MATERIALS AND METHODS: All patients with active Charcot arthropathy treated at the medical centre from 1 January 2013 to 30 June 2020 were included in the study. Efficacy outcome was evaluated based on time to consolidate findings observed through radiographic examination, while safety outcome was evaluated based on the incidence of adverse event (AE) occurrence.
RESULTS: A total of 81 patients (37 male, 44 female) diagnosed with active Charcot arthropathy were included. 64.2% of patients were at stage 1 of Charcot arthropathy whereas 35.8% were at stage 2. The mean time to consolidate for stage 1 and stage 2 was 6.50 ± 4.21 months and 3.63 ± 2.92 months respectively (p-value = 0.139). No significant association was observed between gender, ethnicity and disease stage with the consolidation time (p-value >0.05). The rate of AE incidence was 2.5%, observed in 2 patients who developed a fever during the treatment. No other serious AE was observed in the study.
CONCLUSION: Intravenous Pamidronate infusion is a safe and effective treatment option for Charcot arthropathy.
METHODS: A retrospective analysis was conducted on 126 patients with severe IS (defined as a major Cobb angle ≥90°) who underwent single-stage PSF without osteotomy procedures. Key parameters collected included preoperative Cobb angle (Pre Cobb), postoperative Cobb angle (Post Cobb), correction rate (CR), side-bending Cobb angle (SB Cobb), side-bending flexibility (SBF), side-bending correction index (SBCI), total number of fusion levels, number of pedicle screws utilized, and operative time (Op Time). The estimated total intraoperative blood loss (EBL) was quantified. Multiple regression analysis was employed to identify independent predictors of intraoperative blood loss.
RESULTS: The mean pre Cobb was 103.0 + 12.4° and post Cobb was 45.1 + 14.0°. The mean CR was 56.1 + 12.8 %. The mean SB Cobb and flexibility were 65.0 + 19.4° and 37.7 + 13.7 %. Average SBCI was 1.8 + 1.2. The mean fusion levels and number of screws used were 13.3 + 1.3 and 16.3 + 1.6, respectively. The mean Op time in this study was 185.9 + 49.3 min. The mean EBL was 1493.0 + 841.0 mL, EBL/EBV ratio was 51.6 + 29.1 %, and EBL/level fused was 112.0 ± 62.0 mL. Multiple regression analysis identified Op time, gender, and pre Cobb as the independent predictors for EBL (R2 0.281; p
METHODS: A comprehensive search strategy was applied across Scopus, PubMed, Cochrane Library, ProQuest, and Scopus databases, using expert-validated keywords, with manual searches for relevant articles published from June 2013 to June 2023. The SR followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Eligible studies focused on the use of ATs as OH education tools for individuals with SI and assessed their impact on OH behavior and status.
RESULTS: Eighteen of the 1298 identified studies were included in the data synthesis. ATs, such as images, software, multimedia, audio, video, audio-tactile performance, and combination methods, were effective for OH care in individuals with SI. However, this SR limitations include study heterogeneity in sample sizes, intervention types, and outcomes, as well as the exclusion of non-English studies.
CONCLUSIONS: Oral health education using a combination of video training and audio-tactile performance is particularly effective for individuals with SI, engaging multiple senses for learning. Future research should focus on standardizing methodologies and incorporating larger sample sizes to enhance the efficacy of these technologies in improving OH care for individuals with SI. PROSPERO REG. NO.: CRD42023485523.