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Fabrication of Ni/TiO2 visible light responsive photocatalyst for decomposition of oxytetracycline

Park J, Lam SS, Park YK, Kim BJ, An KH, Jung SC

Environ Res, 2023 Jan 01;216(Pt 3):114657.
PMID: 36328223 DOI: 10.1016/j.envres.2022.114657

Nickel-impregnated TiO2 photocatalyst (NiTP) responding to visible light was prepared by the liquid phase plasma (LPP) method, and its photoactivity was evaluated in degrading an antibiotic (oxytetracycline, OTC). For preparing the photocatalyst, nickel was uniformly impregnated onto TiO2 (P-25) powder, and the nickel content increased as the number of LPP reactions increased. In addition, the morphology and lattice of NiTP were observed through various instrumental analyses, and it was confirmed that NiO-type nanoparticles were impregnated in NiTP. Fundamentally, as the amount of impregnated nickel in the TiO2 powder increased sufficiently, the band gap energy of TiO2 decreased, and eventually, the NiTP excited by visible light was synthesized. Further, OTC had a decomposition reaction pathway in which active radicals generated in OTC photocatalytic reaction under NiTP were finally mineralized through reactions such as decarboxamidation, hydration, deamination, demethylation, and dehydroxylation. In effect, we succeeded in synthesizing a photocatalyst useable under visible light by performing only the LPP single process and developed a new advanced oxidation process (AOP) that can remove toxic antibiotics.

Matched MeSH terms: Oxytetracycline*
Hypersensitivity reactions due to tetracyclines

Diong KI

Med J Malaya, 1972 Dec;27(2):134-5.
PMID: 4268039
Matched MeSH terms: Oxytetracycline/adverse effects*
Fulltext Bleomycin and oxytetracycline sclerotherapy for malignant pleural effusions

Liam CK, Lim KH, Wong CMM

Med J Malaysia, 2000 Jun;55(2):283-4.
PMID: 19839164
Matched MeSH terms: Oxytetracycline/therapeutic use*
Effect of different oxytetracycline addition methods on its degradation behavior in soil

Chen GX, He WW, Wang Y, Zou YD, Liang JB, Liao XD, et al.

Sci Total Environ, 2014 May 1;479-480:241-6.
PMID: 24561929 DOI: 10.1016/j.scitotenv.2014.01.124

The degradation behavior of veterinary antibiotics in soil is commonly studied using the following methods of adding antibiotics to the soil: (i) adding manure collected from animals fed with a diet containing antibiotics, (ii) adding antibiotic-free animal manure spiked with antibiotics and (iii) directly adding antibiotics. No research simultaneously comparing different antibiotic addition methods was found. Oxytetracycline (OTC) was used as a model antibiotic to compare the effect of the three commonly used antibiotic addition methods on OTC degradation behavior in soil. The three treatment methods have similar trends, though OTC degradation half-lives show the following significant differences (P<0.05): manure from swine fed OTC (treatment A)

Matched MeSH terms: Oxytetracycline/analysis; Oxytetracycline/chemistry*
Hierarchically structured ternary heterojunctions based on Ce3+/ Ce4+ modified Fe3O4 nanoparticles anchored onto graphene oxide sheets as magnetic visible-light-active photocatalysts for decontamination of oxytetracycline

Hassandoost R, Pouran SR, Khataee A, Orooji Y, Joo SW

J Hazard Mater, 2019 08 15;376:200-211.
PMID: 31128399 DOI: 10.1016/j.jhazmat.2019.05.035

