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Fulltext Evaluating the possibility of detecting evidence of positive selection across Asia with sparse genotype data from the HUGO Pan-Asian SNP Consortium

Liu X, Saw WY, Ali M, Ong RT, Teo YY

BMC Genomics, 2014;15:332.
PMID: 24885517 DOI: 10.1186/1471-2164-15-332

The HUGO Pan-Asian SNP Consortium (PASNP) has generated a genetic resource of almost 55,000 autosomal single nucleotide polymorphisms (SNPs) across more than 1,800 individuals from 73 urban and indigenous populations in Asia. This has offered valuable insights into the correlation between the genetic ancestry of these populations with major linguistic systems and geography. Here, we attempt to understand whether adaptation to local climate, diet and environment partly explains the genetic variation present in these populations by investigating the genomic signatures of positive selection.

Matched MeSH terms: Asia
Fulltext A cybertaxonomic revision of the micro-landsnail genus Plectostoma Adam (Mollusca, Caenogastropoda, Diplommatinidae), from Peninsular Malaysia, Sumatra and Indochina

Liew TS, Vermeulen JJ, Marzuki ME, Schilthuizen M

Zookeys, 2014.
PMID: 24715783 DOI: 10.3897/zookeys.393.6717

Plectostoma is a micro land snail restricted to limestone outcrops in Southeast Asia. Plectostoma was previously classified as a subgenus of Opisthostoma because of the deviation from regular coiling in many species in both taxa. This paper is the first of a two-part revision of the genus Plectostoma, and includes all non-Borneo species. In the present paper, we examined 214 collection samples of 31 species, and obtained 62 references, 290 pictures, and 155 3D-models of 29 Plectostoma species and 51 COI sequences of 19 species. To work with such a variety of taxonomic data, and then to represent it in an integrated, scaleable and accessible manner, we adopted up-to-date cybertaxonomic tools. All the taxonomic information, such as references, classification, species descriptions, specimen images, genetic data, and distribution data, were tagged and linked with cyber tools and web servers (e.g. Lifedesks, Google Earth, and Barcoding of Life Database). We elevated Plectostoma from subgenus to genus level based on morphological, ecological and genetic evidence. We revised the existing 21 Plectostoma species and described 10 new species, namely, P. dindingensis sp. n., P. mengaburensis sp. n., P. whitteni sp. n., P. kayiani sp. n., P. davisoni sp. n., P. relauensis sp. n., P. kubuensis sp. n., P. tohchinyawi sp. n., P. tenggekensis sp. n., and P. ikanensis sp. n. All the synthesised, semantic-tagged, and linked taxonomic information is made freely and publicly available online.

Matched MeSH terms: Asia, Southeastern
Fulltext Draft Genome Sequence of Pasteurella multocida subsp. multocida Strain PMTB, Isolated from a Buffalo

Yap HY, Ghazali K, Wan Mohamad Nazarie WF, Mat Isa MN, Zakaria Z, Omar AR

Genome Announc, 2013;1(5).
PMID: 24136854 DOI: 10.1128/genomeA.00872-13

Pasteurella multocida serotypes B:2 and E:2 are the main causative agents of ruminant hemorrhagic septicemia in Asia and Africa, respectively. Pasteurella multocida strain PMTB was isolated from a buffalo with hemorrhagic septicemia and has been determined to be serotype B:2. Here we report the draft genome sequence of strain PMTB.

Matched MeSH terms: Asia
Fulltext The Kuala Lumpur Declaration on Promotion of Scholarly Writing Skills and Standards in the Asia Pacific Region

Lim KG

Med J Malaysia, 2012 Aug;67(4):357-8.
PMID: 23082440
Matched MeSH terms: Asia, Southeastern
Fulltext Congenital humeroradial synostosis: a case report

Nema S, Vyas G, Sirsikar A, Bhoj PK

Malays Orthop J, 2012 Jun;6(SupplA):41-2.
PMID: 25279074 MyJurnal DOI: 10.5704/MOJ.1211.010

We present here a unique case of humeroradial synostosis. These anomalies are due to longitudinal failure of differentiation. Approximately 150 cases of humeroradial synostosis have been reported worldwide, the majority of which are familial in nature or associated with syndromes. The case presented here involves an infant aged 1½ months, born with bilateral humeroradial synostosis without familial or syndromic association. To the best of our knowledge, no such case has been reported in Asia.

