Browse publications by year: 2018

  1. Abdul Kadir A, Mohd Arif MF, Ishak A, Hassan II, Mohd Noor N
    Biomed Res Int, 2018;2018:4329751.
    PMID: 29955601 DOI: 10.1155/2018/4329751
    Objective: To adapt and validate the Malay version of Osteoarthritis Knee and Hip Quality of Life (OAKHQOL) questionnaire.

    Design: The OAKHQOL was adapted into Malay version using forward-backward translation methodology. It was then validated in a cross-sectional study of 191 patients with knee osteoarthritis (OA). Patients completed the OAKHQOL and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire. Confirmatory analysis, reliability analysis, and Pearson correlation test were performed.

    Results: The new five-factor model of 28 items demonstrated an acceptable level of goodness of fit (comparative fit index = 0.915, Tucker-Lewis index = 0.905, incremental fit index = 0.916, chi-squared/degree of freedom = 1.953, and root mean square error of approximation = 0.071), signifying a fit model. The Cronbach's alpha value and the composite reliability of each construct ranged from 0.865 to 0.933 and 0.819 to 0.921, respectively. The Pearson correlation coefficient between the OAKHQOL and the WOMAC showed adequate criterion validity. Known groups validity showed statistical difference in body mass index in physical activity, mental health, and pain construct. The pain domain was statistically different between the age groups.

    Conclusion: The Malay version OAKHQOL questionnaire is a valid and reliable instrument to assess health-related quality of life in knee OA patients.
    MeSH terms: Aged; Cross-Sectional Studies; Female; Humans; Malaysia; Male; Middle Aged; Pain Measurement*; Psychometrics; Quality of Life*; Surveys and Questionnaires; Severity of Illness Index; Reproducibility of Results; Osteoarthritis, Hip*; Osteoarthritis, Knee*; Osteoarthritis, Knee/complications*
  2. Sorokowska A, Groyecka A, Karwowski M, Frackowiak T, Lansford JE, Ahmadi K, et al.
    Chem. Senses, 2018 08 24;43(7):503-513.
    PMID: 29955865 DOI: 10.1093/chemse/bjy038
    Olfaction plays an important role in human social communication, including multiple domains in which people often rely on their sense of smell in the social context. The importance of the sense of smell and its role can however vary inter-individually and culturally. Despite the growing body of literature on differences in olfactory performance or hedonic preferences across the globe, the aspects of a given culture as well as culturally universal individual differences affecting odor awareness in human social life remain unknown. Here, we conducted a large-scale analysis of data collected from 10 794 participants from 52 study sites from 44 countries all over the world. The aim of our research was to explore the potential individual and country-level correlates of odor awareness in the social context. The results show that the individual characteristics were more strongly related than country-level factors to self-reported odor awareness in different social contexts. A model including individual-level predictors (gender, age, material situation, education, and preferred social distance) provided a relatively good fit to the data, but adding country-level predictors (Human Development Index, population density, and average temperature) did not improve model parameters. Although there were some cross-cultural differences in social odor awareness, the main differentiating role was played by the individual differences. This suggests that people living in different cultures and different climate conditions may still share some similar patterns of odor awareness if they share other individual-level characteristics.
    MeSH terms: Metacognition/physiology; Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Models, Theoretical; Odors; Surveys and Questionnaires; Smell/physiology*; Social Behavior*; Olfactory Perception/physiology*; Young Adult; Social Norms
  3. Sirunyan AM, Tumasyan A, Adam W, Ambrogi F, Asilar E, Bergauer T, et al.
    Phys Rev Lett, 2018 Jun 15;120(24):241801.