The main prerequisite of an active visible-light-driven photocatalyst is to effectively utilize the visible light to induce electron-hole (e-/h+) pairs of expanded lifetime. To this end, for the first time, the ternary heterojunctions of CeO2/Fe3O4 /Graphene oxide and Ce3+/ Fe3O4 /Graphene oxide (CeO2/Fe3O4/GO and Fe2.8Ce0.2O4/GO) were prepared via facile ultrasonic-assisted procedures and employed for destruction of oxytetracycline (OTC) under visible light irradiation. The changes in the relative crystal structure, morphology, atomic and surface functional group composition, magnetic, and optic properties of magnetite were uncovered by various techniques. The substantial degradation and mineralization of OTC via visible light/Fe2.8Ce0.2O4/GO system were thoroughly discussed in terms of narrowed band gap energy, the principal function of Ce3+/Ce4+ and Fe2+/Fe3+ redox pairs and GO platelets, enhanced charge separation and transfer, and enlarged active surface area. Furthermore, the performance of visible light/Fe2.8Ce0.2O4/GO system was evaluated for treating real wastewater and its efficiency was investigated using a number of enhancers and scavengers. Finally, the generated byproducts in the course of photodegradation were determined and the oxidation pathway, photocatalytic kinetics, and plausible mechanism were proposed. The results confirmed that the introduced Ce ions and graphene oxide sheets boost the photo-catalytic efficiency of magnetite for photodegradation of OTC.

Matched MeSH terms: Oxytetracycline/analysis*
Comparison of oxytetracycline degradation behavior in pig manure with different antibiotic addition methods

Wang Y, Chen G, Liang J, Zou Y, Wen X, Liao X, et al.

Environ Sci Pollut Res Int, 2015 Dec;22(23):18469-76.
PMID: 26278905 DOI: 10.1007/s11356-015-5170-7

Using manure collected from swine fed with diet containing antibiotics and antibiotic-free swine manure spiked with antibiotics are the two common methods of studying the degradation behavior of veterinary antibiotic in manure in the environment. However, few studies had been conducted to co-compare these two different antibiotic addition methods. This study used oxytetracycline (OTC) as a model antibiotic to study antibiotic degradation behavior in manure under the above two OTC addition methods. In addition, the role of microorganisms present in the manure on degradation behavior was also examined. The results showed that degradation half-life of OTC in manure from swine fed OTC (9.04 days) was significantly shorter than that of the manure directly treated with OTC (9.65 days). Concentration of 4-epi-OTC in manure from swine fed OTC peaked earlier than that in manure spiked with OTC, and the degradation rates of 4-epi-OTC and α-apo-OTC in the manure from swine fed OTC were faster, but the peak concentrations were lower, than those in manure spiked with OTC. Bacterial diversity and relative abundance of Bacillus cereus data demonstrated that sterilization of the manure before experiment significantly decreased OTC degradation rate in both of the addition methods. Results of the present study demonstrated that the presence of the metabolites (especially 4-epi-OTC) and microorganisms had significant influence on OTC degradation.

Matched MeSH terms: Oxytetracycline/analysis*
Fulltext Bioguided Fractionation of Local Plants against Matrix Metalloproteinase9 and Its Cytotoxicity against Breast Cancer Cell Models: In Silico and In Vitro Study (Part II)

Hariono M, Rollando R, Yoga I, Harjono A, Suryodanindro A, Yanuar M, et al.

Molecules, 2021 Mar 08;26(5).
PMID: 33800366 DOI: 10.3390/molecules26051464

In our previous work, the partitions (1 mg/mL) of Ageratum conyzoides (AC) aerial parts and Ixora coccinea (IC) leaves showed inhibitions of 94% and 96%, respectively, whereas their fractions showed IC50 43 and 116 µg/mL, respectively, toward Matrix Metalloproteinase9 (MMP9), an enzyme that catalyzes a proteolysis of extracellular matrix. In this present study, we performed IC50 determinations for AC n-hexane, IC n-hexane, and IC ethylacetate partitions, followed by the cytotoxicity study of individual partitions against MDA-MB-231, 4T1, T47D, MCF7, and Vero cell lines. Successive fractionations from AC n-hexane and IC ethylacetate partitions led to the isolation of two compounds, oxytetracycline (OTC) and dioctyl phthalate (DOP). The result showed that AC n-hexane, IC n-hexane, and IC ethylacetate partitions inhibit MMP9 with their respective IC50 as follows: 246.1 µg/mL, 5.66 µg/mL, and 2.75 × 10-2 µg/mL. Toward MDA-MB-231, 4T1, T47D, and MCF7, AC n-hexane demonstrated IC50 2.05, 265, 109.70, and 2.11 µg/mL, respectively, whereas IC ethylacetate showed IC50 1.92, 57.5, 371.5, and 2.01 µg/mL, respectively. The inhibitions toward MMP9 by OTC were indicated by its IC50 18.69 µM, whereas DOP was inactive. A molecular docking study suggested that OTC prefers to bind to PEX9 rather than its catalytic domain. Against 4T1, OTC showed inhibition with IC50 414.20 µM. In conclusion, this study furtherly supports the previous finding that AC and IC are two herbals with potential to be developed as triple-negative anti-breast cancer agents.

