MyMedR

Some notes on the occurence, progress and treatment of granuloma inguinale

Cooke ERC

Malayan Medical Journal, 1929;4:104-5.

Matched MeSH terms: Granuloma Inguinale

Calcifying fibroblastic granuloma. A case report

Taiyeb Ali TB, Siar CH

J N Z Soc Periodontol, 1997.

PMID: 9522721

Matched MeSH terms: Periapical Granuloma/pathology*

Fulltext Erythema nodosum leprosum in Malaysians

Jayalakshmi P, Ganesapillai T, Ganesan J

Int. J. Lepr. Other Mycobact. Dis., 1995 Mar;63(1):109-11.

PMID: 7730709

Matched MeSH terms: Granuloma/pathology

An adjuvant effect of Metformin as an anti-fibrotic agent when administered with the anti-schistosomal Praziquantel in Schistosoma mansoni infected mice

Salama WM, El-Naggar SA, Harras SF, El-Said KS

Trop Biomed, 2021 Jun 01;38(2):205-213.

PMID: 34172712 DOI: 10.47665/tb.38.2.059

Schistosomiasis is the second most common parasitic disease post Malaria around the world. Praziquantel (PZQ) is known as the most efficient anti- schistosomal drug but has no anti-fibrotic effect. Metformin (Met) is a well-known drug for type 2 diabetes. This study aimed to evaluate the role of Met as anti-schistosomal and anti-fibrotic agents alone or in combination with PZQ treatment. Forty male CD1 mice were divided into four groups (n=10 mice) as following; the first group (Gp1) was served as a negative control. Gp2, Gp3, Gp4, and Gp5 were infected with (60-80) S. mansoni cercariae. After a month of infection, Gp3 was administered orally with PZQ (500 mg/Kg) for 2 consecutive days. Gp4 was administered orally with Met (150 mg/Kg) for 15 consecutive days, and Gp5 was orally administered with PZQ followed by Met for 15 consecutive days at the same doses as in Gp 3 and 4. The results showed that PZQ had potent worms and egg reduction in liver and intestine tissues with no anti-fibrotic effect of the granuloma formation. However, Met or PZQ/Met treatment postinfection led to a reduction in egg count in both liver and intestine tissues with a significant reduction in granuloma site. Treatment of S. mansoni-infected mice with Met or PZQ/Met ameliorated the hematological and biochemical alterations induced by S. mansoni infection. Collectively, Met has no anti-schistosomal activity but led to a reduction in egg deposition and showed an anti-fibrotic effect on granulomatous development either when used alone or in combination with PZQ treatment. This study shed light on the possible role of Met as an anti-fibrotic agent when administered with PZQ for S. mansoni infected humans.

Matched MeSH terms: Granuloma/drug therapy

Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews

Sazliyana Shaharir S, Jamil A, Kosasih S, Soo Fin L, Sridharan R, Hayati Md Pauzi S

Acta Med Iran, 2017 Dec;55(12):800-806.

PMID: 29373888

A 59-year-old man presented with proximal myopathy, myalgia, and weight loss, with the initial markedly elevated serum creatine kinase at 11,000 U/L. Due to his refusal for muscle biopsy, he was initially treated as inflammatory myositis and responded well with the corticosteroids. However, he subsequently had a relapse of the symptoms with more extensive systemic involvement, i.e., hypercalcemia, lymphadenopathy and subcutaneous nodules. Finally, a biopsy of the thigh and subcutaneous nodule revealed non-caseating granulomatous inflammation, consistent with sarcoidosis. He responded well to the corticosteroids, and finally, azathioprine was added as a steroid-sparing agent. Including our series, there are 103 cases of symptomatic muscle involvement in sarcoidosis patients published in the English literature to date. Further pool analysis of the cases will be reported in this review.

Matched MeSH terms: Granuloma/diagnosis

Fulltext Maternal Mortality Review: A case of pulmonary haemorrhage due to ruptured lung haemangioma secondary to Ghon's focus invasion

Paranthaman V, Subashini A

Med J Malaysia, 2014 Feb;69(1):35-6.

