Displaying publications 1 - 20 of 5053 in total

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  1. Abstracts of the 24th World Congress of Pathology and Laboratory Medicine, 20-24 August 2007, Petaling Jaya, Malaysia
    Malays J Pathol, 2007 Aug;29 Suppl A:1-238.
    PMID: 18426038
    Matched MeSH terms: Pathology, Clinical*
  2. Digital pathology as a solution for working from home
    Tan GC, Wong YP
    Malays J Pathol, 2021 Aug;43(2):201.
    PMID: 34448785
    No abstract available.
    Matched MeSH terms: Pathology/methods*
  3. Primary pulmonary hyalinising clear cell carcinoma: Two cases and literature review
    Di J, Xiong Y, Li D, Li X, Wang W, Cheng Y, et al.
    Malays J Pathol, 2022 Dec;44(3):509-516.
    PMID: 36591718
    Hyalinising clear cell carcinoma (HCCC) of the lung is an extremely rare tumour that is just recently recognised as one of the salivary gland-type tumours (SGTT) in the latest WHO classification of thoracic tumours. Eleven cases have been reported in English literature since Joaquín et al. reported the first case. Given the very limited number of cases, the clinical and histological features of pulmonary HCCC are equivocal. Herein, we present two cases of pulmonary HCCC. The patients were a 66-year-old man and a 48-year-old woman. The mass was located on the right main bronchus and right middle lobar bronchus separately. One was 2 cm and the other was 3.3 cm in the greatest dimension. The tumours were comprised of small monomorphic cells with clear or eosinophilic cytoplasm and infiltrated in a hyalinising stroma arranged in nests, cords, sheets and trabeculae. Their morphology resembled their head and neck counterparts. Immunohistochemically, the tumour cells were positive for AE1/AE3, P63, while negative for TTF1, Calponin, S-100, HMB45 and PAX8. Ki-67 labeling ranges from 3% to 10%. Fluorescence in situ hybridisation (FISH) demonstrated EWSR1 rearrangement and Next-generation sequencing (NGS) demonstrated EWSR1- ATF1 (exon 11: exon 3) fusion in case one and EWSR1- ATF1 (exon 2: exon 12) fusion in case two. This is the first time to report the EWSR1-ATF1fusion point other than exon 11: exon 3 in pulmonary HCCC. Case one recurred two years after local resection but didn't metastasise during follow-up 36 months. Case two is alive without disease after lobectomy during follow-up 14 months.
    Matched MeSH terms: Lung/pathology
  4. Rare Extranodal Manifestation of Rosai-Dorfman Disease Presenting as Nasal Obstruction and its Management
    Oui TJ, Zahedi FD, Husain S, Wan Hamizan AK
    BMJ Case Rep, 2023 Jul 05;16(7).
    PMID: 37407235 DOI: 10.1136/bcr-2022-251801
    Rosai-Dorfman disease (RDD) is a rare and benign lymphoproliferative disorder that commonly presents as painless, bilateral neck swelling. Extranodal presentations are considered rare, but the most common extranodal locations involved include skin, subcutaneous followed by nasal/paranasal sinuses. Although it is a benign condition, it may be mistaken as a malignant lesion and requires a biopsy for diagnostic confirmation. In this study, we report a rare case of RDD with bilateral neck node and nasal/paranasal sinus involvement which initially presented with bilateral nasal obstruction. And, we reviewed the management in this unusual case and discussed the helpful role imaging studies play in the further workup and subsequent follow-up to treatment response.
    Matched MeSH terms: Nose/pathology
  5. Fulltext Neuroinflammation: A Common Pathway in Alzheimer's Disease and Epilepsy
    Liew Y, Retinasamy T, Arulsamy A, Ali I, Jones NC, O'Brien TJ, et al.
    J Alzheimers Dis, 2023;94(s1):S253-S265.
    PMID: 37092226 DOI: 10.3233/JAD-230059
    BACKGROUND: Neuroinflammation is an innate immunological response of the central nervous system that may be induced by a brain insult and chronic neurodegenerative conditions. Recent research has shown that neuroinflammation may contribute to the initiation of Alzheimer's disease (AD) pathogenesis and associated epileptogenesis.

