Displaying publications 41 - 60 of 310 in total

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  1. Mustafa N, Einstein G, MacNeill M, Watt-Watson J
    Can J Pain, 2020 Sep 24;4(3):40-50.
    PMID: 33987510 DOI: 10.1080/24740527.2020.1768835
    Background: Chronic pain is a growing public health concern affecting 1.5 million people in Canada. In particular, it is a concern among the expanding immigrant population, because immigrant groups report higher pain intensity than non-immigrants. In 2011, the Indian population became the largest visible minority group and continues to be the fastest growing. Though the prevalence of chronic pain among Canadian Indians is unknown, research has found a higher prevalence among Indian women than men in India, Malaysia, Singapore, and the United Kingdom, with women reporting more severe pain. An understanding of how pain is experienced by this particular group is therefore important for providing culturally sensitive care.

    Aims: This study explores the lived experiences of chronic pain among immigrant Indian women in Canada.

    Methods: Thirteen immigrant Indian women participated in one-on-one interviews exploring daily experiences of chronic pain.

    Results: Using thematic analysis informed by van Manen's phenomenology of practice, four themes emerged: (1) the body in pain, (2) pain in the context of lived and felt space, (3) pain and relationships, and (4) pain and time. Women revealed that their experiences were shaped by gender roles and expectations enforced through culture. Specifically, a dual gender role was identified after immigration, in which women had to balance traditional household responsibilities of family labor and care alongside employment outside the home, exacerbating pain.

    Conclusions: This research uncovers the multifaceted nature of chronic pain and identifies factors within the sociocultural context that may place particular groups of women at greater risk of living with pain.

    Matched MeSH terms: Employment
  2. Du S, Cao Y, Zhou T, Setiawan A, Thandar M, Koy V, et al.
    BMC Health Serv Res, 2019 Aug 27;19(1):602.
    PMID: 31455377 DOI: 10.1186/s12913-019-4402-9
    BACKGROUND: Primary health care (PHC) is usually the initial point of contact for individuals seeking to access health care and providers of PHC play a crucial role in the healthcare model. However, few studies have assessed the knowledge, ability, and skills (capacity) of PHC providers in delivering care. This study aimed to identify the capacity of PHC providers in countries of the Southeast and East Asian Nursing Education and Research Network (SEANERN).

    METHODS: A multi-national cross-sectional survey was performed among SEANERN countries. A 1-5 Likert scale was used to measure eight components of knowledge, ability, and skill of PHC providers. Descriptive statistics were employed, and radar charts were used to depict the levels of the three dimensions (knowledge, skill and ability) and eight components.

    RESULTS: Totally, 606 valid questionnaires from PHC providers were returned from seven countries of SEANERN (China, Myanmar, Indonesia, Thailand, Vietnam, Cambodia, and Malaysia), with a responsive rate of 97.6% (606/621). For the three dimensions the ranges of total mean scores were distributed as follows: knowledge dimension: 2.78~3.11; skill dimension: 2.66~3.16; ability dimension: 2.67~3.06. Furthermore, radar charts revealed that the transition of PHC provider's knowledge into skill and from skill into ability decreased gradually. Their competencies in four areas, including safe water and sanitation, nutritional promotion, endemic diseases prevention, and essential provision of drugs, were especially low.

    CONCLUSIONS: The general capacity perceived by PHC providers themselves seems relatively low and imbalanced. To address the problem, SEANERN, through the collaboration of the members, can facilitate the appropriate education and training of PHC providers by developing feasible, practical and culturally appropriate training plans.

    Matched MeSH terms: Employment
  3. Jawahir S, Tan EH, Tan YR, Mohd Noh SN, Ab Rahim I
    BMC Health Serv Res, 2021 Apr 27;21(1):391.
    PMID: 33906646 DOI: 10.1186/s12913-021-06412-5
    BACKGROUND: Provision of informal care may adversely affect health, daily and social activities of the informal caregivers, but few studies have examined these effects in relation to caregiving intensity. This study examined the predictive factors associated with the effects of caregiving roles on health, daily and social activities of informal caregivers, accounting for caregiving intensity.