Matched MeSH terms: Oxytetracycline/isolation & purification; Oxytetracycline/chemistry
Fulltext Antibiotic resistance profiling and phenotyping of Aeromonas species isolated from aquatic sources

Odeyemi OA, Ahmad A

Saudi J Biol Sci, 2017 Jan;24(1):65-70.
PMID: 28053573 DOI: 10.1016/j.sjbs.2015.09.016

This study aimed to investigate antibiotics resistance pattern and phenotyping of Aeromonas species isolated from different aquatic sources in Melaka, Malaysia. A total of 53 Aeromonas species were isolated from the following sources: sediment (n = 13), bivalve (n = 10), sea cucumber (n = 16) and sea water (n = 14) and resistance to 12 antibiotics - Tetracycline (30 μg), Kanamycin (30 μg), Oxytetracycline (30 μg), Ampicillin (10 μg), Streptomycin (10 μg), Gentamicin (10 μg), Sulphamethoxazole (25 μg), Nalixidic acid (30 μg), Trimethoprim (1.25 μg), Novobiocin (5 μg), Penicilin (10 μg) and Chloramphenicol (10 μg) was tested. The results obtained from this study reveal multi drug resistance pattern among the isolates. All the isolates were completely resistant to Ampicillin, Novobiocin, Sulphamethoxazole and Trimethoprim, respectively but susceptible to Tetracycline (100%), Kanamycin (5.7%), Gentamicin (5.7%) and Oxytetracycline (24.5%). Antibiotics phenotyping of the bacteria revealed 21 different phenotypes among the isolates.

Matched MeSH terms: Oxytetracycline
Fulltext Dietary Supplementation of Postbiotics Mitigates Adverse Impacts of Heat Stress on Antioxidant Enzyme Activity, Total Antioxidant, Lipid Peroxidation, Physiological Stress Indicators, Lipid Profile and Meat Quality in Broilers

Humam AM, Loh TC, Foo HL, Izuddin WI, Awad EA, Idrus Z, et al.

Animals (Basel), 2020 Jun 05;10(6).
PMID: 32516896 DOI: 10.3390/ani10060982

The purpose of this work was to evaluate the impacts of feeding different postbiotics on oxidative stress markers, physiological stress indicators, lipid profile and meat quality in heat-stressed broilers. A total of 252 male Cobb 500 (22-day-old) were fed with 1 of 6 diets: A basal diet without any supplementation as negative control (NC); basal diet + 0.02% oxytetracycline served as positive control (PC); basal diet + 0.02% ascorbic acid (AA); or the basal diet diet + 0.3% of RI11, RS5 or UL4 postbiotics. Postbiotics supplementation, especially RI11 increased plasma activity of total-antioxidant capacity (T-AOC), catalase (CAT) and glutathione (GSH), and decreased alpha-1-acid-glycoprotein (α1-AGP) and ceruloplasmin (CPN) compared to NC and PC groups. Meat malondialdehyde (MDA) was lower in the postbiotic groups than the NC, PC and AA groups. Plasma corticosterone, heat shock protein70 (HSP70) and high density lipoprotein (HDL) were not affected by dietary treatments. Postbiotics decreased plasma cholesterol concentration compared to other groups, and plasma triglyceride and very low density lipoprotein (VLDL) compared to the NC group. Postbiotics increased breast meat pH, and decreased shear force and lightness (L*) compared to NC and PC groups. The drip loss, cooking loss and yellowness (b*) were lower in postbiotics groups compared to other groups. In conclusion, postbiotics particularly RI11 could be used as an alternative to antibiotics and natural sources of antioxidants for heat-stressed broilers.

