limitations.
  2. Wrist pain in a 13-year-old gymnast
    Lee YL, Abu Hassan H
    J Paediatr Child Health, 2024 Dec;60(12):891-892.
    PMID: 39470300 DOI: 10.1111/jpc.16714
  3. Hydrogen Gas Sensor Based on Nanocrystalline SnO2 Thin Film Grown on Bare Si Substrates
    Kadhim IH, Hassan HA, Abdullah QN
    Nanomicro Lett, 2016;8(1):20-28.
    PMID: 30464990 DOI: 10.1007/s40820-015-0057-1
    In this paper, high-quality nanocrystalline SnO2 thin film was grown on bare Si (100) substrates by a sol-gel method. A metal-semiconductor-metal gas sensor was fabricated using nanocrystalline SnO2 thin film and palladium (Pd) metal. The contact between Pd and nanocrystalline SnO2 film is tunable. Ohmic barrier contact was formed without addition of glycerin, while Schottky contact formed by adding glycerin. Two kinds of sensor devices with Schottky contact were fabricated (Device 1: 8 h, 500 °C; Device 2: 10 h, 400 °C). The room temperature sensitivity for hydrogen (H2) was 120 and 95 % in 1000 ppm H2, and the low power consumption was 65 and 86 µW for two devices, respectively. At higher temperature of 125 °C, the sensitivity was increased to 195 and 160 %, respectively. The sensing measurements were repeatable at various temperatures (room temperature, 75, 125 °C) for over 50 min. It was found that Device 1 has better sensitivity than Device 2 due to its better crystallinity. These findings indicate that the sensors fabricated on bare Si by adding glycerin to the sol solution have strong ability to detect H2 gas under different concentrations and temperatures.
  4. Catalytic co-pyrolysis of sugarcane bagasse and waste high-density polyethylene over faujasite-type zeolite
    Hassan H, Lim JK, Hameed BH
    Bioresour Technol, 2019 Mar 28;284:406-414.
    PMID: 30965196 DOI: 10.1016/j.biortech.2019.03.137
    This study investigated the catalytic co-pyrolysis of sugarcane bagasse (SCB) and waste high-density polyethylene (HDPE) over faujasite-type zeolite derived from electric arc furnace slag (FAU-EAFS) in a fixed-bed reactor. The effects of reaction temperature, catalyst-to-feedstock ratio, and HDPE-to-SCB ratio on product fractional yields and chemical compositions were discussed. The co-pyrolysis of SCB and HDPE over FAU-EAFS increased the liquid yield and enhanced the quality of bio-oil. The maximum bio-oil (68.56 wt%) and hydrocarbon yield (74.55%) with minimum yield of oxygenated compounds (acid = 0.57% and ester = 0.67%) were achieved under the optimum experimental conditions of catalyst-to-feedstock ratio of 1:6, HDPE-to-SCB ratio of 40:60, and temperature of 500 °C. The oil produced by catalytic co-pyrolysis had higher calorific value than the oil produced by the pyrolysis of SCB alone.
  5. Managing adolescent pregnancy: The unique roles and challenges of private general practitioners in Malaysia
    Malek KA, Abdul-Razak S, Abu Hassan H, Othman S
    Malays Fam Physician, 2019;14(3):37-45.
    PMID: 32175039
    Introduction: Managing adolescent pregnancy in the primary care setting is complex, as it requires doctors to navigate through a combination of medical, social, financial and legal needs. Objective: This study explores the perspectives of private general practitioners on their roles and challenges in managing adolescent pregnancy in Malaysia.

    Methods: Nineteen private general practitioners in Selangor and Kuala Lumpur participated in in-depth interviews in 2015. A topic guide was used for interview navigation. Participants were asked to discuss their experiences and approaches in managing pregnant adolescents. We used purposive sampling to recruit consenting private general practitioners who had experience in managing adolescent pregnancy. The verbatim transcripts of the audio-recorded interviews were analyzed using thematic analysis. Data reached saturation at the nineteenth in-depth interview. Results: Two themes emerged. Under the theme 'inadvertent advocator,' participants described their tasks with regards to building trust, calming angry parents and delivering comprehensive counseling and care related to the sexual and reproductive health of adolescents, including requests for abortions. Theme two, 'challenges of private general practitioners,' refers mainly to personal and religious conflicts arising from a request for an abortion and deficiencies in support and multidisciplinary integration within their practice settings.

