Displaying publications 21 - 40 of 76 in total

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  1. Sayfaldeen Kashmoola, Tengku Fazrina Tengku Mohd Ariff, Hazmyr Abdul Wahab
    ESTEEM Academic Journal, 2020;16(1):27-37.
    MyJurnal
    Anthropometry is defined as the scientific study of the measurements and proportions of the human body. To date, the most used methods for the acquisition of facial anthropometric parameters are direct method employing calipers and protractors tools, which are time-consuming, or indirect methods employing three-dimensional (3D) imaging systems, which are expensive. Despite the possible advantages of two-dimensional (2D) photography, it is not widely explored due to complications such as resolution and distortion of digital photos. The objective of this study is to
    assess the accuracy of the Digital Single-Lens Reflector (DSLR) camera as an indirect method against direct method at different aperture and distance to subject. Adults aged 20-45 years were voluntarily recruited in this study (n=24). Twelve facial anthropometric parameters were measured for each participant using direct anthropometry (sliding caliper), and indirect anthropometry (DSLR camera). When placing the DSLR camera at 2.0 meters from subjects with f/6.3 aperture, nine facial anthropometric parameters were obtained accurately (p> .05). The findings suggested that
    the accuracy of the DSLR camera as an indirect method for the acquisition of facial anthropometric parameters was established at the aperture setting of f/6.3 and the object distance at 2.0 meters. Therefore, it can be recommended as a facial anthropometry acquisition technique.
    Matched MeSH terms: Human Body
  2. Abu Bakar YI, Hassan A, Yusoff MSB, Kasim F, Abdul Manan Sulong H, Hadie SNH
    Anat Sci Educ, 2021 Mar 01.
    PMID: 33650315 DOI: 10.1002/ase.2067
    To become skilled physicians, medical students must master surface anatomy. However, the study of surface anatomy is less emphasized in medical and allied health science curricula, and the time devoted to direct engagement with the human body is limited. This scoping review was designed to answer one research question: "What are the elements and strategies that are effective in teaching surface anatomy?" The review was performed using a five-stage scoping review framework, including research question identification, relevant study identification, study selection, data charting, and result collating and reporting. Three databases were searched using two search terms combined with a Boolean operator: "teaching" and "surface anatomy." The initial pool of 3,294 sources was assessed for duplication, and study eligibility was evaluated using inclusion and exclusion criteria. Data were abstracted from 26 original articles by one researcher and verified by two other researchers. A thematic analysis was performed, and several elements of effective teaching strategies for surface anatomy were identified, namely contextualized teaching, embracing experiential learning, and learning facilitation. This review revealed that a multimodal approach was most commonly used in surface anatomy instruction. Hence, future research should explore the effectiveness of multimodal teaching strategies that adopt the three aforementioned primary elements of effective teaching in an authentic learning environment. It is pertinent to clarify the effectiveness of these teaching strategies by evaluating their impact on student learning, organizational changes, and benefits to other stakeholders.
    Matched MeSH terms: Human Body
  3. A. N. Azahari, N. D.M Yusob, H.A. Saidun, N.K.Y Ali, R. Abdullah, R. Hashim, et al.
    MyJurnal
    Introduction: Various phantom with varied materials has been proposed to replace the human body. Besides, there is always a demand to use the local material as a phantom material, which is readily available and inexpensive. Wood is usually preferred because it is multifunction, environmentally friendly, low in toxic, inexpensive, as well as easy to use and prepare. Previous studies have found that Rhizophora spp. is a suitable natural source material and has been suggested due to its comparable dosimetric properties to commercial phantom. Methods: In this study, fabricated Rhizophora spp. particleboards phantom was opted as a solid-equivalent phantom medium at low energy photon beams using Gafchromic film x-ray quality assurance 2 (XRQA2). Additionally, the characteristics of XRQA2 film in the diagnostic energy range were generated. Results: Interestingly, the density of the fabricated Rhizophora spp particleboards was observed to have the same density with the water equivalent material (ρ= 1.00 g.cm-3) and has shown to have loosened agreement with PDD of water phantom at approximately 25% of the dose error. Also, further analysis using XRQA 2 film showed that energy was independent at different ranges. Conclusion: The analysis of fabricated Rhizophora spp particleboards undertaken here has extended our knowledge of the possibility of man- ufacturing cost-effective water equivalent phantom by using binder-less particleboard from Rhizophora spp. There- fore, a definite need for smaller interspacing particles should be considered to elevate the potential of Rhizophora spp particle boards as water equivalent materials.
