Displaying publications 61 - 80 of 539 in total

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  1. Fulltext The effects of age on the strategic use of pitch accents in memory for discourse: a processing-resource account
    Fraundorf SH, Watson DG, Benjamin AS
    Psychol Aging, 2012 Mar;27(1):88-98.
    PMID: 21639646 DOI: 10.1037/a0024138
    In two experiments, we investigated age-related changes in how prosodic pitch accents affect memory. Participants listened to recorded discourses that contained two contrasts between pairs of items (e.g., one story contrasted British scientists with French scientists and Malaysia with Indonesia). The end of each discourse referred to one item from each pair; these references received a pitch accent that either denoted contrast (L + H* in the ToBI system) or did not (H*). A contrastive accent on a particular pair improved later recognition memory equally for young and older adults. However, older adults showed decreased memory if the other pair received a contrastive accent (Experiment 1). Young adults with low working memory performance also showed this penalty (Experiment 2). These results suggest that pitch accents guide processing resources to important information for both older and younger adults but diminish memory for less important information in groups with reduced resources, including older adults.
    Matched MeSH terms: Attention
  2. Fulltext The effects of a distracting N-back task on recognition memory are reduced by negative emotional intensity
    Buratto LG, Pottage CL, Brown C, Morrison CM, Schaefer A
    PLoS One, 2014;9(10):e110211.
    PMID: 25330251 DOI: 10.1371/journal.pone.0110211
    Memory performance is usually impaired when participants have to encode information while performing a concurrent task. Recent studies using recall tasks have found that emotional items are more resistant to such cognitive depletion effects than non-emotional items. However, when recognition tasks are used, the same effect is more elusive as recent recognition studies have obtained contradictory results. In two experiments, we provide evidence that negative emotional content can reliably reduce the effects of cognitive depletion on recognition memory only if stimuli with high levels of emotional intensity are used. In particular, we found that recognition performance for realistic pictures was impaired by a secondary 3-back working memory task during encoding if stimuli were emotionally neutral or had moderate levels of negative emotionality. In contrast, when negative pictures with high levels of emotional intensity were used, the detrimental effects of the secondary task were significantly attenuated.
    Matched MeSH terms: Attention/physiology*
  3. Fulltext The effect of using games in teaching conservation
    Tan CKW, Lee JW, Hii A, Loo YY, Campos-Arceiz A, Macdonald DW
    PeerJ, 2018;6:e4509.
    PMID: 29736327 DOI: 10.7717/peerj.4509
    Games are an increasingly popular approach for conservation teaching. However, we know little about the effectiveness of the games on students' experiences and knowledge acquisition. Many current games are supplemental games (SG) that have no meaningful interaction with the subject matter. We adapted the experiential gaming (EG) model where students were immersed in goal-orientated tasks found in real-life situations, and they tackled questions to complete actions for their main task. Classroom-based games were created for eight different conservation topics for an annual Wildlife Conservation Course and an annual Diploma in International Wildlife Conservation Practice. Data were collected over two cycles, a total sample size of 55 multinational students. We used a combination of repeated-measures design and counterbalanced measures design; each student was subjected at least twice to each of the EG and didactic instruction (DI) treatments, and at least once to the SG approach. We compared students' perception, learning and behavioural responses to the treatments, including measures of student personality types and learning styles as explanatory variables. Findings revealed multiple benefits of the classroom EG compared to the DI approach, such as increased attention retention, increased engagement and added intrinsic motivation. The improved level of intrinsic motivation was mainly facilitated by increased social bonding between participants. Further, we show that this EG approach appeals to a wide range of learning styles and personalities. The performance of SG was generally intermediate between that of EG and DI. We propose EG as a beneficial complement to traditional classroom teaching and current gamified classes for conservation education.
    Matched MeSH terms: Attention
  4. Fulltext The effect of pH on the survival of leptospires in water
    Smith CE, Turner LH
    Bull World Health Organ, 1961;24(1):35-43.
