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  1. QbD Assisted Systematic Review for Optimizing the Selection of PVP as a Ternary Substance in Enhancing the Complexation Efficiency of Cyclodextrins: a Pilot Study
    Mulenga G, Alahmed TAA, Sami F, Majeed S, Ali MS, Le JLJ, et al.
    AAPS PharmSciTech, 2024 Jun 11;25(5):134.
    PMID: 38862663 DOI: 10.1208/s12249-024-02845-3
    Inclusion complexes require higher concentration of Beta cyclodextrins (βCD) resulting in increased formulation bulk, toxicity, and production costs. This systematic review offers a comprehensive analysis using Quality by design (QbD) as a tool to predict potential applications of Polyvinylpyrrolidone (PVP) as a ternary substance to address issues of inclusion complexes. We reviewed 623 documents from 2013 to 2023 and Eighteen (18) research papers were selected for statistical and meta-analysis using the QbD concept to identify the most critical factors for selecting drugs and effect of PVP on inclusion complexes. The QbD analysis revealed that Molecular weight (MW), Partition coefficient (Log P), and the auxiliary substance ratio directly affected complexation efficiency (CE), thermodynamic stability in terms of Gibbs free energy (ΔG), and percent drug release. However, Stability constant (Ks) remained unaffected by any of these parameters. The results showed that low MW (250), median Log P (6), and a βCD: PVP ratio of 2:3 would result in higher CE, lower G, and improved drug release. PVP improves drug solubility, enhances delivery and therapeutic outcomes, and counteracts increased drug ionization due to decreased pH. In certain cases, its bulky nature and hydrogen bonding with CD molecules can form non-inclusion complexes. The findings of the study shows that there is potential molecular interaction between PVP and β-cyclodextrins, which possibly enhances the stability of inclusion complexes for drug with low MW and log P values less than 9. The systematic review shows a comprehensive methodology based on QbD offers a replicable template for future investigations into drug formulation research.
  2. Fulltext Tacrine Derivatives in Neurological Disorders: Focus on Molecular Mechanisms and Neurotherapeutic Potential
    Mitra S, Muni M, Shawon NJ, Das R, Emran TB, Sharma R, et al.
    Oxid Med Cell Longev, 2022;2022:7252882.
    PMID: 36035218 DOI: 10.1155/2022/7252882
    Tacrine is a drug used in the treatment of Alzheimer's disease as a cognitive enhancer and inhibitor of the enzyme acetylcholinesterase (AChE). However, its clinical application has been restricted due to its poor therapeutic efficacy and high prevalence of detrimental effects. An attempt was made to understand the molecular mechanisms that underlie tacrine and its analogues influence over neurotherapeutic activity by focusing on modulation of neurogenesis, neuroinflammation, endoplasmic reticulum stress, apoptosis, and regulatory role in gene and protein expression, energy metabolism, Ca2+ homeostasis modulation, and osmotic regulation. Regardless of this, analogues of tacrine are considered as a model inhibitor of cholinesterase in the therapy of Alzheimer's disease. The variety both in structural make-up and biological functions of these substances is the main appeal for researchers' interest in them. A new paradigm for treating neurological diseases is presented in this review, which includes treatment strategies for Alzheimer's disease, as well as other neurological disorders like Parkinson's disease and the synthesis and biological properties of newly identified versatile tacrine analogues and hybrids. We have also shown that these analogues may have therapeutic promise in the treatment of neurological diseases in a variety of experimental systems.
  3. Fulltext ASSOCIATION OF SMOKING AND SEVERITY OF COVID-19 INFECTION AMONG 5,889 PATIENTS IN MALAYSIA: A MULTI-CENTER OBSERVATIONAL STUDY
    Ismail N, Hassan N, Abd Hamid MHN, Yusoff UN, Khamal NR, Omar MA, et al.
    Int J Infect Dis, 2022 Mar;116:189-196.
    PMID: 35021062 DOI: 10.1016/j.ijid.2022.01.011
    OBJECTIVE: This study aims to investigate the association between smoking and the severity of COVID-19 infection during the initial wave of this pandemic in Malaysia.

