Displaying publications 401 - 420 of 697 in total

Abstract:
Sort:
  1. Mohd Kamil MK, Ngiu CS, Md Isa N, Yaacob Y Y, Deborah Chew CH, Wong ZQ, et al.
    Med J Malaysia, 2018 02;73(1):60-62.
    PMID: 29531208 MyJurnal
    Neuroendocrine neoplasm is an epithelial neoplasm with predominant neuroendocrine differentiation that can arise from many organs in the body. We reported a rare case of gastric neuroendocrine carcinoma which accounts for less than 1% of all gastric tumours that is associated with poor prognosis. The recognition of this rare tumour in early stage is challenging and high suspicious into it might bring to early detection and so forth might improve the prognostication.
  2. Logakodie S, Azahadi O, Fuziah P, Norizzati B, Tan SF, Zienna Z, et al.
    Malays Fam Physician, 2017;12(2):9-17.
    PMID: 29423124
    Objective: The aim of the study is to determine the prevalence of gestational diabetes mellitus (GDM), its associated risk factors, foeto-maternal outcomes and prevalence of postnatal diabetes mellitus (DM).
    Methods: This is a cross-sectional study using retrospective data from existing antenatal records of new antenatal women who registered at 72 public health clinics in Selangor in January 2014.
    Results: A total of 745 antenatal records were reviewed. The prevalence of GDM women was 27.9% (n = 184). GDM risks were higher in women aged 35 years old and above and in those with maternal obesity. GDM women had a higher risk of having a non-spontaneous vaginal delivery compared to non-GDM women. The prevalence of postnatal DM among GDM mother was 12.1%. Working GDM mothers were at higher risk of developing postnatal DM.
    Conclusion: The prevalence of GDM among newly registered women attending antenatal public health care in Selangor was higher than previous studies. Health care personnel need to be vigilant in screening women with risk factors.
  3. Sheshadri SN, Kwong HC, Chidan Kumar CS, Quah CK, Siddaraju BP, Veeraiah MK, et al.
    Acta Crystallogr E Crystallogr Commun, 2018 May 01;74(Pt 5):752-756.
    PMID: 29850106 DOI: 10.1107/S2056989018006217
    In the cation of the title salt, C20H19N2O+·Br-, the phenyl rings are inclined to one another by 38.38 (8)°, whereas the central phenyl ring and the pyridiniminium ring are almost perpendicular with a dihedral angle of 87.37 (9)°. The N+=C cationic double bond was verified by the shortened bond length of 1.337 (2) Å. In the crystal, the Br- anion is linked to the cation by an N-H⋯Br hydrogen bond. C-H⋯O hydrogen bonds link adjacent pyridiniminium cations into inversion dimers with an R22(18) graph-set motif. These dimers are stacked in a phen-yl-phenyl T-shaped geometry through C-H⋯π inter-actions. A Hirshfeld surface analysis was conducted to verify the contributions of the different inter-molecular inter-actions.
  4. Abd Razak MA, Ahmad NA, Chan YY, Mohamad Kasim N, Yusof M, Abdul Ghani MKA, et al.
    Public Health, 2019 Apr;169:84-92.
    PMID: 30826688 DOI: 10.1016/j.puhe.2019.01.001
    OBJECTIVES: This systematic review aims to provide updated and comprehensive evidence on the validity and feasibility of screening tools for mild cognitive impairment (MCI) and dementia among the elderly at primary healthcare level.

    STUDY DESIGN: A review of articles was performed.

    METHODS: A search strategy was used by using electronic bibliographic databases including PubMed, Embase and CENTRAL for published studies and reference list of published studies. The articles were exported to a bibliographic database for further screening process. Two reviewers worked independently to screen results and extract data from the included studies. Any discrepancies were resolved and confirmed by the consensus of all authors.

    RESULTS: There were three screening approaches for detecting MCI and dementia - screening by a healthcare provider, screening by a self-administered questionnaire and caretaker informant screening. Montreal Cognitive Assessment (MoCA) was the most common and preferable tool for MCI screening (sensitivity [Sn]: 81-97%; specificity [Sp]: 60-86%), whereas Addenbrooke's Cognitive Examination (ACE) was the preferable tool for dementia screening (Sn: 79-100%; Sp: 86%).