    Matched MeSH terms: Human Body
  4. Rahim HA, Abdulmalek M, Soh PJ, Rani KA, Hisham N, Vandenbosch GA
    Sci Rep, 2016 07 20;6:29818.
    PMID: 27436496 DOI: 10.1038/srep29818
    This paper presents the investigation of path loss variation for subject-specific on-body radio propagation channels, considering the effect of metallic spectacles and loop like metallic accessories. Adding metallic items may affect the operability of Body Centric Wireless Communications (BCWC). Measurements were carried out in an RF-shielded room lined with microwave absorbing sheets for strategically placed bodyworn antennas covering the upper front torso and the lower limbs. The path loss of the on-body radio channel was characterized explicitly taking into account the body size of the subjects. For metallic loop-like accessories, the results indicate that for underweight subjects, there was a slightly higher influence, up to 2%, compared to normal and overweight subjects. Our findings indicate that a noticeable effect exists on on-body channels for dynamic movements where the metallic watch acts as a local scatterer that affects the non-line-of-sight (NLOS) signal path between transmitter and receiver for underweight subjects in comparison to normal and overweight subjects. The path loss decreases when the receiving terminal was positioned very close to the metallic item. If a loop-like metallic accessory is not appropriately considered when designing the radio channel on a subject, the reliability of the body-centric wireless system may degrade.
    Matched MeSH terms: Human Body
  5. Hanani Yuhaniz, Asnawi Seraila, Siti Rafedah Abdul Karim, Suhaimi Muhammed, Abdul Hamid Saleh
    MyJurnal
    In developing ergonomically sound furniture, there is a need in evaluating anthropometrics from various aspect such as gender differences. The objectives of this study was to evaluate anthropometrics differences between genders of children in Malaysia in order to determine the need in having specified chairs for each gender. Represented by four states in Malaysia, a total of 2400 children were involved in the study. A custom made measurer and an anthropometer were used to measure the subjects. Six body measurements, which are, sitting shoulder height, sitting subscapular height, shoulder breadth, buttock popliteal length, popliteal height and hip width were documented for evaluation. From this study, there were some significant differences on some body parts while other body parts were similar to male and female. Therefore, chairs are needed to be made according to the suitability of both gender.
    Matched MeSH terms: Human Body
  6. Hari Krishnan, T.
    MyJurnal
    Introductions: Call center has been defined as a working environment in which uses telephone and computer for the purpose of marketing and manage communication with prospect clients or existing clients (Rocha, Glina, Morinho and Nakasato, 2005; Sprigg, Smith and Jackson, 2003).
    Methodology: The study was conducted via observation of working condition and face to face interview with call center operators. Measurement of anthropometrics was also conducted.
    Results: Ergonomics issues found at call center were inappropriate work condition and workstation which lead to awkward sitting posture (sitting with forward leaning posture, raised shoulder, feet not supported on floor). Besides that organizational policy which required high job demand and subsequently lead to prolonged sitting and static posture (very minimal posture changes). Combination all these factors lead to musculoskeletal symptoms and the operators reported of having neck, shoulder, upper back and lower back pain compared to other body parts.
    Conclusion: The management should embark on organization wide ergonomics management program and should review the current policy and create safe and healthy working environment by providing suitable workstation for the operators in order to prevent musculoskeletal.