PMID: 24814628

Haemangioma can be present in the lung but rarely causes complications unless there is a bleed. Ghon's focus is a result of post primary tuberculosis. It is a caseating granuloma which invades the surrounding tissue. It is usually benign and may resolve spontaneously without causing complications or active tuberculosis. This case illustrates an unfortunate patient who had a pre-existing haemangioma in the lung which was in close proximity of a Ghon's focus that had invaded on to the haemangioma leading to haemorrhage causing death. This study seeks to highlight the importance of conducting a full post mortem in cases of maternal mortality.

Matched MeSH terms: Granuloma

Bilateral middle ear cholesterol granuloma in familial hypercholesterolemia

Masaany M, Siti HS, Nurliza I, Mazita A

Otolaryngol Head Neck Surg, 2008 Jun;138(6):803-4.

PMID: 18503863 DOI: 10.1016/j.otohns.2008.02.020

Cholesterol granuloma (CG) is a histologic description of foreign body giant cell formation toward cholesterol crystals. The majority of temporal bone CG is unilateral and most common in the petrous apex. Middle ear CG is usually the result of underlying ear diseases. Primary middle ear CG is very rare. Most reported CG has not been associated with familial hypercholesterolemia (FH). FH, an autosomal dominant disorder, manifests as high levels of serum cholesterol and low density lipoprotein (LDL) cholesterol. We report a rare case of FH and bilateral aggressive primary middle ear CG. This publication has been approved by the IRB, Hospital Alor Setar.

Matched MeSH terms: Granuloma, Foreign-Body/diagnosis; Granuloma, Foreign-Body/etiology*; Granuloma, Foreign-Body/therapy

Fulltext Inflammatory reaction to fish oil coated polypropylene mesh used for laparoscopic incisional hernia repair: a case report

Kong CY, Lai LL, Khoo AYY, Rahman NA, Chin KF

BMC Surg, 2016 Feb 11;16:8.

PMID: 26864939 DOI: 10.1186/s12893-016-0123-8

BACKGROUND: Polypropylene meshes are widely used in hernia repairs. Hernia meshes have been developed incorporating coatings of active agents. One commercially available mesh has a fish oil coating which is promoted as having anti-inflammatory properties. We report a case, a symptomatic foreign body granuloma reaction associated with a fish oil coated polypropylene mesh, which required eventual mesh explantation.

CASE PRESENTATION: A 61-year old lady with previous peptic ulcer disease underwent a laparoscopic intraperitoneal placement of mesh for incisional hernia utilising a fish oil coated polypropylene mesh. The patient presented 3 months after the procedure complaining of dyspepsia and pain at the operative site. There was no discharge. The patient was managed conservatively. She presented 10 months post-operatively with progressively worsening symptoms and a hard palpable mass in the epigastrium. Abdominal laparoscopy revealed dense adhesive disease around the mesh with exudates. Adhesiolysis, mesh explantation and a partial gastrectomy was performed. Histopathological examination revealed a foreign body granuloma formation to the mesh.

CONCLUSION: In-vivo studies looking at intraperitoneal mesh placement with fish oil coatings including data on surgical outcomes such as fistula and adhesive characteristics are scarce in the literature. Further monitoring and studies are required to investigate the safety and efficacy profile of this mesh type in in-vivo models.

Matched MeSH terms: Granuloma, Foreign-Body/etiology*; Granuloma, Foreign-Body/pathology; Granuloma, Foreign-Body/surgery

Recurrent gigantic pyogenic granuloma disturbing speech and mastication: a case report and literature review

Ong MA, Chai WL, Ngeow WC

Ann Acad Med Singap, 1998 Mar;27(2):258-61.

PMID: 9663321

A case of gigantic pyogenic granuloma with three recurrences in the lower anterior gingiva is presented. Surgical wide excision of the lesion is the treatment of choice. The tumour must be excised down to the periosteum and the irritants around it removed to avoid recurrence. A contributing factor to the gigantic lesion is hormonal changes during pregnancy. Long-term review for 18 months after the third surgery showed no evidence of recurrence at the surgical site.

Matched MeSH terms: Granuloma, Pyogenic/complications*; Granuloma, Pyogenic/pathology; Granuloma, Pyogenic/surgery

Granuloma inguinale

Hughes W

Malayan Medical Journal, 1932;7:59-60.

Matched MeSH terms: Granuloma Inguinale

Fulltext A rare case of disseminated sarcoidosis presenting with neurosarcoidosis: a case report

Noorhafini Abdul Sukur, Narisa Sulaiman Sahari, Abdul Aziz Marwan, Rosmadi Ismail

Malaysian Journal of Medicine and Health Sciences, 2020;16(108):81-83.

