Displaying publications 4901 - 4920 of 55765 in total

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  1. Al-Ak'hali MS, Fageeh HN, Halboub E, Alhajj MN, Ariffin Z
    BMC Med Inform Decis Mak, 2021 02 04;21(1):41.
    PMID: 33541345 DOI: 10.1186/s12911-021-01413-0
    BACKGROUND: Currently, the Internet seems to be a helpful tool for obtaining information about everything that we think about, including diseases, their prevention and treatment approaches. However, doubts exist regarding the quality and readability of such information. This study sought to assess the quality and readability of web-based Arabic information on periodontal disease.

    METHODS: In this infodemiological study, the Google, Yahoo!, and Bing search engines were searched using specific Arabic terms on periodontal disease. The first 100 consecutive websites from each engine were obtained. The eligible websites were categorized as commercial, health/professional, journalism, and other. The following tools were applied to assess the quality of the information on the included websites: the Health on the Net Foundation Code of Conduct (HONcode), the Journal of the American Medical Association (JAMA) benchmarks, and the DISCERN tool. The readability was assessed using an online readability tool.

    RESULTS: Of the 300 websites, 89 were eligible for quality and readability analyses. Only two websites (2.3%) were HONcode certified. Based on the DISCERN tool, 43 (48.3%) websites had low scores. The mean score of the JAMA benchmarks was 1.6 ± 1.0, but only 3 (3.4%) websites achieved "yes" responses for all four JAMA criteria. Based on the DISCERN tool, health/professional websites revealed the highest quality of information compared to other website categories. Most of the health/professional websites revealed moderate-quality information, while 55% of the commercial websites, 66% of journalism websites, and 43% of other websites showed poor quality information. Regarding readability, most of the analyzed websites presented simple and readable written content.

    CONCLUSIONS: Aside from readable content, Arabic health information on the analyzed websites on periodontal disease is below the required level of quality.

    Matched MeSH terms: Humans
  2. Wong PS, Lim SW, Tong CV, Mohamad M, Hussein Z
    J ASEAN Fed Endocr Soc, 2022;37(2):106-112.
    PMID: 36578894 DOI: 10.15605/jafes.037.02.17
    Thyroid hormone plays an important role in cardiovascular function. Pericardial effusions are commonly seen in cases of severe hypothyroidism. However, large to massive pericardial effusions with cardiac tamponade are exceptionally rare. Herein, we present two cases of severe hypothyroidism with massive pericardial effusion. Our first case demonstrates that a patient with large pericardial effusion can be managed conservatively with aggressive thyroid hormone replacement therapy. In our second case, pericardiocentesis was performed in addition to thyroid hormone replacement therapy as the underlying aetiology of effusion could not be reasonably limited to hypothyroidism. These two cases served to highlight and demonstrate rapid normalisation of thyroid function test by using aggressive oral thyroid hormone replacement therapy using liothyronine, in combination with levothyroxine, which led to resolution of pericardial effusion and prevent its re-accumulation.
    Matched MeSH terms: Humans
  3. Long Bidin MB, Khan AM, Tan FHS, Aziz NA, Ali NM, Kamaruddin NA, et al.
    J ASEAN Fed Endocr Soc, 2023;38(1):75-80.
    PMID: 37252416 DOI: 10.15605/jafes.038.01.06
    OBJECTIVE: This study aims to report the demographic features of patients with acromegaly, the disease burden, and the corresponding treatment patterns and outcomes in Malaysia.

    METHODOLOGY: This is a retrospective study that included patients from the Malaysian Acromegaly registry who were diagnosed with acromegaly from 1970 onwards. Data collected included patient demographics, clinical manifestations of acromegaly, biochemical results and imaging findings. Information regarding treatment modalities and their outcomes was also obtained.

    RESULTS: Registry data was collected from 2013 to 2016 and included 140 patients with acromegaly from 12 participating hospitals. Median disease duration was 5.5 years (range 1.0 - 41.0 years). Most patients had macroadenoma (67%), while 15% were diagnosed with microadenoma. Hypertension (49.3%), diabetes (37.1%) and hypopituitarism (27.9%) were the most common co-morbidities for patients with acromegaly. Majority of patients had surgical intervention as primary treatment (65.9%) while 20.7% were treated medically, mainly with dopamine agonists (18.5%). Most patients had inadequate disease control after first-line treatment regardless of treatment modality (79.4%).