Matched MeSH terms: Oxytetracycline
Fulltext Antibiotic and heavy metal resistance of Aeromonas hydrophila and Edwardsiella tarda isolated from red hybrid tilapia (Oreochromis spp.) coinfected with motile aeromonas septicemia and edwardsiellosis

Lee SW, Wendy W

Vet World, 2017 Jul;10(7):803-807.
PMID: 28831226 DOI: 10.14202/vetworld.2017.803-807

AIM: The aim of this study is to identify antibiogram and heavy metal resistance pattern of Aeromonas hydrophila and Edwardsiella tarda isolated from red hybrid tilapia (Oreochromis spp.) coinfected with motile aeromonas septicemia and edwardsiellosis in four commercial fish farms.
MATERIALS AND METHODS: A. hydrophila and E. tarda were isolated using glutamate starch phenol red and xylose lysine deoxycholate (Merck, Germany) as a selective medium, respectively. All the suspected bacterial colonies were identified using conventional biochemical tests and commercial identification kit (BBL Crystal, USA). Susceptibility testing of present bacterial isolates to 16 types of antibiotics (nalidixic acid, oxolinic acid, compound sulfonamides, doxycycline, tetracycline, novobiocin, chloramphenicol, kanamycin, sulfamethoxazole, flumequine, erythromycin, ampicillin, spiramycin, oxytetracycline, amoxicillin, and fosfomycin) and four types of heavy metals (mercury, chromium, copper, and zinc) were carried out using disk diffusion and two-fold agar dilution method, respectively.
RESULTS: Three hundred isolates of A. hydrophila and E. tarda were successfully identified by biochemical tests. Antibiotic susceptibility testing results showed that 42.2% of the bacterial isolates were sensitive to compound sulfonamides, sulfamethoxazole, flumequine, oxytetracycline, doxycycline, and oxolinic acid. On the other hand, 41.6% of these isolates were resistant to novobiocin, ampicillin, spiramycin, and chloramphenicol, which resulted for multiple antibiotic resistance index values 0.416. Among tested heavy metals, bacterial isolates exhibited resistant pattern of Zn(2+) > Cr(6+) > Cu(2+) > Hg(2+).
CONCLUSION: Results from this study indicated that A. hydrophila and E. tarda isolated from coinfected farmed red hybrid tilapia were multi-resistant to antibiotics and heavy metals. These resistant profiles could be useful information to fish farmers to avoid unnecessary use of antimicrobial products in the health management of farmed red hybrid tilapia.

Matched MeSH terms: Oxytetracycline
Growth performance and immune response of two commercial broiler strains fed diets containing Lactobacillus cultures and oxytetracycline under heat stress conditions

Zulkifli I, Abdulllah N, Azrin NM, Ho YW

Br Poult Sci, 2000 Dec;41(5):593-7.
PMID: 11201439

1. Hubbard x Hubbard (HH) and Shaver x Shaver (SS) chicks given a dietary supplement of either 50 mg/kg oxytetracycline (OTC) or 1 g/kg Lactobacillus culture (LC) were exposed to 36 +/- 1 degrees C for 3 h daily from day (d) 21 to 42. 2. Prior to heat treatment, body weight (d 21) and weight gain (d 1 to d 21) of OTC and LC birds were greater than those fed the control diet. Chicks given LC had the best food efficiency followed by OTC and control birds during d 1 to d 21. Body weight (d 1 and d 21) and weight gain (d 1 to d 21) were greater for HH tlhan SS chicks. 3. After 3 weeks of heat exposure, birds receiving the LC diet had greater body weight and weight gain, higher food intake and lower food efficiency than OTC and control chicks. 4. Antibody production against Newcastle discase vaccine on d 21 was not affected by strain or diet. On d 42, while diet had negligible effect on this variable among the SS broilers, HH birds fed LC had higher antibody production than those on the control diet. 5. Neither strain nor diet had a significant effect on mortality.