    PMID: 29956995 DOI: 10.1103/PhysRevLett.120.241801
    A search for physics beyond the standard model in events with one or more high-momentum Higgs bosons, H, decaying to pairs of b quarks in association with missing transverse momentum is presented. The data, corresponding to an integrated luminosity of 35.9  fb^{-1}, were collected with the CMS detector at the LHC in proton-proton collisions at the center-of-mass energy sqrt[s]=13  TeV. The analysis utilizes a new b quark tagging technique based on jet substructure to identify jets from H→bb[over ¯]. Events are categorized by the multiplicity of H-tagged jets, jet mass, and the missing transverse momentum. No significant deviation from standard model expectations is observed. In the context of supersymmetry (SUSY), limits on the cross sections of pair-produced gluinos are set, assuming that gluinos decay to quark pairs, H (or Z), and the lightest SUSY particle, LSP, through an intermediate next-to-lightest SUSY particle, NLSP. With large mass splitting between the NLSP and LSP, and 100% NLSP branching fraction to H, the lower limit on the gluino mass is found to be 2010 GeV.
    MeSH terms: Motion; Motivation; Physics; Protons; United States; Physical Phenomena
  4. Oon YL, Ong SA, Ho LN, Wong YS, Dahalan FA, Oon YS, et al.
    Bioresour Technol, 2018 Oct;266:97-108.
    PMID: 29957296 DOI: 10.1016/j.biortech.2018.06.035
    This study explored the influence of azo dye concentration, salinity (with and without aeration) and nitrate concentration on bioelectricity generation and treatment performance in the up-flow constructed wetland-microbial fuel cell (UFCW-MFC) system. The decolourisation efficiencies were up to 91% for 500 mg/L of Acid Red 18 (AR18). However, the power density declined with the increment in azo dye concentration. The results suggest that the combination of salinity and aeration at an optimum level improved the power performance. The highest power density achieved was 8.67 mW/m2. The increase of nitrate by 3-fold led to decrease in decolourisation and power density of the system. The findings revealed that the electron acceptors (AR18, nitrate and anode) competed at the anodic region for electrons and the electron transfer pathways would directly influence the treatment and power performance of UFCW-MFC. The planted UFCW-MFC significantly outweighed the plant-free control in power performance.
    MeSH terms: Azo Compounds/isolation & purification*; Bioelectric Energy Sources*; Electricity; Electrodes; Wetlands*; Waste Water
  5. Khoo LW, Audrey Kow SF, Maulidiani M, Lee MT, Tan CP, Shaari K, et al.
    J Pharm Biomed Anal, 2018 Sep 05;158:438-450.
    PMID: 29957507 DOI: 10.1016/j.jpba.2018.06.038
    The present study sought to identify the key biomarkers and pathways involved in the induction of allergic sensitization to ovalbumin and to elucidate the potential anti-anaphylaxis property of Clinacanthus nutans (Burm. f.) Lindau water leaf extract, a Southeast Asia herb in an in vivo ovalbumin-induced active systemic anaphylaxis model evaluated by 1H-NMR metabolomics. The results revealed that carbohydrate metabolism (glucose, myo-inositol, galactarate) and lipid metabolism (glycerol, choline, sn-glycero-3-phosphocholine) are the key requisites for the induction of anaphylaxis reaction. Sensitized rats treated with 2000 mg/kg bw C. nutans extract before ovalbumin challenge showed a positive correlation with the normal group and was negatively related to the induced group. Further 1H-NMR analysis in complement with Kyoto Encyclopedia of Genes and Genomes (KEGG) reveals the protective effect of C. nutans extract against ovalbumin-induced anaphylaxis through the down-regulation of lipid metabolism (choline, sn-glycero-3-phosphocholine), carbohydrate and signal transduction system (glucose, myo-inositol, galactarate) and up-regulation of citrate cycle intermediates (citrate, 2-oxoglutarate, succinate), propanoate metabolism (1,2-propanediol), amino acid metabolism (betaine, N,N-dimethylglycine, methylguanidine, valine) and nucleotide metabolism (malonate, allantoin). In summary, this study reports for the first time, C. nutans water extract is a potential anti-anaphylactic agent and 1H-NMR metabolomics is a great alternative analytical tool to explicate the mechanism of action of anaphylaxis.