    Matched MeSH terms: Human Body
  7. Muhammad Fikri, Z., Ruzy Haryati, H., Seri Rahayu, K.
    MyJurnal
    Anthropometric study is one of the oldest branches of study in ergonomics where it serves a purpose in study of
    proportion and size for human body. One of the common methods used in anthropometric measurement is traditional
    measurement or direct measurement. However, Malaysia is still left behind other countries in development of national
    anthropometric database. Researchers in Malaysia are still relying on the traditional anthropometric (TA)
    measurement. There are several important factors that contribute to problems in TA such as accuracy, time, posture,
    identification of landmarks, instrument positions and orientations, and pressure exerted due to measuring equipment. In
    view of the fact that the difficulties of obtaining human anthropometry, it becomes necessary to propose a method which
    has less contact executed to respondent. This study aims to propose a new anthropometric measurement method using
    motion capture camera (MCC) method, later to develop the database for youth male population. A pilot test was done
    in order to confirm the measuring procedure as well as the flow of the study. Next, the Minitab statistical software used
    to check the validity and reliability of data using the tests of a) Accuracy-Pearson/Spearman Correlation b) BiasPaired
    T-Test c) Test-Retest Reliability-Pearson/Spearman Correlation d) Precision-Mean Absolute Difference and
    Relative Error Measurement. Results showed that the validity and reliability of this motion camera has successfully
    obtained and the anthropometric data for youth male respondents has successfully constructed. These findings can be
    used and expended to the national anthropometric database to be utilised in ergonomics design.
    Matched MeSH terms: Human Body
  8. Ahmed, M., Huq, M.S., Ibrahim, B.S.K.K., Ahmed, A.
    Movement Health & Exercise, 2018;7(1):211-223.
    MyJurnal
    Functional Electrical Stimulation (FES) can be used to revive movement
    functions of the human body to a certain degree which was lost due to
    occurrences of the nervous system disorders resulting from accidents or
    diseases. It can also be employed for gait rehabilitation as well as therapy.
    Control systems could be employed to improve on the FES-induced motion,
    and the closed-loop was targeted due to its advantages. Based on the papers
    reviewed, studies have shown that the linear control schemes are popular for
    movement restoration in the lower limb, but mostly for continuous standing
    contributing to mainly the stance phase. Therefore, a myriad of limitations
    was observed which include: the need for using improved sensors, re-tuning
    for every subject, tests conducted using patient with more straightforward
    ailments, complexity in implementation and most importantly is the issue of
    stability. The swing phase of gait movement and the full walking motion have
    more complex dynamics and coupled with the nature of the plant (human with
    nervous system disorder and the neuromuscular structure) could render the
    linear control method obsolete or unsuitable. Hence, there is a need to
    investigate other techniques such as the nonlinear and intelligent control
    methods.
    Matched MeSH terms: Human Body
  9. Huang C, Lou C, Chuang Y, Lin J, Liu C, Yu Z
    Sains Malaysiana, 2015;44:1757-1763.
    Following rapid technological and industrial development, factories have been equipped with a great deal of machines.
    The blend of industrial and residential areas in turn resulted in many environmental problems. In particular, machine
    operation causes noise pollution that easily causes physiological and psychological discomfort for the human body thus
    makes noise abatement a crucial and urgent issue. In this study, vermiculite functional fillers were added to polyurethane
    (PU) foam mixtures in order to form sound absorbent PU foams. The correlations between the contents of functional fillers
    and the sound absorption of flexible and rigid PU foams were then examined. The optimal PU foams were combined with
    PET/carbon fiber matrices in order to yield the electromagnetic shielding effectiveness. The sound absorption, noise
    reduction coefficient (NRC), electromagnetic shielding effectiveness and resilience rate of the composite boards were
    finally evaluated. The test results indicated that rigid PU foam composites can reach a sound absorption coefficient of
    0.8 while the flexible PU foam composites have higher mechanical properties.
    Matched MeSH terms: Human Body
  10. Abd Rahman NH, Yamada Y, Amin Nordin MS
    Materials (Basel), 2019 May 19;12(10).
