Displaying publications 1 - 20 of 36 in total

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  1. Nur Syafiqah Abdul Malik, Adekunle Qudus Adeleke
    MyJurnal
    This paper assessed the significant relationship between organizational culture and
    material risk among Kuantan Malaysian construction industries. Survey was
    conducted among 10 registered G7 contractors operating in Kuantan construction
    industry. Proportionate stratified random sampling was used out of which 10
    questionnaires were distributed for pilot study. Methodologically, this research is
    perhaps the first to assess the relationship between organizational culture and
    material risk among Malaysian construction industries with five point Likert scale
    categories of material risk from previous studies. Statistical analysis affirmed a
    significant positive relationship between organizational culture and material risk
    among Malaysian construction industries through Statistical Package for Social
    Sciences (SPSS).
  2. Syarifah Nur Syafiqah Mohd Azmi, Syahrul Bariah Abdul Hamid
    MyJurnal
    Maternal obesity is significantly associated with less intention to breastfeed, low breastfeeding self-efficacy, and poor breastfeeding outcomes. This cross sectional study investigates the determinants of breastfeeding self-efficacy among overweight and obese pregnant mothers using self-administered validated questionnaires. There were 44.9% of overweight and obese from 200 recruited mothers. They had low breastfeeding self-efficacy and less intended to breastfeed as compared to normal-weight mothers. Past breastfeeding experience and exclusive breastfeeding inten- tion are predictors of breastfeeding self-efficacy among overweight and obese pregnant mothers. Effective strategies should be conducted targeting this population with regards to low self-efficacy and intention to breastfeed.
  3. Nur Syafiqah Martang, Nadia Majitol, Farnidah Jasnie, Lo Chor-Wai
    Borneo Akademika, 2020;4(4):15-20.
    MyJurnal
    Most of the plants in the ginger family Zingeberaceae are well-known for their medicinal properties. However, the genus Hornstedtia found in Sabah is less reported. This research aims to investigate the phytochemical constituent and vitamin C content of a fruit, locally known as the Tolidus fruit in Sabah. The dried fruit sample was extracted using three solvents which were water, ethanol and methanol. The phytochemical constituents were determined using standard Colour Test for the presence of alkaloid, flavonoid, saponin and tannin. Then, the content of Vitamin C was determined using the standard Colorimetric Titration and ascorbic acid as standard. The phytochemical evaluation revealed that all three targeted constituents were present in all extracts except for the alkaloid. The vitamin C content was determined in both dried and fresh sample of fruits, where 52.84 mg was quantified in the fresh fruit aqueous extract and 23.93 mg in the dried fruit aqueous extract respectively. These results are comparable to the content of vitamin C in orange and lime fruits. The phytochemical evaluation and vitamin C content of Tolidus suggested the potential of this underutilised fruit to be the natural and affordable source of vitamin C. Additionally, may protect the body against harmful free radicals. However, further analysis is needed to determine other constructive natural contents and evaluate the efficacy of this fruit as a natural source of antioxidant
  4. Mat Zain NS, Lee LK
    Int J Environ Res Public Health, 2022 Dec 06;19(23).
    PMID: 36498443 DOI: 10.3390/ijerph192316371
    Aquaculture is seen as an essential food-producing sector for improving global food security and nutrition indices. This cross-sectional study examined the health complaints and mental health status of aquaculture workers, as well as their relationship with quality of life, with respect to the brackish water and freshwater aquaculture cultivation system in Penang, Malaysia. The workers’ health complaints were collected, and mental health status was evaluated as means of depression, anxiety, stress and self-esteem. Self-perceived quality of life was assessed using a structured questionnaire. This study involved the participation of 88 brackish water (84.6%) and 16 freshwater (15.4%) aquaculture workers. A total of 72.7% of the brackish water aquaculture workers were aged beyond 50 years old and had worked within five years (77.3%) in the aquaculture industry. Both brackish water and freshwater cultivation workers were confronted with fatigue, pain and insomnia. Up to 48%, 40.4%, 26% and 24% of them were facing depression, anxiety, stress and low self-esteem, respectively. A total of 3.4% of the brackish water aquaculture workers were having bad quality of life. The complaints of neck/shoulder/arm pain (F = 13.963; p < 0.001), back pain (F = 10.974; p < 0.01), hand/wrist pain (F = 8.041; p < 0.01), knee/hip pain (F = 12.910; p < 0.01) and insomnia (F = 10.936; p < 0.01) were correlated with bad quality of life among the workers. For mental health status, self-esteem (F = 4.157; p < 0.05) was found to be negatively correlated with quality of life scores. The results outlined the concerning level of health complaints and psychological distress among the aquaculture workers. The study emphasized the importance of developing an appropriate occupational health strategy in the aquaculture industry. Longitudinal investigations aimed to explore the effects of psychological distress on employment productivity among the high-risk workers are warranted.
