Displaying publications 4821 - 4840 of 7301 in total

Abstract:
Sort:
  1. Irfan M, Razzaq A, Suksatan W, Sharif A, Madurai Elavarasan R, Yang C, et al.
    J Therm Biol, 2022 Feb;104:103101.
    PMID: 35180949 DOI: 10.1016/j.jtherbio.2021.103101
    The emergence of new coronavirus (SARS-CoV-2) has become a significant public health issue worldwide. Some researchers have identified a positive link between temperature and COVID-19 cases. However, no detailed research has highlighted the impact of temperature on COVID-19 spread in India. This study aims to fill this research gap by investigating the impact of temperature on COVID-19 spread in the five most affected Indian states. Quantile-on-Quantile regression (QQR) approach is employed to examine in what manner the quantiles of temperature influence the quantiles of COVID-19 cases. Empirical results confirm an asymmetric and heterogenous impact of temperature on COVID-19 spread across lower and higher quantiles of both variables. The results indicate a significant positive impact of temperature on COVID-19 spread in the three Indian states (Maharashtra, Andhra Pradesh, and Karnataka), predominantly in both low and high quantiles. Whereas, the other two states (Tamil Nadu and Uttar Pradesh) exhibit a mixed trend, as the lower quantiles in both states have a negative effect. However, this negative effect becomes weak at middle and higher quantiles. These research findings offer valuable policy recommendations.
  2. Mohd Kamil MK, Zambri A, Azizah MA, Noor Azhar AM, Ahmad R
    Int Emerg Nurs, 2022 Sep;64:101214.
    PMID: 36037702 DOI: 10.1016/j.ienj.2022.101214
    BACKGROUND: The COVID-19 pandemic is an international public health emergency. As hospitals receive more severe forms of COVID-19 that necessitate resuscitation, emergency health care workers (HCW) must follow interim COVID-19 resuscitation guidelines.

    OBJECTIVE: The aim is to evaluate the levels of knowledge, attitude, and practice among emergency HCW of the COVID-19 resuscitation protocol by the European Resuscitation Council (ERC).

    METHODS: A cross-sectional study using a validated questionnaire was conducted among HCW in the emergency department of University of Malaya Medical Centre (UMMC), Malaysia from April to June 2021.

    RESULTS: A total of 159 respondents were included in the analysis (89% response rate). Sixty-eight percent of respondents had adequate knowledge regarding COVID-19 resuscitation. Majority of the respondents had knowledge on airborne-precaution personal protective equipment (PPE) (99%) and infection control measures (98%). Nearly 73% were pessimistic about the COVID-19 prognosis. Seventy-three percent of respondents thought an arrested COVID-19 patient may benefit from cardiopulmonary resuscitation (CPR) and 94% were willing to administer CPR provided airborne-precaution PPE was available. Ninety percent of respondents reported adherence to resuscitation guidelines. There were significant differences in the mean knowledge scores between designation, education levels, and COVID-19 training. Overall, the respondents' level of practice was insufficient (27%), with a mean score of 53.7%(SD = 14.7). There was a lack of practicein the resuscitation oftheintubatedand patients who were beingprone. There was insufficient practice about ventilation technique, use ofsupraglotticdevices, and intubation barriers. There was a positive correlation between adequate knowledge and good practice.

    CONCLUSION: Emergency HCW have adequate knowledge, but poor compliance to the ERC COVID-19 guidelines. Emergency HCW were willing and confident to resuscitate COVID-19 patients, despite fears of nosocomial infection and expectation of poor patients' prognosis. Ongoing education and trainingprogramsare recommended to improve their knowledge, cultivate a positive attitude, andachievegood compliance with COVID-19 resuscitation guidelines.