Matched MeSH terms: Oxytetracycline/immunology; Oxytetracycline/pharmacology*
Fulltext Phenotypic and genetic characterizations of Streptococcus dysgalactiae strains isolated from fish collected in Japan and other Asian countries

Abdelsalam M, Chen SC, Yoshida T

FEMS Microbiol Lett, 2010 Jan;302(1):32-8.
PMID: 19895643 DOI: 10.1111/j.1574-6968.2009.01828.x

Lancefield group C Streptococcus dysgalactiae is an emerging fish pathogen, which was first isolated in 2002 in Japan. Streptococcus dysgalactiae isolates collected from diseased fish in Japan (n=12), Taiwan (n=12), China (n=2), Malaysia (n=3), and Indonesia (n=1) were characterized using biased sinusoidal field gel electrophoresis (BSFGE), sodA gene sequence analysis, and antimicrobial susceptibility. These isolates exhibited high phenotypic homogeneity irrespective of the countries from where the strains were collected. Seventeen isolates were found to be resistant to oxytetracycline and carried the tet(M) gene, except for the strains collected in Taiwan and the PP1564 strain collected in China. The sodA gene sequence analysis revealed that 23 isolates were identical, except for one Japanese isolate (KNH07902), in which a single nucleotide differed from that of the other isolates. Based on BSFGE typing by ApaI macrorestriction, the isolates - including the Japanese, Taiwanese, and Chinese isolates - could be grouped into one main cluster at a 70% similarity level. However, the macrorestriction genotypes of some isolates were apparently distinct from those of the main cluster.

Matched MeSH terms: Oxytetracycline/pharmacology
The control of haemorrhagic septicaemia in West Malaysia

Thomas J

Trop Anim Health Prod, 1972;4(2):95-101.
PMID: 4671395
Matched MeSH terms: Oxytetracycline/therapeutic use
Salmon poisoning disease in two Malayan sun bears

Gai JJ, Marks SL

J Am Vet Med Assoc, 2008 Feb 15;232(4):586-8.
PMID: 18279100 DOI: 10.2460/javma.232.4.586

2 captive sun bears (Helarctos malayanus) were evaluated because of acute onset of vomiting, mucoid diarrhea, lethargy, and anorexia 1 week after eating live trout from a northern California reservoir.

Matched MeSH terms: Oxytetracycline/therapeutic use
Fulltext Identification of Risk Factors Associated with Resistant Escherichia coli Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross Sectional Study

Elmi SA, Simons D, Elton L, Haider N, Abdel Hamid MM, Shuaib YA, et al.

Antibiotics (Basel), 2021 Jan 26;10(2).
PMID: 33530462 DOI: 10.3390/antibiotics10020117

Antimicrobial resistance is of concern to global health security worldwide. We aimed to identify the prevalence, resistance patterns, and risk factors associated with Escherichia coli (E. coli) resistance from poultry farms in Kelantan, Terengganu, and Pahang states of east coast peninsular Malaysia. Between 8 February 2019 and 23 February 2020, a total of 371 samples (cloacal swabs = 259; faecal = 84; Sewage = 14, Tap water = 14) were collected. Characteristics of the sampled farms including management type, biosecurity, and history of disease were obtained using semi-structured questionnaire. Presumptive E. coli isolates were identified based on colony morphology with subsequent biochemical and PCR confirmation. Susceptibility of isolates was tested against a panel of 12 antimicrobials and interpreted alongside risk factor data obtained from the surveys. We isolated 717 E. coli samples from poultry and environmental samples. Our findings revealed that cloacal (17.8%, 46/259), faecal (22.6%, 19/84), sewage (14.3%, 2/14) and tap water (7.1%, 1/14) were significantly (p < 0.003) resistant to at least three classes of antimicrobials. Resistance to tetracycline class were predominantly observed in faecal samples (69%, 58/84), followed by cloacal (64.1%, 166/259), sewage (35.7%, 5/14), and tap water (7.1%, 1/84), respectively. Sewage water (OR = 7.22, 95% CI = 0.95-151.21) had significant association with antimicrobial resistance (AMR) acquisition. Multivariate regression analysis identified that the risk factors including sewage samples (OR = 7.43, 95% CI = 0.96-156.87) and farm size are leading drivers of E. coli antimicrobial resistance in the participating states of east coast peninsular Malaysia. We observed that the resistance patterns of E. coli isolates against 12 panel antimicrobials are generally similar in all selected states of east coast peninsular Malaysia. The highest prevalence of resistance was recorded in tetracycline (91.2%), oxytetracycline (89.1%), sulfamethoxazole/trimethoprim (73.1%), doxycycline (63%), and sulfamethoxazole (63%). A close association between different risk factors and the high prevalence of antimicrobial-resistant E. coli strains reflects increased exposure to resistant bacteria and suggests a concern over rising misuse of veterinary antimicrobials that may contribute to the future threat of emergence of multidrug-resistant pathogen isolates. Public health interventions to limit antimicrobial resistance need to be tailored to local poultry farm practices that affect bacterial transmission.