  5. Yaccob NS, Yunus MM, John DS
    Front Psychol, 2023;14:1007970.
    PMID: 37063540 DOI: 10.3389/fpsyg.2023.1007970
    Education evolves and progresses globally in a technology-driven world, highlighting the integration of VUCA elements of volatility, uncertainty, complexity, and ambiguity in lessons. Learners are molded to equip themselves with the world and real-life knowledge in their readiness to adapt to the VUCA world. Global education consists of preparing learners for the VUCA world. This study aimed to investigate the current English as a Second Language (ESL) teaching practices and the ESL teachers' incorporation of VUCA elements in ESL lessons. This study was conducted quantitatively using a survey questionnaire. This study was administered to 30 ESL teachers from different secondary schools in a district in Malacca. The results from the questionnaire revealed that the ESL participants had positive perceptions toward the adaptation of VUCA in the current ESL lessons. Most of the ESL teachers agreed that they adapted VUCA elements into the activities during lessons, although some showed uncertainty about their knowledge and understanding of VUCA. From the high agreement levels in the findings, it can be concluded that the ESL teachers agreed that VUCA elements through problem-based, digital-based, collaborative, and challenging activities in English lessons are beneficial to assist students' meaningful and autonomous learning. Based on these findings, implications were made for enhancing ESL teachers' knowledge, understanding, and skills in adapting VUCA in lessons in response to global education demand.
  6. Sarina Mohamad, Nur Atiqah Abd Hadi, Tun Mohd Firdaus Azis, Nur Syafiqah Rahim
    Science Letters, 2020;14(2):94-102.
    MyJurnal
    Infection on plant caused by Aspergillus niger leads to the destruction of quantity and quality of crop yields. Normally, this disease is solved by the chemical fungicides. Therefore, this study was carried out to seek a potential natural fungicide from fruit waste which is safer and economical to inhibit Aspergillus niger. Cucurbita maxima (pumpkin) seeds and Punica granatum (pomegaranate) peels were extracted using maceration method with 80% ethanol. Brine Shrimp Lethality Assay (BLSA) was used to test the presence of bioactive components in the extracts at concentration of 10 µg/mL, 100 µg/mL and 1000 µg/mL and they are expressed in terms of LC50 (Median Lethal Concentration) respectively. The study revealed that Cucurbita maxima extract was inactive, while Punica granatum extract and the mixture of both extracts at ratio 1:1 were active at 1000 µg/mL. Furthermore, the antifungal activity of Cucurbita maxima extract, Punica granatum extract, and mixture of both extracts were further tested using well-diffusion method against A. niger at 25 mg/ml, 50 mg/mL, 75 mg/ml and 100 mg/mL respectively. The findings revealed the mixture of both extracts were exerted effectively against A. niger at the lowest concentration with 20.67±2.52 mm and this gave significant zone of inhibition. The result of the study indicates that the mixture extraction of pomegranate peels and pumpkin seeds at 25 mg/mL has a great potential to be formulated as commercial bio-fungicide.
  7. Noor Hidayah Pungot, Nurul Auni Zainal Abidin, Nur Syafiqah Atikah Nazaharuddin
    Science Letters, 2020;14(2):103-109.