    MeSH terms: Anaphylaxis/blood; Anaphylaxis/immunology; Anaphylaxis/prevention & control*; Anaphylaxis/urine; Animals; Carbohydrates/blood; Carbohydrates/urine; Disease Models, Animal; Humans; Lipids/blood; Lipids/urine; Male; Ovalbumin/immunology; Plant Extracts/pharmacology*; Plant Extracts/therapeutic use; Biomarkers/analysis; Rats, Sprague-Dawley; Plant Leaves/chemistry; Protective Agents/pharmacology*; Protective Agents/therapeutic use; Acanthaceae/chemistry*; Carbohydrate Metabolism/drug effects; Carbohydrate Metabolism/immunology; Lipid Metabolism/drug effects; Lipid Metabolism/immunology; Rats; Metabolomics/instrumentation; Metabolomics/methods; Proton Magnetic Resonance Spectroscopy/instrumentation; Proton Magnetic Resonance Spectroscopy/methods*
  6. Wattanapisit A, Saengow U, Ng CJ, Thanamee S, Kaewruang N
    PLoS One, 2018;13(6):e0199813.
    PMID: 29958272 DOI: 10.1371/journal.pone.0199813
    Pokémon GO becomes the most rapidly downloaded mobile application in history. This study aimed to determine the physical activity of medical students, who played Pokémon GO, and the change in their use of Pokémon GO and physical activity over time. An observational study was conducted. Physical activity was measured by using self-administered questionnaires at baseline (phase 0), 1 month (phase 1) and 3 months (phase 2) post-Pokémon GO download. The changes in physical activity (phase 0 to 1 and phase 1 to 2) were analysed using Wilcoxon Signed Ranked test. The trend (3-point analysis) of physical activity from phase 0, 1 to 2 were analysed using Friedman's test. The relationship between physical activity and time spent gaming was analysed by using Spearman's rank correlation. Twenty-six participants (mean age 22.04±1.70 years) participated in the study. There was no statistically significant change in physical activity during the three-month period (p = 0.45). Only 11 participants (42.3%) were still playing Pokémon GO 3 months after download. The key reasons for playing game were 'have fun' and 'pass time/boredom'. The most common commuting mode to play the game was walking; some drove a car or motorcycle while playing the game. There was no correlation between physical activity and time spent gaming. This study highlights how the lack of sustainability of the game and the motivation behind using Pokémon GO as a game rather than a physical activity app may have undermined the potential of using the game to improve physical activity. Further studies need to explore the reasons for the lack of sustainability and how to combine fun with behavioural change.
    MeSH terms: Adolescent; Adult; Female; Humans; Male; Surveys and Questionnaires*; Exercise*; Video Games*; Mobile Applications*
  7. Lim YJ, Jamaluddin R, Hazizi AS, Chieng JY
    Nutrients, 2018 Jun 26;10(7).
    PMID: 29949873 DOI: 10.3390/nu10070824
    Synbiotics approach complementarily and synergistically toward the balance of gastrointestinal microbiota and improvement in bowel functions. A randomised, double-blind, placebo-controlled study was conducted to examine the effects of a synbiotics supplement among constipated adults. A total of 85 constipated adults, diagnosed by Rome III criteria for functional constipation were randomised to receive either synbiotics (n = 43) or placebo (n = 42) once daily (2.5 g) in the morning for 12 weeks. Eight times of follow-up was conducted every fortnightly with treatment response based on a questionnaire that included a record of evacuation (stool frequency, stool type according to Bristol Stool Form Scale), Patients Assessment on Constipation Symptoms (PAC-SYM), and Patients Assessment on Constipation Quality of Life (PAC-QOL). There were no significant differences in stool evacuation, but defecation frequency and stool type in treatment group were improved tremendously than in placebo group. While the treatment group was reported to have higher reduction in severity of functional constipation symptoms, the differences were not statistically significant. Dietary supplementation of synbiotics in this study suggested that the combination of probiotics and prebiotics improved the functional constipation symptoms and quality of life although not significant. This was due to the high placebo effect which synbiotics failed to demonstrate benefit over the controls.
    MeSH terms: Gastrointestinal Microbiome*; Adult; Constipation/diagnosis; Constipation/microbiology; Constipation/physiopathology; Constipation/therapy*; Defecation*; Double-Blind Method; Female; Gastrointestinal Motility*; Humans; Intestines/microbiology*; Intestines/physiopathology*; Malaysia; Male; Quality of Life; Time Factors; Treatment Outcome; Recovery of Function; Young Adult; Synbiotics/administration & dosage*; Synbiotics/adverse effects; Patient Outcome Assessment
  8. Koh KL, Sonny Teo KS, Chong MF, Wan Hitam WH
    BMJ Case Rep, 2018 Jun 27;2018.