    METHODS: This is a multi-center observational study using secondary hospital data collected retrospectively from February 1, 2020, until May 30, 2020. Clinical records of all real-time polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases with smoking status, co-morbidities, clinical features, and disease management were retrieved. Severity was assessed by the presence of complications and outcomes of COVID-19 infection. Logistic regression was used to determine the association between COVID-19 disease severity and smoking status.

    RESULTS: A total of 5,889 COVID-19 cases were included in the analysis. Ever smokers had a higher risk of having COVID-19 complications, such as acute respiratory distress syndrome (odds ratio [OR] 1.69; 95% confidence interval [CI] 1.09-2.55), renal injury (OR 1.55; 95% CI 1.10-2.14), and acute liver injury (OR 1.33; 95% CI 1.01-1.74), compared with never smokers. However, in terms of disease outcomes, there were no differences between the two groups.

    CONCLUSION: Although no significant association was found in terms of disease outcomes, smoking is associated with a higher risk of having complications owing to COVID-19 infection.

  4. Knowledge, attitude and practice levels regarding malaria among the Semai sub-ethnic indigenous Orang Asli communities in Pahang, Peninsular Malaysia: a stepping stone towards the prevention of human malaria re-establishment
    Samsudin L, Mohd Jaafar MF, Kamarulzaman MKA, Mohd Nor NN, Ahmad Shafei S, Mohamad Shukor NA, et al.
    Malar J, 2024 Sep 05;23(1):269.
    PMID: 39238007 DOI: 10.1186/s12936-024-05095-7
    BACKGROUND: In Malaysia, despite a decline in cases, malaria remains a major public health concern, especially among the vulnerable indigenous people (i.e. Orang Asli) in remote areas. Effective preventive and control measures require an evidence-based understanding of their knowledge, attitudes, and practices (KAP) regarding malaria. This study aimed to evaluate the KAP regarding malaria in an indigenous settlement in Peninsular Malaysia.

    METHODS: A household-based cross-sectional study was conducted in March 2024 in six Semai sub-ethnic indigenous villages in Pos Lenjang, Kuala Lipis, Pahang. A structured questionnaire was administered to randomly selected individuals (≥ 12 years old) to collect data on sociodemographic characteristics and KAP. Data were analysed using descriptive statistics and predictors of KAP were determined using logistic regression. A p-value less than 0.05 was considered statistically significant.

    RESULTS: A total of 267 individuals from 160 households were interviewed. Nearly half had good knowledge (49.4%) and positive attitudes (54.3%) towards malaria, with high practice scores for prevention and control (83.1%). Multivariate logistic regression analysis showed higher odds of good knowledge in those aged 40-59 years (adjusted odd ratio [aOR] = 6.90, p = 0.034), with primary (aOR = 2.67, p = 0.015) or secondary education (aOR = 2.75, p = 0.019), and with previous malaria history (aOR = 5.14, p 

  5. Fulltext Strategies to Overcome Erroneous Outcomes in Reverse Transcription-Polymerase Chain Reaction (RT-PCR) Testing: Insights From the COVID-19 Pandemic
    Sajal SSA, Islam DZ, Khandker SS, Solórzano-Ortiz E, Fardoun M, Ahmed MF, et al.
    Cureus, 2024 Nov;16(11):e72954.
    PMID: 39498425 DOI: 10.7759/cureus.72954
    The reverse transcription-polymerase chain reaction (RT-PCR) test to detect SARS-CoV-2, the virus causing COVID-19, has been regarded as the diagnostic gold standard. However, the excessive sensitivity of RT-PCR may cause false-positive outcomes from contamination. Again, its technical complexity increases the chances of false-negatives due to pre-analytical and analytical errors. This narrative review explores the elements contributing to inaccurate results during the COVID-19 pandemic and offers strategies to minimize these errors. False-positive results may occur due to specimen contamination, non-specific primer binding, residual viral RNA, and false-negatives, which may arise from improper sampling, timing, labeling, storage, low viral loads, mutations, and faulty test kits. Proposed mitigation strategies to enhance the accuracy of RT-PCR testing include comprehensive staff training in specimen collection, optimizing the timing of tests, analyzing multiple gene targets, incorporating clinical findings, workflow automation, and implementing stringent contamination control measures. Identifying and rectifying sources of error in RT-PCR diagnosis through quality control and standardized protocols is imperative for ensuring quality patient care and effective epidemic control.