    METHODS: Data of adults aged 18 years and over from the National Health and Morbidity Survey 2019 were used. Respondent's demographic, socioeconomic, health, and caregiving-related characteristics were described using complex samples analysis. Logistic regression analysis was performed to examine the factors affecting health, daily and social activities of caregivers, accounting for caregiving intensity.

    RESULTS: Five point one percent of adults in Malaysia provided informal care. High intensity caregivers were more likely to be actively employed and provided longer duration of care compared with low intensity caregivers. For low intensity caregiving, females, those aged 35-59 years, and those with long-term condition were more likely to have negative effects on health. Daily activities of non-Malays were more likely to be affected, while no factor was found significantly associated with effect on social activities. For high intensity caregiving, caregivers aged 60 and over, those received training and those without assistance were more likely to have negative effects on health. Daily activities of those without assistance were more likely to be affected. Social activities of non-Malays, those received training and those providing care for 2 years or more were more likely to be affected.

    CONCLUSIONS: Our study indicates that both low- and high-intensity caregivers have common features, with the exception of employment status and care duration. Caregiving, regardless of intensity, has a significant impact on caregivers. In order to reduce the negative consequences of caregiving responsibilities, all caregivers need assistance from the community and government, that is customised to their needs. By addressing the factors contributing to the negative effects of caregiving, a continuation of informal caregiving can be sustained through policies supporting the growing demand for informal care necessitated by an ageing population and higher life expectancy in Malaysia.

    Matched MeSH terms: Employment*
  4. Müller M, Igarashi A, Hashiguchi K, Kappel M, Paolini F, Yoshisue H, et al.
    J Med Econ, 2022 1 25;25(1):220-229.
    PMID: 35072591 DOI: 10.1080/13696998.2022.2033051
    AIMS: Japanese cedar pollinosis (JCP) is a form of seasonal allergic rhinitis that affects 38.8% of the Japanese population. Particularly severe and most severe symptoms among JCP patients can lead to impairments of paid work productivity and unpaid work activities. Indeed, the current standard of care (SoC) is not always able to relieve these symptoms. Omalizumab, a novel JCP treatment recently approved in Japan, provides an effective add-on therapy to the SoC. This study estimates the effect of omalizumab on paid and unpaid work activities (i.e. its social impact) in patients with severe and most severe JCP symptoms in Japan.

    METHODS: The impact of omalizumab was estimated through a one-year static cohort model using the Work Productivity and Activity Impairment Allergy Specific (WPAI-AS) questionnaire derived from a clinical trial on omalizumab enrolling patients with severe and most severe JCP symptoms, which had been conducted in Japan. This effect was quantified using Japanese official statistics on employment and time use. The human capital approach and the proxy good approach were employed to monetize paid and unpaid work activities, respectively. A sensitivity analysis was implemented to account for modeling structural uncertainties.

    RESULTS: Our results show that the use of omalizumab might reduce the paid and unpaid work productivity losses due to severe and most severe JCP by nearly one-third. In the severe symptom period of three weeks, 36.6 million hours of lost paid and unpaid work hours could be avoided, which sums up to a monetized productivity loss of 728.3 million USD.

    CONCLUSIONS: Omalizumab could provide substantial benefits in terms of paid and unpaid work activities in patients with severe and most severe JCP. Our results also highlight the importance of considering unpaid work in estimating productivity costs due to poor health.

