Displaying publications 41 - 60 of 76 in total

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  1. James C, Girard O
    PMID: 33345057 DOI: 10.3389/fspor.2020.00066
    Repeated-sprint training in hypoxia (RSH) studies conducted "in-season" are scarce. This study investigated the effect of discontinuous, running-based RSH, on repeated-sprint treadmill performance in hypoxia in a team sport cohort, prior to international competition. Over a 6-week "in-season" period, 11 elite male players (Malaysia national team) completed eight multi-set RSH sessions on a non-motorized treadmill in a normobaric hypoxic chamber (FiO2 = 13.8%). Three testing sessions (Sessions 1, 5, and 8), involved three sets of 5 × 8-s sprints, with 52-s recovery between sprints and 4-5 min between sets. Training sessions (Sessions 2, 3, 4, 6, and 7) consisted of four to five sets of 4-5 × 8-s sprints. During testing sessions, maximum sprinting speed was recorded for each sprint with values averaged for each set. For each set, a peak speed and fatigue index were calculated. Data were compared using two-way repeated measures ANOVA (sessions × sets). Average speed per set increased between testing sessions (p = 0.001,


    η


    p


    2


    = 0.49), with higher values in Session 8 (25.1 ± 0.9 km.h-1, +4 ± 3%, p = 0.005), but not Session 5 (24.8 ± 1.0 km.h-1, +3 ± 3%, p = 0.405), vs. Session 1 (24.2 ± 1.5 km.h-1). Peak sprinting speed in each set also increased across testing sessions (p = 0.008,


    η


    p


    2


    = 0.382), with Session 8 (26.5 ± 1.1 km.h-1) higher than Session 5 (25.8 ± 1.0 km.h-1, +1 ± 4%, p = 0.06) and Session 1 (25.7 ± 1.5 km.h-1, +4 ± 4%, p = 0.034). Fatigue index differed between sessions (p = 0.04,