    PMID: 31109128 DOI: 10.3390/ma12101636
    Previous works have shown that wearable antennas can operate ideally in free space; however, degradation in performance, specifically in terms of frequency shifts and efficiency was observed when an antenna structure was in close proximity to the human body. These issues have been highlighted many times yet, systematic and numerical analysis on how the dielectric characteristics may affect the technical behavior of the antenna has not been discussed in detail. In this paper, a wearable antenna, developed from a new electro-textile material has been designed, and the step-by-step manufacturing process is presented. Through analysis of the frequency detuning effect, the on-body behavior of the antenna is evaluated by focusing on quantifying the changes of its input impedance and near-field distribution caused by the presence of lossy dielectric material. When the antenna is attached to the top of the body fat phantom, there is an increase of 17% in impedance, followed by 19% for the muscle phantom and 20% for the blood phantom. These phenomena correlate with the electric field intensities (V/m) observed closely at the antenna through various layers of mediums (z-axis) and along antenna edges (y-axis), which have shown significant increments of 29.7% in fat, 35.3% in muscle and 36.1% in blood as compared to free space. This scenario has consequently shown that a significant amount of energy is absorbed in the phantoms instead of radiated to the air which has caused a substantial drop in efficiency and gain. Performance verification is also demonstrated by using a fabricated human muscle phantom, with a dielectric constant of 48, loss tangent of 0.29 and conductivity of 1.22 S/m.
    Matched MeSH terms: Human Body
  11. Gundamaraju R, Vemuri R
    Euroasian J Hepatogastroenterol, 2014 Jan-Jun;4(1):51-54.
    PMID: 29264319 DOI: 10.5005/jp-journals-10018-1096
    Greedy colon which is a synonym of constipation is a serious condition in the human body which may lead to complications, like damage of the rectal tissue, cellular dehydration and colorectal cancer. Diabetes mellitus, although a systemic disease with diverse clinical symptoms, is also related with cellular dehydration. Understanding the pathophysiological aspects of diabetes mellitus and greedy colon may shed light in the management of either of these conditions. The main purpose of this article is to demonstrate an association of tissue dehydration during diabetes mellitus and constipation. The adverse side effects of atropine will be discussed due to its M3 blockage effect and reduction in peristalsis keeping in mind the importance of these facts in the context of public health importance, especially in geriatric health. How to cite this article: Gundamaraju R, Vemuri R. Pathophysiology of Greedy Colon and Diabetes: Role of Atropine in worsening of Diabetes. Euroasian J Hepato-Gastroenterol 2014;4(1):51-54.
    Matched MeSH terms: Human Body
  12. Saedi TA, Md Noor S, Ismail P, Othman F
    PMID: 25250054 DOI: 10.1155/2014/494136
    In developing countries, herbal therapy is the first and basis form of treatment for most types of diseases. About 75-80% of the world's population prefers herbal therapy as a major treatment due to its better adequacy and satisfactoriness, which enhance human body's symmetry with minimal side effects. Fruits and plants have been presented from the past as promising tools in becoming a natural anticancer agents. Many of these plant extracts are currently used in cancer therapy and prevention. This review paper will particularly explore and emphasize on herbs and fruits used in the treatment of the leukaemia.
    Matched MeSH terms: Human Body
  13. Saidun S
    J Med Ethics, 2013 Feb;39(2):84-8.
    PMID: 23038799 DOI: 10.1136/medethics-2012-100794
    Visual recording of human subjects is commonly used in biomedical disciplines for clinical, research, legal, academic and even personal purposes. Guidelines on practice standards of biomedical recording have been issued by certain health authorities, associations and journals, but none of the literature discusses this from an Islamic perspective. This article begins with a discussion on the general rules associated with visual recording in Islam, followed by modesty issues in biomedical recording and issues of informed consent and confidentiality. In order to be deemed ethical from the Islamic perspective, all the aforementioned criteria must conform to, or not contradict, Islamic teaching.
    Matched MeSH terms: Human Body*
  14. Ng HW, Doughty SW, Luo H, Ye H, Ge W, Tong W, et al.
    Chem Res Toxicol, 2015 Dec 21;28(12):2343-51.
