Browse publications by year: 2016

  1. Wan Fazilah Fazlil Ilahi, Desa Ahmad
    Sains Malaysiana, 2016;46:975-980.
    A well-known planting medium in soilless culture is a coconut based material famously known in Malaysia as cocopeat.
    It is a viable ecologically friendly peat soil substitute for containerized crop production. The multipurpose growing media
    had received much interest particularly in commercial applications. This study focused on the physical and hydraulic
    characteristics of cocopeat perlite mixture as a growing media in containerized plant production. Perlite was added to
    cocopeat at a ratio of 3 cocopeat: 1 perlite. Bulk density, particle density, porosity, particle size distribution, water holding
    capacity, wettability and hydraulic conductivity of the media were evaluated. About 82.93% of the total particles were
    in the range between 0.425 and 4 mm in diameter at a bulk density of 0.09 g/cm3
    . Total porosity (79%) and wettability
    improved with the incorporation of perlite to cocopeat. This study showed that water holding capacity was very high at
    912.54% whereas the saturated hydraulic conductivity was low at 0.1 cm/s. The results showed that adding perlite to
    cocopeat had improved the physical and hydraulic characteristics of the media.
    MeSH terms: Crop Production; Aluminum Oxide; Cocos; Ecology; Malaysia; Particle Size; Silicon Dioxide; Soil; Water; Porosity; Wettability
  2. Siti Zamratol-Mai Sarah Mukari, Nashrah Maamor, Wan Syafira Ishak, Wan Fazlina Wan Hashim
    Sains Malaysiana, 2016;45:1405-1411.
    There is a lack of population-based data on prevalence of hearing loss in Malaysia. The purpose of this population-based study was to determine the prevalence of hearing loss and its risk factors among 382 older adults aged 60 years and above, recruited through multistage random sampling in Selangor. Hearing level was measured using pure tone audiometry. Hearing loss was classified into at least mild hearing loss and significant hearing loss based on the pure tone average (PTA) of 0.5, 1, 2 and 4 kHz. The examination also included face-to-face interview on hearing related medical history, noise exposure and hearing aid use. Overall, the prevalence of at least mild hearing loss and significant hearing loss were 73.6% (95% CI: 69.4 - 77.4) and 24.6% (95% CI: 20.8 - 28.7), respectively. The odds for at least ‘mild hearing loss’ were male gender, Chinese ethnicity, residing in urban areas, had no formal education or primary school education and history of hypertension. The risk for ‘significant hearing loss’ was significantly higher in males, those who lived in urban areas and elderly with cognitive impairment. Chinese and Indian ethnicities had significantly lower risks than Malay ethnic to have significant hearing loss. Despite the high prevalence of hearing loss, only 4.4% who might benefit from hearing aids wore them. In conclusion, findings from this study show high prevalence of hearing loss among the elderly population. Given the significant association between hearing loss and cognitive impairment, future studies should explore the role of hearing amplification in alleviating or slowing the progress of cognitive decline.
  3. Fun SP, Norhani Mohidin, Azzatul Ainur Mohd Kamal, Zainora Mohammed, Bariah Mohd-Ali
    Sains Malaysiana, 2016;45:1399-1403.
    The purpose of this study was to examine the effects of mild cognitive impairment on pattern electroretinogram (pERG)
    among urban elderly Malays. A total of 36 subjects aged 60 years and above comprising of 18 MCI subjects and 18
    normal controls were recruited for this study. The inclusion criteria for both the MCI and normal subjects included best
    corrected distance visual acuity ≥ 6/9 (Snellen) with refractive error less than ±4.00 DS and/or ±2.00 DC (astigmatism),
    near visual acuity ≥ N8, absence or no previous history of any significant media opacities, retinal disorders and ocular
    pathologies. pERG was recorded with the RetiPort/Scan21 system in accordance with the International Society for the
    Clinical Electrophysiology of Vision standards. The target presented to subjects through a 19” CRT monitor was a black
    and white reversing checkerboard with luminance equal to 80 cd/m2
    , contrast 97% and stimulus frequency 2.00 Hz (4
    rev/s). Amplitudes and implicit times of P50 and N95 waves generated by the system were noted and compared between
    the two groups. The results showed no significant difference in the amplitude and implicit times between the right and left
    eyes so only the right eye was used for comparison between the MCI and control groups. The mean amplitude and implicit
    times of the right eye of the MCI and control groups were 1.86±0.65 μV, 56.27±6.20 ms and 1.54±0.74 μV, 56.15±4.98 ms,
    respectively. T-test showed no significant differences in pERG amplitudes and implicit times between MCI and the control
    groups. In conclusion, our results may imply that the inner retina is intact in early MCI elderly subjects.