    Conclusion: General practitioners practicing in the private sector identify themselves as active players in supporting pregnant adolescents but face many challenges arising from the personal, religious, professional and community levels. Addressing these challenges is important for optimal care delivery to pregnant adolescents in this community.

  6. Recent progress on biomass co-pyrolysis conversion into high-quality bio-oil
    Hassan H, Lim JK, Hameed BH
    Bioresour Technol, 2016 Dec;221:645-655.
    PMID: 27671343 DOI: 10.1016/j.biortech.2016.09.026
    Co-pyrolysis of biomass with abundantly available materials could be an economical method for production of bio-fuels. However, elimination of oxygenated compounds poses a considerable challenge. Catalytic co-pyrolysis is another potential technique for upgrading bio-oils for application as liquid fuels in standard engines. This technique promotes the production of high-quality bio-oil through acid catalyzed reduction of oxygenated compounds and mutagenic polyaromatic hydrocarbons. This work aims to review and summarize research progress on co-pyrolysis and catalytic co-pyrolysis, as well as their benefits on enhancement of bio-oils derived from biomass. This review focuses on the potential of plastic wastes and coal materials as co-feed in co-pyrolysis to produce valuable liquid fuel. This paper also proposes future directions for using this technique to obtain high yields of bio-oils.
  7. Dual-response quadratic model for optimisation of electricity generation and chlorophenol degradation by electro-degradative Bacillus subtilis in microbial fuel cell system
    Hassan H, Jin B, Dai S
    Environ Technol, 2021 Apr 01.
    PMID: 33749543 DOI: 10.1080/09593330.2021.1907451
    The interactions within microbial, chemical and electronic elements in microbial fuel cell (MFC) system can be crucial for its bio-electrochemical activities and overall performance. Therefore, this study explored polynomial models by response surface methodology (RSM) to better understand interactions among anode pH, cathode pH and inoculum size for optimising MFC system for generation of electricity and degradation of 2,4-dichlorophenol. A statistical central composite design by RSM was used to develop the quadratic model designs. The optimised parameters were determined and evaluated by statistical results and the best MFC systematic outcomes in terms of current generation and chlorophenol degradation. Statistical results revealed that the optimum current density of 106 mA/m2 could be achieved at anode pH 7.5, cathode pH 6.3-6.6 and 21-28% for inoculum size. Anode-cathode pHs interaction was found to positively influence the current generation through extracellular electron transfer mechanism. The phenolic degradation was found to have lower response using these three parameter interactions. Only inoculum size-cathode pH interaction appeared to be significant where the optimum predicted phenolic degradation could be attained at pH 7.6 for cathode pH and 29.6% for inoculum size.
  8. Dataset on the influence TPB predictors on environmental responsive behaviour amongst head teachers in the northern region of malaysia
    Uthamaputhran L, Ahmad F, Hassan H, Jaganathan M
    Data Brief, 2021 Apr;35:106815.
    PMID: 33604431 DOI: 10.1016/j.dib.2021.106815
    The study examined the relationship between environmental attitude, environmental subjective norm, environmental perceived behavioural control, and school headteachers' environmental responsive behaviour. The population of the study consists of primary school headteachers in the northern region of Malaysia who are attached to the Ministry of Education (MoE), Malaysia. An online survey was used to collect the data of the study from 167 sampled respondents. While Theory of planned behaviour underpinned the study, the researcher employed explanatory, descriptive, and hypothesis testing quantitative strategies to explain the relationship. Smart PLS 3.0 and SPSS 21 were equally used to analyse the data. The result of the data analysis revealed that environmental attitude, environmental subjective norm, and environmental perceived behavioural control significantly influence school headteachers' environmental responsive behaviour.
