Displaying publications 1 - 20 of 214 in total

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  1. Hajizadeh A, Heath L, Ahmad A, Kebbe M, Jebb SA, Aveyard P, et al.
    Soc Sci Med, 2023 Jul;329:115997.
    PMID: 37327596 DOI: 10.1016/j.socscimed.2023.115997
    Clinical trials have shown that providing advice and support for people with excess weight can lead to meaningful weight loss. Despite this evidence and guidelines endorsing this approach, provision in real-world clinical settings remains low. We used Strong Structuration Theory (SST) to understand why people are often not offered weight management advice in primary care in England. Data from policy, clinical practice and focus groups were analysed using SST to consider how the interplay between weight stigma and structures of professional responsibilities influenced clinicians to raise (or not) the issue of excess weight with patients. We found that general practitioners (GPs) often accounted for their actions by referring to obesity as a health problem, consistent with policy documents and clinical guidelines. However, they were also aware of weight stigma as a social process that can be internalised by their patients. GPs identified addressing obesity as a priority in their work, but described wanting to care for their patients by avoiding unnecessary suffering, which they were concerned could be caused by talking about weight. We observed tensions between knowledge of clinical guidelines and understanding of the lived experience of their patients. We interpreted that the practice of 'caring by not offering care' produced the outcome of an absence of weight management advice in consultations. There is a risk that this outcome reinforces the external structure of weight stigma as a delicate topic to be avoided, while at the same time denying patients the offer of support to manage their weight.
    Matched MeSH terms: Weight Loss*
  2. Lua PL, Roslim NA, Ahmad A, Mansor M, Aung MMT, Hamzah F
    J Evid Based Integr Med, 2021 9 10;26:2515690X211043738.
    PMID: 34496677 DOI: 10.1177/2515690X211043738
    Despite various strategies, overweight and obesity problems are still increasingly prevalent worldwide with serious health outcomes. Consequently, the continuous demand for more effective, safe and acceptable therapies for reducing body weight is also escalating-including complementary and alternative therapies (CATs). The aim of this review is to provide a summary of the most commonly- and recently-used CATs, with evaluation of their safety and efficacy for weight loss. Electronic scientific databases such as Scopus, PubMed and EBSCO Host were explored for articles that reported CATs for overweight and obesity treatment from 2015 to December 2019. Only systematic reviews, meta-analysis and randomized controlled trials (RCTs) published in English were included. Studies whereby CATs were not utilized for reducing body weight were excluded. Eight systematic reviews and meta-analyses and 11 additional RCTs with 765 participants (50.2% overweight and 49.8% obese) related to hypnotherapy, acupuncture and dietary supplements met the inclusion criteria. Their results suggested that spirulina, chitosan, probiotic, EPA + DHA, vitamin D, fiber, and herbal extract supplementation may all provide small reductions in body weight (ranging from 1-10 kg). Interestingly, hypnotherapy and acupuncture reported significantly greater reduction in body weight compared with placebo (p < 0.001 and p < 0.0001, respectively). Nonetheless, the evidence is still relatively limited and not encouraging to provide a definitive conclusion due to the methodological shortcomings and the presence of adverse events in chitosan and fiber supplementation. Hence, studies of this nature need to be further replicated and improved to corroborate the efficacy and safety of the CATs to combat weight issues.
    Matched MeSH terms: Weight Loss*
  3. Abduraman MA, Azizan NA, Teoh SH, Tan ML
    Obes Res Clin Pract, 2020 12 25;15(1):10-18.
    PMID: 33371997 DOI: 10.1016/j.orcp.2020.12.001
    Obesity is a serious chronic disease and a public health concern in both developing and developed countries. Managing obesity has been a great challenge for both health care professionals and patients alike. Among the various diet programs aimed at promoting weight loss, the ketogenic diet, a diet high in fat and low in carbohydrates, has been at the forefront recently and its mechanism in weight loss is much debated. Activation of Sirtuin 1 or SIRT1 is able to circumvent various diseases, including metabolic syndrome and obesity and is thought to be a potentially reliable treatment target for both of them. Augmentation of SIRT1 may be carried out using dietary means such as nicotinamide adenine dinucleotide (NAD) supplementation and/or ketogenic diet. Although ketogenic diet may augment SIRT1 activation in people affected by obesity, recent studies have indicated that the relationship between SIRT1 and ketogenesis is unpredictable. The exact circumstances and mechanisms of SIRT1, NAD and ketogenesis in the clinical setting as an intervention tool in managing obesity remained uncertain. Although several recent literatures have documented significant weight-loss following ketogenic diet interventions, there were limitations with regards to duration of trial, choice and the number of trial subjects. Studies investigating the safety of ketogenic diet in the long term, beyond 46 weeks and related mechanism and pathways are still lacking and the sustainability of this diet remains to be determined. This review explores the recent progress on ketogenic diet and its relationships with SIRT1 as a tool in managing obesity and relevant clinical implications.
    Matched MeSH terms: Weight Loss
  4. Wong ZY, Ramasamy P, Ingels KJAO, Parmar C, Yang W, Pouwels S, et al.