  3. Zhou Z, Asghar MA, Nazir D, Siddique K, Shorfuzzaman M, Mehmood RM
    Cluster Comput, 2023;26(2):1253-1266.
    PMID: 36349064 DOI: 10.1007/s10586-022-03705-0
    Affective Computing is one of the central studies for achieving advanced human-computer interaction and is a popular research direction in the field of artificial intelligence for smart healthcare frameworks. In recent years, the use of electroencephalograms (EEGs) to analyze human emotional states has become a hot spot in the field of emotion recognition. However, the EEG is a non-stationary, non-linear signal that is sensitive to interference from other physiological signals and external factors. Traditional emotion recognition methods have limitations in complex algorithm structures and low recognition precision. In this article, based on an in-depth analysis of EEG signals, we have studied emotion recognition methods in the following respects. First, in this study, the DEAP dataset and the excitement model were used, and the original signal was filtered with others. The frequency band was selected using a butter filter and then the data was processed in the same range using min-max normalization. Besides, in this study, we performed hybrid experiments on sash windows and overlays to obtain an optimal combination for the calculation of features. We also apply the Discrete Wave Transform (DWT) to extract those functions from the preprocessed EEG data. Finally, a pre-trained k-Nearest Neighbor (kNN) machine learning model was used in the recognition and classification process and different combinations of DWT and kNN parameters were tested and fitted. After 10-fold cross-validation, the precision reached 86.4%. Compared to state-of-the-art research, this method has higher recognition accuracy than conventional recognition methods, while maintaining a simple structure and high speed of operation.
  4. Wahab MSA, Jalani MM, Goh KW, Ming LC, Faller EM
    Int J Environ Res Public Health, 2022 Sep 02;19(17).
    PMID: 36078707 DOI: 10.3390/ijerph191710994
    Herbal and dietary supplements (HDSs) are frequently obtained from community pharmacies, but community pharmacists (CPs) have been underutilized for information regarding them. This study aimed to determine the prevalence of, factors behind, and reasons for consultation with CPs among HDS consumers in Malaysia. A cross-sectional study using an online survey was conducted among conveniently sampled individuals in Malaysia. Reasons for consultation or non-consultation with CPs about HDSs were sought from the respondents. A logistic regression analysis was conducted to determine the predictors of consultation with CPs. Overall, 40.3% (239/593) of participants consulted CPs about the HDSs that they purchased. The participants were predominantly unmarried (362/588, 61.6%) and belonged to the 18-29 age group (332/593, 56%). The multivariate analysis showed that a suburban residential setting was the only significant predictor for consultation with CPs (adjusted odds ratio = 0.390, 95% CI = 0.260-0.583). Respondents who consulted CPs generally agreed that the CPs were the right people to consult on HDSs (mean = 4.37, SD = 0.73). However, their discussion with CPs regarding HDSs mostly revolved around the benefits and directions for use, but little on the potential risks. Meanwhile, most respondents who did not consult CPs agreed that they had never thought of consulting CPs about their HDS use (mean = 3.45, SD = 1.02). The majority of them referred to the Internet (61.3%, 217/354) and social media (59.9%, 212/354) for information about HDSs. The findings from this study show that more efforts are warranted in encouraging consumers to consult CPs about their HDS use and to enhance their awareness of the roles of CPs in ensuring the safe use of HDSs.
  5. Fazel MF, Mohamad MHN, Sahar MA, Juliana N, Abu IF, Das S
    Int J Environ Res Public Health, 2022 Sep 02;19(17).
    PMID: 36078684 DOI: 10.3390/ijerph191710968
    Early cardiopulmonary resuscitation (CPR) is a strong link in the of survival for sudden cardiac arrest. Hence, bystander CPR (BPCR) plays an important role in curbing mortality and morbidity from out-of-hospital sudden cardiac arrest. However, the recent global Coronavirus disease 2019 (COVID-19) pandemic has impacted both public training and confidence in performing out-of-hospital CPR. This paper reviews detailed information from databases including Google Scholar, Scopus, PubMed and Web of Science on the readiness of BCPR during the pandemic. We also discussed the challenges bystanders encountered during the COVID-19 pandemic and the precautions to follow. Finally, we also highlighted the limitations which would benefit future endeavours in establishing well-planned and sustainable CPR training programs for the public. Therefore, regardless of the existing COVID-19 pandemic, BCPR must be emphasised to curb out-of-hospital cardiac arrest (OHCA) mortality.
  6. Fadhil Bunyan S, Mohamad Suhaimi F, Mohidden Mostafa Zardawi F, Mohd Noor SNF, Zabidi MA
    Int J Dent, 2022;2022:4082168.
    PMID: 36624857 DOI: 10.1155/2022/4082168
    PURPOSE: To evaluate the effect of nanosilica and nanoalumina addition in Tech-sil25 maxillofacial silicone before and after exposure to artificial weathering conditions.