    OBJECTIVE: This systematic review aimed to investigate the available literature on the shared molecular mechanisms of neuroinflammation in AD and epilepsy.

    METHODS: The search included in this systematic review was obtained from 5 established databases. A total of 2,760 articles were screened according to inclusion criteria. Articles related to the modulation of the inflammatory biomarkers commonly associated with the progression of AD and epilepsy in all populations were included in this review.

    RESULTS: Only 7 articles met these criteria and were chosen for further analysis. Selected studies include both in vitro and in vivo research conducted on rodents. Several neuroinflammatory biomarkers were reported to be involved in the cross-talk between AD and epilepsy.

    CONCLUSION: Neuroinflammation was directly associated with the advancement of AD and epilepsy in populations compared to those with either AD or epilepsy. However, more studies focusing on common inflammatory biomarkers are required to develop standardized monitoring guidelines to prevent the manifestation of epilepsy and delay the progression of AD in patients.

    Matched MeSH terms: Brain/pathology
  6. Changes in the tissues adjacent to oral squamous cell carcinomas
    Yeow CS
    Dent J Malaysia Singapore, 1973 May;13(1):51-62.
    PMID: 4521126
    Matched MeSH terms: Carcinoma, Squamous Cell/pathology; Connective Tissue/pathology; Epithelium/pathology
  7. Intracranial calcifications. II. Pathologic anatomy
    Arumugasamy N
    Med J Malaya, 1966 Dec;21(2):149-60.
    PMID: 4227386
    Matched MeSH terms: Brain Diseases/pathology*; Brain Neoplasms/pathology*; Calcinosis/pathology*
  8. Abstracts of the 5th International Academy of Pathology Malaysian Division, Annual Scientific Meeting 2018: Mediastinal and Breast Pathology
    Malays J Pathol, 2018 Dec;40(3):373-387.
    PMID: 30580371
    No abstract available.
    Matched MeSH terms: Breast Neoplasms/pathology*; Mediastinal Neoplasms/pathology*; Pathology
  9. Synchronous occurrence of neuroblastic tumour and exocrine carcinoma of the pancreas in a child
    Denize T, Irtan S, Tabone MD, Coulomb A, Gharbi S, Ducou Le Pointe H, et al.
    Pathology, 2023 Oct;55(6):890-892.
    PMID: 37393145 DOI: 10.1016/j.pathol.2023.03.015
    Matched MeSH terms: Abdomen/pathology; Pancreas/pathology
  10. Fulltext Images in clinical medicine. Nevus comedonicus
    Bhullar A, Shamsudin N
    N Engl J Med, 2015 Jun 25;372(26):2541.
    PMID: 26107054 DOI: 10.1056/NEJMicm1406555
    Matched MeSH terms: Back/pathology; Hamartoma/pathology*; Nevus/pathology*; Skin Neoplasms/pathology*
  11. Atypical peripheral ameloblastoma of the palate
    Siar CH, Ng KH, Ngui CH, Chuah CH
    J Laryngol Otol, 1990 Mar;104(3):252-4.
    PMID: 2341785
    Clinical, radiological and histological characteristics of the peripheral ameloblastoma are briefly outlined. A case found occurring in the palate and presenting with atypical histological features is reported. The differential diagnosis of this lesion, its treatment and histogenesis are discussed.
    Matched MeSH terms: Ameloblastoma/pathology*; Mucous Membrane/pathology; Palatal Neoplasms/pathology*; Palate/pathology*
  12. A case of acantholytic dermatosis of the vulva with features of pemphigus vegetans
    Wong KT, Wong KK
    J Cutan Pathol, 1994 Oct;21(5):453-6.