    Obes Surg, 2023 Jan;33(1):332-338.
    PMID: 36434358 DOI: 10.1007/s11695-022-06363-8
    This study aims to provide an overview of the facial features and structure after bariatric surgery in the existing literature. A systematic literature search was performed in electronic databases until 15th February 2022. Four cohort studies including 129 patients from 3 countries were included between time period 2011 and 2020. Overall, bariatric surgery would promote massive weight loss associated with positive effects on facial aging. Analysis revealed a proportional relationship between body mass index (BMI) and faster facial aging and more attractive. Undergoing bariatric surgery would result in facial skin sagging and a favorable effect on the upper airway. Bariatric surgery was found to have a significant impact on changes in facial features but the current evidence remains inconclusive and further studies are required to illustrate facial changes post-bariatric surgery.
    Matched MeSH terms: Weight Loss
  5. Ansari RM, Omar NS
    Malays J Med Sci, 2017 May;24(3):1-4.
    PMID: 28814927 DOI: 10.21315/mjms2017.24.3.1
    Dietary health supplements for weight loss seem to be the future nowadays. However, this industry is plagued by lack of regulations and ignorance regarding the constituents of the supplements. Of all the supplements consumed, the ones for weight loss are most commonly found in the market. Reports of liver failure, kidney impairment and worsening of chronic ailments in patients who consume these supplements are surfacing recently which make us question the credibility of these products. The safety of these products lie in the clear stating of the ingredients by the manufacturer, well informed patient, knowledgeable physician and tight regulations from the regulatory board.
    Matched MeSH terms: Weight Loss
  6. Rohin MA, Rozano N, Abd Hadi N, Mat Nor MN, Abdullah S, Dandinasivara Venkateshaiah M
    ScientificWorldJournal, 2013;2013:308041.
    PMID: 24311975 DOI: 10.1155/2013/308041
    This study was done to observe the anthropometry and body composition changes before, during, and after the holy month of Ramadan. This study was carried out on 46 staff from one of the local universities, which comprised of 14 males and 32 females ranging in age from 25 to 40 years old. There were four sessions done to complete this study, namely, a week before Ramadan (T1), 1st week of Ramadan (T2), 3rd week of Ramadan (T3), and a month after Ramadan (T4). All subjects were assessed according to weight, body circumference, and body composition status. It was found that subjects with different weight status showed a significant reduction in weight (P < 0.01) but no significant reduction in body fat percentage (P < 0.05). The findings suggest that weight reduction does not promise a reduction in body fat. Changes in neck circumference were only found in normal subjects. Hence, it can be said that overweight and obese subjects showed no changes in anthropometry status during Ramadan. No changes in body composition were reported in all three weight groups except for trunk body fat. In conclusion, normal subjects showed significant changes in various anthropometry parameters, but overweight and obese subjects showed no obvious difference.
    Matched MeSH terms: Weight Loss/physiology*
  7. Subramaniam K, Low WY, Lau PC, Chin KF, Chinna K, Kosai NR, et al.
    Nutrients, 2018 Nov 02;10(11).
    PMID: 30400129 DOI: 10.3390/nu10111616
    Bariatric surgery is currently the most durable weight loss solution for patients with morbid obesity. The extent of weight loss achieved, however, is subject to variation due to various factors, including patients' behaviour. In this study, we aimed to identify pre- and post-surgical predictors of weight loss following bariatric surgery. This prospective study included 57 participants who went through bariatric surgery (laparoscopic Roux-en-Y gastric bypass: n = 30; laparoscopic sleeve gastrectomy: n = 23; one anastomosis gastric bypass-mini gastric bypass: n = 4) in two tertiary referral hospitals. Consenting participants were assessed prior to surgery (T₀), and three months (T₁) and six months (T₂) after surgery. The assessment included interview and anthropometric measurements. The interview was done with the aid of instruments, including the Hospital Anxiety and Depression Scale (HADS) for anxiety and depression screening and the Dutch Eating Behaviour Questionnaire (DEBQ) for eating behaviour assessment. Baseline comorbidity status was obtained from medical records. A Generalised Estimating Equation (GEE) was developed to determine predictors of weight loss. Participants in the study were mostly women (n = 37, 65%) with a mean age of 39.4 (SD = 10.01) years. The mean excess BMI loss (EBMIL) and total weight loss (TWL) at the sixth month was 63.31% and 23.83%, respectively. Anxiety, depression, and external eating scores reduced over time. Advancing age, high BMI, and higher scores for emotional and external eating emerged as significant negative predictors for TWL%. It can be concluded that the patients experienced substantial weight loss after surgery. Continuous monitoring of psychological well-being and eating behaviour are essential for optimal weight loss.
    Matched MeSH terms: Weight Loss*
  8. Ho C, Samwil SNM, Kahairudin Z, Jamhuri N, Abd Aziz A
    Asian J Surg, 2023 Sep;46(9):3716-3721.
    PMID: 36931924 DOI: 10.1016/j.asjsur.2023.03.026
    BACKGROUND: Bariatric surgery is considered as an effective therapy for those with morbid obesity. Preoperative weight loss with a very low-calorie diet is commonly used to ease the bariatric surgery. Pre-habilitation increases functional and physiological capacity. The study demonstrated the changes of body composition and functional status following short term pre-habilitation before bariatric surgery.