    MATERIALS AND METHODS: A total of 144 samples were divided into four groups, a control group (n = 12) and three test groups, nanosilica (NS) (n = 36), nanoalumina (NA) (n = 36), and a hybrid nanoparticle (HySA) (n = 60) at different weight percentages (1, 2, and 3 wt. %) was added to Tech-sil25. Samples were exposed to artificial weathering for 100 hours, and subjected to characterizations involving tear strength, shore A hardness, roughness, and tensile strength tests. The data were analyzed using descriptive and inferential statistics using a one-way ANOVA test to determine the level of significance between the groups.

    RESULTS: After 100 hours of artificial weathering, the one-way ANOVA result shows a highly significant increase in tensile and tear strengths with a minimal increase in hardness and roughness observed in samples containing 2% nanosilica (NS) followed by hybrid nanoparticle (HySA) of 1% nanoalumina (NA) + 1% nanosilica (NS) compared with a control group and other groups.

    CONCLUSIONS: The addition of nanosilica (NS), nanoalumina (NA), and a hybrid nanoparticle (HySA) to the Tech-sil25 maxillofacial silicone improved its mechanical properties. The combination of several filler reinforcements is essential for enhancing silicone's antiaging properties of silicone and maintaining some of its mechanical properties to prolong the service life.

  7. Chow LS, Tang GS, Solihin MI, Gowdh NM, Ramli N, Rahmat K
    SN Comput Sci, 2023;4(2):141.
    PMID: 36624807 DOI: 10.1007/s42979-022-01545-8
    Coronavirus disease 2019 (COVID-19) is a disease caused by a novel strain of coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), severely affecting the lungs. Our study aims to combine both quantitative and qualitative analysis of the convolutional neural network (CNN) model to diagnose COVID-19 on chest X-ray (CXR) images. We investigated 18 state-of-the-art CNN models with transfer learning, which include AlexNet, DarkNet-19, DarkNet-53, DenseNet-201, GoogLeNet, Inception-ResNet-v2, Inception-v3, MobileNet-v2, NasNet-Large, NasNet-Mobile, ResNet-18, ResNet-50, ResNet-101, ShuffleNet, SqueezeNet, VGG-16, VGG-19, and Xception. Their performances were evaluated quantitatively using six assessment metrics: specificity, sensitivity, precision, negative predictive value (NPV), accuracy, and F1-score. The top four models with accuracy higher than 90% are VGG-16, ResNet-101, VGG-19, and SqueezeNet. The accuracy of these top four models is between 90.7% and 94.3%; the F1-score is between 90.8% and 94.3%. The VGG-16 scored the highest accuracy of 94.3% and F1-score of 94.3%. The majority voting with all the 18 CNN models and top 4 models produced an accuracy of 93.0% and 94.0%, respectively. The top four and bottom three models were chosen for the qualitative analysis. A gradient-weighted class activation mapping (Grad-CAM) was used to visualize the significant region of activation for the decision-making of image classification. Two certified radiologists performed blinded subjective voting on the Grad-CAM images in comparison with their diagnosis. The qualitative analysis showed that SqueezeNet is the closest model to the diagnosis of two certified radiologists. It demonstrated a competitively good accuracy of 90.7% and F1-score of 90.8% with 111 times fewer parameters and 7.7 times faster than VGG-16. Therefore, this study recommends both VGG-16 and SqueezeNet as additional tools for the diagnosis of COVID-19.
  8. Amar M, Akram N, Chaudhary GQ, Kazi SN, Soudagar MEM, Mubarak NM, et al.
    Sci Rep, 2023 Jan 09;13(1):411.
    PMID: 36624198 DOI: 10.1038/s41598-023-27491-w