    η


    p


    2


    = 0.331, Session 1; -6.8 ± 4.8%, Session 5; -3.8 ± 2%, Session 8; -5.3 ± 2.6%). In international field hockey players, a 6-week in-season RSH program improved average and peak, repeated treadmill sprint speeds following eight, but not five sessions.
    Matched MeSH terms: Running
  2. Bhavani, Veasuvalingam
    MyJurnal
    Identifying physiotherapy stakeholders for program evaluation. The Health Professional Education plays a pivotal role in providing quality health work force thus improved care in health service to the public in our country. As such all Allied Health Programs conducted by Higher Education Providers (HEP) should keep close surveillance of the quality of Allied Health Programs to mould health professional graduates to deliver quality healthcare service through proper competency measures. Stakeholders have been defined as on-campus and off campus group for the sake of identifying respective views in institutional effectiveness. Allied health programs are emerging enormously in our country and this revolution is creating major crustal deformation, forming folds and faults towards its profession as many educational institutions in the country is with the enterprising objectives of running such programs and not for the benefits of the society.
    Matched MeSH terms: Running
  3. Ahmad Munir Che Muhamed, Thompson, Martin William
    Movement Health & Exercise, 2012;1(1):11-23.
    MyJurnal
    The combined metabolic and thermoregulatory demands experienced during exercise in the heat impose an exceptional stress on the circulatory system. To date, much of what is known about circulatory stress during exercise in the heat has focused on primarily dry environment (~ 40% rh)
    with limited studies carried in higher humidity (> 60% rh) conditions. This study was designed to investigate the influence of humid condition on circulatory responses during prolonged intense running exercise among elite runners. On separate days, 11 male elite runners ran for 60 minutes at
    an intensity of 70% max across three different humidity levels of HH (71% rh), NH (43% rh) and LH (26.2% rh) with the ambient temperature set at 300C. Thermal stress was found to increase during exercise in the HH condition as both Tre and Tsk steadily rise across time. Circulatory stress markedly increased during exercise in higher humidity levels. Heart rate was significantly higher in the HH condition with its level increasing to 92% of HRmax. The upwards drift in HR was significantly higher in HH within the last ten minutes of exercise. Contrary, stroke volume recorded a
    steady decline during exercise with a significantly lower SV in the HH as compared with the NH and LH. Results implicate rising humidity level will impose greater circulatory stress during prolonged intense exercise. The consequence from this circulatory stress will result in limited ability for an athlete to sustain his exercise capacity when HR reaches maximal level.
    Matched MeSH terms: Running
  4. Noraini Noordin, Nurul Elfieqah Rostam, Nur Ariena Farhana Noor Hamizan
    ESTEEM Academic Journal, 2020;16(2):1-10.
    MyJurnal
    The Morning Shift (MS) flow of passengers on Thursday is similar to any other day in the week at an urban train station. However, passenger congestion occurring in the Evening Shift (ES) affects the system behaviour. The system has been showing this characteristic over the years. However,
    only one counter is opened. This counter also sells different types of tickets. Thus, the system is not cost-effective. The study aims to determine the optimal number of counters that should be opened on Thursday. In order to solve this problem, the study has applied Poisson Queuing Simulation (PQ) to the MS and ES data. Findings indicate that running one or two counters in MS
    maintains the mean of wait time in-queue and in-system at less than one minute, while the mean of in-queue and in-system passengers is also at one person. Extra cost has to be incurred to hire another teller; thus, one counter is optimal. For ES, the service rate was only slightly higher than the arrival rate. Based on the mean number of in-queue and in-system passengers, there was no way that one counter can efficiently service the queue that was formed. A simulation was done to determine if there was a need to set up a two-counter or a three-counter system. Although a two-counter system will be idle 47% of the time, it was not cost-effective for the management to two
    extra tellers for a three-counter system. The management must take future corrective measures. Based on the findings, one counter is optimal for MS, but cost-effectiveness tests must confirm that two counters are optimal for ES. Besides, the management should also identify actions that can be taken during the 47% idle system time in ES.
    Matched MeSH terms: Running
  5. Peng MY, Feng Y, Zhao X, Chong W
    Front Psychol, 2021;12:583722.
    PMID: 33854458 DOI: 10.3389/fpsyg.2021.583722
    Previous studies have explored a multitude of factors influencing student learning outcomes based on various theories. Knowledge transfer theory was adopted to develop the antecedents of student learning outcomes in the complete learning process. This study aims to explore the conspicuousness between various factors within the structural model, such as knowledge transfer, student orientation, and absorptive capacity, by combining marketing and management concepts with higher education studies. This study takes Taiwanese University students as its research samples, and purposive sampling is adopted. A total of 873 questionnaires are collected in this study. PLS-SEM was used to verify the structural relationship in data analysis via running of SmartPLS. The results indicate that knowledge transfer and student orientation have significant impacts on students' absorptive capacity and learning outcomes and that students' prior knowledge has a positive moderating effect on the relationship between knowledge transfer and absorptive capacities. Based on these findings, the researchers propose feasible suggestions for related issues and future research.
    Matched MeSH terms: Running
  6. Abdul Yamin NAA, Basaruddin KS, Salleh AF, Salim MS, Wan Muhamad WZA
    Appl Bionics Biomech, 2021;2021:8842591.
    PMID: 33603827 DOI: 10.1155/2021/8842591
    Objective: The aim of this study was to investigate the effects of surface stiffness on multisegment foot kinematics and temporal parameters during running.

    Methods: Eighteen male subjects ran on three different surfaces (i.e., concrete, artificial grass, and rubber) in both heeled running shoes (HS) and minimal running shoes (MS). Both these shoes had dissimilar sole profiles. The heeled shoes had a higher sole at the heel, a thick base, and arch support, whereas the minimal shoes had a flat base sole. Indeed, the studied biomechanical parameters responded differently in the different footwear during running. Subjects ran in recreational mode speed while 3D foot kinematics (i.e., joint rotation and peak medial longitudinal arch (MLA) angle) were determined using a motion capture system (Qualysis, Gothenburg, Sweden). Information on stance time and plantar fascia strain (PFS) was also collected.