  6. Fulltext Correction: Strategies to Overcome Erroneous Outcomes in Reverse Transcription-Polymerase Chain Reaction (RT-PCR) Testing: Insights From the COVID-19 Pandemic
    Sajal SSA, Islam DZ, Khandker SS, Solórzano-Ortiz E, Fardoun M, Ahmed MF, et al.
    Cureus, 2024 Nov;16(11):c199.
    PMID: 39583600 DOI: 10.7759/cureus.c199
    [This corrects the article DOI: 10.7759/cureus.72954.].
  7. LC-MS/MS profiling of the poisonous wild mushroom, Entoloma mastoideum, (Entolomataceae, Basidiomycota) in Sabah (Northern Borneo), Malaysia
    M H Subari IAA, Mutthumanickam G, Hj Jikal M, Shah MD, Tan JK, Tan YS, et al.
    Toxicon, 2024 Nov 28;251:108133.
    PMID: 39426425 DOI: 10.1016/j.toxicon.2024.108133
    In Malaysia, mushroom poisoning poses a significant public health concern, particularly as local communities frequently consume wild mushrooms without fully recognizing the potential dangers they present. Ingestion of wild mushrooms, which resemble edible species but contain deadly chemicals, is the main cause of poisoning risk. The genus Entoloma (Fr.) P. Kumm is dispersed worldwide, with over 1500 species recorded. Entoloma mastoideum, a poisonous mushroom, was recorded for the first time at Kota Marudu district, Sabah, Malaysia, where ten cases of mushroom poisoning outbreaks were recorded during the rainy season of October 2019. The morphological characters of the specimens were documented and their microscopic features were analyzed using compound microscope and scanning electron microscope. A phylogenetic tree was constructed using Maximum likelihood and Bayesian analysis. Chemical profiling of the poisonous mushroom specimen was done via liquid chromatograph mass spectrometry (LC-MS/MS) to identify toxic metabolites. The phylogenetic analysis showed that the Bornean E. mastoideum is closely related to the Chinese isolates (100% BS/1.0 PP). LC-MS/MS profiling detected a total of 162 metabolites that were classified into ten general groups, where several toxic compounds were detected amongst the aromatics, essential amino acids, and fatty acid derivatives. The toxic compounds identified in the mushroom extract, including amino acid derivatives such as 3,4,5,6-tetrahydroxyynorleucine, valpromide, and betaine, have been reported to cause neurotoxicity, cardiotoxicity, liver damage, and gastrointestinal harm. The presence of these toxic compounds underscores the need for caution when consuming wild mushrooms. Further research on poisonous Entoloma species is vital for developing accurate identification methods and understanding their toxic potential. This knowledge is essential for enhancing public awareness, preventing mushroom poisoning incidents and safeguarding public health.
  8. Contralateral Nasofrontal Trephination: A Novel Corridor for a "Dual Port" Approach to the Petrous Apex
    Abouammo MD, Narayanan MS, Alsavaf MB, Alwabili M, Gosal JS, Bhuskute GS, et al.
    Oper Neurosurg (Hagerstown), 2024 Sep 01;27(3):347-356.
    PMID: 38506519 DOI: 10.1227/ons.0000000000001119
    BACKGROUND AND OBJECTIVES: Expanded endonasal approaches (EEAs) have proven safe and effective in treating select petrous apex (PA) pathologies. Angled endoscopes and instruments have expanded indications for such approaches; however, the complex neurovascular anatomy surrounding the petrous region remains a significant challenge. This study evaluates the feasibility, anatomic aspects, and limitations of a contralateral nasofrontal trephination (CNT) route as a complementary corridor improving access to the PA.

    METHODS: Expanded endonasal and CNT approaches to the PA were carried out bilaterally in 15 cadaveric heads with endovascular latex injections. The distance to the PA, angle between instruments through the 2 approach portals, and surgical freedom were measured and compared.