    The use of solar energy is one of the most prominent strategies for addressing the present energy management challenges. Solar energy is used in numerous residential sectors through flat plate solar collectors. The thermal efficiency of flat plate solar collectors is improved when conventional heat transfer fluids are replaced with nanofluids because they offer superior thermo-physical properties to conventional heat transfer fluids. Concentrated chemicals are utilized in nanofluids' conventional synthesis techniques, which produce hazardous toxic bi-products. The present research investigates the effects of novel green covalently functionalized gallic acid-treated multiwall carbon nanotubes-water nanofluid on the performance of flat plate solar collectors. GAMWCNTs are highly stable in the base fluid, according to stability analysis techniques, including ultraviolet-visible spectroscopy and zeta potential. Experimental evaluation shows that the thermo-physical properties of nanofluid are better than those of base fluid deionized water. The energy, exergy and economic analysis are performed using 0.025%, 0.065% and 0.1% weight concentrations of GAMWCNT-water at varying mass flow rates 0.010, 0.0144, 0.0188 kg/s. The introduction of GAMWCNT nanofluid enhanced the thermal performance of flat plate solar collectors in terms of energy and exergy efficiency. There is an enhancement in efficiency with the rise in heat flux, mass flow rate and weight concentration, but a decline is seen as inlet temperature increases. As per experimental findings, the highest improvement in energy efficiency is 30.88% for a 0.1% weight concentration of GAMWCNT nanofluid at 0.0188 kg/s compared to the base fluid. The collector's exergy efficiency increases with the rise in weight concentration while it decreases with an increase in flow rate. The highest exergy efficiency is achieved at 0.1% GAMWCNT concentration and 0.010 kg/s mass flow rate. GAMWCNT nanofluids have higher values for friction factor compared to the base fluid. There is a small increment in relative pumping power with increasing weight concentration of nanofluid. Performance index values of more than 1 are achieved for all GAMWCNT concentrations. When the solar thermal collector is operated at 0.0188 kg/s and 0.1% weight concentration of GAMWCNT nanofluid, the highest size reduction, 27.59%, is achieved as compared to a flat plate solar collector with water as a heat transfer fluid.
  9. Ebadi M, Rifqi Md Zain A, Tengku Abdul Aziz TH, Mohammadi H, Tee CAT, Rahimi Yusop M
    Polymers (Basel), 2023 Feb 16;15(4).
    PMID: 36850253 DOI: 10.3390/polym15040971
    Iron oxide nanoparticles are one of the nanocarriers that are suitable for novel drug delivery systems due to low toxicity, biocompatibility, loading capacity, and controlled drug delivery to cancer cells. The purpose of the present study is the synthesis of coated iron oxide nanoparticles for the delivery of sorafenib (SFB) and its effects on cancer cells. In this study, Fe3O4 nanoparticles were synthesized by the co-precipitation method, and then sorafenib was loaded onto PEG@Fe3O4 nanoparticles. FTIR was used to ensure polyethylene glycol (PEG) binding to nanoparticles and loading the drug onto the nanoshells. A comparison of the mean size and the crystalline structure of nanoparticles was performed by TEM, DLS, and X-ray diffraction patterns. Then, cell viability was obtained by the MTT assay for 3T3 and HepG2 cell lines. According to FT-IR results, the presence of O-H and C-H bands at 3427 cm-1 and 1420 cm-1 peak correlate with PEG binding to nanoparticles. XRD pattern showed the cubic spinel structure of trapped magnetite nanoparticles carrying medium. The magnetic properties of nanoparticles were examined by a vibrating-sample magnetometer (VSM). IC50 values at 72 h for treatment with carriers of Fe3O4@PEG nanoparticle for the HepG2 cell line was 15.78 μg/mL (p < 0.05). This study showed that Fe3O4 nanoparticles coated by polyethylene glycol and using them in the drug delivery process could be beneficial for increasing the effect of sorafenib on cancer cells.