    CONCLUSION: This registry study provides epidemiological data on patients with acromegaly in Malaysia and serves as an initial step for further population-based studies.

    Matched MeSH terms: Humans
  4. Yasothkumar D, Ramani P, Jayaraman S, Ramalingam K, Tilakaratne WM
    Head Neck Pathol, 2024 Mar 27;18(1):28.
    PMID: 38536520 DOI: 10.1007/s12105-024-01627-4
    OBJECTIVES: This study aims to elucidate the expression of circulating exosomal miRNAs miRNA 21, miRNA 184, and miRNA 145 in the studied groups, including patients with (i) leukoplakia; (ii) oral submucous fibrosis; (iii) oral submucous fibrosis with leukoplakia; (iv) oral squamous cell carcinoma; and (v) healthy individuals.

    STUDY DESIGN: An observational study was conducted among 54 patients who reported to the outpatient department of Saveetha Dental College and Hospitals. The patients were divided into three groups: Group I healthy individuals (n = 18), Group II: case group (leukoplakia, OSMF, and leukoplakia and OSMF) (n = 18), and Group III: OSCC (n = 18). Real-time polymerase chain reaction analysis was carried out to assess the expression profiles of miRNA 21, miRNA 184, and miRNA 145. The statistical analysis was calculated using SPSS software version 23.

    RESULTS: All three miRNAs showed a statistically significant difference in the one-way ANOVA test between the case group (leukoplakia, OSMF, and leukoplakia and OSMF), healthy group, and OSCC group (p 

    Matched MeSH terms: Humans
  5. Zhou K, He S, Zhou Y, Popeska B, Kuan G, Chen L, et al.
    PMID: 33401384 DOI: 10.3390/ijerph18010272
    This study aimed to examine the effects of three-months of classroom-based Brain Breaks Physical Activity Solution (Brain Breaks®) on attitudes toward physical activity levels of primary school children in Henan Province, China. The participants were 704 children enrolled in grades 3-5 who were randomly assigned to either an experimental or a control group. The experimental group participated in Brain Breaks® video intervention for 3-5 min daily, at low-to-moderate intensity for three consecutive months. The control group resumed their normal routine. The children's attitudes in both groups towards physical activity (PA) were evaluated using the self-reported Attitudes toward Physical Activity Scale (APAS), before and after the intervention. The effects of the intervention on APAS scores were analyzed using mixed model analysis of variance with Time as within-subject, and Group as between-subject factors. The analysis revealed evidence in support of the positive effect of classroom video interventions such as Brain Break on children's attitudes toward importance, fun, and trying to do their personal best in physical activity. Also revealed was the important role the teacher plays in this process.
    Matched MeSH terms: Humans
  6. Chiang CY, Islam T, Xu C, Chinnayah T, Garfin AMC, Rahevar K, et al.
    Eur Respir J, 2020 Oct;56(4).
    PMID: 32978310 DOI: 10.1183/13993003.03054-2020
    While COVID-19 has imposed great challenges to national tuberculosis programmes, it has also created opportunities to develop innovative strategies to ensure continuity of TB services and ultimately to strengthen TB care, prevention and control https://bit.ly/3bHDQx0
    Matched MeSH terms: Humans
  7. Ching SM, Mokshashri NR, Kannan MM, Lee KW, Sallahuddin NA, Ng JX, et al.
    BMC Complement Med Ther, 2021 Jan 06;21(1):8.
    PMID: 33407414 DOI: 10.1186/s12906-020-03172-3
    BACKGROUND: The benefits of qigong for systolic and diastolic blood pressure (BP) reduction have been noted in previously published systematic reviews; however, the data on its effectiveness has been at best scarce. We aimed to update the evidence of qigong on blood pressure reduction after taking into consideration the risks of random error and reliability of data in the cumulative meta-analysis using trial sequential analysis (TSA).

    METHODS: Included trials were assessed using Cochrane risk of bias instrument. We performed meta-analysis with random-effects model and random errors were evaluated with TSA. We performed the search for the eligible randomized controlled trial (RCT) through Medline, Cinahl, Cochrane Central Register of Controlled Trials and also PubMed.