  4. Zainora Mohammed, Siti Zawiyah Mansor, Saadah Mohamed Akhir, Bariah Mohd-Ali, Norhani Mohidin
    Sains Malaysiana, 2016;45:1393-1398.
    The first aim of this study was to determine the refractive error and visual acuity of Chinese elderly age 60 and above in Selangor and Johor, Malaysia. The second aim was to determine the percentage of elderly with vision impairment. Participants of this study were from the on-going population-based longitudinal study on neuroprotective model for healthy longevity (TUA) among Malaysian older adults using multistage random sampling. A total of 259 Chinese elderly aged 60 and above from state of Selangor and Johor agreed to participate. Refractive error was determined using autorefractometer Retinomax K-plus followed by subjective refraction. Best corrected visual acuity (VA) was measured using logMAR chart. Analysis was performed on data of 202 participants and the remaining 57 were excluded. Overall percentage of refractive error was higher for hyperopia (54%) compared to myopia (23.2%). High percentage of astigmatism was noted for all age groups (> 50%). Both gender showed similar distribution of refractive status. Mean overall VA was 0.24 ± 0.17 logMAR (≅ 6/9-) and mean VA declined with age. Overall, the percentage of elderly having at least mild vision impairment (> 0.3 logMAR or 6/12) was higher (62.9%) compared to normal vision (≤ 0.3 logMAR). However, percentage of vision impairment (VI) was highest in the mild category compared to others and only one participant had severe VI. This study found a high percentage of Chinese elderly with refractive error. The most common type of refractive error was hyperopia. A high proportion of them had mild vision impairment followed by moderate VI even with best correction. Vision impairment could affect daily life functioning and this effect can be further explored in the future.
  5. Nik Nur Izzati Nik Mohd Fakhruddin, Suzana Shahar, Nurul Atiqah Abd Aziz, Roslee Rajikan, Hanis Mastura Yahya
    Sains Malaysiana, 2016;45:1381-1391.
    Older adults quite often had an inadequate diet leading to micronutrient deficiencies and impaired immune response with subsequent development of degenerative diseases. This study aimed to determine the adequacy of energy and nutrient intake and its distribution among three aging groups i.e. successful aging (SA), usual aging (UA) and mild cognitive impairment (MCI). This is a cross-sectional study involving a large sample size (n = 2322) of older adults recruited through multistage random sampling from four states of Malaysia. An interview was conducted to measure dietary intake, neurocognitive status and functional status by using the Diet History Questionnaire (DHQ), Mini-Mental State Examination (MMSE), Rey Auditory Learning Test (RAVLT), Geriatric Depression Scale (GDS), Instrumental Activity of Daily Living (IADL) and Quality of Life Questionnaire. For comparison of dietary intake, a sub-sample of 173 respondents from each aging groups were matched and selected using a comparative cross-sectional approach. Women in SA group had the highest mean intake of vitamin A, calcium (p <0.05), vitamin C, riboflavin and iron (p<0.001). The same aging group also achieved the highest RNI percentage for the same nutrients. More than 80% of respondents for all aging groups did not met the recommended nutrient intake (RNI) for vitamin E, thiamin, niacin, folate, calcium and zinc. In women, MCI respondents were more likely to have an inadequate intake of vitamin A, C, riboflavin and iron followed by UA and SA. Inadequate vitamin E, niacin, folate and calcium were prevalent among all gender and aging groups. There is a need to further distinguish specific dietary patterns associated with these three aging groups to promote optimal nutrient intake for cognitive health.
    MeSH terms: Adult; Aging; Ascorbic Acid; Energy Intake; Cognition; Cross-Sectional Studies; Depression; Female; Folic Acid; Humans; Iron; Malaysia; Niacin; Nutritional Requirements; Quality of Life; Surveys and Questionnaires; Riboflavin; Thiamine; Vitamin A; Vitamin E; Vitamins; Zinc; Sample Size
  6. Amir Hamzah A, Abu Bakar Z, Abdul Sani N, Tan JK, Ahmad Damanhuri M, Makpol S, et al.
    Sains Malaysiana, 2016;45:1371-1380.