  10. Ali SNM, Cioca LI, Kayati RS, Saputra J, Adam M, Plesa R, et al.
    PMID: 36833563 DOI: 10.3390/ijerph20042866
    Due to unpredictable and demanding working circumstances and the significant potential for dangers and accidents, seafaring has been characterised as one of the world's riskiest and stressful vocations that lead to physical and mental health problems. However, very few instruments measure work-related stress, particularly in a seafaring context. None of the instruments are psychometrically sound. Therefore, a valid and reliable instrument to measure seafaring work-related stress is indispensable. This study aims to review work-related stress instruments and to explore the work-related stress construct among seafarers in Malaysia. This study uses a systematic review and semi-structured interviews across two phases. In Phase 1, we conducted a systematic review of several databases: Academic Search Ultimate, Emerald Journal Premier, Journal Storage (JSTOR), ScienceDirect, Springer Link, Taylor and Francis Online, and Wiley Online Library based on Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA). In 8975 articles, only 4 (four) studies used psychological instruments and 5 (five) studies used survey questionnaires to measure work-related stress. In Phase 2, we conducted a semi-structured interview with 25 (twenty-five) seafarers, online due to COVID-19 restrictions. The semi-structured interview indicated 6 (six) themes, namely, physical stress, personal issues, social living onboard, technostress, work factors, and the effect of the COVID-19 pandemic. In conclusion, the present study has identified three psychometric instruments for measuring work-related stress among seafarers: The Psychological General Well-Being Index, Perceived Stress Scale, and Job Content Questionnaire. We also found psychometric elements in some of the instruments are questionable, such as theoretical basis, construct development, and inadequate internal consistency value. In addition, this study also found that work-related stress is a multidimensional construct that needs to be studied based on work contexts. The findings of this study can contribute to the body of knowledge of a work-related stress construct in a seafaring context and could help to inform policy makers in the maritime industry. This study suggests a psychological instrument to measure work-related stress among seafarers in future studies.
  11. Kamdi MKA, Shafei MN, Musa KI, Hanafi MH, Suliman MA
    Cureus, 2023 Jan;15(1):e34207.
    PMID: 36843743 DOI: 10.7759/cureus.34207
    INTRODUCTION:  Stroke is one of the top causes of adult-acquired disabilities and the fifth most prominent cause of death worldwide. Working-age populations contribute about 40% of the stroke cases which occur annually in Malaysia. The modified Barthel Index (MBI) score has been used for self-care assessment to determine if stroke patients can meet their fundamental needs. The study was designed to compare the trend of MBI scores of workers who had a stroke and underwent robotic rehabilitation therapy to those who had conventional therapy.