    CONCLUSION: This systematic review found that there are three screening approaches for detecting early dementia and MCI at primary health care. ACE and MoCA are recommended tools for screening of dementia and MCI, respectively.

  5. Teh LS, Lee MK, Wang F, Manivasagar M, Charles PJ, Nicholson GD, et al.
    Br J Rheumatol, 1993 Aug;32(8):663-5.
    PMID: 8348266
    We report a significantly increased prevalence of antiribosomal P protein antibodies in Malaysian Chinese patients (38%) with SLE compared to white Caucasian (13%) and Afro-Caribbean (20%) patients. The increased prevalence was not due to a generalized increase in autoantibody production because anti-dsDNA and anti-SSA antibodies were present in comparable frequencies in the three ethnic groups while anti-Sm and anti-SSB antibodies were rarely found in the Malaysian Chinese patients.
  6. Asilah Za'don NH, Amirul Farhana MK, Farhanim I, Sharifah Izwan TO, Appukutty M, Salim N, et al.
    Med J Malaysia, 2019 12;74(6):461-467.
    PMID: 31929469
    INTRODUCTION: High-intensity interval training (HIIT) has been found to improve cardiometabolic health outcome as compared to moderate-intensity continuous exercise. However, there is still limited data on the benefits of HIIT on the expression of regulatory proteins that are linked to skeletal muscle metabolism and insulin sensitivity in obese adults. This study investigated the effects of HIIT intervention on expressions of peroxisome proliferatoractivated receptor-γ coactivator 1-∝ (PGC-1∝) and adiponectin receptor-1 (AdipoR1), insulin sensitivity (HOMAIR index), and body composition in overweight/obese individuals.

    METHODS: Fifty overweight/obese individuals aged 22-29 years were assigned to either no-exercise control (n=25) or HIIT (n=25) group. The HIIT group underwent a 12-week intervention, three days/week, with intensity of 65-80% of age-based maximum heart rate. Anthropometric measurements, homeostatic model of insulin resistance (HOMA-IR) and gene expression analysis were conducted at baseline and post intervention.

    RESULTS: Significant time-by-group interactions (p<0.001) were found for body weight, BMI, waist circumference and body fat percentage. The HIIT group had lower body weight (2.3%, p<0.001), BMI (2.7%, p<0.001), waist circumference (2.4%, p<0.001) and body fat percentage (4.3%, p<0.001) post intervention. Compared to baseline, expressions of PGC-1∝ and AdipoR1 were increased by approximately three-fold (p=0.019) and two-fold (p=0.003) respectively, along with improved insulin sensitivity (33%, p=0.019) in the HIIT group.

    CONCLUSION: Findings suggest that HIIT possibly improved insulin sensitivity through modulation of PGC-1∝ and AdipoR1. This study also showed that improved metabolic responses can occur despite modest reduction in body weight in overweight/obese individuals undergoing HIIT intervention.

  7. Iqhrammullah M, Marlina, Hedwig R, Karnadi I, Kurniawan KH, Olaiya NG, et al.
    Polymers (Basel), 2020 Apr 13;12(4).
    PMID: 32294999 DOI: 10.3390/polym12040903
    The use of polymeric material in heavy metal removal from wastewater is trending. Heavy metal removal from wastewater of the industrial process is of utmost importance in green/sustainable manufacturing. Production of absorbent materials from a natural source for industrial wastewater has been on the increase. In this research, polyurethane foam (PUF), an adsorbent used by industries to adsorb heavy metal from wastewater, was prepared from a renewable source. Castor oil-based polyurethane foam (COPUF) was produced and modified for improved adsorption performance using fillers, analyzed with laser-induced breakdown spectroscopy (LIBS). The fillers (zeolite, bentonite, and activated carbon) were added to the COPUF matrix allowing the modification on its surface morphology and charge. The materials were characterized using Fourier-transform infrared (FTIR), scanning electron microscopy (SEM), and thermal gravimetry analysis (TGA), while their adsorption performance was studied by comparing the LIBS spectra. The bentonite-modified COPUF (B/COPUF) gave the highest value of the normalized Pb I (405.7 nm) line intensity (2.3), followed by zeolite-modified COPUF (Z/COPUF) (1.9), and activated carbon-modified COPUF (AC/COPUF) (0.2), which indicates the adsorption performance of Pb2+ on the respective materials. The heavy metal ions' adsorption on the B/COPUF dominantly resulted from the electrostatic attraction. This study demonstrated the potential use of B/COPUF in adsorption and LIBS quantitative analysis of aqueous heavy metal ions.
  8. Koo HC, Kaur S, Chan KQ, Soh WH, Ang YL, Chow WS, et al.
    J Hum Nutr Diet, 2020 10;33(5):670-677.
    PMID: 32250007 DOI: 10.1111/jhn.12753
    INTRODUCTION: Little is known about the relationship of whole-grain intake with dietary fatty acids intake. The present study aimed to assess the whole-grain intake and its relationships with dietary fatty acids intake among multiethnic schoolchildren in Kuala Lumpur, Malaysia.

