MyMedR

Fulltext A systematic review of olfactory-related brain structural changes in patients with congenital or acquired anosmia

Manan HA, Yahya N, Han P, Hummel T

Brain Struct Funct, 2022 Jan;227(1):177-202.

PMID: 34635958 DOI: 10.1007/s00429-021-02397-3

Brain structural features of healthy individuals are associated with olfactory functions. However, due to the pathophysiological differences, congenital and acquired anosmia may exhibit different structural characteristics. A systematic review was undertaken to compare brain structural features between patients with congenital and acquired anosmia. A systematic search was conducted using PubMed/MEDLINE and Scopus electronic databases to identify eligible reports on anosmia and structural changes and reported according to PRISMA guidelines. Reports were extracted for information on demographics, psychophysical evaluation, and structural changes. Then, the report was systematically reviewed based on various aetiologies of anosmia in relation to (1) olfactory bulb, (2) olfactory sulcus, (3) grey matter (GM), and white matter (WM) changes. Twenty-eight published studies were identified. All studies reported consistent findings with strong associations between olfactory bulb volume and olfactory function across etiologies. However, the association of olfactory function with olfactory sulcus depth was inconsistent. The present study observed morphological variations in GM and WM volume in congenital and acquired anosmia. In acquired anosmia, reduced olfactory function is associated with reduced volumes and thickness involving the gyrus rectus, medial orbitofrontal cortex, anterior cingulate cortex, and cerebellum. These findings contrast to those observed in congenital anosmia, where a reduced olfactory function is associated with a larger volume and higher thickness in parts of the olfactory network, including the piriform cortex, orbitofrontal cortex, and insula. The present review proposes that the structural characteristics in congenital and acquired anosmia are altered differently. The mechanisms behind these changes are likely to be multifactorial and involve the interaction with the environment.

Matched MeSH terms: Olfaction Disorders/etiology

Fulltext Predictors and Outcomes of Neurological Deterioration in Intracerebral Hemorrhage: Results from the TICH-2 Randomized Controlled Trial

Law ZK, Dineen R, England TJ, Cala L, Mistri AK, Appleton JP, et al.

Transl Stroke Res, 2021 Apr;12(2):275-283.

PMID: 32902808 DOI: 10.1007/s12975-020-00845-6

Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data from the Tranexamic acid in IntraCerebral Hemorrhage-2 (TICH-2) randomized controlled trial were analyzed. Neurological deterioration was defined as an increase in National Institutes of Health Stroke Scale (NIHSS) of ≥ 4 or a decline in Glasgow Coma Scale of ≥ 2. Neurological deterioration was considered to be early if it started ≤ 48 h and late if commenced between 48 h and 7 days after onset. Logistic regression was used to identify predictors and effects of neurological deterioration and the effect of tranexamic acid on neurological deterioration. Of 2325 patients, 735 (31.7%) had neurological deterioration: 590 (80.3%) occurred early and 145 (19.7%) late. Predictors of early neurological deterioration included recruitment from the UK, previous ICH, higher admission systolic blood pressure, higher NIHSS, shorter onset-to-CT time, larger baseline hematoma, intraventricular hemorrhage, subarachnoid extension and antiplatelet therapy. Older age, male sex, higher NIHSS, previous ICH and larger baseline hematoma predicted late neurological deterioration. Neurological deterioration was independently associated with a modified Rankin Scale of > 3 (aOR 4.98, 3.70-6.70; p

Matched MeSH terms: Hematoma/etiology

Fulltext The prevalence of bleeding after percutaneous coronary interventions: A systematic review and meta-analysis

Heidary Moghadam R, Mohammadi A, Salari N, Ahmed A, Shohaimi S, Mohammadi M

Indian Heart J, 2024;76(1):16-21.

PMID: 38216122 DOI: 10.1016/j.ihj.2024.01.009

BACKGROUND: Bleeding is a common complication associated with percutaneous coronary intervention (PCI). The aim of this study was to determine the prevalence of bleeding after PCI through a systematic review and meta-analysis.

METHODS: The systematic review and meta-analysis covered the period from 1989 to 2023. Multiple databases, including Embase, PubMed, Scopus, Web of Sciences (WoS), MagIran, Scientific Information Database (SID), and Google Scholar, were searched using validated keywords with MeSH and Emtree. The I2 index was used to check for heterogeneity among studies.

RESULTS: The review of 8 studies, with a sample size of 397,298 participants, showed high heterogeneity (I2: 97.8 %). Therefore, the random effects method was used to analyze the results. The prevalence of bleeding after intervention in percutaneous coronary arteries was reported to be 4.4 % (95%CI: 2-9.1).