    MyJurnal
    Muntingia calabura has a high phytochemical content, especially the phenolic group that can act as antioxidant. In Malaysia country, this M. calabura also known as ‘kerukup siam’ or ‘Ceri Kampung’ and it belongs to Muntingiaceae family. This research was conducted to determine the potential of antioxidant activity application of cherry leaves (M. calabura) from various solvent extracts (methanol, ethyl acetate, and n-hexane). The phytochemical contents was screening by using the established standard procedure. Total phenolic content (TPC) was determined according to the Folin-Ciocalteau colorimetric method, while the antioxidant activity was carried out using 2,2-diphenyl-1-picryhydrazyl (DPPH) radical scavenging assay. Phytochemical screening on the leaves part methanolic extracts revealed that the presence of various biochemicals like flavonoids, phenols, steroids, triterpenes, tannins, reducing sugars, and saponins except the alkaloids. Among the three extracts, the methanol leaf extract gave the highest content of phenolics (8.20 mg GAE/g extract). Analyses of antioxidant activity with DPPH method showed that cherry leaf methanolic extracts produced high antioxidant activity with IC50 value of 167.70 g/mL. The present study confirms that the presence of various phytochemicals which shows good antioxidant activity of M. calabura leaves. Therefore, it has the potential as a therapeutic antioxidant agent and can be used in cosmeceutical and food products.
  8. Noor'Ain Azizan, Seri Rahayu Kamat, Nur Syafiqah Rayme, Ruzy Haryati Hambali
    MyJurnal
    Repetitive movement can lead to the pain muscle, nerves, and tendons that cause by
    repetitive overuse of working task. The muscle will fatigue due to; repetitive
    movement, force that been applied, posture during working and duration of working.
    The stress level during working can influent the energy performance usage during
    working. The aim of this paper is to analyse the influence of heart rate and muscle
    activity of workers in composite manufacturing towards muscle fatigue. The data was
    collected for a worker in hand layup department and the Qualitative method was used
    in a way to investigate the working load and level of pain received by their body. Then,
    the Qualitative data was sorted and the respondent proceeded for a Quantitative
    method which involves muscle activity analysis and heart rate analysis. The tools that
    were used to conduct these experiments were surface electromyography (sEMG),
    Wristwatch with chest strap and perceived stress scale (PSS). The experimentation
    used to calculate the average reading of heart rate and muscle activity during working
    and detect the duration the muscle to start fatigue. Moreover, this paper analysed the
    relationship between heart rate and muscle activity through the duration of working.
    As an overall finding of this research, it was shown that the heart rate of the workers
    influence the muscle activity of workers and has high potential relationship to the
    fatigue of muscles of the workers in the layup department.
  9. Rahman, Abdullah Abdull, Albattat, Ahmad Rasmi, Nurul Fadhillah, Ahmad Fakhry, Nur Syafiqah, Mohd Idris
    MyJurnal
    Bakery industry in Malaysia is a very dynamic and fast-moving industry, where the use of bakery products has become common among society. The purpose of this study is to understand the behaviour of consumers as well as their purchase decision process. Two objectives of this research are to identify consumer’s behaviour towards bakery product in Section 13, Shah Alam, and to study the factors that influence consumers behaviour in their decision making. Researcher has developed a questionnaire to collect the primary data. A survey consisted of a quantitative method and the data were analysed by Statistical Package for Social Science using descriptive statistics. The data were derived from self-administrated questionnaires consisted of structured questions related. A survey is performed by involving 400 bakery consumers. The theoretical framework focusing on the developed marketing mix, consisting of product, price, place, and promotion that resulted positively, and significantly related to consumers’ behaviour in their decision making. Based on the results of this study, it show that the freshness of bakery products leads to the tendency of weekly purchase among consumers. Although consumers’ monthly income is ranging between RM1000-RM4000, the amount of RM51-RM100 as the cost of buying bakery products is considered as preferable and valuable. Moreover, consumers tend to spend their time in bakery within 20 to 30 minutes. Bagus Bakery has become the most visited bakery because of its status as the preferred convenient place with promotional offers during festive season. The most common reason of buying bakery products is determined because of the variety selection. As the study has achieved its objectives, it can be concluded that consumers are having their impression while making the decision towards bakery products during the pre-purchase and post purchase.
  10. Mohd Afandi NS, Habib MAH, Ismail MN
    Physiol Mol Biol Plants, 2022 Feb;28(2):471-484.