    Matched MeSH terms: Employment
  5. Shrestha N, Shad MY, Ulvi O, Khan MH, Karamehic-Muratovic A, Nguyen UDT, et al.
    One Health, 2020 Dec 20;11:100180.
    PMID: 33072836 DOI: 10.1016/j.onehlt.2020.100180
    Globalization has altered the way we live and earn a livelihood. Consequently, trade and travel have been recognized as significant determinants of the spread of disease. Additionally, the rise in urbanization and the closer integration of the world economy have facilitated global interconnectedness. Therefore, globalization has emerged as an essential mechanism of disease transmission. This paper aims to examine the potential impact of COVID-19 on globalization and global health in terms of mobility, trade, travel, and countries most impacted. The effect of globalization were operationalized in terms of mobility, economy, and healthcare systems. The mobility of individuals and its magnitude was assessed using airline and seaport trade data and travel information. The economic impact was measured based on the workforce, event cancellations, food and agriculture, academic institutions, and supply chain. The healthcare capacity was assessed by considering healthcare system indicators and preparedness of countries. Utilizing a technique for order of preference by similarity to ideal solution (TOPSIS), we calculated a pandemic vulnerability index (PVI) by creating a quantitative measure of the potential global health. The pandemic has placed an unprecedented burden on the world economy, healthcare, and globalization through travel, events cancellation, employment workforce, food chain, academia, and healthcare capacity. Based on PVI results, certain countries were more vulnerable than others. In Africa, more vulnerable countries included South Africa and Egypt; in Europe, they were Russia, Germany, and Italy; in Asia and Oceania, they were India, Iran, Pakistan, Saudi Arabia, and Turkey; and for the Americas, they were Brazil, USA, Chile, Mexico, and Peru. The impact on mobility, economy, and healthcare systems has only started to manifest. The findings of this study may help in the planning and implementation of strategies at the country level to help ease this emerging burden.
    Matched MeSH terms: Employment
  6. Chan CY, Tran N, Cheong KC, Sulser TB, Cohen PJ, Wiebe K, et al.
    PLoS One, 2021;16(12):e0261615.
    PMID: 34936682 DOI: 10.1371/journal.pone.0261615
    One of the most pressing challenges facing food systems in Africa is ensuring availability of a healthy and sustainable diet to 2.4 billion people by 2050. The continent has struggled with development challenges, particularly chronic food insecurity and pervasive poverty. In Africa's food systems, fish and other aquatic foods play a multifaceted role in generating income, and providing a critical source of essential micronutrients. To date, there are no estimates of investment and potential returns for domestic fish production in Africa. To contribute to policy debates about the future of fish in Africa, we applied the International Model for Policy Analysis of Agriculture Commodities and Trade (IMPACT) to explore two Pan-African scenarios for fish sector growth: a business-as-usual (BAU) scenario and a high-growth scenario for capture fisheries and aquaculture with accompanying strong gross domestic product growth (HIGH). Post-model analysis was used to estimate employment and aquaculture investment requirements for the sector in Africa. Africa's fish sector is estimated to support 20.7 million jobs in 2030, and 21.6 million by 2050 under the BAU. Approximately 2.6 people will be employed indirectly along fisheries and aquaculture value chains for every person directly employed in the fish production stage. Under the HIGH scenario, total employment in Africa's fish food system will reach 58.0 million jobs, representing 2.4% of total projected population in Africa by 2050. Aquaculture production value is estimated to achieve US$ 3.3 billion and US$ 20.4 billion per year under the BAU and HIGH scenarios by 2050, respectively. Farm-gate investment costs for the three key inputs (fish feeds, farm labor, and fish seed) to achieve the aquaculture volumes projected by 2050 are estimated at US$ 1.8 billion per year under the BAU and US$ 11.6 billion per year under the HIGH scenario. Sustained investments are critical to sustain capture fisheries and support aquaculture growth for food system transformation towards healthier diets.
    Matched MeSH terms: Employment
  7. Osman Che Bakar, Alipah Baharom, Ainsah Omar
    Medical Health Reviews, 2010;2010(1):77-90.
    MyJurnal
    The burden of caring patients with Schizophrenia was extensive and mental health professionals need to be more aware of the burden of mental illness on family members. There are four main sources of burden, namely restriction on the carer’s social and leisure activities, the strain placed on finances and employment, the emotional impact and the difficulty in dealing with dysfunctional and bizarre behaviors. Effective family intervention programs need to be done including to treat the depressive disorders among the carers.
    Matched MeSH terms: Employment
  8. Asef Raiyan Hoque, Mohd Yusof Ibrahim, Mohammad Zahirul Hoque
    MyJurnal
    Introduction: In recent years, the variation in total fertility rate (TFR) has sparked public interest for demographic concerns on the global population shift towards an older age structure. This study aims to investigate the determi-nants of total fertility rate among Brunei, Indonesia, Malaysia and Philippines East Asian Growth Area (BIMP-EAGA) region. Methods: Our empirical study consists of data collected from the United Nations Development Report of the UNDP, World Development Indicators (WDI) of the World Bank and World Health Organization (WHO) report 2018. We investigated the socio-economic determinants of fertility rate by analyzing a panel data set consisting of 28 years from 1990-2017 of the four countries. A statistical and econometric software EViews version 10 (HIS Global Inc., Irvine, CA, USA) were used to run a Pearson’s Correlation and a multiple regression analysis by panel least squares method. To investigate the determinants of TFR we have selected five socio- economic factors, these are- Infant mortality rate (IMR), Gross National Income Per Capita, PPP (GNI), Human Development Index (HDI), percentage of population living in urban areas (URB) and lastly Female Labor Force Participation Rate (FLP). Results:Pearson’s correlation showed that a statistically significant negative relationship exists between TFR and the 3 vari-ables- GNI, URB and HDI. A statistically strong positive relationship exists between IMR and TFR. However, our results from the empirical multiple regression model indicates that there is a statistically significant negative relation-ship exists between TFR and two of the independent variables GNI and FLP. Conclusion: The results of present study showed that an increase in the national income and female labor participation rate in the workforce could result in a decrease in total fertility rate. These findings may have implications for countries national policy for planning, development and resource allocation.