    METHODS: This cross-sectional study was conducted among 392 schoolchildren aged 9-11 years, cluster sampled from five randomly selected schools in Kuala Lumpur. Whole-grain and fatty acids intakes were assessed by 3-day, 24-h diet recalls. All whole-grain foods were considered irrespective of the amount of whole grain they contained.

    RESULTS: In total, 55.6% (n = 218) were whole-grain consumers. Mean (SD) daily intake of whole grain in the total sample was 5.13 (9.75) g day-1 . In the whole-grain consumer's only sample, mean (SD) intakes reached 9.23 (11.55) g day-1 . Significant inverse associations were found between whole-grain intake and saturated fatty acid (SAFA) intake (r = -0.357; P 

  9. Letchumanan I, Gopinath SCB, Md Arshad MK, Mohamed Saheed MS, Perumal V, Voon CH, et al.
    Crit Rev Anal Chem, 2020 Sep 08.
    PMID: 32897761 DOI: 10.1080/10408347.2020.1812373
    Mortality level is worsening the situation worldwide thru blood diseases and greatly jeopardizes the human health with poor diagnostics. Due to the lack of successful generation of early diagnosis, the survival rate is currently lower. To overcome the present hurdle, new diagnostic methods have been choreographed for blood disease biomarkers analyses with the conjunction of ultra-small ideal gold nanohybrids. Gold-hybrids hold varieties of unique features, such as high biocompatibility, increased surface-to-volume ratio, less-toxicity, ease in electron transfer and have a greater localized surface plasmon resonance. Gold-nanocomposites can be physically hybrid on the sensor surface and functionalize with the biomolecules using appropriate chemical conjugations. Revolutionizing biosensor platform can be prominently linked for the nanocomposite applications in the current research on medical diagnosis. This review encloses the new developments in diagnosing blood biomarkers by utilizing the gold-nanohybrids. Further, the current state-of-the-art and the future envision with digital monitoring for facile telediagnosis were narrated.
  10. Ong LC, Boo NY, Chandran V, Zulfiqar A, Zamratol SM, Allison L, et al.
    Singapore Med J, 1997 Mar;38(3):108-11.
    PMID: 9269376
    The aim of the study was to determine the predictive value of cranial ultrasound scans done in the neonatal period for neurodevelopmental outcome of the Malaysian very low birthweight (VLBW, < 1500 grams) infants assessed at 12 months of corrected age. Of the 101 infants studied, 68 (67.3%) were neurodevelopmentally normal at one year of age, 18 (17.8%) had major and 15 (14.9%) had minor neurodevelopmental impairment. Neurodevelopmental outcome was normal in 66/88 (75.0%) infants who did not have severe intraventricular haemorrhage (IVH) or periventricular intraparenchymal echo densities (PVE) in the first week of life, and in 57/73 (78.1%) with uncomplicated scans at discharge. In contrast, 11/13 (84.6%) with parenchymal echo densities or severe intraventricular bleed in the early neonatal period and 17/28 (60.7%) with complicated scans at discharge had adverse sequelae. There was a significant association between lesions seen on cranial ultrasound in the neonatal period and subsequent neurodevelopmental impairment. Late neonatal ultrasound scans appear to be a better predictor of short-term neurodevelopmental outcome than early scans.
  11. Teh BT, Hii SI, David R, Parameswaran V, Grimmond S, Walters MK, et al.
    Hum Genet, 1994 Nov;94(5):468-72.
    PMID: 7959678 DOI: 10.1007/bf00211009
    Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disease characterized by neoplasia of the parathyroid glands, anterior pituitary and endocrine pancreas, is rarely reported in Asian populations. The MEN1 gene, mapped to chromosome 11q13 but yet to be cloned, has been found to be homogeneous in Caucasian populations through linkage analysis. Here, two previously unreported Asian kindreds with MEN1 are described; linkage analysis using microsatellite polymorphic markers in the MEN1 region was carried out. The first kindred, of Mongolian-Chinese origin, is a multigeneration family with over 150 living members, eight of whom are affected to date. The second kindred is of Chinese origin consisting of four affected members. Linkage to chromosome 11q13 was confirmed in both kindreds, supporting evidence for genetic homogeneity. A recombination in the larger kindred localizes the gene distal to marker D11S956, consistent with its placement from previous studies. We also show that it is feasible to use these markers for predictive testing, as four gene carriers were detected in 13 family members with unknown disease status in the first kindred.