    PMID: 26524122 DOI: 10.1021/acs.chemrestox.5b00358
    Some chemicals in the environment possess the potential to interact with the endocrine system in the human body. Multiple receptors are involved in the endocrine system; estrogen receptor α (ERα) plays very important roles in endocrine activity and is the most studied receptor. Understanding and predicting estrogenic activity of chemicals facilitates the evaluation of their endocrine activity. Hence, we have developed a decision forest classification model to predict chemical binding to ERα using a large training data set of 3308 chemicals obtained from the U.S. Food and Drug Administration's Estrogenic Activity Database. We tested the model using cross validations and external data sets of 1641 chemicals obtained from the U.S. Environmental Protection Agency's ToxCast project. The model showed good performance in both internal (92% accuracy) and external validations (∼ 70-89% relative balanced accuracies), where the latter involved the validations of the model across different ER pathway-related assays in ToxCast. The important features that contribute to the prediction ability of the model were identified through informative descriptor analysis and were related to current knowledge of ER binding. Prediction confidence analysis revealed that the model had both high prediction confidence and accuracy for most predicted chemicals. The results demonstrated that the model constructed based on the large training data set is more accurate and robust for predicting ER binding of chemicals than the published models that have been developed using much smaller data sets. The model could be useful for the evaluation of ERα-mediated endocrine activity potential of environmental chemicals.
    Matched MeSH terms: Human Body
  15. Hajeb P, Sloth JJ, Shakibazadeh S, Mahyudin NA, Afsah-Hejri L
    Compr Rev Food Sci Food Saf, 2014 Jul;13(4):457-472.
    PMID: 33412705 DOI: 10.1111/1541-4337.12068
    Toxic elements such as mercury, arsenic, cadmium, and lead, sometimes called heavy metals, can diminish mental and central nervous system function; elicit damage to blood composition as well as the kidneys, lungs, and liver; and reduce energy levels. Food is considered one of the main routes of their entry into the human body. Numerous studies have been performed to examine the effects of common food processing procedures on the levels of toxic elements in food. While some studies have reported negative effects of processing, several have shown that processing practices may have a positive effect on the reduction of toxic elements in foodstuffs. A number of studies have also introduced protocols and suggested chemical agents that reduce the amount of toxic elements in the final food products. In this review, the reported methods employed for the reduction of toxic elements are discussed with particular emphasis on the chemical binding of both the organic and inorganic forms of each element in various foods. The molecular groups and the ligands by which the food products bind with the metals and the types of these reactions are also presented.
    Matched MeSH terms: Human Body
  16. David Matanjun, Mohammad Saffree Jeffree, Freddie Robinson, Falah Abbas Mohamed Salih, Md Shamsur Rahman, Naing Oo Tha
    MyJurnal
    Introduction: The objective of this presentation is to carry out a review of the historical status and possible future outlook of the practice of ethnomedicine in the State of Sabah. As in many parts of the world, there are many types of traditional medicines that have been used for hundreds of years among the various native cultural groups in Sabah. Methods: A literature survey was conducted with the aid of online database, and text books using keywords such as the current as well as previous names of Sabah and various related terminology such as ethnomedicine, CAM, complementary and alternative medicine, TCM, traditional and complementary medicine, herbalism, reflexology, spiritualism, ethnobiology ethnology, ethnoanthropology, biological activities, ethnobotanical uses, medicinal prop-erties, toxicity studies, etc. The status of ethnomedicine in Sabah is largely unknown. Results: Based on a review of previous literature, the study discovered that there is limited empirical documentation on the use of ethnomedicine in Sabah. In this preliminary review, a total number of 25 publications were recorded in the databases for the period up to 2019. There is still a need to realise the full potential of the biocultural diversity of Sabah, and that there is a strong need to focus more on socially relevant research. Ethnomedicine in Sabah consists mainly of herbalism, ma-nipulative practices and spiritualism. Plants can be said to be the central player in race-based traditional medicine. While data on ethnomedicine may be based on original field research, several are primarily derivative, drawing as they do from earlier published accounts and, importantly, anecdotes. Traditional massage and other manipula-tive-practices, based on manipulation and movement of body parts, are also popular because of their simplicity and apparent immediate relief that can be experienced by the patient or client. Spiritualism, which may be considered as a peculiar dimension of the mind-body medicine subset of traditional medicine, continues to have its adherents among the natives of Sabah. Conclusion: List and catalogs and sociological and ethnohistorical data were the fa-voured perspective of research in the past; but future evolution of ethnomedical studies need to address some of the debates related to biological, medical and social sciences . Future research should include systematic inves-tigation into efficacy and risk besides the possible incorporation of some parts of ethnomedicine into the existing healthcare services. Ethnomedicine occupies a distinct place in healthcare in the world in general, and Sabah in particular.