    Higher level of education is associated with better cognitive performance and lower risk of developing dementia. However, the effect of education on cognitive performance varies across different cognitive domains and in different populations. The aim of this study was to determine the relationship between education and performance of different cognitive domains among healthy Malay adults. A total of 53 individuals aged 29 to 77 years participated in a battery of neurophysiological tests consisting of Mini-Mental State Examination, Montreal Cognitive Assessment, digit span, visual reproduction and digit symbol speed test (DSST). Blood test was performed for each participant to obtain their biochemical profile. Educational level was divided into level 1 (PMR), level 2 (SPM), level 3 (STPM), level 4 (Diploma) and level 5 (Degree). Simple linear regression indicated that years of education was positively associated with scores of delayed visual reproduction (b=1.348, p=0.002) and DSST (b=3.257, p=0.012). However, scores of all the tests were not significantly different among different levels of education after controlling for age, gender and blood test profile by ANCOVA. Multiple linear regression analysis showed that MMSE score was associated with red cell distribution width (b=-0.628, p=0.005), age (b=-0.119, p<0.001) and there was interaction between high density lipoprotein (HDL) with age (b=0.047, p<001). MoCA score was associated with age (b=-0.121, p<0.001), gender (male compared to female, b=1.870, p=0.020) and HDL (b=1.681, p=0.047). Age was associated with backward digit span (b=-0098, p<0.001) and immediate visual reproduction (b=-0.348, p<0.001), resp. Delayed visual reproduction was associated with age (b=-0.323, p<0.001) and potassium level (b=-4.471, p=0.016). DSST was associated with age (b=-0.911, p<0.001) and alanine aminotransferase (b=-0.754, p=0.002). The lack of association between educational level and cognitive performance after adjusting for confounders in this study maybe due to multiple factors influencing cognitive performance and further studies with a larger sample size are needed to further identify the factors involved.
    Keywords: Cognitive performance; education; healthy Malay adults
    ABSTRAK
    Tahap pendidikan yang tinggi telah dikaitkan dengan prestasi kognitif yang lebih baik dan risiko perkembangan dementia yang lebih rendah. Namun, kesan pendidikan terhadap prestasi kognitif berbeza antara domain kognitif dan populasi yang berlainan. Kajian ini bertujuan untuk menentukan hubungan antara pendidikan dengan prestasi pada domain kognitif yang berlainan pada individu dewasa Melayu yang sihat. Seramai 53 individu yang berumur antara 29 hingga 77 tahun telah menyertai ujian neuropsikologi yang terdiri daripada Pemeriksaan Keadaan Mental Mini, Penilaian Kognitif Montreal, digit span, penghasilan semula visual dan ujian kelajuan simbol digit (DSST). Tahap pendidikan dibahagikan kepada tahap 1 (PMR), tahap 2 (SPM), tahap 3 (STPM), tahap 4 (Diploma) dan tahap 5 (Ijazah Sarjana Muda). Regresi linear mudah menunjukkan bahawa tahap pendidikan berhubung kait secara positif dengan penghasilan semula visual tertunda (b=1.348, p=0.002) dan DSST (b=3.257, p=0.012). Namun, semua skor ujian menjadi tidak berbeza antara tahap pendidikan yang berbeza selepas mengambil kira kesan konpengasas dengan menggunakan ANCOVA. Regresi linear berganda menunjukkan bahawa skor MMSE berhubung kait dengan lebar taburan sel merah (b=-0.628, p=0.005), umur (b=-0.119, p<0.001) dan interaksi antara lipoprotein ketumpatan tinggi (HDL) dan umur (b=0.047, p<001). MoCA didapati berhubung kait dengan umur (b=-0.121, p<0.001), jantina (lelaki berbanding perempuan, b=1.870, p=0.020) dan HDL (b=1.681, p=0.047). Umur juga berhubung kait dengan digit span ke belakang (b=-0098, P<0.001) dan penghasilan semula visual segera (b=-0.348, p<0.001). Penghasilan semula visual tertunda berhubung kait dengan umur (b=-0.323, p<0.001) dan tahap kalium (b=-4.471, p=0.016). DSST berhubung kait dengan umur (b=-0.911, p<0.001) dan alanin aminotransferase (b=-0.754, p=0.002). Hubungan antara tahap pendidikan dan prestasi kognitif tidak dikesan selepas mengambil kira kesan konpengasas yang mencadangkan bahawa prestasi kognitif mungkin dipengaruhi oleh pelbagai faktor dan kajian lanjut dengan bilangan sampel yang lebih besar diperlukan untuk mengenal pasti faktor ini.