  12. Trache D, Hussin MH, Hui Chuin CT, Sabar S, Fazita MR, Taiwo OF, et al.
    Int J Biol Macromol, 2016 Dec;93(Pt A):789-804.
    PMID: 27645920 DOI: 10.1016/j.ijbiomac.2016.09.056
    Considering its widespread usage in various fields, such as food, pharmaceutical, medical, cosmetic and polymer composites industries, microcrystalline cellulose (MCC) is becoming impellent due to increasing demand of alternatives to non-renewable and scarce fossil materials. Although it still suffers from some drawbacks, MCC has recently gained more interest owing to its renewability, non-toxicity, economic value, biodegradability, high mechanical properties, high surface area and biocompatibility. New sources, new isolation processes, and new treatments are currently under development to satisfy the increasing demand of producing new types of MCC-based materials on an industrial scale. Therefore, this review assembles the current knowledge on the isolation of MCC from different sources using various procedures, its characterization, and its application in bio-composites. Challenges and future opportunities of MCC-based composites are discussed as well as obstacles remaining for their extensive uses.
  13. Gopinath SC, Lakshmipriya T, Chen Y, Arshad MK, Kerishnan JP, Ruslinda AR, et al.
    Appl Microbiol Biotechnol, 2016 Aug;100(16):6955-69.
    PMID: 27350620 DOI: 10.1007/s00253-016-7686-2
    Aptamers are single-stranded nucleic acids or peptides identified from a randomized combinatorial library through specific interaction with the target of interest. Targets can be of any size, from small molecules to whole cells, attesting to the versatility of aptamers for binding a wide range of targets. Aptamers show drug properties that are analogous to antibodies, with high specificity and affinity to their target molecules. Aptamers can penetrate disease-causing microbial and mammalian cells. Generated aptamers that target surface biomarkers act as cell-targeting agents and intracellular delivery vehicles. Within this context, the "cell-internalizing aptamers" are widely investigated via the process of cell uptake with selective binding during in vivo systematic evolution of ligands by exponential enrichment (SELEX) or by cell-internalization SELEX, which targets cell surface antigens to be receptors. These internalizing aptamers are highly preferable for the localization and functional analyses of multiple targets. In this overview, we discuss the ways by which internalizing aptamers are generated and their successful applications. Furthermore, theranostic approaches featuring cell-internalized aptamers are discussed with the purpose of analyzing and diagnosing disease-causing pathogens.
  14. Chan LF, Mohamad Adam B, Norazlin KN, Siti Haida MI, Lee VY, Norazura AW, et al.
    J Adolesc, 2016 10;52:162-9.
    PMID: 27572955 DOI: 10.1016/j.adolescence.2016.08.006
    Pregnant adolescents are a high-risk population for suicide. However, a knowledge gap still exists on how sexual and religious knowledge, attitudes and practices (KAP) influence suicidal ideation (SI) in teenage pregnancy. We aim to explore the interplay between psychiatric diagnoses, sociodemographic factors and KAP of sexual and religious issues as risk factors of SI among 114 pregnant Malaysian adolescents from 6 rehabilitation centers and a tertiary hospital. Single sexual partner was an independent predictor of SI, suggesting the role of less sexual experience as a risk factor for SI after controlling for major depression. Participants who were unsure versus those who agreed with the statement that most religions' viewed sex outside marriage as wrong had a lower risk of SI after controlling for major depression. Pregnant adolescents with a single sexual partner were significantly associated with current SI. Ambivalence towards religious prohibitions on premarital sex may protect against suicidal ideation.