    PMID: 20604084
    One of the factors on which the incidence of leptospirosis is dependent is the survival time of shed leptospires in surface water or soil water, and this time is in turn affected by the acidity or alkalinity of the water. The authors have therefore studied the survival of four leptospiral serotypes in buffered distilled water at pH's ranging from 5.3 to 8.0. All survived longer in alkaline than in acid water, and significant differences between the serotypes were found in response to pH. Survival at pH's under 7.0 ranged from 10 to 117 days and at pH's over 7.0 from 21 to 152 days. Survival was also studied in aqueous extracts of soil samples from different areas in Malaya; no correlation was found between pH and survival time.It was also noted that in a group of Malayan ricefields a low incidence of leptospirosis in man was accompanied by a high infection rate among rodents, and when it was found that this phenomenon could not be explained by pH or salinity, attention was turned to the soil. Bentonite clay, similar to the montmorrillonite clay of the ricefields, was found to adsorb about half the leptospires in suspension. The authors recommend that field study of this laboratory observation be undertaken.
    Matched MeSH terms: Attention
  5. The effect of high lactose-isomaltulose on cognitive performance of young children. A double blind cross-over design study
    Taib MN, Shariff ZM, Wesnes KA, Saad HA, Sariman S
    Appetite, 2012 Feb;58(1):81-7.
    PMID: 21986189 DOI: 10.1016/j.appet.2011.09.004
    Changes in blood glucose are hypothesized to influence cognitive performance and these changes can be affected by certain nutrients. This double-blind 4-period cross-over study evaluated the effects of a slow-release modified sucrose (isomaltulose) in combination with a high concentration of lactose on cognitive performance of 5-6 year old children. Thirty children received a standard growing upmilk (Std GUM), reformulated growing up milk (Reform GUM), standard growing up milk with lactose-isomaltulose (Iso GUM), and a standard glucose drink (Glucose). The CDR System, a computerised cognitive assessment system, was used to assess various measures of attention and memory of the children at baseline (T=0), 60 (T=1), 120 (T=2), and 180 (T=3) minutes following the intake of test products. Overall, there was a decline in performance over the morning on almost every cognitive task. Children showed better attention following consumption of Iso GUM compared to Std GUM but attention was not significantly different than Reform GUM and glucose. Also, Iso GUM conferred a beneficial effect over both Reform GUM and glucose on sensitivity index of numeric working memory with no difference observed between Iso GUM and Std GUM. Surprisingly, glucose group showed lowest decline in the sensitivity index of spatial working memory and highest speed in picture recognition, although the latter was significantly better than Reform GUM only. For speed of spatial working memory, Reform GUM had the lowest decline but was significantly different only with Std GUM. There was, however, no significant difference among conditions for continuity of attention, speed of numeric working memory and picture recognition sensitivity. Despite the small sample size, the findings are intriguing as carbohydrate composition seems to influence some aspects of cognitive performance such as attention and memory. However, further studies are needed to confirm these findings.
    Matched MeSH terms: Attention/drug effects
  6. Fulltext The effect of extrusion screw-speed on the water extractability and molecular weight distribution of arabinoxylans from defatted rice bran
    Fadel A, Plunkett A, Ashworth J, Mahmoud AM, Ranneh Y, El Mohtadi M, et al.
    J Food Sci Technol, 2018 Mar;55(3):1201-1206.
    PMID: 29487463 DOI: 10.1007/s13197-017-3010-0
    Arabinoxylans (AXs) are major dietary fibre in cereals. Recently, AXs have attracted a great deal of attention because of their biological activities. These activities have been suggested to be related to the content of low molecular weight (Mw) AXs, in particular those with Mw below 32 kDa. Rice bran is a rich source of AXs. However, water extraction of AXs is difficult and often gives low yield. Extrusion processing has been used to increase the solubility of cereal dietary fibre. The aim of this research was to study the effect of extrusion screw-speeds (80 and 160) rpm on the extraction yield and Mw of water extractable AXs from rice bran. It was found that the extraction of AXs increased significantly with an increase in screw speed and was accompanied by a significant decrease in the Mw of AXs from extruded rice bran. The percentage of very low molecular weight AXs (0.79-1.58 kDa) significantly increased with increasing screw speed.