    MeSH terms: Adult; Alanine Transaminase; Cognition; Dementia; Educational Status; Erythrocyte Indices; Female; Humans; Lipoproteins, HDL; Malaysia; Male; Potassium; Regression Analysis; Linear Models; Sample Size; D-Alanine Transaminase
  7. Damanhuri H, Abdul Rahim N, Nasri W, Tan J, Makpol S, Wan Ngah W
    Sains Malaysiana, 2016;45:1363-1370.
    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by deterioration of the brain functions
    that result in impairment of memory, cognition and behavioural functions. Oxidative stress is well known to be one of the
    causative factors for AD. Thus this disease is potentially modulated by natural antioxidants such as vitamin E. The aim
    of this study was to evaluate the effect of tocotrienol-rich fraction (TRF) supplementation on antioxidant enzymes and
    DNA damage using APPswe/PS1dE9 transgenic mouse model of AD. Animals were supplemented with TRF (200 mg/kg)
    or alpha-tocopherol (αT) (200 mg/kg) for six months starting from nine months old. We found that superoxide dismutase
    (SOD) activity in AD mouse was decreased by supplementation of TRF and αT as compared with AD control mouse with no
    significant differences in glutathione peroxidise (GPx) activity in all groups. TRF supplementation significantly increased
    catalase (CAT) activity. The level of DNA damage of AD mouse shows significant decrease with supplementation of TRF
    and αT. In conclusion, TRF was able to modulate antioxidant enzymes activity and decreased the level of DNA damage
    of AD transgenic mouse model.
  8. Eshkoor SA, Tengku Aizan Hamid, Chan YM
    Sains Malaysiana, 2016;45:1357-1361.
    The improvement of health care support has greatly extended the average life expectancy over the last 50 years, which
    has increased the rate of cognitive decline consequently. The avoidance of risk factors such as toxins, stress and somatic
    diseases can be protective against the reduction of cognitive function in the elderly. This study aimed to determine the
    effects of socio-demographic factors, constipation and renal failure on cognitive status among 2322 samples who were
    the non-institutionalized Malaysian elderly. The multiple logistic regression analysis was applied to estimate the risk of
    such factors on cognitive decline in subjects. Approximately, 77.54% of samples experienced cognitive impairment. The
    results showed that advanced age (odds ratio (OR) = 1.03), Malay ethnic (OR = 2.15), constipation (OR = 3.31) and renal
    failure (OR= 4.42), significantly increased the risk of cognitive impairment in subjects (p<0.05). In addition, education
    (OR = 0.38) significantly reduced the risk. However, we concluded that age, Malay ethnic, constipation and renal failure
    increased the risk of cognitive impairment in subjects but education reduced the risk.
    MeSH terms: Aged; Cognition; Constipation; Demography; Humans; Life Expectancy; Malaysia; Risk Factors; Logistic Models; Odds Ratio; Renal Insufficiency
  9. Ng TP
    Sains Malaysiana, 2016;45:1351-1355.
    Dementia poses a major global burden of care to society and health systems in ageing populations. The majority (over 60%) of persons with dementia in the world are found in Asia and developing countries with rapid rates of population ageing. Improving and maintaining the cognitive health of older persons is vital to national strategies for dementia prevention. Increasing numbers of population-based ageing cohort studies in the past decade have provided a better understanding of the factors that contribute to cognitive function and decline in old age. The roles of major demographic, psychosocial, lifestyle, behavioral and cardiovascular risk factors contributing to cognitive health were discussed using examples from the Singapore Longitudinal Ageing Studies. They include socio-demographic factors, particularly education and marital status, leisure time activity such as physical activity, social engagement and mental activities, psychological factors such as depression, cardiovascular and metabolic risk factors: obesity, diabetes, hypertension and dyslipidemia, and the metabolic syndrome, under-nutrition, low albumin, low hemoglobin, nutritional factors such as blood folate, B12 and homocysteine, omega-3 poly-unsaturated fatty acids, tea drinking and curcumin-rich turmeric in curry meals. These factors are found to be associated variously with cognitive functions (memory and learning, language, visuospatial, attention and information processing speed), rates of cognitive impairment and cognitive decline, or increased risk of developing MCI and progression to dementia.