CONCLUSION: This meta-analysis showed a significant prevalence of bleeding after PCI, highlighting the need for health policymakers to pay more attention to the complications associated with PCI. Interventional cardiologists should consider the effective factors in these bleeding and how to treat and control them due to the importance of this complication.

Matched MeSH terms: Hemorrhage/etiology

Tongue paraesthesia and dysgeusia post suspension laryngoscopy

Mohamad H, Mohamad I

Kobe J Med Sci, 2012;58(2):E60-2.

PMID: 22972170

Suspension laryngoscopy is a common laryngeal procedure in Endolaryngeal microsurgery (ELMS). Oral mucosa and dental injuries are the known complications of the procedure. Nerve injury however is an infrequent encounter. We report a rare complication of lingual nerve injury which manifested as tongue numbness and altered taste following Endolaryngeal microsurgery procedure. The condition improved completely after few months of conservative management.

Matched MeSH terms: Dysgeusia/etiology*; Paresthesia/etiology*; Tongue Diseases/etiology*; Lingual Nerve Injuries/etiology*

Loh KY, Ogle J

Med J Malaysia, 2004 Oct;59(4):562-8, quiz 569.

PMID: 15779599

Visual impairment among the elderly is a major health problem. With advancing age, the normal function of eye tissues decreases and there is an increased incidence of ocular pathology. Demographic studies have shown that age is the best predictor of blindness and visual impairment. The most common causes of age related visual impairment in the elderly are presbyopia, cataracts, age related macular degeneration, primary open angle glaucoma and diabetic retinopathy. Untreated visual impairment leads to physical handicap, increased incidence of fall, depression, social isolation and dependency. Active screening for visual loss in the elderly should be part of the health examination. The elderly should be encouraged to come for formal 1-2 yearly eye assessment for early detection of visual impairment and to treat all associated problems in order to prevent permanent visual loss.

Matched MeSH terms: Cataract/etiology; Glaucoma, Open-Angle/etiology; Presbyopia/etiology; Vision Disorders/etiology*

Fulltext Cholestatic fibrosing hepatitis and hepatitis B after bone marrow transplantation

Suresh RL, Merican I, Chang KM, Yong SM, Purusothaman V

Med J Malaysia, 2001 Dec;56(4):508-11.

PMID: 12014774

In the setting of transplantation and chronic hepatitis B viral infection there is a unique histological feature termed cholestatic fibrosing hepatitis. The use of nucleoside analogues in the treatment of this condition has been successful. We describe a case of cholestatic fibrosing hepatitis, which occurred after intense immunosuppression for graft versus host disease in a patient with bone marrow transplantations. She was commenced on lamivudine therapy and showed good clinical, biochemical and virological response. However she succumbed due to sepsis.

Matched MeSH terms: Cholestasis/etiology*; Hepatitis/etiology*; Hepatitis B/etiology*; Liver Cirrhosis/etiology*

Primary infertility in a phenotypic male with 46XX chromosomal constitution

Tan TT, Khalid BA

Postgrad Med J, 1993 Apr;69(810):315-7.

PMID: 8321801

The case of a 32 year old male with normal male adrenarchal hair pattern, bilateral gynaecomastia, a small phallus, hypospadias and bilateral poorly developed testes presenting with primary infertility secondary to azoospermia and a pelvic cyst is described. Repeated chromosomal analysis showed 46XX chromosomal constitution. Laparotomy revealed a simple cyst between the urinary bladder and the rectum. XX male syndrome is a rare cause of male infertility. The majority of cases is due to interchange of a fragment of the short arm of the Y chromosome containing the region that encodes the testes determining factor with the X chromosome. The presence of a simple cyst in the anatomical location of the uterus to our knowledge has not been reported in the literature.

Matched MeSH terms: Cysts/etiology; Gynecomastia/etiology; Hypospadias/etiology; Infertility, Male/etiology*

Fulltext Massive pericardial effusion in primary hypothyroidism

Hanip MR, Ong SB, Tan TT, Khalid BA

Med J Malaysia, 1989 Dec;44(4):341-3.

PMID: 2520045

A 44 year old lady with primary hypothyroidism presented with massive pericardial effusion without cardiac tamponade. Pericardial tap was done twice and the effusion resolved as the hypothyroid state improved. She remained hypertensive despite the euthyroid state. She was discharged well with L-thyroxine and anti-hypertensive therapy.

Matched MeSH terms: Galactorrhea/etiology; Hyperprolactinemia/etiology; Hypertension/etiology; Pericardial Effusion/etiology*

Fulltext Clinical Characteristics and Diagnostic Challenges of COVID-19: An Update From the Global Perspective

Israfil SMH, Sarker MMR, Rashid PT, Talukder AA, Kawsar KA, Khan F, et al.