Matched MeSH terms: Oxytetracycline
Fulltext Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice

Idris SB, Abdul Kadir A, Abdullah JFF, Ramanoon SZ, Basit MA, Abubakar MZZA

Front Vet Sci, 2020;7:270.
PMID: 32613011 DOI: 10.3389/fvets.2020.00270

The development and utilization of nano-antibiotics is currently gaining attention as a possible solution to antibiotic resistance. The aim of this study was therefore to determine the pharmacokinetics of free oxytetracycline (OTC) and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle (OTC-CNP) after a single dose of intraperitoneal (IP) administration in BALB/c mice. A total of 100 female BALB/c mice divided into two groups of equal number (n = 50) were administered with 10 mg/kg OTC and OTC-CNP, respectively. Blood samples were collected before and post-administration from both groups at time 0, 5, 10, 15, and 30 min and 1, 2, 6, 24, and 48 h, and OTC plasma concentration was quantified using a validated HPLC-UV method. The pharmacokinetic parameters were analyzed using a non-compartment model. The Cmax values of OTC in OTC-CNP and free OTC treated group were 64.99 and 23.53 μg/ml, respectively. OTC was detected up to 24 h in the OTC-CNP group as against 1 h in the free OTC group following intraperitoneal administration. In the OTC-CNP group, the plasma elimination rate of OTC was slower while the half-life, the area under the curve, and the volume of the distribution were increased. In conclusion, the pharmacokinetic profile of OTC in the OTC-CNP group differs significantly from that of free OTC. However, further studies are necessary to determine the antibacterial efficacy of OTC-CNP for the treatment of bacterial diseases.

Matched MeSH terms: Oxytetracycline
First report of equine Setaria digitata (von Linstow 1906) infestation in Malaysia

Peng TL, Armiladiana MM, Ruhil HH, Maizan M, Choong SS

Vet Parasitol Reg Stud Reports, 2019 08;17:100310.
PMID: 31303218 DOI: 10.1016/j.vprsr.2019.100310

The occurrence of Setaria digitata in a horse is reported for the first time in Malaysia. An 8-year-old Thoroughbred cross mare was referred to the University Veterinary Clinic with the primary complaint of corneal opacity and excessive eye discharge. After initial treatment with Terramycin eye ointment, corneal opacity cleared partially to reveal a moving thread-like cylindrical worm in the anterior chamber of the eye. The parasite was successfully removed surgically, and examination under the light microscope revealed that the isolated worm (length = 45 mm) was a 5th stage larva of S. digitata based on morphological criteria. Confirmation of the species of the worm was through molecular methods. The 12S rRNA gene was PCR-amplified, and the purified amplicon was directly sequenced. Phylogenetic analyses revealed that the isolated roundworm showed 100% sequence similarity with that of S. digitata in NCBI GenBank database (Accession no.: KY284626.1). This report is the first confirmed case of equine ocular setariasis by S. digitata in Malaysia. The current study provides evidence that S. digitata is an etiological agent of ocular infection and its presence in Malaysia.

Matched MeSH terms: Oxytetracycline/therapeutic use

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