    PMID: 29950366 DOI: 10.1136/bcr-2018-225113
    Non-arteritic anterior ischaemic optic neuropathy (NAION) may develop due to severe anaemia and hypotension which is seen in acute blood loss. The devastating visual loss is often irreversible. We report a case of NAION in a 20-year-old healthy woman, who presented on the third day of a heavy menstrual cycle with hypovolaemic shock. On day 2 of admission, she had sudden right eye blurring of vision at the superior field on awakening from sleep. Funduscopy revealed a pale and swollen right optic disc. There was a dense right superior altitudinal visual field defect. Her haemoglobin level was low (3.6 g/dL), but she refused blood transfusion due to her religious belief (Jehovah's Witness) and opted for conservative management. She later developed right optic atrophy with persistent visual field defect despite an improved haemoglobin level of 10.5 g/dL.
    MeSH terms: Female; Humans; Menorrhagia/complications*; Optic Disk/pathology; Vision Disorders/etiology*; Vision Disorders/pathology; Optic Neuropathy, Ischemic/etiology*; Optic Neuropathy, Ischemic/pathology; Young Adult; Visual Field Tests
  9. Tan JH, Ng ZQ, Tan HCL, Vendargon S
    BMJ Case Rep, 2018 Jun 27;2018.
    PMID: 29950501 DOI: 10.1136/bcr-2018-224741
    A 72-year-old Chinese man presented with mild symptoms of heart failure. Transthoracic echocardiography showed signs of cardiac tamponade though clinically he was relatively well. The option of pericardiocentesis was not carried out due to a narrow window for aspiration with only a thin layer of effusion seen surrounding the apex and right ventricle on subcostal view.Pericardial window was done via a left anterolateral thoracotomy. Intraoperatively, 500 cm3 of purulent fluid was drained. Microbiology screens were all negative. We present the atypical clinical course of this elderly man presenting with a large pyopericardium.
    MeSH terms: Aged; Cardiac Tamponade/etiology; Cardiac Tamponade/surgery; Drainage; Echocardiography*; Humans; Male; Medical Illustration; Pericardial Effusion/complications; Pericardial Effusion/surgery; Pericardial Window Techniques; Pericardium/surgery; Thoracotomy/methods
  10. Ismail A
    Nature, 2018 06;558(7711):514-515.
    PMID: 29950635 DOI: 10.1038/d41586-018-05509-y
    MeSH terms: Animals; Humans; Malaysia/epidemiology; Obesity/epidemiology; Science/economics*; Science/organization & administration; Science/trends*; Global Warming; Gross Domestic Product; Inventions/economics
  11. Ma NL, Aziz A, Teh KY, Lam SS, Cha TS
    Sci Rep, 2018 06 27;8(1):9746.
    PMID: 29950688 DOI: 10.1038/s41598-018-27894-0
    Nitrate is required to maintain the growth and metabolism of plant and animals. Nevertheless, in excess amount such as polluted water, its concentration can be harmful to living organisms such as microalgae. Recently, studies on microalgae response towards nutrient fluctuation are usually limited to lipid accumulation for the production of biofuels, disregarding the other potential of microalgae to be used in wastewater treatments and as source of important metabolites. Our study therefore captures the need to investigate overall metabolite changes via NMR spectroscopy approach coupled with multivariate data to understand the complex molecular process under high (4X) and low (1/4X) concentrations of nitrate ([Formula: see text]). NMR spectra with the aid of chemometric analysis revealed contrasting metabolites makeup under abundance and limited nitrate treatment. By using NMR technique, 43 types of metabolites and 8 types of fatty acid chains were detected. Nevertheless, only 20 key changes were observed and 16 were down regulated in limited nitrate condition. This paper has demonstrated the feasibility of NMR-based metabolomics approach to study the physiological impact of changing environment such as pollution to the implications for growth and productivity of microalgae population.