    Matched MeSH terms: Attention
  7. Fulltext The effect of Ramadan fasting on spatial attention through emotional stimuli
    Molavi M, Yunus J, Utama NP
    Psychol Res Behav Manag, 2016;9:105-14.
    PMID: 27307772 DOI: 10.2147/PRBM.S100495
    Fasting can influence psychological and mental states. In the current study, the effect of periodical fasting on the process of emotion through gazed facial expression as a realistic multisource of social information was investigated for the first time. The dynamic cue-target task was applied via behavior and event-related potential measurements for 40 participants to reveal the temporal and spatial brain activities - before, during, and after fasting periods. The significance of fasting included several effects. The amplitude of the N1 component decreased over the centroparietal scalp during fasting. Furthermore, the reaction time during the fasting period decreased. The self-measurement of deficit arousal as well as the mood increased during the fasting period. There was a significant contralateral alteration of P1 over occipital area for the happy facial expression stimuli. The significant effect of gazed expression and its interaction with the emotional stimuli was indicated by the amplitude of N1. Furthermore, the findings of the study approved the validity effect as a congruency between gaze and target position, as indicated by the increment of P3 amplitude over centroparietal area as well as slower reaction time from behavioral response data during incongruency or invalid condition between gaze and target position compared with those during valid condition. Results of this study proved that attention to facial expression stimuli as a kind of communicative social signal was affected by fasting. Also, fasting improved the mood of practitioners. Moreover, findings from the behavioral and event-related potential data analyses indicated that the neural dynamics of facial emotion are processed faster than that of gazing, as the participants tended to react faster and prefer to relay on the type of facial emotions than to gaze direction while doing the task. Because of happy facial expression stimuli, right hemisphere activation was more than that of the left hemisphere. It indicated the consistency of the emotional lateralization concept rather than the valence concept of emotional processing.
    Matched MeSH terms: Attention
  8. Fulltext The consequences of tinnitus and tinnitus severity on cognition: A review of the behavioural evidence
    Mohamad N, Hoare DJ, Hall DA
    Hear Res, 2016 Feb;332:199-209.
    PMID: 26523370 DOI: 10.1016/j.heares.2015.10.001
    People with tinnitus report anecdotal difficulties in mental concentration and psychological treatments for tinnitus advise on concentration difficulties and how to manage them. Yet the literature lacks any coherent discussion about what precise theoretical cognitive constructs might be mediating reported concentration problems. This review addresses this gap by describing and critically appraising the behavioural evidence for the effects of tinnitus on cognitive performance (namely working memory and attention). Empirical evidence is somewhat limited, but there is some support that tinnitus interferes with executive attention, and mixed support that it impairs working memory and selective attention. We highlight a number of methodological considerations to help drive the field forward and we propose a putative model of the complex inter-relationships between tinnitus, cognition and confounding factors. This model provides a basis for hypothesis testing.
    Matched MeSH terms: Attention
  9. Fulltext The association of birth order and sociodemographic factors with caries experience among adolescents in Tumpat
    Wan Salina, W.S., Nizam, A., Naing, L.
    Archives of Orofacial Sciences, 2007;2(1):45-50.
    MyJurnal
    Sociodemographic factors have received considerable attention in the literature with regards its relationship with caries. However, the related information among children ages 12-17 is fairly limited. Birth order has been consistently found to be associated with diseases hypothesized to have an infectious aetiology but only few studies have examined its relationship with dental caries. The aims of this study were to determine the association of birth order and the sociodemographic background of subjects with caries and high caries experience among 16-year-old schoolchildren in Tumpat district, Kelantan. This was a case-control study. A total of 1087 16-year-old schoolchildren were examined intraorally for their caries status. They were categorized into three groups namely caries free (DMFS=0) mild caries (DMFS= 1-7) and high caries (DMFS ≥8) group based on DMFS score. Cases were the caries group and the controls were the caries free group. In each group, 163 subjects were selected by using simple random sampling. A questionnaire was used to obtain personal information of the subjects, birthweight and sociodemographic background. Analysis involved was ordinal logistic regression. The factor that was found to have association with caries and high caries experience determined using multiple ordinal logistic regression analysis was educational level of parents (OR=1.55, 95% CI: 1.06; 2.28). This study showed that birth order was not a significant factor associated with caries experience. Among the sociodemographic factors, only parent’s educational level was found to be associated with caries and high caries experience.