  15. Hussin MH, Pohan NA, Garba ZN, Kassim MJ, Rahim AA, Brosse N, et al.
    Int J Biol Macromol, 2016 Jun 30;92:11-19.
    PMID: 27373428 DOI: 10.1016/j.ijbiomac.2016.06.094
    The present study sheds light on the physical and chemical characteristics of microcrystalline cellulose (MCC) isolated from oil palm fronds (OPF) pulps. It was found that the OPF MCC was identified as cellulose II polymorph, with higher crystallinity index than OPF α-cellulose (CrIOPFMCC: 71%>CrIOPFα-cellulose: 47%). This indicates that the acid hydrolysis allows the production of cellulose that is highly crystalline. BET surface area of OPF MCC was found to be higher than OPF α-cellulose (SBETOPFMCC: 5.64m(2)g(-1)>SBETOPFα-cellulose:Qa(0) 2.04m(2)g(-1)), which corroborates their potential as an adsorbent. In batch adsorption studies, it was observed that the experimental data fit well with Langmuir adsorption isotherm in comparison to Freundlich isotherm. The monolayer adsorption capacity (Qa(0)) of OPF MCC was found to be around 51.811mgg(-1) and the experimental data fitted well to pseudo-second-order kinetic model.
  16. Hiil JL, Kan SK, Parmar SS, Chan MK, Mak JW, Lim PK, et al.
    Am J Trop Med Hyg, 1988 May;38(3):582-8.
    PMID: 3275137
    Mass drug administration via 3 modes of delivery reduced the incidence and prevalence rates and intensity of Brugia malayi infection in 3 rural villages in the Bengkoka Peninsula, Sabah, in 1982-1983. A dosage of 6 mg diethylcarbamazine citrate (DEC-C)/kg body weight was administered either daily or weekly (total of 6 doses, 36 mg/kg body weight), and impact on B. malayi cases were comparable in the 3 villages. A total of 384 people participated in the DEC-C regimens, and all pregnant women and children under 2 years were excluded from the study. Bekessy's method of estimation of incidence and recovery rates was applied to data on B. malayi microfilaremia before drug administration. Treatment with DEC-C by any of the 3 modes of delivery drastically reduced the number of episodes of patent microfilaremia, incidence and prevalence, and median microfilarial density. Reduction was sustained for at least 18 to 24 months after treatment.
  17. Hii JL, Kan S, Vun YS, Chin KF, Tambakau S, Chan MK, et al.
    Ann Trop Med Parasitol, 1988 Feb;82(1):91-101.
    PMID: 3041932
    Holoendemic malaria transmission in two small isolated forest communities and a coastal village was studied by (1) all night human bait collections of Anopheles species from inside and outside houses and (2) buffalo-biting and CDC light-trapping catches during March and November 1984. During the same period thick and thin blood films were collected from the human population, and spleen rates were determined in children from two to nine years of age. Using both the immunoradiometric assay (IRMA) and the dissection technique, more sporozoite-positive infections were detected in An. balabacensis and An. flavirostris in November than in March. IRMA confirmed the presence of Plasmodium falciparum sporozoites. An average of 76.2% of the An. balabacensis population lived long enough to have reached a point where infectivity with P. falciparum was possible in November. Although fewer than five adult females bit humans per night at any time, a resident could theoretically have received more than 160 infective bites in one year. A high frequency of feeding on humans, coupled with increased anopheline life expectancy, contributed to high estimates of falciparum malaria vectorial capacity (number of infections distributed per case per day); for An. balabacensis (1.44-7.44 in March and 9.97-19.7 in November) and for An. flavirostris (0.19-5.14 in March and 6.27-15.8 in November). These high values may explain the increased malaria parasite rates obtained from at least two forest communities. Correlation between actual and calculated rates of gametocytaemia was poorest in Kapitangan due to inadequate sampling of the human population. In Banggi island, malaria is stable and holoendemic, and the population enjoys a high degree of immunity.