    RESULTS: Three-dimensional DICOM-based modeling and visualization indicate that the CNT route reduces the distance to the target located within the contralateral PA by an average of 3.33 cm (19%) and affords a significant increase in the angle between instruments (15.60°; 54%). Furthermore, the vertical vector of approach is improved by 28.97° yielding a caudal reach advantage of 2 cm. The area of surgical freedom afforded by 3 different approaches (endonasal, endonasal with an endoscope in CNT portal, and endonasal with an instrument in CNT portal) was compared at 4 points: the dural exit point of the 6th cranial nerve, jugular foramen, foramen lacerum, and petroclival fissure. The mean area of surgical freedom provided by both approaches incorporating the CNT corridor was superior to EEA alone at each of the surgical targets ( P =

  9. Validation and Measurement Invariance of the Tendency to Avoid Physical Activity and Sport Scale (TAPAS) Among Thai Young Adults
    Ruckwongpatr K, Ahorsu DK, Pimsen A, Paratthakonkun C, Tung SEH, Pramukti I, et al.
    Eval Health Prof, 2024 Aug 16.
    PMID: 39148374 DOI: 10.1177/01632787241271117
    Examining ways of reducing physical inactivity has been at the forefront of public health research. Moreover, valid and reliable scales are needed to objectively assess physical activity (PA) avoidance. Previous research has shown that experiencing weight stigma and physical appearance-related concerns are associated with physical inactivity. However, there is currently no Thai instrument that assesses physical inactivity in relation to weight stigma. Therefore, the present study examined the psychometric properties of the Thai version of the Tendency to Avoid Physical Activity and Sport Scale (TAPAS). Thai university students (N = 612) recruited via convenience sampling completed an online survey using SurveyMonkey between September 2022 and January 2023. Confirmatory factor analysis (CFA), multigroup CFA, and Pearson correlations (between TAPAS scores, age, body mass index, and time spent exercising) were used to analyze the data. The CFA showed robust psychometric properties for the Thai version of TAPAS regarding its unidimensional structure. The TAPAS was measurement invariant across sex, weight status, and daily hours of exercise. However, no significant Pearson correlations were found. In general, the results showed that the TAPAS is a good scale for assessing PA avoidance among Thai young adults across different sexes, weight status, and daily hours of exercise.
  10. Fulltext Phylogeographic Evidence for 2 Genetically Distinct Zoonotic Plasmodium knowlesi Parasites, Malaysia
    Yusof R, Ahmed MA, Jelip J, Ngian HU, Mustakim S, Hussin HM, et al.
    Emerg Infect Dis, 2016 Aug;22(8):1371-80.
    PMID: 27433965 DOI: 10.3201/eid2208.151885
    Infections of humans with the zoonotic simian malaria parasite Plasmodium knowlesi occur throughout Southeast Asia, although most cases have occurred in Malaysia, where P. knowlesi is now the dominant malaria species. This apparently skewed distribution prompted an investigation of the phylogeography of this parasite in 2 geographically separated regions of Malaysia, Peninsular Malaysia and Malaysian Borneo. We investigated samples collected from humans and macaques in these regions. Haplotype network analyses of sequences from 2 P. knowlesi genes, type A small subunit ribosomal 18S RNA and cytochrome c oxidase subunit I, showed 2 genetically distinct divergent clusters, 1 from each of the 2 regions of Malaysia. We propose that these parasites represent 2 distinct P. knowlesi types that independently became zoonotic. These types would have evolved after the sea-level rise at the end of the last ice age, which separated Malaysian Borneo from Peninsular Malaysia.
  11. Fulltext Microplastics pollution in salt pans from the Maheshkhali Channel, Bangladesh
    Rakib MRJ, Al Nahian S, Alfonso MB, Khandaker MU, Enyoh CE, Hamid FS, et al.
    Sci Rep, 2021 Nov 30;11(1):23187.