    Results: Running on different surface stiffness was found to significantly affect the peak MLA angles and stance times for both HS and MS conditions. However, the results showed that the joint rotation angles were not sensitive to surface stiffness. Also, PFS showed no relationship with surface stiffness, as the results were varied as the surface stiffness was changed.

    Conclusion: The surface stiffness significantly contributed towards the effects of peak MLA angle and stance time. These findings may enhance the understanding of biomechanical responses on various running surfaces stiffness in different shoe conditions.

    Matched MeSH terms: Running
  7. Manaf H, Justine M, Hassan N
    Malays Orthop J, 2021 Mar;15(1):21-26.
    PMID: 33880144 DOI: 10.5704/MOJ.2103.004
    Introduction: Hockey is a team sport that involves running, sprinting, and making sudden changes in directions of movement to control a ball against the opposing team. Therefore, due to its nature of fast movement, hockey players may be at risk of various musculoskeletal injuries. This study aimed to identify the prevalence and pattern of musculoskeletal injuries sustained among Malaysian Hockey League players.

    Materials and Method: Data were collected from 84 field hockey players that participated in the Malaysian Hockey League competition from June 2016 until December 2016. All injuries were recorded by the participating medical team using a structured questionnaire. A descriptive statistical analysis and Chi-Square test were used to explore the prevalence of the injury.

    Result: More than half of the players were reported to have lower limb injuries (51.6%). Sprain and strain were the most prevalent injuries (63%) and mostly affected the ankle (29%). Male players sustained more injuries (50.8%) compared to female players (49.2%).

    Conclusion: This study suggests that a guideline is needed for injury prevention strategies that will benefit the hockey players in preventing injuries.

    Matched MeSH terms: Running
  8. Rayes IK, Hassali MA, Abduelkarem AR
    Pharm Pract (Granada), 2015 06 15;13(2):506.
    PMID: 26131039
    BACKGROUND: In many developing countries, pharmacists are facing many challenges while they try to enhance the quality of services provided to patients approaching community pharmacies.

    OBJECTIVE: To explore perception of community pharmacists in Dubai regarding the obstacles to enhanced pharmacy services using a part of the results from a nation-wide quantitative survey.

    METHODS: A questionnaire was distributed to 281 full-time licensed community pharmacists in Dubai. The questionnaire had 5 inter-linked sections: demographic information, information about the pharmacy, interaction with physicians, pharmacists' current professional role, and barriers to enhanced pharmacy services.

    RESULTS: About half of the respondents (45.4%, n=90) agreed that pharmacy clients under-estimate them and 52.5% (n=104) felt the same by physicians. About 47.5% (n=94) of the respondents felt that they are legally unprotected against profession's malpractice. Moreover, 64.7% (n=128) stated that pharmacy practice in Dubai turned to be business-focused. In addition, 76.8% (n=252) found that one of the major barriers to enhanced pharmacy services is the high business running cost. Pharmacists screened tried to prove that they are not one of the barriers to optimized pharmacy services as 62.7% (n=124) disagreed that they lack appropriate knowledge needed to serve community and 67.7% (n=134) gave the same response when asked whether pharmacy staff lack confidence when treating consumers or not.

    CONCLUSIONS: Although being well established within the community, pharmacists in Dubai negatively perceived their own professional role. They stated that there are number of barriers which hinder optimized delivery of pharmacy services like under-estimation by pharmacy clients and other healthcare professionals, pressure to make sales, and high running cost.

    Matched MeSH terms: Running
  9. Noroozi S, Ong ZC, Khoo SY, Aslani N, Sewell P
    Prosthet Orthot Int, 2019 Feb;43(1):62-70.
    PMID: 30051756 DOI: 10.1177/0309364618789449
    BACKGROUND:: The current method of prescribing composite running-specific energy-storing-and-returning feet is subjective and is based only on the amputee's static body weight/mass.