    RESULTS: A total of 370 subjects sourced from seven eligible RCTs were entered into the analysis. The pooled results demonstrated the significant reduction with the use of qigong of the systolic blood pressure [weighted mean difference (WMD), - 10.66 mmHg (95% confidence interval (CI) = - 17.69,-3.62, p 

    Matched MeSH terms: Humans
  8. Khade S, Gite S, Thepade SD, Pradhan B, Alamri A
    Sensors (Basel), 2021 Nov 08;21(21).
    PMID: 34770715 DOI: 10.3390/s21217408
    Iris biometric detection provides contactless authentication, preventing the spread of COVID-19-like contagious diseases. However, these systems are prone to spoofing attacks attempted with the help of contact lenses, replayed video, and print attacks, making them vulnerable and unsafe. This paper proposes the iris liveness detection (ILD) method to mitigate spoofing attacks, taking global-level features of Thepade's sorted block truncation coding (TSBTC) and local-level features of the gray-level co-occurrence matrix (GLCM) of the iris image. Thepade's SBTC extracts global color texture content as features, and GLCM extracts local fine-texture details. The fusion of global and local content presentation may help distinguish between live and non-live iris samples. The fusion of Thepade's SBTC with GLCM features is considered in experimental validations of the proposed method. The features are used to train nine assorted machine learning classifiers, including naïve Bayes (NB), decision tree (J48), support vector machine (SVM), random forest (RF), multilayer perceptron (MLP), and ensembles (SVM + RF + NB, SVM + RF + RT, RF + SVM + MLP, J48 + RF + MLP) for ILD. Accuracy, precision, recall, and F-measure are used to evaluate the performance of the projected ILD variants. The experimentation was carried out on four standard benchmark datasets, and our proposed model showed improved results with the feature fusion approach. The proposed fusion approach gave 99.68% accuracy using the RF + J48 + MLP ensemble of classifiers, immediately followed by the RF algorithm, which gave 95.57%. The better capability of iris liveness detection will improve human-computer interaction and security in the cyber-physical space by improving person validation.
    Matched MeSH terms: Humans
  9. Tariq MU, Ismail SB
    PLoS One, 2024;19(3):e0294289.
    PMID: 38483948 DOI: 10.1371/journal.pone.0294289
    The COVID-19 pandemic has had a significant impact on both the United Arab Emirates (UAE) and Malaysia, emphasizing the importance of developing accurate and reliable forecasting mechanisms to guide public health responses and policies. In this study, we compared several cutting-edge deep learning models, including Long Short-Term Memory (LSTM), bidirectional LSTM, Convolutional Neural Networks (CNN), hybrid CNN-LSTM, Multilayer Perceptron's, and Recurrent Neural Networks (RNN), to project COVID-19 cases in the aforementioned regions. These models were calibrated and evaluated using a comprehensive dataset that includes confirmed case counts, demographic data, and relevant socioeconomic factors. To enhance the performance of these models, Bayesian optimization techniques were employed. Subsequently, the models were re-evaluated to compare their effectiveness. Analytic approaches, both predictive and retrospective in nature, were used to interpret the data. Our primary objective was to determine the most effective model for predicting COVID-19 cases in the United Arab Emirates (UAE) and Malaysia. The findings indicate that the selected deep learning algorithms were proficient in forecasting COVID-19 cases, although their efficacy varied across different models. After a thorough evaluation, the model architectures most suitable for the specific conditions in the UAE and Malaysia were identified. Our study contributes significantly to the ongoing efforts to combat the COVID-19 pandemic, providing crucial insights into the application of sophisticated deep learning algorithms for the precise and timely forecasting of COVID-19 cases. These insights hold substantial value for shaping public health strategies, enabling authorities to develop targeted and evidence-based interventions to manage the virus spread and its impact on the populations of the UAE and Malaysia. The study confirms the usefulness of deep learning methodologies in efficiently processing complex datasets and generating reliable projections, a skill of great importance in healthcare and professional settings.
    Matched MeSH terms: Humans
  10. Yang L, Lei Y, Chu D, Jiang J, Li Z, Tang Y, et al.
    PLoS One, 2024;19(3):e0300040.
    PMID: 38483916 DOI: 10.1371/journal.pone.0300040
    INTRODUCTION: High levels of burnout are prevalent among Emergency Department staff due to chronic exposure to job stress. There is a lack of knowledge about anteceding factors and outcomes of burnout in this population.