    PMID: 34848770 DOI: 10.1038/s41598-021-02457-y
    Microplastics (MP) were recognized as an emergent pollution problem due to their ubiquitous nature and bioaccumulative potential. Those present in salt for consumption could represent a human exposure route through dietary uptake. The current study, conducted in Bangladesh, reports microplastics contamination in coarse salt prepared for human consumption. Sea salt samples were collected from eight representative salt pans located in the country's largest salt farming area, in the Maheshkhali Channel, along the Bay of Bengal. Microplastics were detected in all samples, with mean concentrations ranging from 78 ± 9.33 to 137 ± 21.70 particles kg-1, mostly white and ranging in size from 500-1000 µm. The prevalent types were: fragments (48%) > films (22%) > fibers (15%) > granules and lines (both 9%). Fourier transform mid-IR and near-IR spectra (FT-MIR-NIR) analysis registered terephthalate (48%), polypropylene (20%), polyethylene (17%), and polystyrene (15%) in all samples. These results contribute to the MP's pollution knowledge in sea salts to understand and reduce this significant human exposure route and environmental pollution source in the future.
  12. Recent advances in nanocellulose-based adsorbent for sustainable removal of pharmaceutical contaminants from water bodies: A review
    Nordin AH, Yusoff AH, Husna SMN, Noor SFM, Norfarhana AS, Paiman SH, et al.
    Int J Biol Macromol, 2024 Nov;280(Pt 2):135799.
    PMID: 39307484 DOI: 10.1016/j.ijbiomac.2024.135799
    The long-term presence of pharmaceutical pollution in water bodies has raised public awareness. Nanocellulose is often used in adsorption to remove pollutants from wastewater since it is an abundant, green and sustainable material. This paper offers an extensive overview of the recent works reporting the potential of nanocellulose-based adsorbents to treat pharmaceutical wastewater. This study distinguishes itself by not only summarizing recent research findings but also critically integrating discussions on the improvements in nanocellulose production and sorts of alterations based on the type of pharmaceutical contaminants. Commonly, charged, or hydrophobic characteristics are introduced onto nanocellulose surfaces to accelerate and enhance the removal of pharmaceutical compounds. Although adsorbents based on nanocellulose have considerable potential, several significant challenges impede their practical application, particularly concerning cost and scalability. Large-scale synthesis of nanocellulose is technically challenging and expensive, which prevents its widespread use in wastewater treatment plants. Continued innovation in this area could lead to breakthroughs in the practical application of nanocellulose as a superior adsorbent. The prospects of utilization of nanocellulose are explained, providing a sustainable way to address the existing restriction and maximize the application of the modified nanocellulose in the field of pharmaceutical pollutants removal.
  13. Fulltext Green Metallic Nanoparticles: Biosynthesis to Applications
    Chopra H, Bibi S, Singh I, Hasan MM, Khan MS, Yousafi Q, et al.
    Front Bioeng Biotechnol, 2022;10:874742.
    PMID: 35464722 DOI: 10.3389/fbioe.2022.874742
    Current advancements in nanotechnology and nanoscience have resulted in new nanomaterials, which may pose health and environmental risks. Furthermore, several researchers are working to optimize ecologically friendly procedures for creating metal and metal oxide nanoparticles. The primary goal is to decrease the adverse effects of synthetic processes, their accompanying chemicals, and the resulting complexes. Utilizing various biomaterials for nanoparticle preparation is a beneficial approach in green nanotechnology. Furthermore, using the biological qualities of nature through a variety of activities is an excellent way to achieve this goal. Algae, plants, bacteria, and fungus have been employed to make energy-efficient, low-cost, and nontoxic metallic nanoparticles in the last few decades. Despite the environmental advantages of using green chemistry-based biological synthesis over traditional methods as discussed in this article, there are some unresolved issues such as particle size and shape consistency, reproducibility of the synthesis process, and understanding of the mechanisms involved in producing metallic nanoparticles via biological entities. Consequently, there is a need for further research to analyze and comprehend the real biological synthesis-dependent processes. This is currently an untapped hot research topic that required more investment to properly leverage the green manufacturing of metallic nanoparticles through living entities. The review covers such green methods of synthesizing nanoparticles and their utilization in the scientific world.
  14. Kinetic model derived from machine learning for accurate prediction of microalgal hydrogen production via conversion from low thermally pre-treated palm kernel expeller waste
    Ahmad Sobri MZ, Khoo KS, Sahrin NT, Ardo FM, Ansar S, Hossain MS, et al.