    Matched MeSH terms: Attention
  10. The association between the behavior rating inventory of executive functioning and cognitive testing in children diagnosed with a brain tumor
    de Vries M, de Ruiter MA, Oostrom KJ, Schouten-Van Meeteren AYN, Maurice-Stam H, Oosterlaan J, et al.
    Child Neuropsychol, 2018 08;24(6):844-858.
    PMID: 28693404 DOI: 10.1080/09297049.2017.1350262
    Pediatric brain tumor survivors (PBTS) suffer from cognitive late effects, such as deteriorating executive functioning (EF). We explored the suitability of the Behavior Rating Inventory of Executive Function (BRIEF) to screen for these late effects. We assessed the relationship between the BRIEF and EF tasks, and between the BRIEF-Parent and BRIEF-Teacher, and we explored the clinical utility. Eighty-two PBTS (8-18 years) were assessed with EF tasks measuring attention, cognitive flexibility, inhibition, visual-, and working memory (WM), and with the BRIEF-Parent and BRIEF-Teacher. Pearson's correlations between the BRIEF and EF tasks, and between the BRIEF-Parent and BRIEF-Teacher were calculated. The BRIEF-Parent related poorly to EF tasks (rs < .26, ps > .01), but of the BRIEF-Teacher the WM-scale, Monitor-scale, Behavioral-Regulation-Index, and Meta-cognition-Index, and Total-score (rs > .31, ps < .01) related significantly to some EF tasks. When controlling for age, only the WM scale and Total score related significantly to the attention task (ps < .01). The inhibit scales of the BRIEF-Parent and BRIEF-Teacher correlated significantly (r = .33, p < .01). Children with clinically elevated scores on BRIEF scales that correlated with EF tasks performed worse on all EF tasks (ds 0.56-1.23, ps < .05). The BRIEF-Teacher Total and Index scores might better screen general EF in PBTS than the BRIEF-Parent. However, the BRIEF-Teacher is also not specific enough to capture separate EFs. Solely relying on the BRIEF as a screening measure of EFs in BPTS is insufficient. Questionnaires and tasks give distinctive, valuable information.
    Matched MeSH terms: Attention Deficit Disorder with Hyperactivity/psychology
  11. Fulltext The association between the attention deficit hyperactivity disorder(ADHD) symptoms and bully/victim problem among malaysian sixth-graders
    Wan Ismail WS, Nik Jaafar NR, Mohd Daud TI, Shah SA, Ismail A, Shafiee Z
    ASEAN Journal of Psychiatry, 2010;11(1):79-86.
    MyJurnal
    Objective: School bullying in Malaysia is on the rise. While efforts are put together to combat the problem, the psychiatric aspect has been neglected. This is a cross-sectional study aimed to determine the association between the symptoms of ADHD and bully/victim problems among Malaysian sixthgraders attending primary schools in Kuala Lumpur.
    Methods: A total of 410 sixth-graders from seven randomly selected schools were assessed with regards to bully/victim problems and ADHD symptoms using self-reported questionnaires. Malaysian Bullying Questionnaire was used to rate bully/victim problems while ADHD symptoms were assessed using ConnersWells’ Adolescent Self-report Scale (CASS). Teachers and parents also assessed students’ ADHD symptoms using Conner’s Teachers Rating Scale (CTRS) and Conner’s Parents Rating Scale (CPRS), respectively.