MyJurnal

Sarcoidosis is characterized by formation of inflammatory granulomas affecting all over the body, with pulmonary predilection (1). Neurosarcoidosis is a rare but potentially dangerous manifestation of sarcoidosis. We report a case of disseminated sarcoidosis presenting with a neurological diagnostic dilemma. Worsening mediastinal lymphade- nopathy, together formation of lung and liver nodules making a sarcoidosis diagnosis favourable. Histology from these lesions showed non-caseating granulomatous inflammation. She was treated as a rare case of disseminated sarcoidosis. To date, there is no specific or clear guideline on the management of disseminated sarcoidosis.

Matched MeSH terms: Granuloma

Fulltext Giant Cell Reparative Granuloma Mimicking Aneurysmal Bone Cyst in Proximal Phalanx of Toe

Huan CM, Norzila AB

Malays Orthop J, 2016 Mar;10(1):55-56.

PMID: 28435549 MyJurnal DOI: 10.5704/MOJ.1603.011

Giant Cell Reparative Granuloma (GCRG) of phalanx is uncommon. It is a benign osteolytic lesion but can be locally aggressive. GCRG has certain radiology and histological features that are similar to other giant cell lesions of the bone. We present a case report of a young patient with giant cell reparative granuloma of proximal phalanx of left third toe. The bone lesion was successfully treated surgically.

Matched MeSH terms: Granuloma, Giant Cell

Fulltext Granuloma formation and loss of tooth vitality following the use of bone wax in third molar surgery: rep ort of a case

Raman, Rajeswary, Yap, Hsiao Fern

Archives of Orofacial Sciences, 2014;9(1):1-3.

MyJurnal

In the present case, granuloma formation and loss of tooth vitality following the use of bone wax in third molar surgery in a 16 - year- old male patient were reported. Endodontic and surgical treatments were carried out on the patient. As foreign body granulomatous reaction to bone wax is not uncommon in the literature review, alternative haemostatic agents should be taken into consideration to avoid any potential complications and untoward effects of using bone wax for haemorrhage control in surgical procedures.

Matched MeSH terms: Granuloma

Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial

Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA

J Pediatr Surg, 2022 Feb;57(2):261-265.

PMID: 34838305 DOI: 10.1016/j.jpedsurg.2021.10.032

BACKGROUND: Umbilical granuloma is a common infantile condition which usually responds to non operative management. Copper sulphate (CuSO4) is often used as chemical cauterization but can cause superficial skin burns. An alternative is table salt (NaCl), which osmotically dehydrates wet granulation tissue causing necrosis. We aimed to compare the effectiveness of NaCl versus CuSO4 in treating umbilical granuloma.

METHOD: We performed a multi centerrandomized controlled trial involving three regional pediatricsurgical units. We included children who presented with umbilical granuloma from December 2018 to May 2020. Children who received treatment prior to index visit were excluded. They were randomly allocated to receive NaCl (twice/day application for 5 days by caregiver) or CuSO4 (single application by clinician). Demographic data, compliance in the NaCl group by pill counting method, treatment outcomes, and complications were recorded. Treatment success was defined as complete lesion resolution. Partial or no response was considered treatment failure. Subsequent treatment then reverted to the respective center's routine management.

RESULT: We recruited 70 participants with 6 dropouts (2 defaulters, 1 vitellointestinal duct, 3 urachal remnants), leaving 64 subjects for final analysis: 31 NaCl, 33 CuSO4. Compliance rate of 77.4% was recorded for NaCl, with 6 (20%) 'poor compliance' participants stopping therapy before completion owing to complete resolution. NaCl group had a significantly higher complete resolution rate (90.4%) compared to CuSO4 (69.7%), p = 0.040. No NaCl participant developed complications versus 9% (n = 3) in CuSO4 (periumbilical superficial skin burn).

CONCLUSION: Table salt is an ideal treatment choice for umbilical granuloma as it is effective, safe, and readily available.

LEVEL OF EVIDENCE: II.

Matched MeSH terms: Granuloma

Microfilarial granulomas in the spleens of wild-caught cynomolgus monkeys (Macaca fascicularis)

Narama I, Miura K, Tsuruta M, Tsuchitani M

Vet Pathol, 1985 Jul;22(4):355-62.