    PMID: 35400887 DOI: 10.1007/s12298-022-01145-z
    Hevea brasiliensis is one of the most important agricultural commodities globally, heavily cultivated in Southeast Asia. Fatal leaf fall diseases cause aggressive leaf defoliation, linked to lower latex yield and death of crops before maturity. Due to the significant consequences of the disease to H. brasiliensis, the recent gene expression studies from four fall leaf diseases of H. brasiliensis were gathered; South American leaf blight, powdery mildew, Corynespora cassiicola and Phytophthora leaf fall disease. The differential analysis observed the pattern of commonly expressed genes upon fungi triggers using RT-PCR, DDRT-PCR, Real-time qRT-PCR and RNA-Seq. We have observed that RNA-Seq is the best tool to seek novel genes. Among the identified genes with defence-against fungi were pathogenesis-related genes such as β-1,3-glucanase and chitinase, the reactive oxygen species, and the phytoalexin biosynthesis. This manuscript also provided functional elaboration on the responsive genes and predicted possible biosynthetic pathways to identify and characterise novel genes in the future. At the end of the manuscript, the PCR methods and proteomic approaches were presented for future molecular and biochemical studies in the related diseases to H. brasiliensis.
  11. Fauzan NS, Sukadarin EH, Widia M, Irianto I, Ghazali I
    PMID: 36833630 DOI: 10.3390/ijerph20042934
    This systematic literature review (SLR) aims to determine the factors influencing the use of hearing protection devices (HPDs) among industrial workers. This study was guided by the PRISMA Statement (Preferred Reporting Items for Systematic reviews and Meta-Analyses) review method, and four databases comprising Scopus, Science Direct, PubMed, Wiley Online Library, and Google Scholar were employed. A total of 196 articles were identified, and 28 studies on the factors associated with HPD use among industrial workers from 2006 to 2021 met the inclusion criteria. Resultantly, five main themes emerged from this review: sociodemographic (29%), interpersonal influences (18%), situational influences (18%), cognitive-perceptual (29%), and health-promoting behavior (6%) associated with HPD use among industrial workers. A total of 17 sub-themes were identified, including age, gender, educational level, noise level, working experience, social models, interpersonal support, social norms, safety climate, training, organizational support, perceived barrier, perceived susceptibility, perceived severity, perceived benefit, self-efficacy, and cues to action. The significant factors influencing workers to use HPDs are sociodemographic, interpersonal influences, situational influences, and health-promoting behavior. Future studies should focus on the cues to action toward human behavior influencing the use of HPDs, workers' health status, and comorbidities of hearing loss. Therefore, this systematic study gives valuable reference resources for up-and-coming researchers as well as new knowledge to expert professionals and academics in various industries.
  12. Rohani R, Dzulkharnien NSF, Harun NH, Ilias IA
    Bioinorg Chem Appl, 2022;2022:3077747.
    PMID: 35966407 DOI: 10.1155/2022/3077747
    Interest in the use of zinc oxide nanoparticles (ZnO NPs) in surface coatings and films has increased as its incorporation can significantly improve the mechanical and antimicrobial properties of coatings and film solutions. In an effort to produce green or eco-friendly products, the potential use of ZnO NPs biosynthesized from natural resources to replace conventional petroleum-derived polymers has been investigated. This review provides an insight into the growing trend of incorporating ZnO NPs into synthetic or semi-synthetic or bio-based polymeric materials via different synthesis methods as well as its characteristics and potential applications in surface coatings and films. The antimicrobial potential of ZnO NPs to inhibit the growth of various types of microorganisms as well as its use in surface coatings or films to impart antimicrobial activities that prevent the spread of microorganisms, especially the COVID-19 virus, was also discussed.
  13. Tengku Shafazila Tengku Saharuddin, Lailatun Nazirah Ozair, Ayuni Shahira Zulkifli, Nursarah Syazwani Hairul Shah, Nur Syafiqah Sahidan
    MyJurnal
    Ginger essential oils (GEO) are natural products with antibacteria properties consisting of many different volatile
    compounds have high potential to be used in many applications. In this study, the ginger GEO was successfully
    encapsulated in chitosan as a carrier agent using a spray drying technique. The extraction of Zingiber officinale
    (ginger) essential oil is performed by steam distillation method. The GEO was encapsulated in chitosan as a carrier
    agents at 1:3, GEO:chitosan ratio by using spray drying technique. GEO together with encapsulated GEO were
    further assayed for antimicrobial activity by disc-diffusion method. For characterization of encapsulated GEO,
    Fourier transform infrared spectroscopy (FTIR) and Field emission scanning electron microscopy (FESEM) were
    used. FTIR analysis revealed that there was no existence of a new functional group in the encapsulated GEO
    showing that there is only physical interaction between GEO and chitosan. Besides, FESEM analysis showed the
    encapsulated GEO were in micro in sizes and possessed spherical shape with smooth and porous surface.