    MeSH terms: Animals; Fatty Acids; Lipids; Magnetic Resonance Imaging; Nitrates; Magnetic Resonance Spectroscopy; Water Pollution; Metabolomics; Biofuels; Microalgae; Waste Water
  12. Khamis NK, Deros BM
    J Phys Ther Sci, 2018 Jun;30(6):764-769.
    PMID: 29950761 DOI: 10.1589/jpts.30.764
    [Purpose] The purpose of this study was to investigate the effects of seat pressure distribution measurements based on a specific posture to predict the pressure felt level when seated. [Subjects and Methods] To examine the relationship between body pressure data and the driver's perception, eleven subjects were selected to participate in a simulated driving experiment using a pressure mat as a direct measurement method to measure the seat pan's pressure distribution. The buttock-popliteal length was measured using an anthropometer, and the pressure felt ratings evaluated after the body pressure measurements were recorded. Accordingly, this was then followed by performing statistical analysis using seat pressure measurements, and the buttock-popliteal length as independent variables along with subjective ratings selected of the pressure felt by the drivers' as dependent variables. [Results] The findings of this study suggest that the direct measurements and anthropometric body data are positively correlated with the predictive model thereby confirming the validity of the model with an R2 value of 0.952. [Conclusion] The proposed model is expected to provide a useful reference value for new vehicle drivers by providing the pressure felt level based on direct and body measurements in a specific posture.
    MeSH terms: Anthropometry; Automobile Driving; Buttocks; Posture; Pressure; Reference Values
  13. Ahmad Kamil MA, Mohd Affandi A
    Dermatol Res Pract, 2018;2018:2017959.
    PMID: 29951091 DOI: 10.1155/2018/2017959
    Introduction: Hidradenitis Suppurativa (HS) is a chronic inflammatory skin condition characterized by inflamed nodules, abscesses, sinus tracts, and scarring, which can occur in any skin containing folliculopilosebaceous units. We aim to identify the demographic and clinical characteristics and treatment modalities in patients with HS.

    Methods: A retrospective analysis involving records of patients diagnosed with HS in Hospital Kuala Lumpur from July 2009 to June 2016.

    Results: Sixty-two patients were identified, with equal cases involving males and females. Majority of patients were Malays (41.9%), followed by Indians (35.5%), Chinese (17.7%), and other ethnicities (4.8%). Median age at diagnosis was 25 (IQR: 14) years. There is a delay in diagnosis with a median of 24 (IQR: 52) months. Most of the patients had lesions on the axilla (85.5%), followed by groin (33.9%) and gluteal region (29%). Gluteal lesions were more common in males. Nodules (67.7%), sinuses (56.5%), and abscesses (33.9%) were the main clinical features, with 43.5% classified under Hurley stage 2. There was no difference in terms of symptoms and types of lesions among different ethnicities and genders. Majority received systemic antibiotics, more than half had retinoid, and third of the patients had surgical intervention.

    Conclusions: A prompt recognition of HS is imperative, to screen for comorbidities and to initiate early treatment to reduce physical and psychological complications.

    MeSH terms: Abscess; Anti-Bacterial Agents; Axilla; Buttocks; Cicatrix; Ethnic Groups; Female; Groin; Humans; Malaysia; Male; Retinoids; Retrospective Studies; Skin; Comorbidity; Hidradenitis Suppurativa
  14. Zainuri DA, Razak IA, Arshad S
    Acta Crystallogr E Crystallogr Commun, 2018 Jun 01;74(Pt 6):780-785.