    PMID: 7868757
    We report an unusual case of vulvar acantholytic dermatosis with features of pemphigus vegetans in a 22-year-old Indian girl who presented with a "warty" lesion in her left labium majus. Following excision of this lesion, she presented with 2 localized recurrent lesions on the left and right labia majora about 2 1/2 years later which were also excised. All 3 biopsies showed histological features typical of pemphigus which included extensive suprabasal acantholysis with bullae formation, prominent villus-like processes at the base of the bullae, focal hyperkeratosis and papillomatosis, and the occasional mixed neutrophil and eosinophilic intraepidermal abscess. IgG and C3 immunofluorescence was positive in the intercellular spaces of the epidermis. These lesions, which probably represent a form of pemphigus vegetans, have not been previously reported as a cause of localized vulvar acantholytic dermatosis.
    Matched MeSH terms: Acantholysis/pathology*; Pemphigus/pathology*; Vulva/pathology; Vulvar Diseases/pathology*
  13. Lightning fatality with blast, flame, heat and current effects: a macroscopic and microscopic view
    Murty OP
    J Forensic Leg Med, 2009 Apr;16(3):162-7.
    PMID: 19239970 DOI: 10.1016/j.jflm.2008.07.009
    A case is presented of a fatal environmental accidental injuries of lightning. A pedestrian was struck by lightning. The macroscopic and microscopic lightning injuries are reviewed.
    Matched MeSH terms: Brain Edema/pathology; Burns/pathology; Hemorrhage/pathology; Intestines/pathology; Liver/pathology; Lung/pathology; Myocardium/pathology; Spleen/pathology; Lightning Injuries/pathology*; Forensic Pathology
  14. Multiple milia in a newborn with congenital malformations: oral-facial-digital syndrome type 1
    Nanda A, Sharaf A, Alsaleh QA
    Pediatr Dermatol, 2011 4 22;27(6):669-70.
    PMID: 21510010
    Oral-facial-digital syndrome type 1 (OMIM #311200) is an X-linked dominant, developmental disorder. Among the 13 described clinical variants of oral-facial-digital syndrome, oral-facial-digital syndrome type 1 is of significance to dermatologists due to presence of congenital milia and hypotrichosis, not described in other variants. Since oral-facial-digital syndrome type 1 is genetically a distinct entity, awareness of these features help to clinically delineate this from other variants.
    Matched MeSH terms: Cleft Palate/pathology*; Epidermal Cyst/pathology*; Hand Deformities, Congenital/pathology*; Hypotrichosis/pathology*; Orofaciodigital Syndromes/pathology
  15. One patient, two lymphomas, three primaries
    Eshra A, Al-Hendal A, Al Enezi M, Al-Mishaan M, Abo Dief W
    Gulf J Oncolog, 2010 Jul.
    PMID: 20601338
    Concomitant adenocarcinoma and non-Hodgkin's lymphoma, both located in the intestinal tract, are unusual. Collision tumors of the colon on the other hand are extremely rare neoplasms. A case of true collision tumor of a marginal zone lymphoma and a moderately differentiated adenocarcinoma of the ascending colon (hepatic flexure) is reported. Simultaneously, a third primary is identified as follicular lymphoma involving the terminal ileum. Correlation with clinical history, radiology investigations, endoscopic findings and histological examination of the resected specimen as well as the use of ancillary techniques such as immunohistochemistry are the most useful in making the correct diagnosis of a synchronous three primaries involving the small bowel and colon. Therefore, we present these three primary synchronous neoplasms involving two different parts of the gastrointestinal tract, with two of these three primaries colliding at one organ.
    Matched MeSH terms: Adenocarcinoma/pathology*; Colonic Neoplasms/pathology*; Ileal Neoplasms/pathology*; Lymphoma, Non-Hodgkin/pathology*; Neoplasms, Multiple Primary/pathology*
  16. Fulltext Synchronous adenocarcinoma of caecum, transverse colon and jejunum
    Leong BD, Ramu P, Kumar VM, Chuah JA
    Med J Malaysia, 2008 Jun;63(2):148-9.
    PMID: 18942304 MyJurnal
    Synchronous cancers are defined as malignant tumours that occur simultaneously, each of which must be distinct with no possibility of one being the metastasis of the other. A 65 year old gentleman presented to us with two month history of epigastric pain associated with anaemia, loss of appetite and weight. He has no history of malignancy in his family. Colonoscopy revealed tumours at transverse colon and caecum. Intra-operatively, tumours were sited at caecum, transverse colon and jejunum. Tumours were diagnosed as synchronous adenocarcinoma histopathologically with loss of expression of MLH1 and MSH2. From literature search, this is the first reported triple synchronous tumours of the caecum, transverse colon and jejunum. We believe that this gentleman developed triple synchronous tumour through the sporadic MSI pathway.