    MeSH terms: Aging; Albumins; Asia; Attention; Cardiovascular Diseases; Cognition; Curcumin; Dementia; Demography; Depression; Developing Countries; Diabetes Mellitus; Folic Acid; Hemoglobins; Homocysteine; Hypertension; Language; Leisure Activities; Life Style; Longitudinal Studies; Memory; Obesity; Risk Factors; Singapore; Tea; Cohort Studies; Exercise; Fatty Acids, Omega-3; Marital Status; Curcuma; Malnutrition; Dyslipidemias
  10. Normaz Wana Ismail, Siti Wardah Abd Rahman, Tengku Aizan Tengku Abdul Hamid, Rusmawati Said
    Sains Malaysiana, 2016;45:1345-1350.
    The purpose of this study was to examine the impact of aging on economic growth. The study used dynamic growth model and employed Autoregressive Distributed Lag (ARDL) approach for the period of 1980 to 2011. Three proxies for aging are used namely fertility rate, life expectancy and old dependency ratio. However, only fertility rate is detected to have a long run cointegration. The major finding of this study showed that a reduction of fertility rate lead to higher economic growth. This implied that even though Malaysia will face aging society by 2020, the economic growth is still stable and can increase by investing more on human capital.
    MeSH terms: Birth Rate; Dependency (Psychology); Employment; Humans; Investments; Life Expectancy; Malaysia; Economic Development
  11. Normah Che Din, Suzana Shahar, Baitil Husna Zulkifli, Rosdinom Razali, Chyn AV, Azhadi Omar
    Sains Malaysiana, 2016;45:1337-1343.
    The goal of this study was to examine the reliability and validity of the Bahasa Malaysia version of the Montreal cognitive assessment (MoCA-BM) and to determine its optimal cut-off score among older adults with mild cognitive impairment (MCI), after adjustments for age, gender, levels of education, physical functioning and depressive symptoms. A total of 2237 community dwelling older adults aged 60 years and above were randomly selected for the study, excluding those with MMSE score below 14. Instruments administered were the MoCA-BM, the Malay Mini-Mental State Examination (MMMSE), the Rey Auditory Verbal Learning Test (RAVLT), the Digit Span and the Digit Symbol subtests of the Wechsler Adult Intelligence Scale (WAIS), activities of daily living (ADL) and the Geriatric Depression Scale (GDS). MCI were determined using the Petersen’s 2014 criteria as the gold standard. SPSS version 22 was used for reliability and validity analysis and optimal cut-off score detection. Cronbach’s α of the MoCA-BM was 0.691 and concurrent validity was high between MoCA-BM and MMMSE scores (r=0.741). Optimal cut-off point for MoCA-BM to detect MCI among older adults in Malaysia was 17/18, with sensitivity of 68.2% and specificity of 61.3%. Using this cut-off, 38.9% of participants were detected to be at risk of MCI. In conclusion, MoCA-BM is a reliable and valid screening instrument for MCI among Malaysian elderly community. The newly derived optimal cut-off for MCI is much lower than the original MoCA with modest ability to discriminate between normal and MCI older adults in the community.
  12. Hasnah Haron, Tasneem Shaari, Chan BK
    Sains Malaysiana, 2016;45:1329-1335.
    Soy-based products are one of famous raw ingredients used in the preparation of Asian cuisines. These soy-based products are good source of isoflavones. This study was carried out to observe the effects of different cooking methods on isoflavone content in soy-based products. A total of eight Malaysian dishes prepared using soy-based products with different cooking methods was selected as samples for this study. Daidzein and genestein contents in raw and cooked soy-based products were both quantified using high performance liquid chromatography (HPLC). The results showed that dishes containing tempe as ingredients had significantly higher (p<0.05) amount of isoflavone content, in both raw and cooked forms, as compared to those prepared from other types of soy-based products when based on dry and wet. In conclusion, the isoflavone content was significantly reduced (p<0.05) in some cooked soy-based products (tempe (TSS and ML), fu jook (ML) and firm tofu (FTC)) based on dry weight as compared with the raw ones. However, the correlations between isoflavone content with cooking methods, durations and temperatures were not significant (p>0.05) in this study.