    OBJECTIVES:: The aim was to investigate their dynamic characteristics and create a relationship between these dynamic data and the prescription of foot.

    STUDY DESIGN:: Experimental Assessment.

    METHODS:: This article presents the modal analysis results of the full range of Össur Flex-Run™ running feet that are commercially available (1LO-9LO) using experimental modal analysis technique under a constant mass at 53 kg and boundary condition.

    RESULTS:: It was shown that both the undamped natural frequency and stiffness increase linearly from the lowest to the highest stiffness category of foot which allows for a more informed prescription of foot when tuning to a matched natural frequency. The low damping characteristics determined experimentally that ranged between 1.5% and 2.0% indicates that the feet require less input energy to maintain the steady-state cyclic motion before take-off from the ground. An analysis of the mode shapes also showed a unique design feature of these feet that is hypothesised to enhance their performance.

    CONCLUSION:: A better understanding of dynamic characteristics of the feet can help tune the feet to the user's requirements in promoting a better gait performance.

    CLINICAL RELEVANCE: The dynamic data determined from this study are needed to better inform the amputees in predicting the natural frequency of the foot prescribed. The amputees can intuitively tune the cyclic body rhythm during walking or running to match with the natural frequency. This could eventually promote a better gait performance.

    Matched MeSH terms: Running/physiology
  10. Kamaruddin HK, Ooi CH, Mündel T, Aziz AR, Che Muhamed AM
    Eur J Appl Physiol, 2019 Aug;119(8):1711-1723.
    PMID: 31098832 DOI: 10.1007/s00421-019-04161-2
    PURPOSE: To examine the effect of carbohydrate (CHO) mouth rinsing on endurance running responses and performance in dehydrated individuals.

    METHODS: In a double blind, randomised crossover design, 12 well-trained male runners completed 4 running time to exhaustion (TTE) trials at a speed equivalent to 70% of VO2peak in a thermoneutral condition. Throughout each run, participants mouth rinsed and expectorated every 15 min either 25 mL of 6% CHO or a placebo (PLA) solution for 10 s. The four TTEs consisted of two trials in the euhydrated (EU-CHO and EU-PLA) and two trials in the dehydrated (DY-CHO and DY-PLA) state. Prior to each TTE run, participants were dehydrated via exercise and allowed a passive rest period during which they were fed and either rehydrated equivalent to their body mass deficit (i.e., EU trials) or ingested only 50 mL of water (DY trials).

    RESULTS: CHO mouth rinsing significantly improved TTE performance in the DY compared to the EU trials (78.2 ± 4.3 vs. 76.9 ± 3.8 min, P = 0.02). The arousal level of the runners was significantly higher in the DY compared to the EU trials (P = 0.02). There was no significant difference among trials in heart rate, plasma glucose and lactate, and psychological measures.

    CONCLUSIONS: CHO mouth rinsing enhanced running performance significantly more when participants were dehydrated vs. euhydrated due to the greater sensitivity of oral receptors related to thirst and central mediated activation. These results show that level of dehydration alters the effect of brain perception with presence of CHO.