    Matched MeSH terms: Employment
  9. Rhaffor, Kauthar A., Nurul Hafieza Azizul, Rahim Jamian, Jum’azulhisham Abdul Shukor
    MyJurnal
    he practice of 5S has been adopted by many organizations as a method to organize the workplace towards reducing waste and improving productivity. Moreover, the practice also promotes a safe and efficient environment in organisations. As safety performance of the workplace is among the key issues in most industries including universities to become world class organizations, this study seeks to address empirically the impact of 5S practice on safety management performance. In this context, a survey questionnaire is employed and distributed to 60 employees of the selected university to examine the employees’ perception on the adoption of 5S practice as well as the impact of 5S practice towards safety management performance. The questionnaires were validated by a pilot test with an acceptable value of Cronbach's alpha. Overall findings highlight there was positive perceptions toward 5S practice among the respondents. The results also revealed that 5S Audit has a very strong positive correlation with safety management performance. Furthermore, 5S Training and Top Management Commitment were (2) factors that strongly correlated to safety management performance. These factors are highly important in contributing toward the success of safety management performance. Additionally, since most of the employees were not exposed with Occupational Safety and Health (OSH), this study reveals moderate negative correlation between compliance to OSH Requirements and safety management performance.
    Matched MeSH terms: Employment
  10. Mohd Hafizan Musa, Ahmad Kamalrulzaman Othman, Rusnani Mohamad Khalid, Yusnita Sokman, Wan Mohd Farid Wan Zakaria
    MyJurnal
    Technological innovations are significant in human and professional life. A new online correction and
    prevention system called eTPP to replace old traditional system has introduced new major changes in
    the reporting process. Therefore, this study was carried out to determine the level of user's acceptance
    towards eTPP and to investigate the factors that influence user's behavioural intentions to use eTPP in
    UiTM Cawangan Johor, Kampus Segamat. A Technology Acceptance Model (TAM) was employed
    as a conceptual framework to investigate the factors that influence users' acceptance to use eTPP. To
    test the model, data were collected from 44 respondents from various departments in UiTM
    Cawangan Johor, Kampus Segamat. Questionnaires were distributed to collect primary data from the
    respondents about their acceptability of eTPP. The results were presented through multiple regression
    analysis and supported by mediating analysis (Preacher and Hayes, 2008; Baron and Kenny, 1986),
    whereby it showed consistent mediating result with the regression result. The overall finding of the
    study showed that the perceived ease of use was the main factor influencing eTPP acceptance among
    the users.
    Matched MeSH terms: Employment
  11. Kwan SSM, Tuckey MR, Dollard MF
    PLoS One, 2020;15(1):e0223235.
    PMID: 31971942 DOI: 10.1371/journal.pone.0223235
    Workplace bullying is a significant cause of stress at work. Existing studies, primarily based on Western-oriented frameworks and instruments, have largely overlooked the role of culture. This oversight questions whether understandings generated from those studies can be generalised to employees working in Eastern countries, which differ on important cultural dimensions. To date, there is no Eastern-based instrument for measuring workplace bullying. In two studies, we developed and validated such a measure: the Malaysian Workplace Bullying Index (MWBI). Study 1 entailed a content validation of bullying behaviours via written records (diaries) completed by Malaysian bullying victims. The 19 validated behaviours formed the basis of Study 2, with additions from the wider literature. Study 2 used survey data collected at three time-points from Malaysian employees exposed to bullying at work. The final result was an 18-item scale with two nine-item factors: work-related bullying and person-related bullying. Overall, the MWBI is a psychometrically sound measure of workplace bullying in Eastern workplaces.
    Matched MeSH terms: Employment/psychology
  12. Nur Aizzah Hanan Kamarul Zaman, Mohd Zulfaezal Che Azemin
    MyJurnal
    Previous work employed digital image analysis using a fully-automated computer software to quantify changes in MG, which is meibomian gland loss. However, semi-automated software is more favorable for clinical applications as it allows clinicians to manually delete undesired noise or artifacts.
    Matched MeSH terms: Employment
  13. Tan C, Yi L, Haider A, Kwen L, Mamnoon R, Li K, et al.
    J Environ Public Health, 2022;2022:1663120.
    PMID: 36060872 DOI: 10.1155/2022/1663120
    Teachers' management effectiveness can reflect the comprehensive ability and effective evaluation of the teaching management objectives of the school and can also reflect the effectiveness management of the school to a certain extent. In the environment of sustainable and innovative development, the rapid development of education has made improving the management efficiency and motivation of university teachers became the key direction of university management. In order to study the impact of teachers' management efficacy and motivation on college students' academic achievement and postemployment social responsibility cognition under sustainable innovation, this study compares the impact of teachers in different periods on students and analyzes the changes of teachers in different periods on students. Finally, it is concluded that teachers' management efficiency and motivation under sustainable innovation can promote students' employment achievement and social responsibility cognition, improve the teaching quality of colleges and universities, and provide high-quality talents for the country. The educational concept of sustainable innovation is conducive to improving teachers' independent innovation and realizing the educational function of cultivating students' personalized development in colleges and universities.