    Furthermore, Both GEO and encapsulated GEO showed in vitro antimicrobial activity against Escheriachia coli,
    Pseudomonas aeruginosa, Staphylococcus aureus and Salmonella typhi with encapsulated GEO possessed higher in
    the activities for all studied bacteria compared to GEO. The encapsulated GEO demonstrated a superior performance
    against Salmonella typhi with the inhibition zone of 22.5 mm compared to GEO only 13.5 mm. The results obtained
    indicated that due to the volatility and instability of the GEO when exposed to environmental factors, its encapsulation considerably improve and enhanced its performance.
  14. Amiratul Aifa Mohamad Asri, Siti Marwanis Anua, Sabreena Safuan, Siti Farhanah Md Shakri, Nur Safuraa Mat Hussein, Nur Syafiqah Ishak, et al.
    MyJurnal
    Introduction: Exposure to total inhalable dust has become a public concern because constant exposure to the dust
    concentration exceeding workplace exposure limit may cause decline in lung function. This study aims to compare
    the total inhalable dust exposure among rice mill, sawmill, furniture factory and non-exposed workers as well as
    to correlate the dust exposure with lung function. Methods: A total of 77 exposed and 39 non-exposed workers
    were recruited into this study utilising purposive sampling method. The total inhalable dust concentration was
    collected using Institute of Occupational Medicine (IOM) personal airborne sampler loaded with glass microfibre
    filter connected to a sampling pump via tygon tubing which was attached to the workers. Post-shift lung function
    test was also measured. Results: There was a significant difference in the dust concentration between rice mill,
    sawmill, furniture factory and non-exposed workers (p = 0.001) with the highest median value of 2.4 x 103
    µg/m3
    (IQR: 1.1 x 103
    – 5.8 x 103
    ) among sawmill workers. Significant difference (p = 0.001) was shown between
    workers for measured forced expiratory value in one second (FEV1), measured forced expiratory value in one second
    and forced vital capacity ratio (FEV1/FVC) and predicted FEV1/FVC. Among the exposed workers, weak negative
    significant correlations were portrayed between total inhalable dust with the predicted forced vital capacity (FVC)
    (r = -0.282, p = 0.013) and predicted FEV1 (r = -0.241, p = 0.035). Conclusion: Dust concentration might be attributable to the lung function decline among exposed workers especially sawmill workers.
  15. Emma Aishah, A., Muhammad Firdaus, M.F., Nur Syafiqah, T., Rozana, M.S., Sugasini, S.L., Syamsa Rizal, A., et al.
    Medicine & Health, 2020;15(2):224-235.
    MyJurnal
    Ovitrap autosidal berperanan penting dalam pemantauan dan kawalan vektor denggi, Aedes aegypti and Aedes albopictus. Beberapa jenis ovitrap ini telah digunakan di Malaysia termasuklah Mosquito Larvae Trapping Device (MLTD) yang diperkenalkan oleh Dewan Bandaraya Kuala Lumpur. Kajian ini bertujuan untuk menilai kepadatan larva Aedes dan pembolehubah meteorologi setempat di sebuah penempatan pelajar di Cheras, Kuala Lumpur. MLTD (n=30) dengan umpan larutan baja NPK (5:5:5) organik telah digunakan. Pengumpulan larva dan penyelenggaraan ovitrap telah dilakukan setiap minggu selama lapan minggu. Pemeliharaan larva dan penentuan spesies telah dijalankan di makmal. Daripada sejumlah 2,152 larva Aedes, 85% merupakan Ae. albopictus manakala selebihnya Ae. aegypti. Ae. albopictus lebih banyak dikumpulkan di luar berbanding di dalam bangunan (purata larva per ovitrap, 9.28 lawan 6.08). Sebaliknya, Ae. aegypti lebih banyak dikumpulkan di dalam berbanding di luar bangunan (1.72 lawan 0.86). Ovitrap indeks yang paling tinggi adalah semasa minggu kelima (90%) dan keenam (93%). Minggu pertama menunjukkan ovitrap indeks yang paling rendah (30%). Analisis mendapati korelasi positif antara kepadatan larva Aedes dan suhu maksimum (r=0.830, p=0.011), manakala kelembapan relatif minimum menunjukkan korelasi negatif (r=-0.778, p=0.023). Pemantauan rutin bagi peringkat pramatang vektor denggi boleh memberikan maklumat mengenai kepadatan dan naik turun populasi nyamuk setempat. Apabila digandingkan dengan faktor meteorologi sejajar, maklumat ini dapat memberi panduan bagi perlaksanaan kawalan vektor sebagai sebahagian strategi pencegahan denggi.