Front Public Health, 2020;8:567395.

PMID: 33505949 DOI: 10.3389/fpubh.2020.567395

Clinical characteristics are essential for the correct diagnosis of diseases. The current review aimed to summarize the global clinical characteristics of the COVID-19 patients systematically and identify their diagnostic challenges to help the medical practitioners properly diagnose and for better management of COVID-19 patients. We conducted a systematic search in PubMed, Web of Science, Scopus, Science Direct, and Google Scholar databases for original articles containing clinical information of COVID-19 published up to 7th May 2020. Two researchers independently searched the databases to extract eligible articles. A total of 34 studies from 8 different countries with 10889 case-patients were included for clinical characteristics. The most common clinical symptoms were cough 59.6, fever 46.9, fatigue 27.8, and dyspnea 20.23%. The prominent laboratory findings were lymphocytopenia 55.9, elevated levels of CRP 61.9, aspartate aminotransferase 53.3, LDH 40.8, ESR 72.99, serum ferritin 63, IL-6 52, and prothrombin time 35.47%, and decreased levels of platelets 17.26, eosinophils 59.0, hemoglobin 29, and albumin 38.4%. CT scan of the chest showed an abnormality in 93.50% cases with bilateral lungs 71.1%, ground-glass opacity 48%, lesion in lungs 78.3%, and enlargement of lymph node 50.7%. Common comorbidities were hypertension, diabetes, obesity, and cardiovascular diseases. The estimated median incubation period was 5.36 days, and the overall case fatality rate was 16.9% (Global case fatality outside China was 22.24%: USA 21.24%, Italy 25.61%, and others 0%; whereas the case fatality inside the Hubei Province of China was found to be 11.71%). Global features on the clinical characteristics of COVID-19 obtained from laboratory tests and CT scan results will provide useful information to the physicians to diagnose the disease and for better management of the patients as well as to address the diagnostic challenges to control the infection.

Matched MeSH terms: Cough/etiology*; Dyspnea/etiology; Fatigue/etiology*; Fever/etiology*

Fulltext Ophthalmic problems among the elderly in Malaysia

Singh P

Med J Malaysia, 1997 Sep;52(3):213-6.

PMID: 10968087

Matched MeSH terms: Cataract/etiology; Diabetic Retinopathy/etiology; Eye Diseases/etiology*; Eyelid Diseases/etiology; Glaucoma/etiology; Macular Degeneration/etiology

Fulltext Recurrent gall-stone ileus: a case report

Baruah DR

Med J Malaysia, 1983 Sep;38(3):228-31.

PMID: 6672566

Gall stone is responsible for about 1% of total small bowel obstruction, 1.2 and recurrent gall stone ileus is even more unusual. 3 Gall stone ileus is caused by the impaction of the stone in bowel lumen. It was first described in a patient examined at autopsy by Bartholin in 1654. This paper based on unusual recurrent intestinal obstructions by a gall stone. The patient presented with large bowel obstruction and it was due to a large gall stone impacted in the pelvic colon. Four months later the same patient presented with small bowel obstruction due to large gall stone impacted in the terminal part of the ileum at 61 cms from the ileo-caecal valve. Gall stone obstruction of the colon is one of the rare complications. This rare complication usually occurs in elderly females' in whom there is frequently an underlying pathological condition at the site of obstruction in the colon. The calculus usually migrates through a cholecysto-colonic fistula in case of large bowel obstruction. In case of a small bowel obstruction the calculus usually migrates through a cholecysto-duodenal fistula. Diagnosis can be established by plain X-rays of the abdomen where there is gas shadow in the biliary system, sometimes the gall stone can be seen if it is radio opague (10-16% gall stone is radio opaque) at the site of obstruction. Otherwise diagnosis is always
made at laparotomy.

Matched MeSH terms: Biliary Fistula/etiology; Duodenal Diseases/etiology; Gallbladder Diseases/etiology; Ileal Diseases/etiology*; Intestinal Fistula/etiology; Intestinal Obstruction/etiology*

Musculoskeletal lesions in yaws

Sengupta S

Clin Orthop Relat Res, 1985 Jan-Feb;?(192):193-8.

PMID: 3967422

Yaws, a spirochetal infection that is endemic in certain tropical countries, including Malaysia, may present with various orthopedic problems. As the condition is relatively unknown, diagnosis is often missed, which leads to poor management. There are initial, early, and late phases of the disease process. By involving skin, bone, and joints, yaws can produce deep ulcerations, joint deformities, and bone destruction. Within a ten-year period in Malaysia, 14 cases of serologically proven yaws have been treated for chronic ulcers, gross joint deformities, and pathologic fractures.