    Matched MeSH terms: Running*
  11. James CA, Richardson AJ, Watt PW, Willmott AGB, Gibson OR, Maxwell NS
    J Strength Cond Res, 2018 May;32(5):1366-1375.
    PMID: 28486332 DOI: 10.1519/JSC.0000000000001979
    James, CA, Richardson, AJ, Watt, PW, Willmott, AGB, Gibson, OR, and Maxwell, NS. Short-term heat acclimation and precooling, independently and combined, improve 5-km time trial performance in the heat. J Strength Cond Res 32(5): 1366-1375, 2018-Following heat acclimation (HA), endurance running performance remains impaired in hot vs. temperate conditions. Combining HA with precooling (PC) demonstrates no additive benefit in intermittent sprint, or continuous cycling exercise protocols, during which heat strain may be less severe compared to endurance running. This study investigated the effect of short-term HA (STHA) combined with mixed methods PC, on endurance running performance and directly compared PC and HA. Nine amateur trained runners completed 5-km treadmill time trials (TTs) in the heat (32° C, 60% relative humidity) under 4 conditions; no intervention (CON), PC, short-term HA (5 days-HA) and STHA with PC (HA + PC). Mean (±SD) performance times were; CON 1,476 (173) seconds, PC 1,421 (146) seconds, HA 1,378 (116) seconds and HA + PC 1,373 (121) seconds. This equated to the following improvements versus CON; PC -3.7%, HA -6.6% and HA + PC -7.0%. Statistical differences were only observed between HA and CON (p = 0.004, d = 0.68, 95% CI [-0.27 to 1.63]) however, similar effect sizes were observed for HA + PC vs. CON (d = 0.70, 95% CI [-0.25 to 1.65]), with smaller effects between PC vs. CON (d = 0.34, 95% CI [-0.59 to 1.27]), HA vs. PC (d = 0.33, 95% CI [-0.60 to 1.26]) and HA + PC vs. PC (d = 0.36, 95% CI [-0.57 to 1.29]). Pilot testing revealed a TT typical error of 16 seconds (1.2%). Precooling offered no further benefit to performance in the acclimated individual, despite modest alleviation of physiological strain. Maintenance of running speed in HA + PC, despite reduced physiological strain, may indicate an inappropriate pacing strategy therefore, further familiarization is recommended to optimize a combined strategy. Finally, these data indicate HA, achieved through cycle training, yields a larger ergogenic effect than PC on 5-km running performance in the heat, although PC remains beneficial when HA is not possible.
    Matched MeSH terms: Running/physiology*
  12. Singh R, Sirisinghe RG
    Singapore Med J, 1999 Feb;40(2):84-7.
    PMID: 10414164
    To investigate the acute effects of an 18 km run on the haematological and plasma electrolyte parameters, in recreational runners under conditions of high temperatures and humidity.
    Matched MeSH terms: Running/physiology*
  13. Burdon CA, Johnson NA, Chapman PG, Munir Che Muhamed A, O'Connor HT
    Int J Sport Nutr Exerc Metab, 2013 Aug;23(4):418-24.
    PMID: 23295183
    The aim of this study was to measure the effect of environmental conditions and aid-station beverage- cooling practices on the temperature of competitor beverages.
    Matched MeSH terms: Running/physiology*
  14. Daneshjoo A, Mokhtar AH, Rahnama N, Yusof A
    PLoS One, 2012;7(12):e51568.
    PMID: 23251579 DOI: 10.1371/journal.pone.0051568
    The study investigated the effects of FIFA 11+ and HarmoKnee, both being popular warm-up programs, on proprioception, and on the static and dynamic balance of professional male soccer players.
    Matched MeSH terms: Running/physiology
  15. Ping FW, Keong CC, Bandyopadhyay A
    Indian J Med Res, 2011 Jan;133:96-102.
    PMID: 21321426
    Athletes in Malaysia need to perform in a hot and humid environment due to the climatic nature of the country. Chronic supplementation of Panax ginseng (PG) (a deciduous perennial plant belonging to the Araliaceae family) enhances physical performance. As the ergogenic effect of acute supplementation of PG on endurance performance has not been explored in the Malaysian population especially in a hot and humid condition this study was taken up.
    Matched MeSH terms: Running*
  16. Liu Y, Williams CA, Weston KL, Duncombe SL, Malik AA, Barker AR
    Pediatr Exerc Sci, 2025 Feb 01;37(1):11-17.
    PMID: 38194950 DOI: 10.1123/pes.2023-0084
    PURPOSE: Rating of perceived exertion (RPE) is a convenient and cost-effective tool that can be used to monitor high-intensity interval exercise (HIIE). However, no methodological study has demonstrated the validity of RPE in this context. Therefore, the aim of this study was to validate and calibrate RPE for monitoring HIIE in adolescents.