    Results: Self-reported questionnaires showed that 61.2% of the children were involved in bully/victim problems. The ADHD symptoms were found significant in relation to bully/victim problems as tested by multiple logistic regression. Only students and parents reported significant ADHD symptoms among the bully/victim groups. The ADHD symptoms reported by students were significant among bullies(OR=0.59,CI=0.42-0.83, p
    Matched MeSH terms: Attention Deficit Disorder with Hyperactivity
  12. Fulltext The association between physical fitness with successful ageing and risk of cognitive impairment among Malaysian older adults
    Huijin, Lau, Nor Fadilah Rajab, Arimi Fitri Mat Ludin, Suzana Shahar
    Jurnal Sains Kesihatan Malaysia, 2015;15(22):97-102.
    MyJurnal
    The expansion of ageing population has gained much public attention on the importance of healthy and successful ageing,
    which is absence of major chronic diseases, preserved physiological and cognitive functioning and active engagement
    with life. Previous studies have found there was a significant correlation between physical fitness with cognition. However,
    the relationship between physical fitness with successful and unsuccessful cognitive ageing groups are very limited. This
    study was aimed to identify the significant physical fitness components that contribute in reducing risk of cognitive decline
    represented as different cognitive ageing groups. A total of 300 community-based elderly aged 60 and above from the
    states of Selangor, Perak and Kelantan were recruited using multistage random sampling method in this cross-sectional
    study. Cognitive function of subjects was categorized into three groups, namely Mild Cognitive Impairment (MCI) (n
    = 100), Usual Ageing (UA) (n = 100) and Successful Ageing (SA) (n = 100) based on defined criteria. Senior Fitness
    Tests included 2-minute step, handgrip strength, chair stand, chair sit-and-reach, 8 foot up-and-go and back scratch
    were measured to determine the cardiorespiratory fitness; muscle strength; agility and flexibility of subjects. SA group
    had significantly better performance than non-SA groups in all fitness components, except for chair sit-and-reach. After
    controlling for age, gender, education years and smoking status, handgrip strength and chair stand tests were associated
    with a reduced risk of MCI by 7% [OR: 0.93, 95% C.I: 0.88-0.99, p < 0.05] and 15% [OR: 0.85, 95% C.I: 0.75-0.95, p <
    0.01], respectively. These findings suggest that older adults with higher upper and lower body muscular strength could
    serve as protective factors for cognitive impairment. Further research is warranted to evaluate the mechanism of physical
    and cognitive decline such as Motoric Cognitive Risk Syndrome (MCR) in more detailed for the purpose for promoting
    healthy and successful ageing.
    Matched MeSH terms: Attention
  13. The Time Course of Activity within the Dorsal and Rostral-Ventral Anterior Cingulate Cortex in the Emotional Stroop Task
    Feroz FS, Leicht G, Steinmann S, Andreou C, Mulert C
    Brain Topogr, 2017 Jan;30(1):30-45.
    PMID: 27659288 DOI: 10.1007/s10548-016-0521-3
    Growing evidence from neuroimaging studies suggest that emotional and cognitive processes are interrelated. Anatomical key structures in this context are the dorsal and rostral-ventral anterior cingulate cortex (dACC and rvACC). However, up to now, the time course of activations within these regions during emotion-cognition interactions has not been disentangled. In the present study, we used event-related potentials (ERP) and standardized low-resolution electromagnetic tomography (sLORETA) region of interest (ROI) source localization analyses to explore the time course of neural activations within the dACC and rvACC using a modified emotional Stroop paradigm. ERP components related to Stroop conflict (N200, N450 and late negativity) were analyzed. The time course of brain activations in the dACC and rvACC was strikingly different with more pronounced initial responses in the rvACC followed by increased dACC activity mainly at the late negativity window. Moreover, emotional valence modulated the earlier N450 stage within the rvACC region with higher neural activations in the positive compared to the negative and neutral conditions. Emotional arousal modulated the late negativity stage; firstly in the significant arousal × congruence ERP effect and then the significant higher current density in the low arousal condition within the dACC. Using sLORETA source localization, substantial differences in the activation time courses in the dACC and rvACC could be found during the emotional Stroop task. We suggest that during late negativity, within the dACC, emotional arousal modulated the processing of response conflict, reflected in the correlation between the ex-Gaussian µ and the current density in the dACC.