PMID: 4035940

Splenic nodules from 38 cynomolgus monkeys (Macaca fascicularis) which were captured in Malaysia and Indonesia were studied histologically. The lesions were characterized by well-circumscribed focal fibrosis, accumulation of eosinophils and histiocytes, hemorrhage or hemosiderosis, and loss of normal splenic architecture. Small arteries in the lesion frequently had intimal thickening and narrowing of the lumen in addition to the presence of microfilariae. Microfilariae were also seen in the extravascular area of the lesion, and were occasionally engulfed by multinucleated giant cells. The splenic lesion was thought to have been initiated by incomplete infarction caused by intimal thickening and microfilarial occupation of the small arteries.

Matched MeSH terms: Granuloma/parasitology; Granuloma/pathology; Granuloma/veterinary*

Fulltext Cholesterol granuloma in a post-mastoidectomy for cholesteatoma

Mohd Khairi MD, Ramiza Ramza R

Med J Malaysia, 2012 Apr;67(2):217-8.

PMID: 22822649 MyJurnal

Cholesterol granuloma is a histological term used to describe the foreign body reaction towards cholesterol crystals causing granuloma. We report a case of cholesterol granuloma in a patient who presented with a mass in her ear after 6 years of mastoidectomy. The diagnosis has been confirmed by MRI and postoperative findings. The difference between cholesterol granuloma and the other entities especially cholesteatoma and meningoencephalic herniation must be made in view of its implications and surgical management of each lesion.

Matched MeSH terms: Granuloma, Foreign-Body/diagnosis*; Granuloma, Foreign-Body/surgery*

Sarcoid-like foreign body reaction in body piercing: a report of two cases

Ng KH, Siar CH, Ganesapillai T

Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1997 Jul;84(1):28-31.

PMID: 9247945

We report two cases of body piercing as a religious practice that subsequently led to the development of granulomatous nodules at previously punctured sites of the skin and oral mucosa. These lesions were diagnosed as sarcoid-like foreign body reaction after other possible causes including sarcoidosis, tuberculosis, tuberculoid leprosy, fungal infections, viral infections, and Crohn's disease were excluded.

Matched MeSH terms: Granuloma, Foreign-Body/diagnosis; Granuloma, Foreign-Body/etiology*

Oral pyogenic granuloma (excluding pregnancy tumour)--a clinical analysis of 304 cases

Zain RB, Khoo SP, Yeo JF

Singapore Dent J, 1995 Jul;20(1):8-10.

PMID: 9582682

A clinical analysis of 304 cases of pyogenic granuloma (excluding pregnancy tumour) were obtained from the clinical evaluations submitted by clinicians while sending specimens for biopsy. The average age of the patients with pyogenic granuloma was 28.9 years with a peak age incidence in the second decade. More female patients were affected and the lesions present mainly in the Chinese. The majority of the lesions were ulcerated and pedunculated. The lesions had a mean diameter of 10.8 mm with a mean lesion duration of 6.0 months. The gingiva was the prevalent site for these lesions with a greater number being located in the maxilla. The recurrence rate was found to be 14.1%.

Matched MeSH terms: Granuloma, Pyogenic/epidemiology*; Granuloma, Pyogenic/pathology

Fulltext Xanthogranulomatous pyelonephritis in a Malaysian population

Koh KB

Singapore Med J, 1993 Aug;34(4):341-2.

PMID: 8266209

Xanthogranulomatous pyelonephritis is a clinico-pathological entity that is gaining awareness amongst urologists worldwide. It is an unusual chronic inflammatory lesion involving the kidney that destroys renal parenchyma and may mimic renal carcinoma. It is usually seen in middle-aged women and is associated with urinary tract infections and urinary calculi. Most reports and reviews of this condition come from the West; this study reviews the incidence and presentation of the condition in a Malaysian population.

Matched MeSH terms: Granuloma/epidemiology*; Granuloma/pathology

Fulltext Granulomatous reaction secondary to intramammary silicone injection

Majedah S, Alhabshi I, Salim S

BMJ Case Rep, 2013;2013.

PMID: 23417932 DOI: 10.1136/bcr-2012-007961

Matched MeSH terms: Granuloma, Foreign-Body/chemically induced*; Granuloma, Foreign-Body/diagnosis

Displaying publications 21 - 40 of 99 in total