  9. 18F-labeled Bisphosphonate as an Alternative Candidate to the Gold Standard[18F]sodium fluoride ([18F]NaF) for PET Bone Imaging
    Hassan H, Othman MF, Razak HRA
    Curr Med Imaging, 2021;17(11):1271-1275.
    PMID: 33593263 DOI: 10.2174/1573405617666210216091202
    Bone metastases are a common source of malignancy in the skeleton and occur much more often than primary bone cancer. Several works were being performed to identify early markers for bone metastasis and novel drug targets to improve patients' quality of life. As some concerns exist with the [18F]sodiumfluoridein positron emission tomography (PET) bone imaging, there has been an increase in the number of targeted radiopharmaceutical markers for bone metastases imaging in its competitor, 68Ga. Since 18F properties are superior to those of 68Ga, there is a distinct motivation for developing 18F radiopharmaceuticals for bone metastases imaging.
  10. Risk mapping of dengue in Selangor and Kuala Lumpur, Malaysia
    Hassan H, Shohaimi S, Hashim NR
    Geospat Health, 2012 Nov;7(1):21-5.
    PMID: 23242677
    Dengue fever is a recurring public health problem afflicting thousands of Malaysians annually. In this paper, the risk map for dengue fever in the peninsular Malaysian states of Selangor and Kuala Lumpur was modelled based on co-kriging and geographical information systems. Using population density and rainfall as the model's only input factors, the area with the highest risk for dengue infection was given as Gombak and Petaling, two districts located on opposite sides of Kuala Lumpur city that was also included in the risk assessment. Comparison of the modelled risk map with the dengue case dataset of 2010, obtained from the Ministry of Health of Malaysia, confirmed that the highest number of cases had been found in an area centred on Kuala Lumpur as predicted our risk profiling.
  11. Fulltext An Incidental Detection of Popliteal Vein Aneurysm during Labeled Leukocyte Scintigraphy
    Hassan HA, Nazri M, Azman RR
    World J Nucl Med, 2012 May;11(2):81-3.
    PMID: 23372443 DOI: 10.4103/1450-1147.103421
    Technetium (99mTc) exametazime (hexamethylpropyleneamine oxime, HMPAO) labeled leukocyte scintigraphy is mainly used to exclude occult infection in our institution. On review of previously published article, no case of popliteal venous aneurysm was ever diagnosed and detected on labeled leukocyte scintigraphy. We present a rare case of popliteal venous aneurysm which was detected on labeled leukocyte scintigraphy and was further confirmed with single-photon emission computed tomography and computed tomography fusion.
  12. Quaternary ultraviolet AlInGaN MQW laser diode performance using quaternary AlInGaN electron blocking layer
    Ghazai AJ, Thahab SM, Abu Hassan H, Hassan Z
    Opt Express, 2011 May 9;19(10):9245-54.
    PMID: 21643179 DOI: 10.1364/OE.19.009245
    The effect of polarization-matched Al(0.25)In(0.08)Ga(0.67)N electron-blocking layer (EBL) on the optical performance of ultraviolet Al(0.08)In(0.08)Ga(0.84)N/Al(0.1)In(0.01)Ga(0.84)N multi-quantum well (MQW) laser diodes (LDs) was investigated. The polarization-matched Al(0.25)In(0.08)Ga(0.67)N electron blocking layer (EBL) was employed in an attempt to reduce the polarization effect inside the active region of the diodes. The device performance which is affected by piezoelectric was studied via drift-diffusion model for carrier transport, optical gain and losses using the simulation program of Integrated System Engineering Technical Computer Aided design (ISE TCAD). The optical performance of the LD using quaternary Al(0.25)In(0.08)Ga(0.67)N EBL was compared with the LD using ternary Al(0.3)Ga(0.7)N EBL where both materials have the same energy band gap of Eg = 3.53 eV. The self-consistent ISE-TCAD simulation program results showed that the polarization-matched quaternary Al(0.25)In(0.08)Ga(0.67)N EBL is beneficial as it confines the electrons inside the quantum well region better than ternary Al(0.3)Ga(0.7)N EBL. The results indicated that the use of Al(0.25)In(0.08)Ga(0.67)N EBL has lower threshold current and higher optical intensity than those for Al(0.3)Ga(0.7)N EBL. The effect of Al(0.25)In(0.08)Ga(0.67)N EBL thickness on the performance of LDs has also been studied. Results at room temperature indicated that lower threshold current, high slope efficiency, high output power, and high differential quantum efficiency DQE occurred when the thickness of Al(0.25)In(0.08)Ga(0.67)N EBL was 0.25 µm.