    METHOD: This prospective study targeted those admitted for bariatric surgery. Participants underwent the biweekly pre-habilitation program included an individualized high whey-based protein very low-calorie (VLCHP) enteral regime (600-900 kcal/day) and moderate intensive exercise before bariatric surgery. Body composition and waist circumference were assessed after fortnight. Participants were segregated into morbid obese (MOG) (BMI <49 kg/m2) and super morbid obese group (SMOG) (BMI ≥50 kg/m2) for analysis.

    RESULT: Majority of participants were female (71%) with median age 36.0 years old (MOG) and 34.3 years old (SMOG) respectively. SMOG achieved significant greater loss in weight (-7.4 kg vs -4.0 kg), fat percentage (-4.4% vs -1.7%) and fat mass (-9.9 kg vs -3.8 kg); but MOG had a significant increment in muscle mass (3.2 kg vs 2.8 kg) as compared to SOG (p weight loss; increases muscle mass and strength; improve function status prior to bariatric surgery.

    Matched MeSH terms: Weight Loss/physiology
  9. Tang HB, Jalil NIBA, Tan CS, He L, Zhang SJ
    BMC Public Health, 2024 Jan 29;24(1):322.
    PMID: 38287333 DOI: 10.1186/s12889-024-17848-9
    BACKGROUND: Self-monitoring is crucial for behavioral weight loss. However, few studies have examined the role of self-monitoring using mixed methods, which may hinder our understanding of its impact.

    METHODS: This study examined self-monitoring data from 61 Chinese adults who participated in a 5-week online group intervention for weight loss. Participants reported their baseline Body Mass Index (BMI), weight loss motivation, and engaged in both daily quantitative self-monitoring (e.g., caloric intake, mood, sedentary behavior, etc.) and qualitative self-monitoring (e.g., daily log that summarizes the progress of weight loss). The timeliness of participants' daily self-monitoring data filling was assessed using a scoring rule. One-way repeated measurement ANOVA was employed to analyze the dynamics of each self-monitoring indicator. Correlation and regression analyses were used to reveal the relationship between baseline data, self-monitoring indicators, and weight change. Content analysis was utilized to analyze participants' qualitative self-monitoring data. Participants were categorized into three groups based on their weight loss outcomes, and a chi-square test was used to compare the frequency distribution between these groups.