Matched MeSH terms: Bone Diseases/etiology*; Contracture/etiology; Joint Diseases/etiology*; Muscular Diseases/etiology*; Osteitis/etiology; Osteomyelitis/etiology; Periostitis/etiology; Ulcer/etiology

The psychiatric aspects of epilepsy

Teoh JI

Med J Malaysia, 1973 Sep;28(1):8-15.

PMID: 4273788

Matched MeSH terms: Mental Disorders/etiology*; Delusions/etiology; Dissociative Disorders/etiology; Hallucinations/etiology; Hysteria/etiology; Paraphilic Disorders/etiology; Personality Disorders/etiology; Psychotic Disorders/etiology

Swordfish attack--death by penetrating head injury

Gooi BH, Khamizar W, Suhani MN

Asian J Surg, 2007 Apr;30(2):158-9.

PMID: 17475591

There have been very few reports of swordfish attacks on humans and none have resulted in death. Although there are no reports of unprovoked attacks on humans, swordfish can be very dangerous when provoked and they can jump and use their swords to pierce their target. We describe here an unusual case of death that resulted from intracranial penetrating injury caused by a swordfish.

Matched MeSH terms: Brain Injuries/etiology*; Wounds, Stab/etiology*

Fulltext Bilateral lacrimal sac mucocele with punctal and canalicular atresia

Ong CA, Prepageran N, Sharad G, Luna D

Med J Malaysia, 2005 Dec;60(5):660-2.

PMID: 16515124

Congenital absence of lacrimal puncta may be an isolated finding or associated with other developmental abnormality. Nasolacrirnal ducts can be absent thus predisposing to the formation of a congenital lacrimal mucocele. Punctal and canalicular agenesis is very rare. Four percent of new patients attending the lacrimal clinic at Moorfields Eye Hospital, London, UK. from 1981 to 1990 inclusive were diagnosed to have this condition. We describe a case of bilateral congenital absence of lacrimal puncta with lacrimal mucocele. Combined surgery was carried out by Ophthalmologist and Otolaryngologist with successful results.

Matched MeSH terms: Dacryocystitis/etiology*; Mucocele/etiology*

Bird-related eye injuries

Shriwas SR

Trop Doct, 1993 Jul;23(3):140.

PMID: 8356755

Matched MeSH terms: Eye Injuries/etiology*; Wounds, Penetrating/etiology*

Unusual ritual burns of the hand

Tay YG, Tan KK

Burns, 1996 Aug;22(5):409-12.

PMID: 8962663

Six hands from five patients were seen with full-thickness burns following a ritual practice between June 1993 and June 1994. Three hands were treated with excision and medium-thickness split-skin grafts, one patient was treated with a medium-thickness split skin graft taken from the instep of the foot. The first patient with bilateral burns of the palms refused surgery and returned 3 months later with contractures of the palms. The results of the treated hands are presented.

Matched MeSH terms: Burns/etiology*; Hand Injuries/etiology*

Transient blindness in pregnancy induced hypertension

Achanna S, Monga D, Sivagnanam

Asia Oceania J Obstet Gynaecol, 1994 Mar;20(1):49-52.

PMID: 8172527

Sudden blindness in pregnancy is a devastating experience for the patient, her family and the treating obstetrician. Four cases of cortical blindness with pregnancy induced hypertension are presented, seen at the General Hospital Kota Bharu, Kelantan, in 1990. The incidence at the GHKB was 1: 1559 (4 cases out of 6,237 deliveries) which is higher as compared to neighbouring Singapore. The pathophysiology of this condition is still not well understood, though it is hoped that newer sophisticated imaging techniques like magnetic resonance imaging (MRI), CT scan, and blood flow waveform analysis by Doppler ultrasound will throw some light on the subject. Two of our cases presented with antepartum and two with postpartum cortical blindness. Therefore, termination of pregnancy alone may not provide the solution to this therapeutic dilemma.

Matched MeSH terms: Blindness/etiology*; Puerperal Disorders/etiology

Fulltext Schistosoma haematobium infection in Malaysia--a case report

Hung LC, Shekar KC

Med J Malaysia, 1992 Dec;47(4):328-30.

PMID: 1303489

An imported case of Schistosoma haematobium infection presenting with haematuria and proteinuria is described. This would constitute a first case of urinary schistosomiasis in Malaysia. The patient failed to respond to multiple antibiotic treatment and was successfully treated with praziquantel.

Matched MeSH terms: Hematuria/etiology; Proteinuria/etiology

Fulltext Delirium acutum -- an uncommon life-threatening psychiatric emergency

Chew PH, Leong LC, Yao SK

Med J Malaysia, 1982 Dec;37(4):370-2.

PMID: 7167091

Matched MeSH terms: Catatonia/etiology; Fever/etiology*

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