  16. Sharir,Aizat,Kamaruddin,, Nor,Atikah,Husna,Ahmad,Nasir,, Nur,Syafiqah,Rahim,, Norlin,Shuhaime,, Mohd,Akmal,Hashim,, Ahmad,Suhail,Khazali,, et al.
    Science Letters, 2021;15(2):117-132.
    MyJurnal
    ABSTRACT
    This research is conducted to assess the accuracy of spline interpolation methods to predict and
    model the surface water pH of Pulau Tuba, Langkawi, Kedah, Malaysia. In-situ sampling
    activities using pH-meter and Geographic Positioning Systems (GPS) were carried out during
    high tides and at noon in November 2018. The development of spatial models was constructed
    using Regularized and Tension spline methods. Then, validation of models was carried out to
    compare the observed and predicted values of pH using correlation analysis, regression analysis,
    and error analysis. The accuracy of the developed map was calculated using the overall accuracy
    equation. This research found that the regularized spline method had more accuracy in estimating
    surface water pH variability than the tension spline method. Pearson correlation coefficient (r),
    Coefficient of determination (R2
    ), Mean Absolute Error (MAE) and Root Mean Square Error
    (RMSE) were reported at 0.896, 0.803, 0.0265 and 0.0344 for the regularized spline method,
    respectively. The developed spatial model was then transformed into a map by adding map
    elements such as legend, title, north arrow, and scales for effective visualization. The developed
    map has an accuracy of 87.50%. The surface water pH was found at the range of 7-8. Low
    reading of pH is expected due to the addition of rainwater to the coastal water of Pulau Tuba,
    Langkawi, Kedah. The research outcomes would benefit government and non-government
    agencies to monitor the coastal and ocean acidification and the development of strategic policies
    and rules to reduce the impact of anthropogenic activities and climate changes for this area.
  17. Majeed S, Aripin FHB, Shoeb NSB, Danish M, Ibrahim MNM, Hashim R
    Mater Sci Eng C Mater Biol Appl, 2019 Sep;102:254-263.
    PMID: 31146998 DOI: 10.1016/j.msec.2019.04.041
    The aim of the current study was to biosynthesize the silver nanoparticles (AgNPs) from the bacterial strain of Bacillus cereus (ATCC 14579) extracellularly. When bacterial extract was challenged with 1 mM silver nitrate (AgNO3) the color of the extract changed into brown confirms the formation of nanoparticles. These nanoparticles were capped with bovine serum albumin (BSA). UV- visible spectroscopy showed the absorption peak at 420 nm indicates the formation of AgNPs. Fourier Infra -red (FTIR) attenuated total reflection (ATR) spectroscopy showed amide and amine group associated with AgNPs that stabilizes the nanoparticles. Energy dispersive x-ray spectroscopy (EDX) showed a strong peak of silver confirms the presence of silver. Thermo gravimetric analysis (TGA) analysis was used to determine the protein degradation showed less protein degradation at higher temperature confirms the stability of nanoparticles. Transmission electron microscopy (TEM) showed the AgNPs are well dispersed and spherical, and 5.37 nm to 17.19 whereas albumin coated nanoparticles are size ranges from 11.26 nm to 23.85 nm. The anticancer effect of capped AgNPs (cAgNPs) showed the IC50 value against breast cancer MCF-7 at 80 μg/mL, intestinal colon cancer HCT- 116 60 μg/mL, and bone cancer osteosarcoma MG-63 cell line80 μg/mL while against normal fibroblast cells 3T3 cells showed the IC50 value at 140 μg/mL. Lactate dehydrogenase assay (LDH) showed higher toxicity on MCF-7, HCT-116, and MG-63 cells. The apoptotic study clearly showed the blebbing of membrane, chromatin condensation due to the production of reactive oxygen species (ROS) by ethidium bromide and acridine orange dual staining method. The DNA analysis showed the complete fragmentation of the DNA of treated cells when compared with control cells.