Matched MeSH terms: Asia
Fulltext Asian School of Urology, Young Leaders' Workshop, Kyoto 2010

Ogawa O

Int J Urol, 2011 Jan;18(1):87-91.
PMID: 21198942 DOI: 10.1111/j.1442-2042.2010.02659.x

As part of the 20th Anniversary Celebration of the Urological Association of Asia (UAA), the Asian School of Urology, Young Leaders' Workshop was held in Kyoto, 23-25 April 2010. The workshop focused on future national Asian leaders in the field of Urology and was arranged by the Asian School of Urology (ASU), an educational branch of the UAA, and Dr Osamu Ogawa, the workshop Organizer. Urologists from several Japanese universities contributed to the workshop as advisors, taskforce members, and group members. The workshop was also actively supported by Dr Allen Chiu (Taiwan) and Dr Stephen Lim (Singapore). A younger generation of urologists was invited to attend the workshop and, in all, 29 delegates from 17 countries (Australia, Bangladesh, Cambodia, China, India, Indonesia, Iran, Korea, Malaysia, Myanmar, Nepal, Philippines, Singapore, Sri Lanka, Taiwan, Thailand, and Vietnam), chosen on the basis of recommendations from local councils, attended. The purpose of the workshop was to open channels of communication between future Asian leaders in Urology. The workshop topic was "Asian Clinical Guidelines". Workshop participants were divided into five groups addressing distinct issues associated with the notion of clinical guidelines: Group A, General Problems; Group B, Prostate Cancer; Group C, Stone Disease; Group D, Infectious Diseases; and Group E, Bladder Cancer. The workshop consisted of an introductory session, followed by three main sessions, each of which consisted of a group discussion of specific problems associated with the establishment of Asian Guidelines for Urological Diseases and how best to deal with them, followed by a plenary presentation of the outcomes.

Matched MeSH terms: Asia
Fulltext Extending Asia Pacific bioinformatics into new realms in the "-omics" era

Ranganathan S, Eisenhaber F, Tong JC, Tan TW

BMC Genomics, 2009;10 Suppl 3:S1.
PMID: 19958472 DOI: 10.1186/1471-2164-10-S3-S1

The 2009 annual conference of the Asia Pacific Bioinformatics Network (APBioNet), Asia's oldest bioinformatics organisation dating back to 1998, was organized as the 8th International Conference on Bioinformatics (InCoB), Sept. 7-11, 2009 at Biopolis, Singapore. Besides bringing together scientists from the field of bioinformatics in this region, InCoB has actively engaged clinicians and researchers from the area of systems biology, to facilitate greater synergy between these two groups. InCoB2009 followed on from a series of successful annual events in Bangkok (Thailand), Penang (Malaysia), Auckland (New Zealand), Busan (South Korea), New Delhi (India), Hong Kong and Taipei (Taiwan), with InCoB2010 scheduled to be held in Tokyo, Japan, Sept. 26-28, 2010. The Workshop on Education in Bioinformatics and Computational Biology (WEBCB) and symposia on Clinical Bioinformatics (CBAS), the Singapore Symposium on Computational Biology (SYMBIO) and training tutorials were scheduled prior to the scientific meeting, and provided ample opportunity for in-depth learning and special interest meetings for educators, clinicians and students. We provide a brief overview of the peer-reviewed bioinformatics manuscripts accepted for publication in this supplement, grouped into thematic areas. In order to facilitate scientific reproducibility and accountability, we have, for the first time, introduced minimum information criteria for our pubilcations, including compliance to a Minimum Information about a Bioinformatics Investigation (MIABi). As the regional research expertise in bioinformatics matures, we have delineated a minimum set of bioinformatics skills required for addressing the computational challenges of the "-omics" era.

Matched MeSH terms: Asia
Global overview of injecting drug use and HIV infection among injecting drug users

Aceijas C, Stimson GV, Hickman M, Rhodes T, United Nations Reference Group on HIV/AIDS Prevention and Care among IDU in Developing and Transitional Countries