    METHODOLOGY:  A cohort study was conducted among workers who had a stroke in northeastern Malaysia. They were assigned either to undergo robotic or conventional rehabilitation therapy. The robotic therapy is performed three times per day for four weeks. Meanwhile, conventional therapy involved walking exercises five days per week for two weeks. Data were collected for both therapies on the admission, at week 2 and week 4. The MBI, modified Rankin Scale (mRS) and Hospital Anxiety and Depression Scale (HADS) trends were examined one month after the therapies. The R (version 4.2.1) (R Core Team, Vienna, Austria) and RStudio (R Studio PBC, Boston, USA) were applied to perform the descriptive analyses on the respective platforms. Repeated measures of analysis of variance were performed to evaluate the outcomes trend and the effectiveness of the two therapies was also compared.

    RESULTS: A total of 54 stroke patients participated in this study of which 30 (55.6%) of them received robotic therapy. The age of the subjects ranged from 24 to 59 years and the majority (74.1%) were male. Stroke outcomes were evaluated using mRS, HADS, and MBI scores. Except for their age, the individuals' characteristics did not significantly differ between those undergoing conventional therapy and those receiving robotic therapy. After four weeks, it was found that the good mRS had increased, whereas the poor mRS had decreased. Comparing the therapy groups, the MBI scores improved significantly with time, although there were no significant differences between the therapy groups. However, the interaction term between the treatment group (p=0.031) and improvements over time was significant (p=0.001), indicating that robotic was more effective than conventional therapy in improving the MBI scores. For HADS score, there was a significant difference between the therapy groups (p=0.001), with those receiving robotic therapy having higher HADS score.

    CONCLUSION:  Functional recovery occurs in acute stroke patients when the mean Barthel Index score rises from the baseline (on admission) to week 2 (during therapy) and subsequently on discharge (week 4). Based on these findings, it appears that there was not one therapy superior to the other; nevertheless, robotic therapy may be better tolerated and more effective in certain individuals.

  12. Cheah YK, Lim KK, Ismail H, Mohd Yusoff MF, Kee CC
    J Taibah Univ Med Sci, 2023 Aug;18(4):844-854.
    PMID: 36852251 DOI: 10.1016/j.jtumed.2022.12.016
    OBJECTIVES: Physical inactivity, hypertension and non-communicable diseases are major public concerns across the globe. To our knowledge, there is a lack of research that has investigated the moderating effect of age on the relationship between hypertension and physical activity in developing countries. This study had two objectives: (1) investigating hypertension and sociodemographic factors associated with physical activity and (2) investigating whether age moderates the relationship between hypertension and physical activity.

    METHODS: Nationally representative data of Malaysia were used to generate cross-sectional evidence. The sample size was 2156 respondents. An ordered probit regression was utilized to assess factors associated with the practice of physical activity.

    RESULTS: Respondents aged 40-49 years with hypertension were 7.3% less likely to participate in high-level physical activity when compared to those without hypertension. The probability of having a low level of physical activity was 12.3% higher among hypertensive patients aged ≥60. Males, married individuals, less-educated adults, low-income earners, and individuals who were aware of their BMI, had a higher tendency to indulge in a highly active lifestyle than others.

    CONCLUSION: The effect of hypertension on physical activity was moderated by age. Factors influencing physical activity levels among adults were income, gender, marital status, education, employment status, and BMI awareness.