    Chemosphere, 2023 Oct;338:139526.
    PMID: 37459926 DOI: 10.1016/j.chemosphere.2023.139526
    The depletion of fossil fuel sources and increase in energy demands have increased the need for a sustainable alternative energy source. The ability to produce hydrogen from microalgae is generating a lot of attention in both academia and industry. Due to complex production procedures, the commercial production of microalgal biohydrogen is not yet practical. Developing the most optimum microalgal hydrogen production process is also very laborious and expensive as proven from the experimental measurement. Therefore, this research project intended to analyse the random time series dataset collected during microalgal hydrogen productions while using various low thermally pre-treated palm kernel expeller (PKE) waste via machine learning (ML) approach. The analysis of collected dataset allowed the derivation of an enhanced kinetic model based on the Gompertz model amidst the dark fermentative hydrogen production that integrated thermal pre-treatment duration as a function within the model. The optimum microalgal hydrogen production attained with the enhanced kinetic model was 387.1 mL/g microalgae after 6 days with 1 h thermally pre-treated PKE waste at 90 °C. The enhanced model also had better accuracy (R2 = 0.9556) and net energy ratio (NER) value (0.71) than previous studies. Finally, the NER could be further improved to 0.91 when the microalgal culture was reused, heralding the potential application of ML in optimizing the microalgal hydrogen production process.
  15. Factors associated with outcomes of severe acute necrotizing encephalopathy: A multicentre experience in Malaysia
    Lee VWM, Khoo TB, Teh CM, Heng HS, Li L, Yusof YLM, et al.
    Dev Med Child Neurol, 2023 Sep;65(9):1256-1263.
    PMID: 36748407 DOI: 10.1111/dmcn.15536
    This case series compared clinical variables and various combinations of immunotherapy received with outcomes of patients with severe acute necrotizing encephalopathy (ANE). We performed a retrospective review of clinical variables, immunotherapy received, and outcomes (based on the modified Rankin Scale) in Malaysia between February 2019 and January 2020. Twenty-seven children (12 male), aged 7 months to 14 years (mean 4 years) at diagnosis were included. Of these, 23 had an ANE severity score of 5 to 9 out of 9 (high risk). Eleven patients received tocilizumab (four in combination with methylprednisolone [MTP], seven with MTP + intravenous immunoglobulin [IVIG]) and 16 did not (two received MTP alone, 14 received MTP + IVIG). Nine died. Among the survivors, six had good outcomes (modified Rankin Score 0-2) at 6 months follow-up. All patients who received tocilizumab in combination with MTP + IVIG survived. Twenty children received first immunotherapy within 48 hours of admission. No significant association was found between the timing of first immunotherapy with outcomes. Those with brainstem dysfunction (p = 0.016) were observed to have poorer outcomes. This study showed a trend towards better survival when those with severe ANE were treated with tocilizumab in combination with MTP + IVIG. However, larger studies will be needed to determine the effect of this regime on the long-term outcomes.
  16. Fulltext Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review
    Yuandani, Jantan I, Haque MA, Rohani AS, Nugraha SE, Salim E, et al.
    Front Pharmacol, 2023;14:1222195.
    PMID: 37533631 DOI: 10.3389/fphar.2023.1222195
    Zingiber and Alpinia species (family: Zingiberaceae) are popularly used in food as spices and flavoring agents and in ethnomedicine to heal numerous diseases, including immune-related disorders. However, their ethnomedicinal uses have not been sufficiently supported by scientific investigations. Numerous studies on the modulating effects of plants and their bioactive compounds on the different steps of the immune system have been documented. This review aimed to highlight up-to-date research findings and critically analyze the modulatory effects and mechanisms of the extracts and secondary compounds of several Zingiber and Alpinia species, namely, Zingiber officinale Roscoe, Z. cassumunar Roxb., Z. zerumbet (L.) Roscoe ex Sm., Alpinia galanga Linn., A. conchigera Griff, A. katsumadai Hayata, A. oxyphylla Miq., A. officinarum Hance, A. zerumbet (Pers.) Burtt. et Smith, and A. purpurata (Viell.) K. Schum. on the immune system, particularly via the inflammation-related signaling pathways. The immunomodulating activities of the crude extracts of the plants have been reported, but the constituents contributing to the activities have mostly not been identified. Among the extracts, Z. officinale extracts were the most investigated for their in vitro, in vivo, and clinical effects on the immune system. Among the bioactive metabolites, 6-, 8-, and 10-gingerols, 6-shogaol, and zerumbone from Zingiber species and cardamomin, 1'-acetoxychavicol acetate, yakuchinone, rutin, 1,8-cineole, and lectin from Alpinia species have demonstrated strong immunomodulating effects. More experimental studies using cell and animal models of immune-related disorders are necessary to further understand the underlying mechanisms, together with elaborate preclinical pharmacokinetics, pharmacodynamics, bioavailability, and toxicity studies. Many of these extracts and secondary metabolites are potential candidates for clinical development in immunomodulating agents or functional foods to prevent and treat chronic inflammatory disorders.