  18. Dzulkharnien NSF, Karim MR, Zahid NI, Rahman NMMA, Abdullah I, Salleh NM
    J Fluoresc, 2019 Jul;29(4):1049-1056.
    PMID: 31338718 DOI: 10.1007/s10895-019-02418-9
    The optical properties of a series of side chain liquid crystalline polymers (P1-P3) containing azo-benzothiazole mesogen with different terminal substituents (-H, -CH3 and -OCH2CH3) in four organic solvents of varying polarity have been investigated by absorption and fluorescence spectral analysis. Solvatochromic studies of P1-P3 did not show any regular variation on the absorption and emission intensities with changing the polarity of solvent. Theoretical studies were performed based on different solvent correlation methods such as Dimroth-Reichardt and Kamlet-Taft methods to investigate the solute-solvent interactions. Both absorption and emission maxima of investigated polymers were bathochromically shifted with the replacement of sixth position hydrogen atom by electron donating groups in benzothiazole moiety. The emission intensities of the studied polymers showed decreasing trend with increasing temperature.
  19. Rahim NS, Lim SM, Mani V, Hazalin NAMN, Majeed ABA, Ramasamy K
    J Diet Suppl, 2020 Oct 14.
    PMID: 33962540 DOI: 10.1080/19390211.2020.1830223
    Neuroinflammation is associated with neuronal cell death and could lead to chronic neurodegeneration. This study investigated the neuroprotective potential of virgin coconut oil (VCO) against lipopolysaccharide (LPS)-induced cytotoxicity of neuroblastoma SK-N-SH cells. The findings were validated using Wistar rats, which were fed with 1-10 g/kg VCO for 31 days, exposed to LPS (0.25 mg/kg) and subjected to the Morris Water Maze Test. Brain homogenate was subjected to biochemical analyses and gene expression studies. α-Tocopherol (α-T; 150 mg/kg) served as the positive control. VCO (100 µg/mL) significantly (p 
  20. Mad Nasir N, Ezam Shah NS, Zainal NZ, Kassim NK, Faudzi SMM, Hasan H
    Plants (Basel), 2021 Jul 21;10(8).
    PMID: 34451533 DOI: 10.3390/plants10081488
    Curculigo is a potent plant with a variety of traditional uses, such as anti-oxidant, anti-diabetic, anti-tumor, anti-bacterial, anti-cancer, anti-osteoporosis, and wound-healing. The comprehensive profiling of the Curculigolatifolia metabolome was carried out by generating a molecular network (MN) from Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) data to profile the methanol extract and correlating them with their antioxidant (2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), total phenolic contents (TPC), and β-carotene) and antimicrobial (disk-diffusion agar method, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC)) properties. The antioxidant capacity was observed to be significantly higher in the rhizome crude extract, with 18.10 ± 0.91 µg/mL DPPH activity, and a β-carotene bleaching result of 35.20%. For the antimicrobial activity, the leaf crude extract exhibited a strong Staphylococcus aureus and Salmonella choleraesuis (8-15 ± 3.0 mm) inhibition in the disk-diffusion agar. The leaf extract also exhibited maximum antibacterial activity against S. aureus (MIC = ±0.25 mg/mL, MBC = ±0.25 mg/mL) and S. choleraesuis (MIC = ±0.25 mg/mL, MBC = ±0.25 mg/mL). LC-MS/MS analysis and MN revealed norlignans and phenolic glycosides as major metabolites in the rhizome and leaf extracts of the negative mode (M - H)-. Fourteen known compounds were identified, and three unknown compounds were putatively identified in the rhizome extract, while ten known compounds and six unknown compounds were putatively identified in the leaf extract.
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