    Matched MeSH terms: Employment
  14. Salih, F.A.M., Haque, Q.M.
    MyJurnal
    The number of people worldwide living with human immunodeficiency virus/ acquired immunodeficiency virus (HIV/AIDS) is more than 40 million, among them 17.7 millions are women (UNAIDS/WHO, 2006) The latest report from the Eastern Mediterranean Region shows that at least one million people are infected with HIV; among them 30% are women. The great majority of reported cases in the Region are men. However, the ratio of men to women cases varies in different countries. It ranges between “9:1 (as for example in Egypt), to 2:1” (as in Morocco and some parts of Yemen). Due to religious, social and cultural values regarding female purity, women and girls living with HIV and AIDS are subjected to greater discrimination than men. WHO reports show that a large percentage of the infected women in Arab countries have contacted the infection from their husbands especially migrants and drug abusers. In Arab countries, studies conducted show that 86% of women choose not to disclose their status of infection for the fear of abandonment, rejection, discrimination, violence, upsetting family members, and accusations of infidelity from their partners, families, and communities. As a result, many women only seek help at the last minute when they are already been terminally ill. Violence against women and girls in its different forms increases women's vulnerability to HIV infection and undermines AIDS control efforts. The fear of violence prevents many women from accessing HIV information, from getting testing and seeking treatment. Stigma and discrimination may also prevent them from carrying out their normal life activities. When women are blamed, this can lead to heightened levels of sexual and domestic violence, abandonment by families and communities, forced abortion or sterilization, dismissal from employment and loss of livelihood opportunities. A study of AIDS-related discrimination in Arab region found that over ten percent of women had lost financial support from family members since being diagnosed as HIV positive. There is a great deal of evidence to establish the significant link between gender-based violence and rising rates of HIV infection among women and girls throughout the world. HIV-positive women must be supported to make their own reproductive choices about whether and/or when to have children. Promote male involvement in sexual and reproductive health programmes. Finally the stigma, discrimination and violations must be stopped.
    Matched MeSH terms: Employment
  15. Abacan M, Alsubaie L, Barlow-Stewart K, Caanen B, Cordier C, Courtney E, et al.
    Eur J Hum Genet, 2019 Feb;27(2):183-197.
    PMID: 30291341 DOI: 10.1038/s41431-018-0252-x
    The profession of genetic counseling (also called genetic counselling in many countries) began nearly 50 years ago in the United States, and has grown internationally in the past 30 years. While there have been many papers describing the profession of genetic counseling in individual countries or regions, data remains incomplete and has been published in diverse journals with limited access. As a result of the 2016 Transnational Alliance of Genetic Counseling (TAGC) conference in Barcelona, Spain, and the 2017 World Congress of Genetic Counselling in the UK, we endeavor to describe as fully as possible the global state of genetic counseling as a profession. We estimate that in 2018 there are nearly 7000 genetic counselors with the profession established or developing in no less than 28 countries.
    Matched MeSH terms: Employment/statistics & numerical data
  16. Spaan E
    Int Migr Rev, 1994;28(1):93-113.
    PMID: 12287280
    "This article discusses international migration from Java in the past and present and the role brokers have played in stimulating this movement. It describes legal and clandestine labor migration to Singapore, Malaysia, and Saudi Arabia, the influence of employment brokers on the process, and the organization of the recruitment networks. The involvement of brokers is crucial but not always beneficial for the migrants. Migrants are dependent on the brokers and risk exploitation. In the case of movement to Saudi Arabia, there is a linkage with religious institutions and the Islamic pilgrimage."
    Matched MeSH terms: Employment*
  17. Azeem MU, De Clercq D, Haq IU
    J Soc Psychol, 2021 Jan 02;161(1):86-102.
    PMID: 32544025 DOI: 10.1080/00224545.2020.1778617
    Building on conservation of resources theory, this study investigates the relationship between employees' exposure to coworker incivility and their job performance ratings, while also considering the mediating role of their deviant work behaviors and the moderating role of their ingratiation skills. Results based on multisource, three-wave data from employees and their supervisors in Pakistani organizations show that disrespectful coworker treatment diminishes employees' performance evaluations, because they seek purposefully to cause harm to their employing organization, as a way to vent their frustrations. This mediating role of organizational deviance is mitigated to the extent that employees have a greater ability to ingratiate with others though. This study accordingly identifies a key mechanism - deviant work behaviors that undermine organizational well-being - through which coworker incivility leads to negative performance consequences, and it reveals how organizations can subdue this process by honing pertinent personal resources within their ranks.
    Matched MeSH terms: Employment
  18. Zhang L, Hussain Z, Ren Z
    Curr Drug Targets, 2019 Feb 14.
    PMID: 30767742 DOI: 10.2174/1389450120666190214141626
    BACKGROUND: Normal pressure hydrocephalus (NPH) is a critical brain disorder in which excess cerebrospinal fluid (CSF) is accumulated in the brain's ventricles causing damage or disruption of the brain tissues. Amongst various signs and symptoms, difficulty in walking, blurred speech, impaired decision making and critical thinking, and loss of bladder and bowl control are considered the hallmark features of NPH.