  17. Broadband near unity absorption meta-structure for solar thermophotovoltaic systems and optical window applications
    Soliman MM, Islam MT, Alam T, Misran N, Abdul Rahim SK, Alzamil A, et al.
    Nanoscale, 2023 Aug 10;15(31):12972-12994.
    PMID: 37477438 DOI: 10.1039/d3nr01941a
    Developing a meta-structure with near-unity absorbance in the visible and infrared spectra for solar energy harvesting, photodetection, thermal imaging, photo-trapping, and optical communications is a long-term research challenge. This research presents a four-layered (insulator-metal-insulator-metal) meta-structure unit cell that showed a peak absorbance of 99.99% at 288-300 nm and the average absorbance of 99.18% over the 250-2000 nm wavelength range in TE and TM modes, respectively. The symmetric pattern of the resonator layer shows polarization insensitivity with an average absorption of 99.18% in both TE and TM modes. Furthermore, the proposed design shows a wide incident angle stability up to ≤60 degrees in both TE and TM modes. The proposed structure also exhibits negative index properties at 288-300 nm and 1000-2000 nm, respectively. The negative index properties of the proposed design generate an anti-parallel surface current flow in the ground and resonator layers, which induces magnetic and electric field resonance and increases absorption. The performance of the proposed design is further validated by the interference theory model and a zero value for the polarization conversion ratio (PCR). The electric field E, magnetic field H, and current distribution are analyzed to explain the absorption mechanism of the proposed meta-structure unit cell. It also exhibits the highest photo-thermal conversion efficiency of 99.11%, demonstrating the viability of the proposed design as a solar absorber. The proposed design promises potentially valuable applications such as solar energy harvesting, photodetection, thermal imaging, photo-trapping, and optical communications because of its decent performance.
  18. Fulltext Antimicrobial Potential of Aqueous Extract of Giant Sword Fern and Ultra-High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry Analysis
    Venmathi Maran BA, Palaniveloo K, Mahendran T, Chellappan DK, Tan JK, Yong YS, et al.
    Molecules, 2023 Aug 15;28(16).
    PMID: 37630329 DOI: 10.3390/molecules28166075
    Vibriosis and parasitic leech infestations cause the death of various farmed fish, such as groupers, hybrid groupers, sea bass, etc., in Malaysia and other Southeast Asian countries. In the absence of natural control agents, aquaculture operators rely on toxic chemicals to control Vibrio infections and parasitic leeches, which can have a negative impact on the environment and health. In the present study, we investigated the antivibrio and antiparasitic activities of the aqueous extract of giant sword fern (GSF) (Nephrolepis biserrata, Nephrolepidaceae, locally known as "Paku Pedang") against four Vibrio spp. and the parasitic leech Zeylanicobdella arugamensis, as well as its metabolic composition using the ultra-high-performance liquid chromatography-high-resolution mass spectrometry system (UHPLC-HRMS). The data show that the aqueous extract of GSF at a concentration of 100 mg/mL exhibits potent bactericidal activity against V. parahaemolyticus with a zone of inhibition of 19.5 mm. In addition, the extract showed dose-dependent activity against leeches, resulting in the complete killing of the parasitic leeches within a short period of 11-43 min when tested at concentrations ranging from 100 to 25 mg/mL. The UHPLC-HRMS analysis detected 118 metabolites in the aqueous extract of GSF. Flavonoids were the primary metabolites, followed by phenolic, aromatic, fatty acyl, terpenoid, vitamin and steroidal compounds. Notably, several of these metabolites possess antibacterial and antiparasitic properties, including cinnamaldehyde, cinnamic acid, apigenin, quercetin, cynaroside, luteolin, naringenin, wogonin, 6-gingerol, nicotinamide, abscisic acid, daidzein, salvianolic acid B, etc. Overall, our study shows the significant antibacterial and antiparasitic potential of the GSF aqueous extract, which demonstrates the presence of valuable secondary metabolites. Consequently, the aqueous extract is a promising natural alternative for the effective control of Vibrio infections and the treatment of parasitic leeches in aquaculture systems.