    RESULTS: After the intervention, participants achieved an average weight loss of 2.52 kg (SD = 1.36) and 3.99% (SD = 1.96%) of their initial weight. Daily caloric intake, weight loss satisfaction, frequency of daily log, and the speed of weight loss showed a downward trend, but daily sedentary time gradually increased. Moreover, regression analysis showed that baseline BMI, weight loss motivation, and timeliness of daily filling predicted final weight loss. Qualitative self-monitoring data analysis revealed four categories and nineteen subcategories. A significant difference in the frequency of qualitative data was observed, with the excellent group reporting a greater number of daily logs than expected in all categories and most subcategories, and the moderate and poor groups reporting less than expected in all categories and most subcategories.

    CONCLUSION: The self-monitoring data in short-term online group intervention exhibited fluctuations. Participants with higher baseline BMI, higher levels of weight loss motivation, and timely self-monitoring achieved more weight loss. Participants who achieved greater weight loss reported a higher quantity of qualitative self-monitoring data. Practitioners should focus on enhancing dieters' weight loss motivation and promote adherence to self-monitoring practices.

    Matched MeSH terms: Weight Loss*
  10. Mior Azmai, W. N. S., Abdul Latif, N. S., Md Zain, N.
    MyJurnal
    Tomatoes require appropriate environment to stay sturdy due to earlier decay process. Deterioration causes short shelf life of tomatoes with unfavourable quality, resulting in potential rejection by customers. The objective of the study is to observe the effect of combined coatings of chitosan (Ch) and cinnamic acid (CA) in extending the tomato shelf life. Layer by layer coating of chitosan prior to the cinnamic acid (single coating for each) were applied on fresh graded tomato at two maturity stages; breaker and turning. Twelve days observations at ambient temperature with three-day intervals were recorded. Combined coating of chitosan and cinnamic acid were expected to influence firmness, TSS value, hue angle and weight loss. Results showed that a combined coating of 1.0% Ch + 3 mM CA has significant increament at breaker stage to firmness (8.26 N), hue angle (60.42%) and weight loss value (6.51%) compared to untreated tomato whereas for turning stage, the results showed there were no significant different in all parameters observed except the changes of fruit sweetness (TSS). 1.0% Ch + 4 mM CA show highest TSS value, 3.48% indicating 21% difference than untreated tomato (3.27%). Cinnamic acid helped chitosan in improving coating ability by serving better barrier from pathogen and oxidative gas penetration to prevent earlier spoilage problem.
    Matched MeSH terms: Weight Loss
  11. Sabapathy L, Mohammed BS, Al-Fakih A, Wahab MMA, Liew MS, Amran YHM
    Materials (Basel), 2020 Jul 13;13(14).
    PMID: 32668788 DOI: 10.3390/ma13143125
    The objective of this research was to determine the durability of an engineered cementitious composite (ECC) incorporating crumb rubber (CR) and graphene oxide (GO) with respect to resistance to acid and sulphate attacks. To obtain the mix designs used for this study, response surface methodology (RSM) was utilized, which yielded the composition of 13 mixes containing two variables (crumb rubber and graphene oxide). The crumb rubber had a percentage range of 0-10%, whereas the graphene oxide was tested in the range of 0.01-0.05% by volume. Three types of laboratory tests were used in this study, namely a compressive test, an acid attack test to study its durability against an acidic environment, and a sulphate attack test to examine the length change while exposed to a sulphate solution. Response surface methodology helped develop predictive responsive models and multiple objectives that aided in the optimization of results obtained from the experiments. Furthermore, a rubberized engineered cementitious composite incorporating graphene oxide yielded better chemical attack results compared to those of a normal rubberized engineered cementitious composite. In conclusion, nano-graphene in the form of graphene oxide has the ability to enhance the properties and overcome the limitations of crumb rubber incorporated into an engineered cementitious composite. The optimal mix was attained with 10% crumb rubber and 0.01 graphene oxide that achieved 43.6 MPa compressive strength, 29.4% weight loss, and 2.19% expansion. The addition of GO enhances the performance of rubberized ECC, contributing to less weight loss due to the deterioration of acidic media on the ECC. It also contributes to better resistance to changes in the length of the rubberized ECC samples.
    Matched MeSH terms: Weight Loss
  12. Siti Rohana Ahmad, Salmah Husseinsyah, Kamarudin Hussin
    MyJurnal