    Matched MeSH terms: Human Body
  17. Fuloria S, Subramaniyan V, Karupiah S, Kumari U, Sathasivam K, Meenakshi DU, et al.
    Antioxidants (Basel), 2020 Nov 02;9(11).
    PMID: 33147856 DOI: 10.3390/antiox9111075
    Continuous oxidation of carbohydrates, lipids, and amino acids generate extremely reactive carbonyl species (RCS). Human body comprises some important RCS namely hexanal, acrolein, 4-hydroxy-2-nonenal, methylglyoxal, malondialdehyde, isolevuglandins, and 4-oxo-2- nonenal etc. These RCS damage important cellular components including proteins, nucleic acids, and lipids, which manifests cytotoxicity, mutagenicity, multitude of adducts and crosslinks that are connected to ageing and various chronic diseases like inflammatory disease, atherosclerosis, cerebral ischemia, diabetes, cancer, neurodegenerative diseases and cardiovascular disease. The constant prevalence of RCS in living cells suggests their importance in signal transduction and gene expression. Extensive knowledge of RCS properties, metabolism and relation with metabolic diseases would assist in development of effective approach to prevent numerous chronic diseases. Treatment approaches for RCS associated diseases involve endogenous RCS metabolizers, carbonyl metabolizing enzyme inducers, and RCS scavengers. Limited bioavailability and bio efficacy of RCS sequesters suggest importance of nanoparticles and nanocarriers. Identification of RCS and screening of compounds ability to sequester RCS employ several bioassays and analytical techniques. Present review describes in-depth study of RCS sources, types, properties, identification techniques, therapeutic approaches, nanocarriers, and their role in various diseases. This study will give an idea for therapeutic development to combat the RCS associated chronic diseases.
    Matched MeSH terms: Human Body
  18. Estrada A, Garber PA, Chaudhary A
    PeerJ, 2020;8:e9816.
    PMID: 32884865 DOI: 10.7717/peerj.9816
    Currently, ~65% of extant primate species (ca 512 species) distributed in 91 countries in the Neotropics, mainland Africa, Madagascar, South Asia and Southeast Asia are threatened with extinction and 75% have declining populations as a result of deforestation and habitat loss resulting from increasing global market demands, and land conversion for industrial agriculture, cattle production and natural resource extraction. Other pressures that negatively impact primates are unsustainable bushmeat hunting, the illegal trade of primates as pets and as body parts, expanding road networks in previously isolated areas, zoonotic disease transmission and climate change. Here we examine current and future trends in several socio-economic factors directly or indirectly affecting primates to further our understanding of the interdependent relationship between human well-being, sustainable development, and primate population persistence. We found that between 2001 and 2018 ca 191 Mha of tropical forest (30% canopy cover) were lost as a result of human activities in the five primate range regions. Forty-six percent of this loss was in the Neotropics (Mexico, Central and South America), 30% in Southeast Asia, 21% in mainland Africa, 2% in Madagascar and 1% in South Asia. Countries with the greatest losses (ca 57% of total tree cover loss) were Brazil, Indonesia, DRC, China, and Malaysia. Together these countries harbor almost 50% of all extant primate species. In 2018, the world human population was estimated at ca 8bn people, ca 60% of which were found in primate range countries. Projections to 2050 and to 2100 indicate continued rapid growth of the human populations in these five primate range regions, with Africa surpassing all the other regions and totaling ca 4bn people by the year 2100. Socioeconomic indicators show that, compared to developed nations, most primate range countries are characterized by high levels of poverty and income inequality, low human development, low food security, high levels of corruption and weak governance. Models of Shared Socioeconomic Pathway scenarios (SSPs) projected to 2050 and 2100 showed that whereas practices of increasing inequality (SSP4) or unconstrained growth in economic output and energy use (SSP5) are projected to have dire consequences for human well-being and primate survivorship, practices of sustainability-focused growth and equality (SSP1) are expected to have a positive effect on maintaining biodiversity, protecting environments, and improving the human condition. These results stress that improving the well-being, health, and security of the current and future human populations in primate range countries are of paramount importance if we are to move forward with effective policies to protect the world's primate species and promote biodiversity conservation.