    PMID: 29951229 DOI: 10.1107/S2056989018006527
    The mol-ecular and crystal structure of two new chalcone derivatives, (E)-1-(anthracen-9-yl)-3-[4-(piperidin-1-yl)phen-yl]prop-2-en-1-one, C28H25NO, (I), and (E)-1-(anthracen-9-yl)-3-[4-(di-phenyl-amino)-phen-yl]prop-2-en-1-one, C35H25NO, (II), with the fused-ring system at the same position are described. In the crystals of (I) and (II), the mol-ecules are linked via C-H⋯O hydrogen bonds into inversion dimers, forming R22(22) and R22(14) ring motifs, respectively. Weak inter-molecular C-H⋯π inter-actions further help to stabilize the crystal structure, forming a two-dimensional architecture. The mol-ecular structures are optimized using density functional theory (DFT) at B3LYP/6-311 G++(d,p) level and compared with the experimental results. The smallest HOMO-LUMO energy gaps of (I) (exp . 2.76 eV and DFT 3.40 eV) and (II) (exp . 2.70 eV and DFT 3.28 eV) indicates the suitability of these crystals in optoelectronic applications. All inter-molecular contacts and weaker contributions involved in the supra-molecular stabilization are investigated using Hirshfeld surface analysis. The mol-ecular electrostatic potential (MEP) further identifies the positive, negative and neutral electrostatic potential regions of the mol-ecules.
  15. Shawkataly OB, Abdelnasir HMH, Sirat SS, Jotani MM, Tiekink ERT
    Acta Crystallogr E Crystallogr Commun, 2018 Jun 01;74(Pt 6):791-795.
    PMID: 29951231 DOI: 10.1107/S2056989018006989
    The title cluster compound, [Ru3(C19H17PS)(CO)11], comprises a triangle of Ru0 atoms, two of which are bonded to four carbonyl ligands. The third metal atom is bound to three carbonyl ligands and the phosphane-P atom of a dissymmetric phosphane ligand, PPh2(C6H4SMe-4); no Ru⋯S inter-actions are observed. The phosphane occupies an equatorial position and its proximity to an Ru-Ru edge results in the elongation of this bond with respect to the others [2.8933 (2) Å cf. 2.8575 (2) and 2.8594 (3) Å]. In the crystal, phenyl-C-H⋯O(carbon-yl) and carbonyl-O⋯O(carbon-yl) [2.817 (2) Å] inter-actions combine to form a supra-molecular chain propagating along [111]; the chains pack without directional inter-actions between them. The carbonyl-O⋯O(carbon-yl) and other weak contacts have an influence upon the Hirshfeld surfaces with O⋯H contacts making the greatest contribution, i.e. 37.4% cf. 15.8% for O⋯O and 15.6% for H⋯H contacts.
  16. Kwong HC, Sim AJ, Chidan Kumar CS, Quah CK, Chantrapromma S, Naveen S, et al.
    Acta Crystallogr E Crystallogr Commun, 2018 Jun 01;74(Pt 6):835-839.
    PMID: 29951241 DOI: 10.1107/S2056989018007429
    In the bis-chalcone mol-ecule of the title compound, C24H18O4·2C3H7NO, the central benzene and terminal hy-droxy-phenyl rings form a dihedral angle of 14.28 (11)° and the central C=C double bond adopts a trans configuration. In the crystal, the bis-chalcone and solvate mol-ecules are inter-connected via O-H⋯O hydrogen bonds, which were investigated by Hirshfeld surface analysis. Solid-state fluorescence was measured at λex = 4400 Å. The emission wavelength appeared at 5510 Å, which corresponds to yellow light and the solid-state fluorescence quantum yield (Ff) is 0.18.
  17. Nurul Adilah Z, Liew WP, Mohd Redzwan S, Amin I
    Biomed Res Int, 2018;2018:9568351.
    PMID: 29951550 DOI: 10.1155/2018/9568351
    Probiotic Lactobacillus casei Shirota (LcS) is a potential decontaminating agent of aflatoxin B1 (AFB1). However, few studies have investigated the influence of diet, especially a high protein (HP) diet, on the binding of AFB1 by probiotics. This research was conducted to determine the effect of HP diet on the ability of LcS to bind AFB1 and reduce aflatoxin M1 (AFM1) in AFB1-induced rats. Sprague Dawley rats were randomly divided into three groups: A (HP only), B (HP + 108 CFU LcS + 25 μg AFB1/kg BW), and C (HP + 25 μg AFB1/kg BW). Levels of AST and ALP were higher in all groups but other liver function's biomarkers were in the normal range, and the liver's histology showed no structural changes. The urea level of rats in group B (10.02 ± 0.73 mmol/l) was significantly lower (p < 0.05) than that of rats in group A (10.82 ± 0.26 mmol/l). The presence of carcinoma in the small intestine and colon was more obvious in group C than in group B. Moreover, rats in group B had significantly (p < 0.05) lower AFM1 concentration (0.39 ± 0.01 ng/ml) than rats in group C (5.22 ± 0.28 ng/ml). Through these findings, LcS supplementation with HP diet alleviated the adverse effects of AFB1 by preventing AFB1 absorption in the small intestine and reducing urinary AFM1.