  13. Pujiarti H, Pangestu ZA, Sholeha N, Nasikhudin N, Diantoro M, Utomo J, et al.
    Micromachines (Basel), 2023 Feb 04;14(2).
    PMID: 36838094 DOI: 10.3390/mi14020394
    Nanofiber membranes are starting to be used as an electrolyte storage medium because of their high porosity, which causes ionic conductivity, producing high energy. The ability of nanofiber membranes to absorb electrolytes proves their stability when used for a long time. In this study, the loading of acetylene carbon black (ACB) on polyacrylonitrile (PAN) is made by the electrospun method, which in turn is applied as an electrolyte medium in DSSC. Materials characterization was carried out through FTIR to determine the functional groups formed and SEM to observe morphology and diameter distribution. Furthermore, for DSSC performance, efficiency and EIS tests were carried out. The optimum nanofiber membrane was shown by esPACB1, with the highest efficiency reaching 1.92% with a porosity of 73.43%, nanofiber diameter of 172.9 ± 2.2 nm, an absorbance of 1850, and an electron lifetime of 0.003 ms.
  14. Razali RA, Yazid MD, Saim A, Idrus RBH, Lokanathan Y
    Int J Mol Sci, 2023 Feb 16;24(4).
    PMID: 36835384 DOI: 10.3390/ijms24043974
    Hydroxytyrosol (HT) is an olive polyphenol with anti-inflammatory and antioxidant properties. This study aimed to investigate the effect of HT treatment on epithelial-mesenchymal transition (EMT) in primary human respiratory epithelial cells (RECs) isolated from human nasal turbinate. HT dose-response study and growth kinetic study on RECs was performed. Several approaches on HT treatment and TGFβ1 induction with varying durations and methods was studied. RECs morphology and migration ability were evaluated. Vimentin and E-cadherin immunofluorescence staining and Western blotting [E-cadherin, vimentin, SNAIL/SLUG, AKT, phosphorylated (p)AKT, SMAD2/3 and pSMAD2/3] were performed after 72-h treatment. In silico analysis (molecular docking) of HT was performed to evaluate the potential of HT to bind with the TGFβ receptor. The viability of the HT-treated RECs was concentration-dependent, where the median effective concentration (EC50) was 19.04 μg/mL. Testing of the effects of 1 and 10 µg/mL HT revealed that HT suppressed expression of the protein markers vimentin and SNAIL/SLUG while preserving E-cadherin protein expression. Supplementation with HT protected against SMAD and AKT pathway activation in the TGFβ1-induced RECs. Furthermore, HT demonstrated the potential to bind with ALK5 (a TGFβ receptor component) in comparison to oleuropein. TGFβ1-induced EMT in RECs and HT exerted a positive effect in modulating the effects of EMT.
  15. Hossain MAM, Uddin SMK, Hashem A, Mamun MA, Sagadevan S, Johan MR
    Malays J Med Sci, 2022 Dec;29(6):15-33.
    PMID: 36818907 DOI: 10.21315/mjms2022.29.6.3
    Diagnostic testing to identify individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a key role in selecting appropriate treatments, saving people's lives and preventing the global pandemic of COVID-19. By testing on a massive scale, some countries could successfully contain the disease spread. Since early viral detection may provide the best approach to curb the disease outbreak, the rapid and reliable detection of coronavirus (CoV) is therefore becoming increasingly important. Nucleic acid detection methods, especially real-time reverse transcription polymerase chain reaction (RT-PCR)-based assays are considered the gold standard for COVID-19 diagnostics. Some non-PCR-based molecular methods without thermocycler operation, such as isothermal nucleic acid amplification have been proved promising. Serologic immunoassays are also available. A variety of novel and improved methods based on biosensors, Clustered-Regularly Interspaced Short Palindromic Repeats (CRISPR) technology, lateral flow assay (LFA), microarray, aptamer etc. have also been developed. Several integrated, random-access, point-of-care (POC) molecular devices are rapidly emerging for quick and accurate detection of SARS-CoV-2 that can be used in the local hospitals and clinics. This review intends to summarize the currently available detection approaches of SARS-CoV-2, highlight gaps in existing diagnostic capacity, and propose potential solutions and thus may assist clinicians and researchers develop better technologies for rapid and authentic diagnosis of CoV infection.
  16. Rasool U, Aslam MZ, Mahmood R, Barzani SHH, Qian J
    Heliyon, 2023 Feb;9(2):e13405.
    PMID: 36816292 DOI: 10.1016/j.heliyon.2023.e13405