    Matched MeSH terms: Human Body
  19. Fallahiarezoudar E, Ahmadipourroudposht M, Yusof NM, Idris A, Ngadiman NHA
    Polymers (Basel), 2017 Nov 06;9(11).
    PMID: 30965883 DOI: 10.3390/polym9110584
    Valvular dysfunction as the prominent reason of heart failure may causes morbidity and mortality around the world. The inability of human body to regenerate the defected heart valves necessitates the development of the artificial prosthesis to be replaced. Besides, the lack of capacity to grow, repair or remodel of an artificial valves and biological difficulty such as infection or inflammation make the development of tissue engineering heart valve (TEHV) concept. This research presented the use of compound of poly-l-lactic acid (PLLA), thermoplastic polyurethane (TPU) and maghemite nanoparticle (γ-Fe₂O₃) as the potential biomaterials to develop three-dimensional (3D) aortic heart valve scaffold. Electrospinning was used for fabricating the 3D scaffold. The steepest ascent followed by the response surface methodology was used to optimize the electrospinning parameters involved in terms of elastic modulus. The structural and porosity properties of fabricated scaffold were characterized using FE-SEM and liquid displacement technique, respectively. The 3D scaffold was then seeded with aortic smooth muscle cells (AOSMCs) and biological behavior in terms of cell attachment and proliferation during 34 days of incubation was characterized using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and confocal laser microscopy. Furthermore, the mechanical properties in terms of elastic modulus and stiffness were investigated after cell seeding through macro-indentation test. The analysis indicated the formation of ultrafine quality of nanofibers with diameter distribution of 178 ± 45 nm and 90.72% porosity. In terms of cell proliferation, the results exhibited desirable proliferation (109.32 ± 3.22% compared to the control) of cells over the 3D scaffold in 34 days of incubation. The elastic modulus and stiffness index after cell seeding were founded to be 22.78 ± 2.12 MPa and 1490.9 ± 12 Nmm², respectively. Overall, the fabricated 3D scaffold exhibits desirable structural, biological and mechanical properties and has the potential to be used in vivo.
    Matched MeSH terms: Human Body
  20. SUWATYRA LETCHUMANAN, RUWAIDIAH IDRIS
    MyJurnal
    The Greek letter φ (Phi) represents one of the most mysterious numbers (1.618…) known to humankind. Historical approbation for φhas led to the monikers “The Golden Number” or “The Divine Proportion”. This simple, but inscrutable number, is inseparably linked to the recursive mathematical sequence which produces Fibonacci numbers. The study of the Fibonacci sequence exists in most aspects of life starting from the leaves of a non-flowering plant, design, paintings, animals, and even human body. Despite its wide-spread prevalence and existence, the Fibonacci series and also the Rule of Golden Proportions have not been widely documented within the human body. The main objective of this study is to prove that the length of the human hand bone is in step with the Fibonacci series to spot the degree of movement and variation for every finger. Victimization of the sample z test with 95% confidence interval, this analysis shows that just one of the four bone length ratios contained the ratio phi φ within the 95% confidence interval and follow the Fibonacci series, that of the little finger metacarpal and proximal phalanx in both hands. The largest variability was seen within the little finger phalangeal relationships and other fingers will follow mathematical relative series. Due to the relationship with the golden number, it will facilitate in monitoring the individual with an injured hand, especially if injured in small fingers throughout a medical aid, or to identify the cause of the problem of physical functioning of the hands or individual fingers. Hence, it should be helpful for the length of the clenched fist to perform in reconstruction or placement of the prosthesis.
    Matched MeSH terms: Human Body
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