    AIMS: To provide a comprehensive overview of burnout and identify its workplace antecedents and outcomes among Emergency Department staff.

    METHODS: The scoping study will follow the methodology outlined by the Joanna Briggs Institute. PubMed, Scopus, Web of Science, APA PsycInfo, and CINAHL databases will be searched using predefined strategies. Two reviewers will screen the title, abstract and full text separately based on the eligibility criteria. Data will be charted, coded, and narratively synthesized based on the job demands-resources model.

    CONCLUSION: The results will provide insights into the underlying work-related factors contributing to burnout and its implications for individuals, healthcare organizations, and patient care.

    Matched MeSH terms: Humans
  11. Sim DKL, Mittal S, Zhang J, Hung CL, Azman WAW, Choi JO, et al.
    Int J Cardiol, 2024 May 15;403:131890.
    PMID: 38382854 DOI: 10.1016/j.ijcard.2024.131890
    BACKGROUND: Iron deficiency is a common comorbidity in heart failure (HF) and is independently associated with a worse quality-of-life and exercise capacity, as well as increased risk of hospitalization, regardless of anemia status. Although international guidelines have provided recommendations for the management of iron deficiency in patients with HF, guidelines in Asia are less established, and practical use of guidelines for management of iron deficiency is limited in the region.

    METHODS: A panel comprising cardiologists from China, Hong Kong, India, Japan, Malaysia, Pakistan, Philippines, Singapore, South Korea, Taiwan, and Thailand convened to share insights and provide guidance for the optimal management of iron deficiency in patients with HF, tailored for the Asian community.

    RESULTS: Expert opinions were provided for the screening, diagnosis, treatment and monitoring of iron deficiency in patients with HF. It was recommended that all patients with HF with reduced ejection fraction should be screened for iron deficiency, and iron-deficient patients should be treated with intravenous iron. Monitoring of iron levels in patients with HF should be carried out once or twice yearly. Barriers to the management of iron deficiency in patients with HF in the region include low awareness of iron deficiency amongst general physicians, lack of reimbursement for screening and treatment, and lack of proper facilities for administration of intravenous iron.

    CONCLUSIONS: These recommendations provide a structured approach to the management of iron deficiency in patients with HF in Asia.

    Matched MeSH terms: Humans
  12. Lim SH, Wong TW, Tay WX
    Adv Colloid Interface Sci, 2024 Mar;325:103094.
    PMID: 38359673 DOI: 10.1016/j.cis.2024.103094
    Nanoparticles as cancer therapeutic carrier fail in clinical translation due to complex biological environments in vivo consisting of electrolytes and proteins which render nanoparticle aggregation and unable to reach action site. This review identifies the desirable characteristics of nanoparticles and their constituent materials that prevent aggregation from site of administration (oral, lung, injection) to target site. Oral nanoparticles should ideally be 75-100 nm whereas the size of pulmonary nanoparticles minimally affects their aggregation. Nanoparticles generally should carry excess negative surface charges particularly in fasting state and exert steric hindrance through surface decoration with citrate, anionic surfactants and large polymeric chains (polyethylene glycol and polyvinylpyrrolidone) to prevent aggregation. Anionic as well as cationic nanoparticles are both predisposed to protein corona formation as a function of biological protein isoelectric points. Their nanoparticulate surface composition as such should confer hydrophilicity or steric hindrance to evade protein corona formation or its formation should translate into steric hindrance or surface negative charges to prevent further aggregation. Unexpectedly, smaller and cationic nanoparticles are less prone to aggregation at cancer cell interface favoring endocytosis whereas aggregation is essential to enable nanoparticles retention and subsequent cancer cell uptake in tumor microenvironment. Present studies are largely conducted in vitro with simplified simulated biological media. Future aggregation assessment of nanoparticles in biological fluids that mimic that of patients is imperative to address conflicting materials and designs required as a function of body sites in order to realize the future clinical benefits.
    Matched MeSH terms: Humans
  13. Khairul Amin KHA, Bujang NNA, Abas SA, Zulkifli NI, Amir SA, Shah SM, et al.
    PMID: 37475779 DOI: 10.5365/wpsar.2023.14.2.985
    OBJECTIVE: Malaysia's first case of coronavirus disease (COVID-19) was reported in January 2020, with the first case in the state of Negeri Sembilan diagnosed on 17 February 2020. The National COVID-19 Immunization Programme commenced in early March 2021 in Negeri Sembilan. This study describes the COVID-19 cases and vaccination coverage in Seremban District, Negeri Sembilan, during 2021.