    Matched MeSH terms: Attention/physiology*
  14. Fulltext The Reactive Bounding Coefficient as a Measure of Horizontal Reactive Strength to Evaluate Stretch-Shortening Cycle Performance in Sprinters
    Washif JA, Kok LY
    J Hum Kinet, 2020 Jul;73:45-55.
    PMID: 32774536 DOI: 10.2478/hukin-2020-0003
    Plyometric exercises such as drop jumping and bounding offer athletes a substantiated means of enhancing athletic performance. Between the two exercises, reactive measurement using bounding (reactive bounding coefficient [RBC]) has received scant attention within the domain of training and conditioning. Therefore, this study aimed to identify the viability of utilising a speed-bounding exercise to assess horizontal reactive strength. Eleven young, male elite sprinters (age: 17.8 ± 1.3 yr; body height: 1.72 ± 0.06 m; body mass: 66.05 ± 6.10 kg; best 100 m sprint time: 10.77 ± 0.32 s) were tested for static jumps (SJ), drop jumps (DJ), 10 speed-bounding (RBC10), and 50 m sprint performance. Between-group comparisons based on sprint ability (fast [FSG] vs. slow [SSG] sprint-group) and correlation coefficients were computed subsequently. The FSG (n = 5; 50 m time: 5.82 ± 0.11 s; RBC10: 7.46 ± 0.27) performed significantly better in the RBC10 (p = 0.036) than the SSG (n = 5; 50 m time: 6.09 ± 0.13 s; RBC10: 7.09 ± 0.25). A very high correlation was attained between the RBC10 and the criterion measure, the SJ (r = 0.83). Additionally, RBC10 appeared to be correlated with 30, 50, 10-30 and 30-50 m sprint times (r = -0.52 to -0.60). This positive trend, however, was not observed for the DJ reactive strength index (trivial to moderate correlations). Good reliability was shown for the RBC10 and all sprint distances ("1.5% coefficient variation). Furthermore, all sprinters attained ground contact times of 0.12-0.18 s during the RBC10 which was indicative of fast stretch-shortening cycles during movement, suggesting that the RBC10 could be utilised to assess plyometric ability and enhance sprint performance. Overall, the RBC10 seems able to discriminate between the FSG and the SSG, indicating it has acceptable levels of validity and reliability.
    Matched MeSH terms: Attention
  15. Fulltext The Predictor Role of Perceived Social Support and Spiritual Intelligence in Hope Among Thalassemia Patients
    Pasyar N, Rambod M, Behrouzi Z
    Malays J Med Sci, 2020 May;27(3):75-83.
    PMID: 32684808 DOI: 10.21315/mjms2020.27.3.8
    Background: Thalassemia is a prevalent chronic blood disorder, which is accompanied with a wide range of challenges. This study aimed to determine the predictor role of perceived social support and spiritual intelligence in hope among thalassemia patients.

    Methods: This cross-sectional study was conducted on 300 thalassemia patients. The data were collected using Miller hope scale, spiritual intelligence scale, and personal resource questionnaire. The data were analysed using Pearson's correlation coefficient and multiple regression analysis.

    Results: The results indicated that the mean score of hope was 173.38 (standard deviation [SD] = 24.6). Besides, 86.7% of the patients showed high levels of hope. The mean score of spiritual intelligence was 134.66 (SD = 18.07). In addition, 91.7% of the patients showed moderate levels of spiritual intelligence. The mean score of social support was 127.87 (SD = 20.19) and the patients showed high social support levels. The results revealed a significant association between hope and perceived social support (r = 0.65, P < 0.001) as well as between hope and spiritual intelligence (r = 0.63, P < 0.001). Moreover, perceived social support (b = 0.43, P < 0.001) and spiritual intelligence (b = 0.37, P < 0.001) were the predictors of hope among thalassemia patients.