    In this study, dynamic vulcanization process was used to improve the thermal properties of calcium carbonate filled composites. The composites were prepared using a Z-blade mixer at 180oC and rotor speed 50rpm. Thermogravimetric analysis (TGA) and Differential scanning calorimetry (DSC) techniques were used to analyze the thermal properties of the composites. The vulcanized and unvulcanized PP/EPDM composites were filled by CaCO3 at 0, 10, 20, 30, and 40 %wt. Meanwhile, thermogravimetric analysis indicates that the total weight loss of PP/EPDM/CaCO3 composites decreased with increasing filler loading. Dynamic vulcanized composites have higher thermal stability, while the crystallinity of PP/EPDM/CaCO3 composites were increased as compared to unvulcanized composites. Therefore, the thermal properties were improved by the presence of
    dynamic vulcanization process.
    Matched MeSH terms: Weight Loss
  13. Nik Ruzyanei, N.J., Wan Salwina, W.I., Choo, S.P., Rosdinom, R.
    MyJurnal
    Schizophrenia poses challenges in diagnosis and treatment strategies when the predominant clinical features represent another spectrum of disorder like eating disorders. Nevertheless, symptoms of eating disorder in schizophrenia are not entirely uncommon although never included in the diagnostic criteria. We reported a case of a woman who first presented at seventeen years old with food refusal and underlying psychosis resulting in severe weight loss, but defaulted treatment for almost a decade. In 2009, she presented again with sinus bradycardia and secondary amenorrhoea. In this report, we discussed about the patient’s vulnerability for psychosis and its psychodynamic drive which led to a complex symptoms manifestation. Our aim is to highlight its diagnostic dilemma and suggestions to treatment strategies unique to this presentation.
    Matched MeSH terms: Weight Loss
  14. Jafarizadeh Malmiri, H., Osman, A., Tan, C.P., Abdul Rahman, R.
    MyJurnal
    Response surface methodology (RSM) was used to optimize the concentrations of chitosan and glycerol for coating Berangan banana (Musa sapientum cv. Berangan). The effects of main edible coating components, chitosan (0.5-2.5%, w/w) and glycerol (0-2%, w/w) on weight loss, firmness, total colour difference, total soluble solids content (TSS) and titratable acidity (TA) of coated banana were studied during 10 days of storage at 26±2°C and 40-50% relative humidity. Results showed that the experimental data could be adequately fitted into a second-order polynomial model with coefficient of determination (R 2 ) ranging from 0.745 to 0.930 for all the variables studied. In general, the chitosan concentration appeared to be the most significant (P< 0.1) factor influencing all variables except for TSS. The optimum concentration of chitosan and glycerol were predicted to be 2.02% and 0.18%, respectively. Statistical assessment showed insignificant difference between experimental and predicted values.
    Matched MeSH terms: Weight Loss
  15. Siti Rohana Ahmad, Salmah Husseinsyah, Kamarudin Hussin
    MyJurnal
    A chemical modifier (acrylic acid) was used to improve the thermal properties of polypropylene/ ethylene propylene diene terpolymer/calcium carbonate (PP/EPDM/CaCO3) composites. Treated
    and untreated PP/EPDM composites were filled by CaCO3 at 0, 20 and 40% wt. The composites
    were prepared using Z-blade mixer machine at 180oC and 50 rpm of rotor speed. Thermogravimetric
    analysis (TGA) and differential scanning calorimetry (DSC) methods were used to analyze the thermal properties of the composites. Thermogravimetric analysis indicated that the total weight loss of PP/EPDM/CaCO3 composites decreased with the increasing filler loading for the treated and untreated composites. Meanwhile, the presence of acrylic acid was found to have increased the thermal stability and crystallinity of PP/EPDM/CaCO3
    .
    Matched MeSH terms: Weight Loss
  16. Saifuddin, T.M., Rahim, N., Mansor, N.Z.
    MyJurnal
    Sibutramine is a prohibited weight-reducing agent used in many weight-loss
    products, which has been banned in many countries since 2010 including
    Malaysia due to it toxicities and mortality effect. The widespread use of these
    sibutramine-containing products has raised concerns regarding their side
    effects, which include psychological symptoms. In this case report, we
    highlight a case of psychosis induced by the use of this product. We present a
    case of 36-year-old Burmese lady who has three admissions to psychiatry
    ward with psychotic presentation after on-going consumption of weight-loss
    product containing sibutramine.
    Matched MeSH terms: Weight Loss
  17. Hanipah ZN, Punchai S, McCullough A, Dasarathy S, Brethauer SA, Aminian A, et al.
    Obes Surg, 2018 11;28(11):3431-3438.
    PMID: 30109667 DOI: 10.1007/s11695-018-3372-z
    INTRODUCTION: Studies on bariatric patients with cirrhosis and portal hypertension are limited. The aim of this study was to review our experience in cirrhotic patients with portal hypertension who had bariatric surgery.