  19. Field data on pre-season rice straw degradation using a microbial substrate and the effects on methane emissions during rice cultivation
    Jumat F, Rahman MHA, Bakar SA, Shakri NA, Kamaruzaman R, Bakar NAA, et al.
    Data Brief, 2023 Aug;49:109383.
    PMID: 37600135 DOI: 10.1016/j.dib.2023.109383
    Rice straw is one of the most abundant biomass wastes derived from rice cultivation activities. The current rice straw management practice during the wet (rainy) season in Malaysia involves the integration of straw into the soil. This practice offers both advantages and disadvantages to rice farmers and the environment. Straw integration may improve nutrient availability while concurrently causing high greenhouse gas (GHG) emissions due to the increase in soil carbon activity. In this work, the use of microbial substrate to enhance the degradation of straw was compared to an existing technique that used no additional inputs during soil integration. The data collected consisted of overall microbial enzyme production, soil organic carbon, soil nitrogen content, seasonal greenhouse gas emissions, plant characteristics, and crop yield. In brief, these data can be used as means of demonstrating the effects of improved straw degradation during the pre-season on the overall GHG emissions during the planting season.
  20. Fulltext In Silico Analysis Reveals High Levels of Genetic Diversity of Plasmodium knowlesi Cell Traversal Protein for Ookinetes and Sporozoites (PkCelTOS) in Clinical Samples
    Ahmed MA, Baruah P, Saif A, Han JH, Al-Zharani M, Wazid SW, et al.
    Trop Med Infect Dis, 2023 Jul 26;8(8).
    PMID: 37624318 DOI: 10.3390/tropicalmed8080380
    The cell-traversal protein for ookinetes and sporozoites (CelTOS), expressed on the surface of ookinetes and sporozoitesin Plasmodium species, is a promising malaria vaccine candidate. CelTOS is essential for parasite invasion into mosquito midgut and human hepatocytes, thereby contributing to malaria transmission and disease pathogenesis. This study explores the genetic diversity, polymorphisms, haplotypes, natural selection, phylogenetic analysis, and epitope prediction in the full-length Plasmodium knowlesi CelTOS gene in clinical samples from Sarawak, Malaysian Borneo, and long-term laboratory strains from Peninsular Malaysia and the Philippines. Our analysis revealed a high level of genetic variation in the PkCelTOS gene, with a nucleotide diversity of π ~ 0.021, which was skewed towards the 3' end of the gene. This level of diversity is double that observed in PfCelTOS and 20 times that observed in PvCelTOS from worldwide clinical samples. Tests of natural selection revealed evidence for positive selection within clinical samples. Phylogenetic analysis of the amino acid sequence of PkCelTOS revealed the presence of two distinct groups, although no geographical clustering was observed. Epitope prediction analysis identified two potential epitopes (96AQLKATA102 and 124TIKPPRIKED133) using the IEDB server and one epitope (125IKPPRIKED133) by Bcepred server on the C' terminal region of PkCelTOS protein. Both the servers predicted a common epitope region of nine amino acid length (IKPPRIKED) peptide, which can be studied in the future as a potential candidate for vaccine development. These findings shed light on the genetic diversity, polymorphism, haplotypes, and natural selection within PkCelTOS in clinical samples and provide insights about its future prospects as a potential candidate for P. knowlesi malaria vaccine development.
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