    MeSH terms: Chromatography, High Pressure Liquid; Cooking; Isoflavones; Lidocaine; Prilocaine; Temperature; Genistein; Soy Foods
  13. Khaw HW, Hasnah Haron, Chan BK
    Sains Malaysiana, 2016;45:1319-1327.
    ABSTRACT
    There is an increasing trend of fruit juice consumption due to increasing reported health benefits of antioxidant content present in fruit juices. The aim of this study was to compare the total phenolic contents (TPC) and antioxidant activities of fresh fruit juices, commercial 100% fruit juices and fruit drinks. Seven types of freshly blended fruit juices and their commercial counterparts were selected. Folin-Ciocalteu method was used to determine the total phenolic content, whilst ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays were performed to evaluate the antioxidant activities of fruit juices. The TPC contents of fresh fruit juices, commercial 100% fruit juices and fruit drinks were at the ranges of 13.38-80.40, 21.65-130.39 and 3.32-45.10 mg GAE/100 mL, respectively. Both fresh guava juice and commercial guava drinks have exhibited the highest antioxidant activities in DPPH assay (205.71-770.12 μmol TE/100 mL) and FRAP assay (320.80-843.13 μmol TE/100 mL). Pomegranate juices demonstrated the highest antioxidant activities among commercial 100% fruit juices with DPPH and FRAP values of 2705.01 and 2953.85 μmol TE/100 mL, respectively. Fruits drinks group had the lowest TPC and antioxidant activities for all types of fruits. TPC was significantly correlated (p<0.05) to FRAP (r=0.954) and DPPH (r=0.908) assays. In conclusion, the TPC and antioxidant activities of commercial 100% fruit juices and fresh juices were comparable as no significantly difference (p>0.05) was found between these two groups. Commercial fruit drinks in this study were not good source of antioxidants. These findings provide some useful information especially for ageing population in choosing healthy fruit juice or drinks for their health maintenance purposes.
  14. Alia Hamad, Mani V, Ramasamy K, Lim SM, Abu Bakar Abdul Majeed
    Sains Malaysiana, 2016;45:1299-1310.
    The continued progression of neurodegeneration may result in dementia. The present study compared the neuroprotective
    activities between soybean and tempeh extracts in rats. The extracts were administered orally at 10, 20 and 40 mg/kg for
    15 days. Radial arm maze and elevated plus maze served as exteroceptive behavioural models for memory measuring.
    Brain cholinergic activities (acetylcholine and acetylcholinesterase) and neuroinflammatory related cytokines interleukin
    1β and interleukin-10 were also tested. Soybean and tempeh extracts significantly improved memory, but overall 40 mg/
    kg tempeh showed better improvement (p<0.05). The tempeh extracts at 20 and 40 mg/kg exhibited a significant (p<0.05)
    increase and decrease in the level of acetylcholine and acetylcholinesterase activities, respectively. Tempeh extract (40
    mg/kg) resulted in greater reduction (p<0.05) of inflammation than soybean extract. Altogether, tempeh extract may be
    beneficial in the management and prevention of dementia and Alzheimer’s disease.
  15. Mohamad Fakri E, Lim S, Musa N, Hazizul Hasan M, Adam A, Ramasamy K
    Sains Malaysiana, 2016;45:1289-1297.
    This study examined lactic acid bacteria (LAB)-fermented soymilk for their ability in hydrolyzing glucosides to aglycones
    and corresponding antioxidant capacity and memory enhancing effect. Twelve LAB isolated from Malaysian fermented food
    and milk products were incubated in commercially available soymilk for 48 h. Generally, soymilk supported LAB growth
    and significantly increased (p<0.05) conversion to bioactive aglycone by 2.1-6.5 fold when compared to unfermented
    soymilk. Lactobacillus fermentum LAB 9- fermented soymilk, in particular, was presented with increased total phenolic
    content (+10%) as opposed to unfermented soymilk. Lactobacilli (LAB 10-12)- and pediococci (LAB 5)-fermented soymilk
    elicited maximal DPPH radical-scavenging activity. LAB 1, 7, 8, 9 and 12 exhibited significantly higher (p<0.05) ferrous
    ion chelating activity when compared to control. Interestingly, LAB 9 had significantly improved memory deficit (p<0.05)
    in LPS-challenged mice. LAB-enriched nutritional value of soymilk could be useful against oxidative stress and memory
    deficit.