    METHOD: All cirrhotic patients with portal hypertension who underwent laparoscopic bariatric surgery, from 2007 to 2017, were retrospectively reviewed.

    RESULTS: Thirteen patients were included; eight (62%) were female. The median age was 54 years (interquartile range, IQR 49-60) and median BMI was 48 kg/m2 (IQR 43-55). Portal hypertension was diagnosed based on endoscopy (n = 5), imaging studies (n = 3), intraoperative increased collateral circulation (n = 2), and endoscopy and imaging studies (n = 3). The bariatric procedures included sleeve gastrectomy (n = 10, 77%) and Roux-en-Y gastric bypass (n = 3, 23%). The median length of hospital stay was 3 days (IQR 2-4). Three 30-day complications occurred including wound infection (n = 1), intra-abdominal hematoma (n = 1), and subcutaneous hematoma (n = 1). No intraoperative or 30-day mortalities. There were 11 patients (85%) at 1-year follow-up and 9 patients (69%) at 2-year follow-up. At 2 years, the median percentage of excess weight loss (EWL) and total weight loss (TWL) were 49 and 25%, respectively. There was significant improvement in diabetes (100%), dyslipidemia (100%), and hypertension (50%) at 2 years after surgery.

    CONCLUSION: Bariatric surgery in selected cirrhotic patients with portal hypertension is relatively safe and effective.

    Matched MeSH terms: Weight Loss
  18. Hoshino S, Seino S, Azumano A, Tuuga A, Nathan SKSS, Ramirez Saldivar DA, et al.
    Primates, 2023 Jan;64(1):123-141.
    PMID: 36357633 DOI: 10.1007/s10329-022-01031-y
    In animal husbandry, diets should help in maintaining a healthy body condition, support reproduction, and promote species-specific longevity. It is recommended to feed folivorous primates kept in zoos a high-fiber diet, i.e., leaves, although satisfying such a requirement is challenging in temperate regions because it is difficult to obtain fresh leaves, especially in autumn and winter. As equally important for their appropriate treatment, it is valuable to provide details of clinical reports of medical problems and pathological findings, although such clinical reports are rather limited. Therefore, in foregut-fermenting proboscis monkeys (Nasalis larvatus), we (1) described the individual clinical reports of renal disease and weight loss at the Yokohama Zoological Gardens in Japan, (2) determined the nutritional profile of the diets supplied to these animals because other potential triggers for their renal disease and weight loss could be excluded, (3) modified the diet regimen to minimize weight loss and the development of hypercalcemia and hypophosphatemia, and (4) assessed the effects of such dietary modification by comparing the body weight and the Ca and P concentrations and the Ca/P ratios in the blood before and after diet modification with a comparison of these measurements between zoo and free-ranging individuals. Based on the nutritional profile of the diets, we concluded that the reported cases of renal failure might be caused by consumption of leaves with a Ca/P ratio far above the appropriate level in autumn and winter. Additionally, the dietary modification of minerals and metabolizable energy achieved certain beneficial effects on zoo-kept proboscis monkeys.
    Matched MeSH terms: Weight Loss
  19. Yeap SS, Abu Amin SR, Baharuddin H, Koh KC, Lee JK, Lee VKM, et al.
    BMC Musculoskelet Disord, 2021 Jun 04;22(1):514.
    PMID: 34088302 DOI: 10.1186/s12891-021-04381-8
    BACKGROUND: The 2013 Malaysian Clinical Practice Guidelines on the Management of Osteoarthritis (OA) recommend a linear step-up approach to manage knee OA. However, patients with knee OA often require a multimodal approach to address OA-related pain symptoms and functional limitations. This consensus aimed to provide doctors with an updated set of evidence-based, clinical experience-guided recommendations to manage knee OA.