    Conclusion: Considering the study results, in addition to common treatments for thalassemia, policymakers' are recommended to pay attention to spiritual intelligence and more importantly social support to enhance thalassemia patients' hope.

    Matched MeSH terms: Attention
  16. The Potential use of Honey as a Remedy for Allergic Diseases: A Mini Review
    Aw Yong PY, Islam F, Harith HH, Israf DA, Tan JW, Tham CL
    Front Pharmacol, 2020;11:599080.
    PMID: 33574752 DOI: 10.3389/fphar.2020.599080
    Honey has been conventionally consumed as food. However, its therapeutic properties have also gained much attention due to its application as a traditional medicine. Therapeutic properties of honey such as anti-microbial, anti-inflammatory, anti-cancer and wound healing have been widely reported. A number of interesting studies have reported the potential use of honey in the management of allergic diseases. Allergic diseases including anaphylaxis, asthma and atopic dermatitis (AD) are threatening around 20% of the world population. Although allergic reactions are somehow controllable with different drugs such as antihistamines, corticosteroids and mast cell stabilizers, modern dietary changes linked with allergic diseases have prompted studies to assess the preventive and therapeutic merits of dietary nutrients including honey. Many scientific evidences have shown that honey is able to relieve the pathological status and regulate the recruitment of inflammatory cells in cellular and animal models of allergic diseases. Clinically, a few studies demonstrated alleviation of allergic symptoms in patients after application or consumption of honey. Therefore, the objective of this mini review is to discuss the effectiveness of honey as a treatment or preventive approach for various allergic diseases. This mini review will provide insights into the potential use of honey in the management of allergic diseases in clinical settings.
    Matched MeSH terms: Attention
  17. The Potential Role of miRNAs as Predictive Biomarkers in Neurodevelopmental Disorders
    Juvale IIA, Che Has AT
    J Mol Neurosci, 2021 Jul;71(7):1338-1355.
    PMID: 33774758 DOI: 10.1007/s12031-021-01825-7
    Neurodevelopmental disorders are defined as a set of abnormal brain developmental conditions marked by the early childhood onset of cognitive, behavioral, and functional deficits leading to memory and learning problems, emotional instability, and impulsivity. Autism spectrum disorder, attention-deficit/hyperactivity disorder, Tourette syndrome, fragile X syndrome, and Down's syndrome are a few known examples of neurodevelopmental disorders. Although they are relatively common in both developed and developing countries, very little is currently known about their underlying molecular mechanisms. Both genetic and environmental factors are known to increase the risk of neurodevelopmental disorders. Current diagnostic and screening tests for neurodevelopmental disorders are not reliable; hence, individuals with neurodevelopmental disorders are often diagnosed in the later stages. This negatively affects their prognosis and quality of life, prompting the need for a better diagnostic biomarker. Recent studies on microRNAs and their altered regulation in diseases have shed some light on the possible role they could play in the development of the central nervous system. This review attempts to elucidate our current understanding of the role that microRNAs play in neurodevelopmental disorders with the hope of utilizing them as potential biomarkers in the future.
    Matched MeSH terms: Attention Deficit Disorder with Hyperactivity/diagnosis; Attention Deficit Disorder with Hyperactivity/genetics
  18. The Novelty of Bupropion As a Dopaminergic Antidepressant for the Treatment of Adult Attention Deficit Hyperactive Disorder
    Deang KT, Sidi H, Zakaria H, Adam RL, Das S, Hatta NH, et al.
    Curr Drug Targets, 2019;20(2):210-219.