    METHODS: The demographic and clinical characteristics of COVID-19 cases and the district's vaccination coverage were described. Vaccination coverage was plotted against COVID-19 cases on the epidemic curve. The χ2 test was used to examine the differences between the vaccination status of COVID-19 cases and severity category, hospitalization status and mortality.

    RESULTS: In Seremban District, there were 65 879 confirmed cases of COVID-19 in 2021. The data revealed that the 
21-30-year age group had the highest proportion of cases (16 365; 24.8%), the majority of cases were male (58.3%), and most cases were from the subdistrict of Ampangan (23.1%). The majority of cases were Malaysian. Over half (53.5%) were symptomatic, with fever (29.8%) and cough (22.8%) being the most frequently reported symptoms. COVID-19 vaccination status was significantly associated with severity category, hospitalization and mortality (P 

    Matched MeSH terms: Humans
  14. Pan W, Zhou D, Hijazi ZM, Qureshi SA, Promphan W, Feng Y, et al.
    Catheter Cardiovasc Interv, 2024 Mar;103(4):660-669.
    PMID: 38419402 DOI: 10.1002/ccd.30978
    Transcatheter pulmonary valve replacement (TPVR), also known as percutaneous pulmonary valve implantation, refers to a minimally invasive technique that replaces the pulmonary valve by delivering an artificial pulmonary prosthesis through a catheter into the diseased pulmonary valve under the guidance of X-ray and/or echocardiogram while the heart is still beating not arrested. In recent years, TPVR has achieved remarkable progress in device development, evidence-based medicine proof and clinical experience. To update the knowledge of TPVR in a timely fashion, and according to the latest research and further facilitate the standardized and healthy development of TPVR in Asia, we have updated this consensus statement. After systematical review of the relevant literature with an in-depth analysis of eight main issues, we finally established eight core viewpoints, including indication recommendation, device selection, perioperative evaluation, procedure precautions, and prevention and treatment of complications.
    Matched MeSH terms: Humans
  15. Ahmad J, Al Mamun A, Reza MNH, Makhbul ZKM, Ali KAM
    Environ Sci Pollut Res Int, 2023 Aug;30(37):87938-87957.
    PMID: 37432578 DOI: 10.1007/s11356-023-28624-4
    This study investigates the effect of green human resource management practices on green competitive advantage and the mediating role of competitive advantage between the green human resource management practices and green ambidexterity. This study also examined the effect of green competitive advantage on green ambidexterity and the moderating effect of firm size on green competitive advantage and ambidexterity. The results reveal that green recruitment and green training and involvement are not sufficient, but they are necessary for any outcome level of green competitive advantage. The other three constructs (green performance management and compensation, green intellectual capital, and green transformational leadership) are sufficient and necessary; however, green performance management and compensation is necessary only at an outcome level of more than or equal to 60%. The findings revealed that the mediating effect of green competitive advantage is significant only between three constructs (green performance management and compensation, green intellectual capital, and green transformational leadership) and green ambidexterity. The results also indicate that a green competitive advantage has a significant positive effect on green ambidexterity. Exploring the necessary and sufficient factors using a combination of partial least squares structural equation modeling and necessary condition analysis provides valuable guidance for practitioners to optimize firm outcomes.
    Matched MeSH terms: Humans
  16. Abdul Rahman NF, Davies N, Suhaimi J, Idris F, Syed Mohamad SN, Park S
    Educ Prim Care, 2023 Jul;34(4):211-219.
    PMID: 37742228 DOI: 10.1080/14739879.2023.2248070
    Clinical reasoning is a vital medical education skill, yet its nuances in undergraduate primary care settings remain debated. This systematic review explores clinical reasoning teaching and learning intricacies within primary care. We redefine clinical reasoning as dynamically assimilating and prioritising synthesised patient, significant other, or healthcare professional information for diagnoses or non-diagnoses. This focused meta-synthesis applies transformative learning theory to primary care clinical reasoning education. A comprehensive analysis of 29 selected studies encompassing various designs made insights into clinical reasoning learning dimensions visible. Primary care placements in varying duration and settings foster diverse instructional methods like bedside teaching, clinical consultations, simulated clinics, virtual case libraries, and more. This review highlights the interplay between disease-oriented and patient-centred orientations in clinical reasoning learning. Transformative learning theory provides an innovative lens, revealing stages of initiation, persistence, time and space, and competence and confidence in students' clinical reasoning evolution. Clinical teachers guide this transformation, adopting roles as fortifiers, connoisseurs, mediators, and monitors. Patient engagement spans passive to active involvement, co-constructing clinical reasoning. The review underscores theoretical underpinnings' significance in shaping clinical reasoning pedagogy, advocating broader diversity. Intentional student guidance amid primary care complexities is vital. Utilising transformative learning, interventions bridging cognitive boundaries enhance meaningful clinical reasoning learning experiences. This study contributes insights for refining pedagogy, encouraging diverse research, and fostering holistic clinical reasoning development.
    Matched MeSH terms: Humans
  17. Pennay A, van Egmond K, Anderson-Luxford D, Wright CJC, Caluzzi G, Livingston M, et al.
    Drug Alcohol Rev, 2023 Sep;42(6):1349-1357.
    PMID: 37399138 DOI: 10.1111/dar.13706
    INTRODUCTION: The aim of this study was to: (i) determine the feasibility of using ecological momentary assessment to collect data from Australian Football League (AFL) fans; (ii) explore pre-game, during-game and post-game consumption patterns of AFL fans; and (iii) explore the social and setting-related factors associated with risky single occasion drinking (5+ drinks) among AFL fans.