  18. Ang HL, Mohamad Adam B, Tajuddin A, Isnoni I, Suzanna A, Anwar Hau M, et al.
    MyJurnal
    The incidence of hip fractures is increasing within the aging population.We determined the risk factors of in-hospital mortality following hip fracture across major hospitals in Malaysia. This is a retrospective cohort review from 18 hospitals across Malaysia in National Orthopaedic Registry of Malaysia (NORM) . We collected demographic data, prefracture co-morbidities, previous hip fracture, pre-fracture walking ability, fracture type and stability, mechanism of injury, type of management (operative or non-operative), operation types and grade of surgeon. Between 2008 and 2009, 685 patients were admitted with a hip fracture to 18 government hospitals with orthopaedic service. The overall in-hospital mortality was 2.2%. We found more in-hospital mortality in elderly patients and patients with eye and hearing problems as pre-fracture morbidity. In conclusion, patients who were elderly with multiple comorbidities especially those with eye and hearing impairment were had higher risk for immediate mortality
  19. Saufi SASA, Zuhri MYM, Dezaki ML, Sapuan SM, Ilyas RA, As'arry A, et al.
    Polymers (Basel), 2021 Dec 14;13(24).
    PMID: 34960939 DOI: 10.3390/polym13244388
    The bio-inspired structure (e.g., honeycomb) has been studied for its ability to absorb energy and its high strength. The cell size and wall thickness are the main elements that alter the structural ability to withstand load and pressure. Moreover, adding a secondary structure can increase the compressive strength and energy absorption (EA) capability. In this study, the bio-inspired structures are fabricated by fused deposition modelling (FDM) technology using polylactic acid (PLA) material. Samples are printed in the shape of a honeycomb structure, and a starfish shape is used as its reinforcement. Hence, this study focuses on the compression strength and EA of different cell sizes of 20 and 30 mm with different wall thicknesses ranging from 1.5 to 2.5 mm. Subsequently, the deformation and failure of the structures are determined under the compression loading. It is found that the smaller cell size with smaller wall thickness offered a crush efficiency of 69% as compared to their larger cell size with thicker wall thickness counterparts. It is observed that for a 20 mm cell size, the EA and maximum peak load increase, respectively, when the wall thickness increases. It can be concluded that the compression strength and EA capability increase gradually as the cell size and wall thickness increase.
  20. Osman H, Raafat BM, Faizo NL, Ahmed RM, Alamri S, Alghamdi AJ, et al.
    Appl Radiat Isot, 2021 Nov 27;180:110049.
    PMID: 34864437 DOI: 10.1016/j.apradiso.2021.110049
    The current study was aimed to estimate the entrance surface air kerma (ESAK, mGy) for adult patients undergoing conventional radiography of Anteroposterior pelvis examination, and finally to establish a local diagnostic reference level (DRL). A total of 500 patients were exposed to diagnostic radiation in four hospitals (coded A, B, C, and D) in Taif and Kharaj city, Saudi Arabia, with different X-ray equipment specifications. Patient demographic data like age (y), body mass index (BMI) in kg/m2 as well as exposure factors and X-ray tube output were recorded. ESAK (mGy) was first calculated using the exposure data and tube output values, then the ESAK values were used to estimate entrance surface dose (ESD). The average BMI was 23.9 kg/m2. The mean tube potential used in A, B, C, and D hospitals and the corresponding estimated ESD were found to be 74.2, 69.8, 73, 76,7 kVp, and 2.54, 2.64, 2.94, 3.03 mGy respectively. The correlation coefficient between ESAK and BMI was found to be 0.98. When compared to computed radiography (CR), the conventional X-ray digital radiography reduces the radiation exposure in pelvic imaging by a factor of 1.18. The third quartile of median proposed a lower than the DRL of the previous studies.
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links