    OBJECTIVE: The current review was aimed to present a comprehensive overview and critical appraisal of majorly employed neuroimaging techniques for rational diagnosis and effective monitoring of effectiveness of employed therapeutic intervention for NPH. Moreover, a critical overview of recent developments and utilization of pharmacological agents for treatment of hydrocephalus has also been appraised.

    RESULTS: Considering the complications associated with the shunt-based surgical operations, consistent monitoring of shunting via neuroimaging techniques hold greater clinical significance. Despite having extensive applicability of MRI and CT scan, these conventional neuroimaging techniques are associated with misdiagnosis or several health risks to patients. Recent advances in MRI (i.e., Sagittal-MRI, coronal-MRI, Time-SLIP (time-spatial-labeling-inversion-pulse), PC-MRI and diffusion-tensor-imaging (DTI)) have shown promising applicability in diagnosis of NPH. Having associated with several adverse effects with surgical interventions, non-invasive approaches (pharmacological agents) have earned greater interest of scientists, medical professional, and healthcare providers. Amongst pharmacological agents, diuretics, isosorbide, osmotic agents, carbonic anhydrase inhibitors, glucocorticoids, NSAIDs, digoxin, and gold-198 have been employed for management of NPH and prevention of secondary sensory/intellectual complications.

    CONCLUSION: Employment of rational diagnostic tool and therapeutic modalities avoids misleading diagnosis and sophisticated management of hydrocephalus by efficient reduction of cerebrospinal fluid (CSF) production, reduction of fibrotic and inflammatory cascades secondary to meningitis and hemorrhage, and protection of brain from further deterioration.