    METHODS: A multi-speciality expert panel consisting of nine Malaysian physicians from different healthcare settings who manage a diverse OA patient population was convened. Using a combination of the ADAPTE process and modified Delphi method, the panel reviewed current evidence on the management of knee OA and synthesised a set of nine recommendations on the management of knee OA, supported by an algorithm that summarises the consensus' core messages.

    RESULTS: A multimodal intervention strategy is the mainstay of OA management and the choice of any single or multimodal intervention may vary over the course of the disease. Overall, a non-pharmacological core treatment set of patient education, weight loss and exercise is recommended for all patients. When pharmacotherapy is indicated, symptomatic slow-acting drugs for osteoarthritis are recommended at the early stage of disease, and they can be paired with physical therapy as background treatment. Concurrent advanced pharmacotherapy that includes non-steroidal anti-inflammatory drugs, intraarticular injections and short-term weak opioids can be considered if patients do not respond sufficiently to background treatment. Patients with severe symptomatic knee OA should be considered for knee replacement surgery. Management should begin with specific treatments with the least systemic exposure or toxicity, and the choice of treatment should be determined as a shared decision between patients and their team of healthcare providers.

    CONCLUSIONS: This consensus presents nine recommendations that advocate an algorithmic approach in the management of patients living with knee OA. They are applicable to patients receiving treatment from primary to tertiary care providers in Malaysia as well as other countries.

    Matched MeSH terms: Weight Loss
  20. Yunus NA, Russell G, Muhamad R, Soh SE, Sturgiss E
    BMC Health Serv Res, 2023 Jul 10;23(1):744.
    PMID: 37430243 DOI: 10.1186/s12913-023-09759-z
    BACKGROUND: Practitioners' perceptions of patients with obesity and obesity management shape their engagement in obesity care delivery. This study aims to describe practitioners' perceptions, experiences and needs in managing patients with obesity, determine the extent of weight stigma among health practitioners, and identify the factors associated with negative judgment towards patients with obesity.

    METHODS: A cross-sectional online survey was conducted from May to August 2022 with health practitioners commonly involved in obesity management in Peninsular Malaysia, including doctors in primary care, internal medicine and bariatric surgery, and allied health practitioners. The survey explored practitioners' perceptions, barriers and needs in managing obesity, and evaluated weight stigma using the Universal Measures of Bias - Fat (UMB Fat) questionnaire. Multiple linear regression analysis was used to identify demographic and clinical-related factors associated with higher negative judgment towards patients with obesity.

    RESULTS: A total of 209 participants completed the survey (completion rate of 55.4%). The majority (n = 196, 94.3%) agreed that obesity is a chronic disease, perceived a responsibility to provide care (n = 176, 84.2%) and were motivated to help patients to lose weight (n = 160, 76.6%). However, only 22% (n = 46) thought their patients were motivated to lose weight. The most frequently reported barriers to obesity discussions were short consultation time, patients' lack of motivation, and having other, more important, concerns to discuss. Practitioners needed support with access to multi-disciplinary care, advanced obesity training, financing, comprehensive obesity management guidelines and access to obesity medications. The mean (SD) of the UMB Fat summary score was 2.99 (0.87), with the mean (SD) domain scores ranging between 2.21 and 4.36 (1.06 to 1.45). No demographic and clinical-related factors were significantly associated with negative judgment from the multiple linear regression analyses.

    CONCLUSION: Practitioners in this study considered obesity a chronic disease. While they had the motivation and capacity to engage in obesity management, physical and social opportunities were the reasons for not discussing obesity with their patients. Practitioners needed more support to enhance their capability and opportunity to engage with obesity management. Weight stigma in healthcare settings in Malaysia should be addressed, given the possibility of hindering weight discussions with patients.

    Matched MeSH terms: Weight Loss
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