AIDS, 2004 Nov 19;18(17):2295-303.
PMID: 15577542

OBJECTIVE: To provide global estimates of the prevalence of injecting drug use (IDU) and HIV prevalence among IDU, in particular to provide estimates for developing and transitional countries.
METHODS: Collation and review of existing estimates of IDU prevalence and HIV prevalence from published and unpublished documents for the period 1998-2003. The strength of evidence for the information was assessed based on the source and type of study.
RESULTS: Estimates of IDU prevalence were available for 130 countries. The number of IDU worldwide was estimated as approximately 13.2 million. Over ten million (78%) live in developing and transitional countries (Eastern Europe and Central Asia, 3.1 million; South and South-east Asia, 3.3 million; East-Asia and Pacific, 2.3 million). Estimates of HIV prevalence were available for 78 countries. HIV prevalence among IDU of over 20% was reported for at least one site in 25 countries and territories: Belarus, Estonia, Kazakhstan, Russia, Ukraine, Italy, Netherlands, Portugal, Serbia and Montenegro, Spain, Libya, India, Indonesia, Malaysia, Myanmar, Nepal, Thailand, Viet Nam, China, Argentina, Brazil, Uruguay, Puerto Rico, USA and Canada.
CONCLUSIONS: These findings update previous assessments of the number of countries with IDU and HIV-infected IDU, and the previous quantitative global estimates of the prevalence of IDU. However, gaps remain in the information and the strength of the evidence often was weak.

Matched MeSH terms: Asia, Central/epidemiology; Asia, Southeastern/epidemiology
The Asian consensus statements on endoscopic management of walled-off necrosis Part1: Epidemiology, diagnosis and treatment

Isayama H, Nakai Y, Rerknimitr R, Khor C, Lau J, Wang HP, et al.

J Gastroenterol Hepatol, 2016 Apr 4.
PMID: 27044023 DOI: 10.1111/jgh.13394

Walled-off necrosis (WON) is a relatively new term for encapsulated necrotic tissue after severe acute pancreatitis. Various terminologies such as pseudocyst, necroma, pancreatic abscess and infected necrosis were previously used in the literature, resulting in confusion. The current and past terminologies must be reconciled to meaningfully interpret past data. Recently, endoscopic necrosectomy was introduced as a treatment option and is now preferred over surgical necrosectomy when the expertise is available. However, high-quality evidence is still lacking, and there is no standard management strategy for WON. The consensus meeting aimed to clarify the diagnostic criteria for WON and the role of endoscopic interventions in its management. In the Consensus Conference, 25 experts from 8 Asian countries took an active role and examined key clinical aspects of WON diagnosis and endoscopic management. Statements were crafted based on literature review and expert opinion, employing the modified Delphi method. All statements were substantiated by the level of evidence and the strength of the recommendation. We created 27 consensus statements for WON diagnosis and management, including details of endoscopic procedures. When there was not enough solid evidence to support the statements, this was clearly acknowledged to facilitate future research. Proposed management strategies were formulated and are illustrated using flow charts. These recommendations, which are based on the best current scientific evidence and expert opinion, will be useful for guiding endoscopic management of WON. Part 1 of this statement focused on the epidemiology, diagnosis and timing of intervention.

Matched MeSH terms: Asia
Fulltext Epidemiology and molecular characterization of multidrug-resistant Gram-negative bacteria in Southeast Asia

Suwantarat N, Carroll KC

Antimicrob Resist Infect Control, 2016;5:15.
PMID: 27148448 DOI: 10.1186/s13756-016-0115-6

Multidrug-resistant Gram-negative bacteria (MDRGN), including extended-spectrum β-lactamases (ESBLs) and multidrug-resistant glucose-nonfermenting Gram-negative bacilli (nonfermenters), have emerged and spread throughout Southeast Asia.

Matched MeSH terms: Asia, Southeastern
Fulltext Historical perspective on the synonymization of the four major pest species belonging to the Bactrocera dorsalis species complex (Diptera, Tephritidae)

Hee AK, Wee SL, Nishida R, Ono H, Hendrichs J, Haymer DS, et al.

Zookeys, 2015.
PMID: 26798266 DOI: 10.3897/zookeys.540.6028

An FAO/IAEA-sponsored coordinated research project on integrative taxonomy, involving close to 50 researchers from at least 20 countries, culminated in a significant breakthrough in the recognition that four major pest species, Bactrocera dorsalis, Bactrocera philippinensis, Bactrocera papayae and Bactrocera invadens, belong to the same biological species, Bactrocera dorsalis. The successful conclusion of this initiative is expected to significantly facilitate global agricultural trade, primarily through the lifting of quarantine restrictions that have long affected many countries, especially those in regions such as Asia and Africa that have large potential for fresh fruit and vegetable commodity exports. This work stems from two taxonomic studies: a revision in 1994 that significantly increased the number of described species in the Bactrocera dorsalis species complex; and the description in 2005 of Bactrocera invadens, then newly incursive in Africa. While taxonomically valid species, many biologists considered that these were different names for one biological species. Many disagreements confounded attempts to develop a solution for resolving this taxonomic issue, before the FAO/IAEA project commenced. Crucial to understanding the success of that initiative is an accounting of the historical events and perspectives leading up to the international, multidisciplinary collaborative efforts that successfully achieved the final synonymization. This review highlights the 21 year journey taken to achieve this outcome.