    MeSH terms: Animals; Antioxidants; Fermentation; Glucosides; Lactobacillus; Memory Disorders; Milk; Nutritive Value; Pediococcus; Oxidative Stress; Soy Milk; Mice; Lactobacillus fermentum; Lactobacillales
  16. Al-Sharabi A, Sarah Yasmin Tajuddin, Au Diya Fatihah Wan Saffiey, Syazana Jasman, Alwi H, Jumali M, et al.
    Sains Malaysiana, 2016;45:1959-1968.
    Kesan penambahan PbO dengan saiz 10 hingga 30 nm terhadap kekondukisan lebihan YBa2Cu3O7-δ telah dikaji. Kekonduksian lebihan ialah fluktuasi kekonduksian elektrik disebabkan oleh interaksi pasangan Cooper dengan elektron biasa berhampiran suhu genting, Tc. Sampel dengan komposisi permulaan YBa2Cu3O7-δ(PbO)x untuk x = 0.00- 0.45 peratus berat (% bt.) telah disediakan melalui tindak balas keadaan pepejal. Analisis fluktuasi dan kekonduksian lebihan menggunakan teori Aslamazov-Larkin (AL) untuk menentukan dimensi kekonduksian l telah dijalankan. Teori Lawrence-Donaich (LD) pula digunakan untuk menentukan panjang koheren ξc(0), gandingan Josephson J dan anisotropi γ = (ξab(0)/ξc(0)). Suhu genting mula adalah tertinggi (Tc mula = 94 K) untuk sampel x = 0.35. Analisis kekonduksian menunjukkan PbO menyebabkan peralihan kekonduksian daripada 2 dimensi ke 3 dimensi dengan suhu peralihan, T2D–3D tertinggi bagi sampel x = 0.20 (120 K). Model Lawrence-Donaich menunjukkan panjang koheren ξc(0) adalah terpanjang dan anisotropi terendah bagi sampel x = 0.25. Sampel ini juga menunjukkan gandingan Josephson tertinggi, J = 0.296. Dua kesan yang mungkin berlaku akibat penambahan PbO ialah pembentukan bahan bukan superkonduktor dalam sampel dan peningkatan hubungan antara butiran yang meningkatkan sifat-sifat kesuperkonduksian.
  17. Afifah-radiah Fauzi, Mariati Abdul Rahman, Saliana A. Aziz, Norashikin Hamzah, Badiah Baharin, Norzana Abdul Ghafar
    Sains Malaysiana, 2016;45:1923-1930.
    Periodontitis adalah penyakit kronik yang melibatkan kehilangan tulang dan inflamasi pada tisu periodontium. Interleukin-6 (IL-6) dan Tumor Necrosis Factor-α (TNF-α) merupakan penanda pro-inflamasi yang penting yang terlibat dalam periodontitis. Sebanyak 20 ekor tikus Sprague-Dawley dibahagikan kepada empat kumpulan iaitu: Kumpulan kawalan dengan salin normal (CS); kumpulan kawalan dengan madu Gelam 3 g/mL (CH); kumpulan ujian periodontitis dengan salin normal (TS); dan kumpulan ujian periodontitis dengan madu Gelam 3 g/mL (TH). Benang bersaiz 4/0 diikat pada molar pertama gigi tikus sebelah kiri bagi tujuan rangsangan penyakit periodontitis. Madu Gelam diberi secara paksa oral selama 15 hari. Selepas 15 hari, sampel plasma dan tisu dianalisis menggunakan kaedah Elisa dan pewarnaan histologi. Kehilangan tulang alveolar pada kumpulan TS adalah paling tinggi berbanding dengan kumpulan kawalan, CS dan CH namun, tiada perbezaan yang signifikan berbanding dengan kumpulan TH. Berdasarkan ujian imunohistokimia, ekspresi IL-6 dan TNF-α pada tisu periodontium adalah tinggi secara signifikan pada kumpulan TS berbanding dengan kumpulan lain. Namun, tiada perubahan aras IL-6 dan TNF-α yang signifikan pada plasma ke semua tikus kajian.