  13. Emerging potential of hemp and potato milk: nutritional composition, production, and health benefits - a narrative review
    Ahmed Hassan H, Ahmed IA, Tan CH
    Biol Futur, 2026 Oct 30.
    PMID: 42961618 DOI: 10.1007/s42977-026-00347-w
    The expanding global desire for sustainable and nourishing dietary options has increased interest in plant-based milk (PBM). This review explored the nutritional composition, production methods, and health benefits of PBM, with a particular focus on lesser-known and less commercialized types such as hemp and potato milk. These alternatives offer unique nutritional profiles including essential fatty acids, proteins, vitamins, and minerals, making them suitable substitutes for traditional dairy milk. Hemp milk, derived from Cannabis sativa seeds, is rich in omega-3 and omega-6 fatty acids, while potato milk is a low-fat, allergen-friendly option with a high carbohydrate content. Both contribute to nutritional diversity and address concerns like lactose intolerance, dairy allergies, and environmental sustainability. The review also described the production methods for hemp and potato milk, both at the industrial level and in home settings. Additionally, it discussed the current market status of these lesser-known plant-based dairy alternatives.
  14. Phenolic components and assessment of biological properties of Tchihatchewia isatidea Boiss. extracts: Docking and functional approaches for designing novel products
    Zengin G, Abdallah HH, Dogan A, Mollica A, Aumeeruddy-Elalfi Z, Mahomoodally MF
    Food Chem Toxicol, 2018 Jan;111:423-431.
    PMID: 29198858 DOI: 10.1016/j.fct.2017.11.055
    The potentiality of bioactive phenolic compounds may result in plant extracts having multiple biological activities. The aim of this study was to investigate into the biological activities of the methanolic, ethyl acetate, and water extracts of Tchihatchewia isatidea Boiss, an endemic medicinal plant of Turkey. The phenolic compositions of the extracts were confirmed using RP-HPLC. Extracts were screened for their potential antioxidant through a panoply of assays; their anti-diabetic potential, and plausible inhibitory activity against tyrosinase and acetylcholinesterase. Molecular modelling methods were also used to assess the docking properties of phenolic compounds on tyrosinase. The major and most abundant compounds were rosmarinic acid (570 ± 14 μg/g extract in the methanolic extract), ferrulic acid (336 ± 6 μg/g extract in the methanolic extract), (+)-catechin (340 ± 4 μg/g extract in the water extract), apigenin (182 ± 4 μg/g extract in the methanolic extract), and epicatechin (188 ± 12 μg/g extract in the water extract). Radical scavenging, reducing capacity, and metal chelating activities were detected in the extracts, with preponderance activity observed in the methanolic extract. In conclusion, the potential clinical applications observed during this study may provide new insights into the molecular aspect particularly for neuroprotective and anti-diabetic mechanisms involving oxidative stress.
  15. Fulltext Are vanadium complexes druggable against the main protease Mpro of SARS-CoV-2? - A computational approach
    Scior T, Abdallah HH, Mustafa SFZ, Guevara-García JA, Rehder D
    Inorganica Chim Acta, 2021 May 01;519:120287.