Matched MeSH terms: Asia
Occupational safety and health management among five ASEAN countries: Thailand, Indonesia, Malaysia, Philippines, and Singapore

Buranatrevedh S

J Med Assoc Thai, 2015 Mar;98 Suppl 2:S64-9.
PMID: 26211106

Occupational safety and health is one of important issues for workforce movement among ASEAN countries. The objective was to study laws, main agencies, and law enforcement regarding occupational safety and health in Thailand, Indonesia, Malaysia, Philippines, and Singapore. This documentary research covered laws, main agencies' duties, and occupational safety and health law enforcement in Thailand, Indonesia, Malaysia, Philippines, and Singapore. Thailand has its Occupational Safety, Health, and Work EnvironmentAct 2011. Its main agency was Department of Labor Protection and Welfare. Indonesia had WorkSafety Act (Law No. 1, 1970). Its main agency was Department of Manpower and Transmigration. Malaysia had Occupational Safety and Health Act (OSHA) 1994. Its main agency is the Department of Occupational Safety and Health. The Philippines has its Occupational Safety and Health Standards. Its main agency was Department ofLabor and Employment. Singapore has its Workplace Safety and Health Act 2006. Its main agency is Occupational Safety and Health Division. Occupational safety and health law enforcement among each county covers work environment surveillance, workers' health surveillance, advice about prevention and control of occupational health hazards, training and education of employers and employees, data systems, and research. Further in-depth surveys of occupational safety and health among each ASEAN county are needed to develop frameworks for occupational safety and health management for all ASEAN countries.

Matched MeSH terms: Asia, Southeastern
Bufavirus genotype 3 in Turkish children with severe diarrhoea

Altay A, Yahiro T, Bozdayi G, Matsumoto T, Sahin F, Ozkan S, et al.

Clin Microbiol Infect, 2015 Oct;21(10):965.e1-4.
PMID: 26086570 DOI: 10.1016/j.cmi.2015.06.006

Recently a parvovirus called bufavirus (BuV) has been implicated as a causative agent of diarrhoea. To further reveal the epidemiology and genetic characteristics of BuV, this study was performed in Turkish children with diarrhoea. BuV was detected in 1.4% (8/583) of stool samples. All stool samples from healthy children (n = 148) were negative for BuV. Diarrhoea in BuV-positive patients was severe and occurred mainly during the colder months of the year. Complete genome sequences were generated from four BuVs. Only BuV3 was found, which was genetically and phylogenetically similar to Bhutanese BuV3, indicating that BuV3 is prevalent in Asian countries.

Matched MeSH terms: Asia
Fulltext Substance abuse and the doctor

Deva MP

Med J Malaysia, 1993 Jun;48(2):99-100.
PMID: 8350811
Matched MeSH terms: Asia, Southeastern
Epidemiological survey of the use and abuse of agonist-antagonist analgesics in the Western Pacific region

Navaratnam V

Drug Alcohol Depend, 1987 Dec;20(4):367-73.
PMID: 2894290

Epidemiological studies are carried out by the National Drug Research Centre, Malaysia on various aspects of drug use and abuse. One of the groups of substances studied are the opioid agonist-antagonists. The study utilised information submitted to international agencies and obtained through a questionnaire survey. The results showed that out of 28 countries studied, 18 reported existence of illicit traffic in these substances and of this, 17 indicated seizures. A majority of countries were unable to give consumption data and the limited information available did not allow any significant conclusions. The study did not demonstrate a significant problem of abuse globally.

Matched MeSH terms: Asia
In Reply to the Letter to the Editor Regarding "Impact of COVID-19 on Neurosurgical Training in Southeast Asia"

Baticulon RE, Nga VDW, Sobana M, Bahuri NFA, Wittayanakorn N

World Neurosurg, 2020 12;144:332.
PMID: 33227873 DOI: 10.1016/j.wneu.2020.09.086
Matched MeSH terms: Asia, Southeastern
Fulltext The APEC Digital Hub-WONCA Collaborative Framework on Integration of Mental Health into Primary Care in the Asia Pacific

Dowrick C, Kassai R, Lam CLK, Lam RW, Manning G, Murphy J, et al.