  18. Nabilah Afiqah Mohd Radzuan, Abu Bakar Sulong, Somalu MR
    Sains Malaysiana, 2016;45:1931-1921.
    Proses penyemperitan merupakan salah satu proses pra-pencampuran yang dapat membantu meningkatkan tahap serakan
    bahan pengalir dalam komposit polimer pengalir (CPC). Tahap keberaliran elektrik dilihat tidak begitu memuaskan
    walaupun telah melalui proses serakan melalui pengacuan mekanik. Kajian ini dijalankan bagi mengoptimumkan
    proses penyemperitan bahan gentian karbon terkisar (MCF) dan polipropilena (PP) iaitu suhu penyemperitan dan halaju
    putaran melalui kaedah reka bentuk eksperimen (Taguchi). Susunan orthogonal Taguchi L9 digunakan bagi menentukan
    aras yang paling optimum serta menjalankan analisis varian bagi memperoleh nilai keberaliran elektrik yang paling
    baik. Pengoptimuman parameter pada suhu penyemperitan 210ºC hingga 250ºC dan halaju putaran 50 hingga 90 rpm
    menggunakan komposisi bahan sebanyak 80 % bt. MCF dan 20 % bt. PP dengan tahap keberaliran elektrik meningkat
    pada tahap maksimum 3.67 S/cm. Pengoptimuman parameter ini menunjukkan bahawa reka bentuk eksperimen yang
    terhasil mampu menghasilkan nilai keberaliran elektrik yang tinggi serta mempunyai sifat mekanik yang baik.
  19. Mohamad Hanif Kamal Roslan, Che Aziz Ali, Kamal Roslan Mohamed
    Sains Malaysiana, 2016;45:1897-1904.
    Batuan Formasi Singa yang terdiri daripada batu lumpur dominan, berselang lapis dengan batu lodak, batu pasir dan
    juga sedikit unit konglomerat tertabur secara meluas di kepulauan Langkawi. Formasi Singa boleh dibahagikan kepada
    sepuluh fasies sedimen dan empat sekutuan fasies. Keputusan kajian menunjukkan Formasi Singa telah terendap di
    lautan cetek, iaitu di sub-sekitaran luar pesisir, transisi, muka pesisir serta dalam alur. Lautan cetek Lembangan Singa
    dipengaruhi oleh iklim sejuk kerana terdapat sedimen asalan glasier, iaitu fasies batu lumpur berpebel. Kertas kerja ini
    akan menjelas dan membincangkan segala aspek sedimentologi formasi batuan ini.
    MeSH terms: Animals; Tetrahydroisoquinolines; Gastropoda
  20. Mohd. Suhaimi Ahmad, Muhammad Ridwan Fahmi, Mustaqqim Abdul Rahim, Naimah Ibrahim
    Sains Malaysiana, 2016;45:1857-1867.
    Suatu kajian untuk menilai kesan gabungan aktiviti guna tanah dan perubahan musim terhadap kualiti sumber air telah dijalankan di Terusan Utara, Kedah. Kajian ini dijalankan di lima stesen terpilih selama 12 bulan berdasarkan Indeks Kualiti Air (WQI) dan Piawaian Interim Kualiti Air Kebangsaan (INWQS). Kajian mendapati kualiti air di Terusan Utara berada pada Kelas III dan berlaku peningkatan kualiti air dari hulu ke hilir. Hampir semua stesen berpotensi sebagai punca pencemaran berdasarkan aktiviti guna tanah terutamanya di Pelubang, Jitra serta Tunjang. Kajian menunjukkan terdapat perbezaan yang signifikan ketika perubahan musim pada DO, TSS serta BOD, namun tidak pada ammonia, pH dan COD. Secara amnya, kombinasi aktiviti guna tanah dan perubahan musim boleh mempengaruhi atau memberi kesan terhadap kualiti sumber air. Oleh itu, tindakan segera perlu dilakukan untuk mengawal punca pencemaran bagi memastikan kualiti sumber air di Terusan Utara kekal terpelihara.
    MeSH terms: Ammonia; Animals; Hydrocarbons, Chlorinated; Tetrahydroisoquinolines; Bivalvia
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