    METHODS: RPE, heart rate (HR), and oxygen uptake (V˙O2) data were retrospectively extracted from 3 lab-based crossover studies, with a pooled sample size of 45 adolescents, performing either cycling-based or running-based HIIE sessions. Within-participant correlations were calculated for RPE-HR and RPE-V˙O2, and receiver operator characteristic curve analysis was used to establish RPE cut points.

    RESULTS: The results showed that RPE-HR demonstrated acceptable criterion validity (r = .53-.74, P < .01), while RPE-V˙O2 had poor validity (r = .40-.48, P < .01), except for HIIE at 100% peak power (r = .59, P < .01). RPE cut points of 4 and 5 were established in corresponding to HR/V˙O2 based thresholds.

    CONCLUSION: RPE has some utility in evaluating intensity during lab-based running or cycling HIIE in adolescents. Future studies should expand the validation and calibration of RPE for prescribing and monitoring HIIE in children and adolescents in field-based contexts.

    Matched MeSH terms: Running/physiology
  17. Abdullah R., Wan Md Adnan W.A.H.
    JUMMEC, 2018;21(2):4-9.
    MyJurnal
    Long-distance running has gathered some momentum among health-conscious participants. However, some
    studies have revealed association between long-distance running and development of acute kidney injury.
    Although the impact usually lasts only for a few days after the event, some participants have been admitted for
    severe acute kidney injury, the minority of which require dialysis treatment. The mechanisms underlying the
    injury may include dehydration, development of rhabdomyolysis, heat stroke and concomitant use of NSAIDS.
    Unfortunately, there is no long-term follow-up study to determine the long-term effect on kidney function.
    Acute hyponatremia may develop in a significant proportion of long-distance runners. Majority of them were
    asymptomatic but a few fatal cases which were supposedly due to cerebral oedema have been reported.
    Excessive intake of hypotonic drinks, excessive sweating and secretion of non-osmotic antidiuretic hormone
    have been postulated to be the causes of hyponatremia. This mini review will discuss the pathophysiology of
    the development of acute kidney injury and hyponatremia. It will also discuss the prevention and treatment
    of both conditions.
    Matched MeSH terms: Running
  18. Rohaizar MH, Sepeai S, Surhada N, Ludin NA, Ibrahim MA, Sopian K, et al.
    Heliyon, 2019 Nov;5(11):e02790.
    PMID: 31768436 DOI: 10.1016/j.heliyon.2019.e02790
    Continuing trend in silicon wafer thickness directed at cost reduction approaches basic boundaries created by: (a) mismatch between Al paste and Si wafer thermal expansion and (b) incomplete optical absorption. With its symmetrical front and back electrical contacts, the bifacial solar cell setup reduces stress due to mismatch thermal expansion, decreases metal use and increases high temperature efficiency. Efficiency improvement is accomplished in bifacial solar cells by capturing light from the back surface. Partially transparent wafers provide an option to improve near-infrared radiation absorption within Si wafer. To fully absorb optical radiation, three-dimensional texture of these kinds of wafers is essential. Pulsed laser interactions, thermal oxidation, and wet chemical etching are included in this research. A feature of its energy and pattern setup is the interaction of pulsed laser with Si, running at 1.064 μm wavelength and micro-second length. Two experimental settings were explored: (a) post-laser chemical etching with potassium hydro-oxide etching with thermal oxide as etching mask and (b) post-laser heat Si surface oxidation. Due to fast melting and recrystallization, laser pulsed processing inherently produces its own texture. Some of these spherically-shaped, randomly focused characteristics improve inner scattering and boost near-infrared absorption within the wafer. These characteristics are separated during chemical etching with the thermally-grown oxide layer as an etch mask. Comparison of optical absorption in both surfaces shows almost a rise in the magnitude of absorption in non-etched surfaces. Detailed optical (optical microscope and IR absorption), morphological (field emission scanning electron microscope) and heat imaging (far IR camera) analyses were performed to comprehend physical processes that contribute to near-IR absorption improvement. Such kinds of partially-transparent, three-dimensional textured Si wafers are anticipated to discover applications for bifacial solar cells as substrates.
    Matched MeSH terms: Running
  19. Muhamad AS, Puad NFRM, Kuan G
    Malays J Med Sci, 2020 Feb;27(1):87-96.
    PMID: 32158348 MyJurnal DOI: 10.21315/mjms2020.27.1.9
    Introduction: Carbohydrate (CHO) mouth rinsing can enhance sports performance through a central action mediated by receptors in the mouth. This study examined the effect of a CHO mouth rinse on salivary lysozyme concentrations, mood states and running performances.