    Matched MeSH terms: Employment
  19. Ramzi AB, Baharum SN, Bunawan H, Scrutton NS
    Front Bioeng Biotechnol, 2020;8:608918.
    PMID: 33409270 DOI: 10.3389/fbioe.2020.608918
    Increasing demands for the supply of biopharmaceuticals have propelled the advancement of metabolic engineering and synthetic biology strategies for biomanufacturing of bioactive natural products. Using metabolically engineered microbes as the bioproduction hosts, a variety of natural products including terpenes, flavonoids, alkaloids, and cannabinoids have been synthesized through the construction and expression of known and newly found biosynthetic genes primarily from model and non-model plants. The employment of omics technology and machine learning (ML) platforms as high throughput analytical tools has been increasingly leveraged in promoting data-guided optimization of targeted biosynthetic pathways and enhancement of the microbial production capacity, thereby representing a critical debottlenecking approach in improving and streamlining natural products biomanufacturing. To this end, this mini review summarizes recent efforts that utilize omics platforms and ML tools in strain optimization and prototyping and discusses the beneficial uses of omics-enabled discovery of plant biosynthetic genes in the production of complex plant-based natural products by bioengineered microbes.
    Matched MeSH terms: Employment
  20. Samsudin EZ, Yasin SM, Ruslan NH, Abdullah NN, Noor AFA, Hair AFA
    BMC Infect Dis, 2024 Jan 16;24(1):93.
    PMID: 38229063 DOI: 10.1186/s12879-024-08993-y
    BACKGROUND: Recent pandemics have had far-reaching effects on the world's largest economies and amplified the need to estimate the full extent and range of socioeconomic impacts of infectious diseases outbreaks on multi-sectoral industries. This systematic review aims to evaluate the socioeconomic impacts of airborne and droplet-borne infectious diseases outbreaks on industries.

    METHODS: A structured, systematic review was performed according to the PRISMA guidelines. Databases of PubMed, Scopus, Web of Science, IDEAS/REPEC, OSHLINE, HSELINE, and NIOSHTIC-2 were reviewed. Study quality appraisal was performed using the Table of Evidence Levels from Cincinnati Children's Hospital Medical Center, Joanna Briggs Institute tools, Mixed Methods Appraisal Tool, and Center of Evidence Based Management case study critical appraisal checklist. Quantitative analysis was not attempted due to the heterogeneity of included studies. A qualitative synthesis of primary studies examining socioeconomic impact of airborne and droplet-borne infectious diseases outbreaks in any industry was performed and a framework based on empirical findings was conceptualized.

    RESULTS: A total of 55 studies conducted from 1984 to 2021 were included, reporting on 46,813,038 participants working in multiple industries across the globe. The quality of articles were good. On the whole, direct socioeconomic impacts of Coronavirus Disease 2019, influenza, influenza A (H1N1), Severe Acute Respiratory Syndrome, tuberculosis and norovirus outbreaks include increased morbidity, mortality, and health costs. This had then led to indirect impacts including social impacts such as employment crises and reduced workforce size as well as economic impacts such as demand shock, supply chain disruptions, increased supply and production cost, service and business disruptions, and financial and Gross Domestic Product loss, attributable to productivity losses from illnesses as well as national policy responses to contain the diseases.

    CONCLUSIONS: Evidence suggests that airborne and droplet-borne infectious diseases have inflicted severe socioeconomic costs on regional and global industries. Further research is needed to better understand their long-term socioeconomic impacts to support improved industry preparedness and response capacity for outbreaks. Public and private stakeholders at local, national, and international levels must join forces to ensure informed systems and sector-specific cost-sharing strategies for optimal global health and economic security.

    Matched MeSH terms: Employment
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