J Multidiscip Healthc, 2020;13:1693-1704.
PMID: 33268991 DOI: 10.2147/JMDH.S271070

Mental ill health affects individual well-being and national economic prosperity and makes up a substantial portion of the burden of disease globally, especially in the Asia-Pacific region. Integrating mental health into primary care is widely considered a key strategy to improve access to mental health care. Integration, however, is a complex process that needs to be addressed at multiple levels. A collaboration between the Asia-Pacific Economic Cooperation (APEC) Digital Hub for Mental Health and the World Organization of Family Doctors (WONCA) is described in this paper, which outlines a framework and next steps to improve the mental health of communities in APEC economies. This paper notes gaps related to the integration of mental health into primary care across the region and identifies enablers and current best practices from several APEC economies. The potential of digital technology to benefit primary mental health care for populations in the APEC region, including delivery of training programs for healthcare staff and access to resources for patients, is described. Finally, key next steps are proposed to promote enhanced integration into primary care and improve mental health care throughout the APEC region.

Matched MeSH terms: Asia
Fulltext Molecular epidemiology of the emerging human malaria parasite "Plasmodium knowlesi"

Hakimi H, Kawai S, Kawazu S

Trop Parasitol, 2014 Jan;4(1):20-4.
PMID: 24754022 DOI: 10.4103/2229-5070.129154

Malaria is the most important parasitic disease with global concern. Plasmodium knowlesi recently has emerged from its natural simian host as a significant cause of human malaria, particularly in Malaysian Borneo. Therefore, it has been added as the fifth human Plasmodium specie which is widely distributed in Southeast Asia. Recent developments of new molecular tools enhanced our understanding about the key features of this malaria parasite. Here, we review some of the ways in which molecular approaches might be used for epidemiology of P. knowlesi and finally lead to an efficient control of malaria.

Matched MeSH terms: Asia, Southeastern
Fulltext Prediction of damage cost of bronchitis due to haze in Malaysia

Mohd Khairul Amri Kamarudin, Noorjima Abd Wahab, Khalid Abdul Rahim

Malaysian Journal of Applied Sciences, 2018;1(2):1-8.
MyJurnal

Awareness of haze pollution and management increased in Southeast Asia since 1990. However, the
focus on environmental management is decreasing especially in Malaysia due to the abundant
resources and increased development pressure. The total health damage cost because of haze in the
country became significantly high due to the long duration of haze events year by year. This paper
discusses the health damage caused by bronchitis due to the haze events in Malaysia. The analysis
shows positive coefficient of independent variables which indicates the positive relationship between
dependent variable and independent variables. Multiple linear regression analysis shows that 45.3%
variation in damage cost of bronchitis could be explained by FAI, GDPPC, and CO2.

Matched MeSH terms: Asia, Southeastern
Assessing the impact of transition from nonrenewable to renewable energy consumption on economic growth-environmental nexus from developing Asian economies

Mohsin M, Kamran HW, Atif Nawaz M, Sajjad Hussain M, Dahri AS

J Environ Manage, 2021 Apr 15;284:111999.
PMID: 33556829 DOI: 10.1016/j.jenvman.2021.111999

Greenhouse gasses have adverse effects on global warming and air pollution and need to be optimized by minimizing the contributing factors. This work analyzes the effects of economic growth and energy resources (renewable and nonrenewable) on the emissions of greenhouse gasses (GHG). A 2000-2016 panel data from 25 developing Asian countries is analyzed through a robust Random Effect (RE) approach and Hausman Taylor Regression (HTR). Findings show a positive correlation between economic growth and energy consumption, while a 1% increase in renewable energy consumption results in a 0.193% decrease in carbon emissions. Economic growth and renewable energy are positively correlated in both the short and long term, which implies a valid feedback hypothesis. The findings indicate the significant contribution of nonrenewable energy resources to greenhouse gas emissions and the positive impact of renewable resources on greenhouse gas emissions' control. Furthermore, this study highlights the potential of developing Asian economies to preserve the environment through more robust regional environmental policies and renewable energy resources. In light of this study's findings, policymakers in Asian developing economies should develop policies on Renewable Energy infrastructure (RE) to improve GDP and reduce greenhouse gas emissions.

Matched MeSH terms: Asia

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