    MeSH terms: Animals; Lactobacillus casei; Male; Aflatoxin M1/metabolism*; Rats, Sprague-Dawley; Probiotics*; Rats
  18. Hak CH, Sim LC, Leong KH, Lim PF, Chin YH, Saravanan P
    Environ Sci Pollut Res Int, 2018 Sep;25(25):25401-25412.
    PMID: 29951757 DOI: 10.1007/s11356-018-2632-8
    In this work, natural sunlight successfully induced the deposition of gold (Au), silver (Ag), and palladium (Pd) nanoparticles (NPs) with 17.10, 9.07, and 12.70 wt% onto the surface of graphitic carbon nitride (g-C3N4). The photocatalytic evaluation was carried out by adopting Bisphenol A (BPA) as a pollutant under natural sunlight irradiation. The presence of noble metals was confirmed by EDX, HRTEM, and XPS analysis. The deposition of Ag NPs (7.9 nm) resulted in the degradation rate which was 2.15-fold higher than pure g-C3N4 due to its relatively small particle size, contributing to superior charge separation efficiency. Au/g-C3N4 unveiled inferior photoactivity because the LSPR phenomenon provided two pathways for electron transfer between Au NPs and g-C3N4 further diminished the performance. The improved degradation lies crucially on the particle size and Schottky barrier formation at the interface of M/g-C3N4 (M=Au, Ag, and Pd) but not the visible light harvesting properties. The mechanism insight revealed the holes (h+) and superoxide radical (•O2-) radical actively involved in photocatalytic reaction for all composites.
    MeSH terms: Benzhydryl Compounds*; Catalysis; Gold/radiation effects*; Graphite/chemistry; Light; Nitriles/chemistry*; Palladium/radiation effects*; Particle Size; Phenols*; Silver/radiation effects*; Sunlight*; Water Pollutants, Chemical/radiation effects*; Surface Plasmon Resonance; Nanoparticles
  19. Alfonso CA, Sutanto L, Zakaria H, Kalayasiri R, Lukman PR, Elvira SD, et al.
    BJPsych Int, 2018 Feb;15(1):8-11.
    PMID: 29953132 DOI: 10.1192/bji.2017.5
  20. Fung SY, Cheong PCH, Tan NH, Ng ST, Tan CS
    Int J Med Mushrooms, 2018;20(5):459-469.
    PMID: 29953361 DOI: 10.1615/IntJMedMushrooms.2018026252
    A cultivar of fruiting bodies of Ophiocordyceps sinensis (FBOS; OCS02) was analyzed for nutrients, bioactive compounds, and heavy metal content to showcase its potential as a competitive, sustainable, and safe alternative to wild types and other cultivars. A previous 28-day subacute toxicity study showed that doses up to 1 g · kg-1 did not cause any adverse effects in Sprague-Dawley rats. The OCS02 cultivar contained large amounts of cordycepin, polysaccharides, and essential and semi-essential amino acids (0.66, 482.80, 99.02, and 101.04 g · kg-1, respectively) compared with levels reported in wild types and in cultivated mycelia. β-1,3/1,6-glucan content was considerably high at 342.50 g · kg-1. The potassium level (5.14 g kg-1) tied in well with the low sodium content (0.121 g · kg-1)-6 times lower than amounts in wild types. We found no detectable levels of heavy metals such as lead, arsenic, cadmium, and mercury. The major amino acids found in FBOS (0CS02 cultivar) were arginine, lysine, serine, and threonine at 45.20, 20.30, 18.60, and 18.20 g · kg-1, respectively. The cultivated FBOS (OCS02 cultivar) is a comparable alternative to wild-type and other cultivated strains of O. sinensis. It has potential as a nutraceutical to meet market demand.
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