    Matched MeSH terms: Adenocarcinoma/pathology*; Cecal Neoplasms/pathology*; Colonic Neoplasms/pathology*; Jejunal Neoplasms/pathology*; Neoplasms, Multiple Primary/pathology*
  17. Cellular protrusions--lamellipodia, filopodia, invadopodia and podosomes--and their roles in progression of orofacial tumours: current understanding
    Alblazi KM, Siar CH
    Asian Pac J Cancer Prev, 2015;16(6):2187-91.
    PMID: 25824735
    BACKGROUND: Protrusive structures formed by migrating and invading cells are termed lamellipodia, filopodia, invadopodia and podosomes. Lamellipodia and filopodia appear on the leading edges of migrating cells and function to command the direction of the migrating cells. Invadopodia and podosomes are special F-actin-rich matrix-degrading structures that arise on the ventral surface of the cell membrane. Invadopodia are found in a variety of carcinomatous cells including squamous cell carcinoma of head and neck region whereas podosomes are found in normal highly motile cells of mesenchymal and myelomonocytic lineage. Invadopodia-associated protein markers consisted of 129 proteins belonging to different functional classes including WASP, NWASP, cortactin, Src kinase, Arp 2/3 complex, MT1-MMP and F-actin. To date, our current understanding on the role(s) of these regulators of actin dynamics in tumors of the orofacial region indicates that upregulation of these proteins promotes invasion and metastasis in oral squamous cell carcinoma, is associated with poor/worst prognostic outcome in laryngeal cancers, contributes to the persistent growth and metastasis characteristics of salivary gland adenoid cystic carcinoma, is a significant predictor of increased cancer risk in oral mucosal premalignant lesions and enhances local invasiveness in jawbone ameloblastomas.
    Matched MeSH terms: Podosomes/pathology; Facial Neoplasms/pathology*; Mouth Neoplasms/pathology*; Pseudopodia/pathology; Cell Surface Extensions/pathology*
  18. Peripheral odontogenic fibroma with clear cell odontogenic epithelium
    Siar CH, NG KH
    J N Z Soc Periodontol, 1995.
    PMID: 9227094
    The clinical and histological features of the peripheral odontogenic fibroma are briefly outlined. A case arising from the attached lingual gingiva between the mandibular right permanent first molar and the second molar in a 67 year old Indian female is reported here. The unusual occurrence of marked clear cell differentiation within the odontogenic epithelial component, and histogenetic link to the clear cell rests of the dental lamina and surface epithelium are discussed.
    Matched MeSH terms: Cytoplasm/pathology; Epithelium/pathology; Fibroma/pathology*; Gingival Neoplasms/pathology*; Odontogenic Tumors/pathology*
  19. Fulltext Erythema nodosum leprosum in Malaysians
    Jayalakshmi P, Ganesapillai T, Ganesan J
    Int. J. Lepr. Other Mycobact. Dis., 1995 Mar;63(1):109-11.
    PMID: 7730709
    Matched MeSH terms: Erythema Nodosum/pathology*; Granuloma/pathology; Neutrophils/pathology; Skin/pathology; Leprosy, Lepromatous/pathology*
  20. Fulltext Traumatic neuroma in wall of recurrent unicystic ameloblastoma: a case report
    Zain R, Ling KC
    Med J Malaysia, 1985 Mar;40(1):49-51.
    PMID: 3831736
    This is a case report of a recurrent lesion diagnosed histologically as a unicystic ameloblastoma. The concomitant presence of a traumatic neuroma was observed within the wall of the recurrent lesion. The mode of development of the traumatic neuroma, and the reason for the recurrence were presented.
    Matched MeSH terms: Ameloblastoma/pathology*; Mandible/pathology*; Mandibular Neoplasms/pathology*; Neoplasm Recurrence, Local/pathology*; Neuroma/pathology*
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