    PMID: 33589845 DOI: 10.1016/j.ica.2021.120287
    In silico techniques helped explore the binding capacities of the SARS-CoV-2 main protease (Mpro) for a series of metalloorganic compounds. Along with small size vanadium complexes a vanadium-containing derivative of the peptide-like inhibitor N3 (N-[(5-methylisoxazol-3-yl)carbonyl]alanyl-l-valyl-N1-((1R,2Z)-4-(benzyloxy)-4-oxo-1-{[(3R)-2-oxopyrrolidin-3-yl] methyl }but-2-enyl)-l-leucinamide) was designed from the crystal structure with PDB entry code 6LU7. On theoretical grounds our consensus docking studies evaluated the binding affinities at the hitherto known binding site of Chymotrypsin-like protease (3CLpro) of SARS-CoV-2 for existing and designed vanadium complexes. This main virus protease (Mpro) has a Cys-His dyad at the catalytic site that is characteristic of metal-dependent or metal-inhibited hydrolases. Mpro was compared to the human protein-tyrosine phosphatase 1B (hPTP1B) with a comparable catalytic dyad. HPTP1B is a key regulator at an early stage in the signalling cascade of the insulin hormone for glucose uptake into cells. The vanadium-ligand binding site of hPTP1B is located in a larger groove on the surface of Mpro. Vanadium constitutes a well-known phosphate analogue. Hence, its study offers possibilities to design promising vanadium-containing binders to SARS-CoV-2. Given the favourable physicochemical properties of vanadium nuclei, such organic vanadium complexes could become drugs not only for pharmacotherapy but also diagnostic tools for early infection detection in patients. This work presents the in silico design of a potential lead vanadium compound. It was tested along with 20 other vanadium-containing complexes from the literature in a virtual screening test by docking to inhibit Mpro of SARS-CoV-2.
  16. Fulltext Chemical reaction of soybean flavonoids with DNA: a computational study using the implicit solvent model
    Abdallah HH, Mavri J, Repič M, Lee VS, Wahab HA
    Int J Mol Sci, 2012;13(2):1269-83.
    PMID: 22408390 DOI: 10.3390/ijms13021269
    Genistein, daidzein, glycitein and quercetin are flavonoids present in soybean and other vegetables in high amounts. These flavonoids can be metabolically converted to more active forms, which may react with guanine in the DNA to form complexes and can lead to DNA depurination. We assumed two ultimate carcinogen forms of each of these flavonoids, diol epoxide form and diketone form. Density functional theory (DFT) and Hartree-Fock (HF) methods were used to study the reaction thermodynamics between active forms of flavonoids and DNA guanine. Solvent reaction field method of Tomasi and co-workers and the Langevin dipoles method of Florian and Warshel were used to calculate the hydration free energies. Activation free energy for each reaction was estimated using the linear free energy relation. Our calculations show that diol epoxide forms of flavonoids are more reactive than the corresponding diketone forms and are hence more likely flavonoid ultimate carcinogens. Genistein, daidzein and glycitein show comparable reactivity while quercetin is less reactive toward DNA.
  17. Fulltext Host-Guest Inclusion Complexes between Amlodipine Enantiomers in the Biphasic Recognition Chiral Extraction System using Tartaric Acid and β-Cyclodextrin Derivatives as Positive Confirmation by using their Enantioselective Extraction
    Al Azzam KM, Abdallah HH, Halim HN, Ahmad MA, Shaibah H
    Sci Pharm, 2015 06 22;83(4):683-98.
    PMID: 26839848 DOI: 10.3797/scipharm.1501-15
    The current work reports an extended theoretical study from our previous experimental work for the enantioselective extraction of amlodipine enantiomers in a biphasic recognition chiral extraction system (BRCES) consisting of hydrophobic D-diisopropyl tartrate dissolved in organic phase (n-decanol) and hydrophilic hydroxypropyl-β-cyclodextrin (HP-β-CD) in aqueous phase (acetate buffer) which preferentially recognize the R-enantiomer and S-enantiomer, respectively. The calculations were simulated using a semi-empirical PM3 method as a part of the Gaussian09 software package and were used to optimize the structures of the hosts, guests, and host-guest complexes in the gas phase without any restrictions. It was found that HP-β-CD has the strongest recognition ability among the three β-CD derivatives studied, namely HP-β-CD, hydroxyethyl-β-cyclodextrin (HE-β-CD), and methylated-β-cyclodextrin (Me-β-CD), due to the large interaction energies (Ecomp = -14.3025 kcal/ mol), while D-diisopropyl tartrate has the strongest ability among the four tartaric acid derivatives studied namely; L-diisopropyl tartrate, D-diisopropyl tartrate, L-diethyl tartrate, and D-diethyl tartrate (Ecomp = -5.9964 kcal/ mol). The computational calculations for the enantioselective partitioning of amlodipine enantiomers rationalized the reasons for the different behaviors for this extraction. The present theoretical results may be informative to scientists who are devoting themselves to developing models for their experimental parts or for enhancing the hydrophobic drug solubility in drug delivery systems.