    PMID: 28494748 DOI: 10.2174/1389450118666170511145628
    Attention deficit hyperactive disorder (ADHD), a hyperactivity disorder prevalent among children may continue as an adulthood attention deficit. To date, treating an individual with an adult ADHD may be an arduous task as it involves numerous challenges, which include a need for high index of suspicion to diagnose this medical condition. Many psychiatric disorders masquerade as ADHD and delay the necessary assessment and proper treatment for this debilitating medical disorder. Adult ADHD is often misdiagnosed (or under diagnosed) due to the fact that this medical condition is being masked by the patients' high level of intellectual achievement. As the ADHD in adult persists, it may end-up with impairment in the personal-social-occupational function in which the management becomes a great challenge. The treatment of ADHD can be optimized by using various drugs targets agents like norepinephrine-dopamine reuptake inhibitor (NDRI), with or without psycho stimulants like methylphenidate, which is marketed as Ritalin. Bupropion, an NDRI has a novel effect on ADHD as the molecule exerts its effects by modulating the reward-pleasure mesolimbic dopaminergic system and at the same time regulates the elevating mood dimension of the noradrenergic neurotransmission. The role of Bupropion in the neural and psychopharmacological perspective treatment of ADHD was deliberated. The present review highlights the novel effects of Bupropion in ADHD treatment, together with the help of other successful bio-psycho-social measures. This may be of immense benefit to the psychiatrists for treating their patients.
    Matched MeSH terms: Attention Deficit Disorder with Hyperactivity/diagnosis*; Attention Deficit Disorder with Hyperactivity/drug therapy*; Attention Deficit Disorder with Hyperactivity/psychology
  19. The Impact of Plant Bioactive Compounds on Aging and Fertility of Diverse Organisms: A Review
    Noordin MAM, Noor MM, Aizat WM
    Mini Rev Med Chem, 2020;20(13):1287-1299.
    PMID: 32348218 DOI: 10.2174/1389557520666200429101942
    It is expected that in 2050, there will be more than 20% of senior citizens aged over 60 years worldwide. Such alarming statistics require immediate attention to improve the health of the aging population. Since aging is closely related to the loss of antioxidant defense mechanisms, this situation eventually leads to numerous health problems, including fertility reduction. Furthermore, plant extracts have been used in traditional medicine as potent antioxidant sources. Although many experiments had reported the impact of various bioactive compounds on aging or fertility, there is a lack of review papers that combine both subjects. In this review, we have collected and discussed various bioactive compounds from 26 different plant species known to affect both longevity and fertility. These compounds, including phenolics and terpenes, are mostly involved in the antioxidant defense mechanisms of diverse organisms such as rats, mites, fruit flies, roundworms, and even roosters. A human clinical trial should be considered in the future to measure the effects of these bioactive compounds on human health and longevity. Ultimately, these plant-derived compounds could be developed into health supplements or potential medical drugs to ensure a healthy aging population.
    Matched MeSH terms: Attention
  20. Fulltext The Impact of Ethylene Glycol on Droplet Growth Inhibition in Ethylene Vinyl Acetate Emulsions
    Rosdi MRH, Ahmad Razali MA, Ku Ishak KM, Ariffin A
    ACS Omega, 2020 Jun 23;5(24):14473-14480.
    PMID: 32596585 DOI: 10.1021/acsomega.0c01114
    Pour point depressant (PPD) emulsion has been gaining attention in crude oil transportation owing to its potential to solve solidification issues that arise in cold climate environments. An emulsion system provides a wide range of temperature application that combines good shelf life and tunable thermal properties to tackle this problem. These features can be achieved by incorporating an antifreeze agent into the emulsion. One of the most commonly used antifreeze agents is ethylene glycol (EG). Hence, this study focuses on the thermal properties and droplet size growth of PPD emulsions that were aged in variable concentrations of EG solution. EG50 exhibited the lowest freezing temperature of -44 °C, while EG25 demonstrated the lowest vitrification temperature of -68.7 °C. The particle size of the emulsions underwent a significant reduction from 332.3 to 228.9 nm upon the stepwise EG concentration increment to EG50. However, when the concentration was increased to EG75, a slight increase in the emulsion particle size was observed with a recorded value of 237.8 nm. Thus, it is concluded that EG50 represents the optimum concentration for delivering the best freezing protection and producing a smaller droplet particle size.
    Matched MeSH terms: Attention
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