    Researchers have been striving to investigate the causes and consequences associated with writing anxiety experienced by students of foreign languages. This study aimed to investigate the level and nature of writing anxiety experienced by learners of foreign languages, considering gender as a variable. The study's second goal was to uncover the learners' perspectives on writing anxiety and the factors that contribute to it. The convenience sample method was used to choose seventy-six students to participate in the English language teacher training course. Second Language Writing Anxiety Reasons Inventory (SLWARI) and Second Language Writing Anxiety Inventory (SLWAI) (Cheng, 2004; Kara, 2013) [1,2] were used in order to determine the levels and types of anxiety that are associated with learners' foreign language writing. Both inventories were used to determine what causes learners' foreign language writing. In order to gain a comprehensive understanding of how students perceive the level of anxiety they feel when writing, a semi-structured interview was conducted with each participant. The data showed that there was no difference when taking into account learners' gender concerning their anxiety levels and kinds. The vast majority of individuals reported feeling a significant amount of anxiety. The subjects exhibited cognitive anxiety symptoms, although there were no indications of gender effect. The responses to the interview questions highlighted a deficiency in both writing practice and linguistic expertise as critical contributors to anxious sentiments.
  17. Sayani JKS, English NJ, Khan MS, Lal B, Kamireddi VR
    ACS Omega, 2023 Feb 21;8(7):6218-6224.
    PMID: 36844557 DOI: 10.1021/acsomega.2c02823
    This work presents the effect of hydrogen sulfide gas on the phase behavior of both methane gas hydrate formation and CO2 gas hydrate formation. For this, the thermodynamic equilibrium conditions for various gas mixtures containing CH4/H2S and CO2/H2S are initially found by simulation using PVTSim software. These simulated results are compared using an experimental approach and the available literature. Then, the thermodynamic equilibrium conditions generated by simulation are used for generating Hydrate Liquid-Vapor-Equilibrium (HLVE) curves to understand the phase behavior of gases. Further, the effect of hydrogen sulfide on the thermodynamic stability of methane and carbon dioxide hydrates was studied. It was clearly observed from the results that an increase in H2S composition in the gas mixture decreases the stability of CH4 and CO2 hydrates.
  18. Hawarna S, Ahmed S, Alqasmi I, Ashrafi DM, Rahman MK, Paraman P
    Hosp Top, 2023 Mar 23.
    PMID: 36951405 DOI: 10.1080/00185868.2023.2192995
    The lean approach is a value-added system that reduces cost and waste to continuously improve the quality performance of the healthcare organization. The present study investigates the relationships of the lean approach with top management team and employee engagement toward quality improvement of the public hospitals in Malaysia. This study used stratified random sampling to collect data from the public hospitals' staff who were directly involved with patient services. In this study, PLS-SEM 3.3.4 was applied to measure the research constructs and hypotheses. The research findings indicate that the lean approach has a significant relationship with the top management team and employee engagement to positively impact the quality improvement of the public hospital. However, research findings also indicate that the top management team has no significant influence on quality improvement in public hospitals, but it has an indirect effect through the lean approach and employee engagement. The findings of the study will provide guidelines on how the lean approach contributes to the body of knowledge and practical implications to continuously improve the quality performance of public healthcare system.
  19. Rahim S, Sharif MM, Amin MR, Rahman MT, Karim MM
    PLOS Glob Public Health, 2022;2(12):e0000834.
    PMID: 36962767 DOI: 10.1371/journal.pgph.0000834
    Diagnosis of visceral leishmaniasis (VL) through the detection of its causative agents namely Leishmania donovani and L. infantum is traditionally based on immunochromatographic tests, microscopy of bone marrow, spleen aspirates, liver or lymph node and differential diagnosis. While the first process has low specificity, the later one carries the risk of fatal hemorrhage. Over the last decade, multiple Polymerase Chain Reaction (PCR) based diagnosis has been developed using blood and urine sample with a varying degree of sensitivity and specificity, an issue worth improving for precision diagnosis. Earlier, we reported a PCR-based diagnosis of L. donovani in peripheral blood using a novel set of PCR primers with absolute specificity. Using the same set of primers and PCR conditions, here we describe diagnosis of L. donovani from urine, for a non-invasive, rapid and safe diagnosis. Diagnosis of VL was carried out using urine samples collected from clinically diagnosed VL patients (n = 23) of Bangladesh in Real Time PCR. Test results were validated by comparing blood samples from the same set of patients. Sensitivity and specificity of this diagnosis was analyzed using retrospective bone marrow samples, collected earlier from confirmed VL patients (n = 19). The method showed 100% sensitivity in detecting L. donovani in urine and corresponding blood and retrospective bone marrow samples, as well as 100% specificity in control groups. A Real Time PCR-based molecular detection system using urine sample is hereafter presented what could be a, non-invasive approach for VL detection with precision and perfection.
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links