    Methods: Ten males recreational runners were randomised to three running trials with a 1 week recovery period between the trials. Each trial involved running at 75% maximum heart rate (HRmax) for 1 h, followed by a 15 min time trial. The participants used a CHO mouth rinse, placebo (PLA) solution or control (CON, no solution) every 15 min during the exercise. Heart rate (HR), rating of perceived exertion (RPE) and mood states were recorded pre-, during and post-exercise. Saliva samples were collected pre-, post- and 1 h post-exercise.

    Results: There was no significant interaction and time effect (P > 0.05) on the salivary lysozyme concentration and running performance, but it was significant (P < 0.05) for HR and RPE (increase in all trials). However, there was no significant difference (P > 0.05) in salivary lysozyme concentrations, running performances, HR values or RPE between the trials. Mood states were not significantly different (P > 0.05) between the trials, but one of the mood sub-scales showed a significant (P < 0.001) time effect (increase fatigue in all trials).

    Conclusion: CHO mouth rinsing did not affect physiological parameters, salivary lysozyme concentrations, mood states or running performance among recreational runners.

    Matched MeSH terms: Running
  20. Bongartz U, Hochmann U, Pohl U, Bothe G, Costa P, Chong PW, et al.
    Exp Ther Med, 2021 Feb;21(2):144.
    PMID: 33456511 DOI: 10.3892/etm.2020.9575
    Intense and prolonged exercise leads to immune suppression, causing upper respiratory tract infections (URTI). A proprietary standardized dietary supplement, IQP-AS-119 has been previously developed to aid immune responses under such conditions. The current randomized, double-blind, placebo-controlled pilot study aimed to investigate the effects of IQP-AS-119 on marathon runners. A total of 80 participants were randomized equally into groups receiving either placebo (P group) or IQP-AS-119 (V group) treatment, starting 3 weeks before and for 14 days after the marathon. Benefit assessment was performed using different questionnaires. Post-marathon, the V and P groups reported 1±2.38 and 2.11±3.25 days with upper respiratory tract symptoms (URTS), respectively (P=0.038). During the 14 days post-marathon, 20.0% of the participants in the V group compared with 44.4% in the P group reported URTS (P=0.042). The V group reported significantly milder URTS compared with the P group on Days 9, 12, 13 and 14 post-marathon (P<0.05). The total Perceived Stress Questionnaire-20 score on days 2-14 were significantly lower for the V group compared with the P group (P=0.035). In the Short Form 12 Health Survey, the V group exhibited significant improvement in mental composite score on days -5 to 14 compared with the P group (P=0.038). In the overall treatment effect assessment, there were no statistically significant differences between the groups. The IQP-AS-119 was rated 'very good' or 'good' by investigators and participants, respectively, for 71 and 65% of the participants. The tolerability of IQP-AS-119 was rated as 'very good' or 'good' by both investigators and 95% of participants. No clinically relevant differences were observed between groups regarding adverse events or other safety parameters. Therefore, IQP-AS-119 was demonstrated to reduce the incidence and severity of URTI in marathon runners. Given its good tolerability profile, IQP-AS-119 may be a good nutritional supplement for the reduction of URTS in susceptible individuals.
    Matched MeSH terms: Running
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