  18. Deciphering key proteins of oil palm (Elaeis guineensis Jacq.) fruit mesocarp development by proteomics and chemometrics
    Hassan H, Amiruddin MD, Weckwerth W, Ramli US
    Electrophoresis, 2019 01;40(2):254-265.
    PMID: 30370930 DOI: 10.1002/elps.201800232
    Palm oil is an edible vegetable oil derived from lipid-rich fleshy mesocarp tissue of oil palm (Elaeis guineensis Jacq.) fruit and is of global economic and nutritional relevance. While the understanding of oil biosynthesis in plants is improving, the fundamentals of oil biosynthesis in oil palm still require further investigations. To gain insight into the systemic mechanisms that govern oil synthesis during oil palm fruit ripening, the proteomics approach combining gel-based electrophoresis and mass spectrometry was used to profile protein changes and classify the patterns of protein accumulation during these complex physiological processes. Protein profiles from different stages of fruit ripening at 10, 12, 14, 15, 16, 18 and 20 weeks after anthesis (WAA) were analysed by two-dimensional gel electrophoresis (2DE). The proteome data were then visualised using a multivariate statistical analysis of principal component analysis (PCA) to get an overview of the proteome changes during the development of oil palm mesocarp. A total of 68 differentially expressed protein spots were successfully identified by matrix-assisted laser desorption/ionisation-time of flight (MALDI-TOF/TOF) and functionally classified using ontology analysis. Proteins related to lipid production, energy, secondary metabolites and amino acid metabolism are the most significantly changed proteins during fruit development representing potential candidates for oil yield improvement endeavors. Data are available via ProteomeXchange with identifier PXD009579. This study provides important proteome information for protein regulation during oil palm fruit ripening and oil synthesis.
  19. Fulltext 18F[AlF]-radiolabelled Peptides on the Automated Synthesis Platform: Translating the Laboratory Bench Work to Bedside
    Hassan H, Razak HRA, Saad FFA, Kumar V
    Malays J Med Sci, 2019 Jul;26(4):122-126.
    PMID: 31496901 MyJurnal DOI: 10.21315/mjms2019.26.4.14
    Using radiolabelled peptides that bind, with high affinity and specificity, to receptors on tumour cells is one of the most promising fields in modern molecular imaging and targeted radionuclide therapy (1). In the emergence of molecular imaging and nuclear medicine diagnosis and therapy, albeit theranostic, radiolabelled peptides have become vital tools for in vivo visualisation and monitoring physiological and biochemical processes on molecular and cellular levels (2). This approach may benefit patients in the era of personalised medicine.
  20. Concurrent stroke and ST-elevation myocardial infarction: Is it a contraindication for intravenous tenecteplase?
    Wan Asyraf WZ, Elengoe S, Che Hassan HH, Abu Bakar A, Remli R
    Med J Malaysia, 2020 03;75(2):169-170.
    PMID: 32281601
    Acute ischemic stroke (AIS) and acute ST-elevation myocardial infarction (STEMI) are leading causes of mortality worldwide. Concurrent AIS presentation with STEMI is rare and potentially fatal. Most importantly to date many centres in Malaysia are still not aware on how to treat this condition. We report a case of AIS, which was treated with intravenous tenecteplase (TNK) according to ischemic stroke dosage and lead to improvement of neurological deficit.
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