    METHODS: Thirty-four participants completed up to 10 ecological momentary assessment surveys before, during and after 63 AFL games (n = 437 completed surveys). Surveys collected data about their drinking, and their social and environmental milieu (e.g., location, company). Binary logistic regression analyses clustered by participant identified which game-day characteristics were associated with higher odds of risky single occasion drinking. Significant differences between pre-game, during-game and post-game drinking on social and environmental factors were explored using pairwise comparisons.

    RESULTS: Risky single occasion drinking was more likely when games began in the early-afternoon (1-3 pm) than late-afternoon (3-6 pm), when participants watched the game at a stadium or pub compared to home, and when participants watched the game with friends compared to family. Pre-drinking was more likely before night games and post-drinking was more likely after day games. Drinking during the game was heavier when watching the game at a pub and when watching with a combined group of friends and family.

    DISCUSSION AND CONCLUSIONS: Preliminary findings suggest that social and contextual factors matter in the way alcohol is consumed while watching AFL games. These findings require further investigation in larger samples.

    Matched MeSH terms: Humans
  18. Wong RS
    J Biomed Biotechnol, 2011;2011:459510.
    PMID: 21822372 DOI: 10.1155/2011/459510
    Mesenchymal stem cells (MSCs) have been used in cell-based therapy in various disease conditions such as graft-versus-host and heart diseases, osteogenesis imperfecta, and spinal cord injuries, and the results have been encouraging. However, as MSC therapy gains popularity among practitioners and researchers, there have been reports on the adverse effects of MSCs especially in the context of tumour modulation and malignant transformation. These cells have been found to enhance tumour growth and metastasis in some studies and have been related to anticancer-drug resistance in other instances. In addition, various studies have also reported spontaneous malignant transformation of MSCs. The mechanism of the modulatory behaviour and the tumorigenic potential of MSCs, warrant urgent exploration, and the use of MSCs in patients with cancer awaits further evaluation. However, if MSCs truly play a role in tumour modulation, they can also be potential targets of cancer treatment.
    Matched MeSH terms: Humans
  19. Qazi HH, bin Mohammad AB, Akram M
    Sensors (Basel), 2012 Nov 29;12(12):16522-56.
    PMID: 23443392 DOI: 10.3390/s121216522
    Optical chemical sensors have promoted escalating interest in the determination of various pollutants in the environment, which are creating toxicity and may cause serious health problems. This review paper focuses particularly on the recent progress and developments in this field; the working principles and basic classes of optical chemical sensors have been briefly described.
    Matched MeSH terms: Humans
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